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100 results for “coagulopathies”
Data from: New criteria for sepsis-induced coagulopathy (SIC) following the revised sepsis definition: a retrospective analysis of a nationwide survey
OBJECTIVE: Recent clinical studies have shown that anticoagulant therapy might be effective only in specific at-risk subgroups of patients with sepsis and coagulation dysfunction. The definition of sepsis was recently modified and old scoring systems may no longer be proper for the diagnosis of sepsis-associated coagulopathy. The aim of this study was to evaluate prognostic factors in patients diagnosed as sepsis and coagulopathy according to the new sepsis definition and assess their accuracy in comparison to existing models. DESIGN, SETTING AND SUBJECTS: The data set was obtained from a post-marketing survey examining recombinant human soluble thrombomodulin and offered by Japanese Society on Thrombosis and Hemostasis. A total of 1498 patients with sepsis and coagulopathy complications who were treated with recombinant thrombomodulin were analyzed in this study. MAIN OUTCOME MEASURES: The platelet count, prothrombin time (PT) ratio, fibrinogen and fibrin degradation products (FDP), systemic inflammatory response syndrome (SIRS) score, and sequential organ failure assessment (SOFA) score obtained just before the start of treatment were examined in relation to the 28-day mortality rate. RESULTS: The platelet count, PT ratio, and total SOFA were independent predictors of a fatal outcome in a logistic regression model. A sepsis-induced coagulation (SIC) score was defined using the 3 above-mentioned variables with a positivity threshold of 4 points or more. The SIC score predicted higher 28-day mortality rate compared to the Japanese Association for Acute Medicine (JAAM)-DIC score (38.4% vs. 34.7%). CONCLUSIONS: The SIC scoring is based on readily available parameters, is easy to calculate and owns a high predictive value for 28-day mortality. Future studies are warranted to evaluate whether the SIC score may guide the decision to initiate anticoagulant therapy.
Pre-hospital Administration of Fibrinogen in Trauma-Induced Coagulopathy
ClinicalTrials.gov study NCT06582420. IPD Sharing: NO. Countries: 0. Publications: 19.
Management of Coagulopathy in Cirrhotic Patients Undergoing Invasive Procedures
ClinicalTrials.gov study NCT02987712. IPD Sharing: NO. Countries: 0. Publications: 16.
Thromboelastometry in Assessment of Sepsis Coagulopathy
ClinicalTrials.gov study NCT02971111. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Nafamostat Mesilate in the Treatment of Severe Infection-associated Coagulopathy
ClinicalTrials.gov study NCT06078839. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Data from: New criteria for sepsis-induced coagulopathy (SIC) following the revised sepsis definition: a retrospective analysis of a nationwide survey
Open the record for dataset details and reuse information.
A novel in vitro model of trauma-induced endotheliopathy provides a platform for studying mechanisms of coagulopathy
GEO Series GSE301085. Homo sapiens. 24 samples. Type: Expression profiling by high throughput sequencing.
Integrated single-cell multiomics reveals novel immune candidate markers for post-traumatic coagulopathy
GEO Series GSE223245. Homo sapiens. 16 samples. Type: Expression profiling by array.
Coagulopathy in Malnourished Mice is Sexually Dimorphic and Regulated by Nutrient-sensing Nuclear Receptors
GEO Series GSE156856. Mus musculus. 19 samples. Type: Expression profiling by high throughput sequencing.
Neutrophils restrain sepsis associated coagulopathy via extracellular vesicles carrying superoxide dismutase 2 in a murine model of lipopolysaccharide induced sepsis
GEO Series GSE206825. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Covid-19 Associated Coagulopathy Predicted by Thrombodynamic Markers (CoViTro-I)
ClinicalTrials.gov study NCT05330832. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Role of Fibrinolytic Activity in Neoplastic Pathologies Complicated by Coagulopathy
ClinicalTrials.gov study NCT07234630. IPD Sharing: NO. Countries: 1. Publications: 0.
Coagulopathy of Immunodermatologic Diseases
ClinicalTrials.gov study NCT06037187. IPD Sharing: NO. Countries: 1. Publications: 0.
Coagulopathy and SIRS During ECC in Intensive Care
ClinicalTrials.gov study NCT02352805. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Evaluating the Use of Thromboelastography to Diagnose Coagulopathy After Traumatic Brain Injury
ClinicalTrials.gov study NCT01589172. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Trauma Induced Coagulopathy and Inflammation
ClinicalTrials.gov study NCT03128658. IPD Sharing: NO. Countries: 1. Publications: 0.
Registry for Vascular Anomalies Associated With Coagulopathy
ClinicalTrials.gov study NCT00576888. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Comparison of the Diagnosis Time of VET and SCL in Patients With Intraoperative Coagulopathy
ClinicalTrials.gov study NCT06637943. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Embolization in Hereditary Coagulopathies
ClinicalTrials.gov study NCT05629130. IPD Sharing: NO. Countries: 1. Publications: 0.
Characterization of the Early Sex Hormone Milieu Post Injury and Relationship With Resuscitation Requirements and Coagulopathy
ClinicalTrials.gov study NCT01485419. IPD Sharing: Not stated. Countries: 1. Publications: 0.
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.