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363 results for “consciousness”
Multi-center observational study on occurrence and related clinical factors of neurogenic heterotopic ossification in patients with disorders of consciousness
<p><strong>Aims</strong>: to assess occurrence and clinical correlates of neurogenic heterotopic ossifications (NHO) in patients with prolonged disorder of consciousness (DoC).<strong>Design</strong>: multi-center cross-sectional observational study.<strong>Setting</strong>: 23 intensive neurorehabilitation units.<strong>Subjects</strong>: 287 patients with prolonged disorder of consciousness (DoC; 150 in vegetative state, VS, and 128 in minimally conscious state, MCS) of different etiology (vascular = 125, traumatic = 83, anoxic = 56, others = 14).<strong>Main Measures</strong>: clinical evidence of NHO confirmed by standard radiological and/or sonographic evaluation; Coma Recovery Scale-Revised; Disability Rating Scale (DRS); Early Rehabilitation Barthel Index; presence of ventilator support, spasticity, bone fractures and paroxysmal sympathetic hyperactivity.<strong>Results</strong>: 31 patients (11.2%) presented NHO. Univariate analyses showed that NHO was associated with VS diagnosis, traumatic etiology, high DRS category and total score, and high occurrence of limb spasticity and bone fractures. A cluster-corrected binary logistic regression model (excluding spasticity available in a subset of patients) showed that only lower DRS total score and presence of bone fractures were independently associated with NHO.<strong>Conclusions</strong>: NHO are relatively frequent in patients with DoC, and are independently associated with functional disability, bone fractures and spasticity. These findings contribute to identifying patients with DoC prone to develop NHO and requiring special interventions to improve functional recovery.</p>
Pupil dilation during orienting of attention and conscious detection of visual targets in patients with left spatial neglect
<p>Right Brain-Damaged patients (RBD) with left spatial neglect (N+), are characterised by deficits in orienting and re-orienting attention to stimuli in the contralesional left side of space. In a recent ERPs study with visual stimuli (Lasaponara et al., 2018) we have pointed out that the pathological attentional bias of N+ is matched with exaggerated novelty reaction and contextual updating of targets in the right ipsilesional space and reduced novelty reaction and contextual updating of targets in the left contralesional space. To characterise further the attentional performance of N+, here we measured Pupil Dilation (PDil), which is a reliable marker of noradrenergic-locus coeruleus activity and response to unexpected events/rewards. Compared to Neutral and Valid targets, N+ patients displayed a pathological reduction of PDil in response to infrequent Invalid targets in the left side of space, while in Healthy Controls (HC) and RBD without neglect (N-) the same targets enhanced PDil with respect to Neutral and frequent Valid targets. Invalid targets in the right side of space enhanced PDil in all experimental groups. Interestingly, both N- and N+ showed a consistent number of target omissions both in the left and right side of space. With respect to seen targets, N- showed reduced PDil in response to unseen targets both in the left and right side of space. In contrast, N+ had reduced PDil in response to unseen targets in the left side of space though not in the right side, where seen and unseen targets evoked comparable levels of PDil. These results disclose, for the first time, the PDil correlates of spatial attention in left spatial neglect and suggest that the pathological attentional bias suffered by N+ might enhance the autonomic responses reflected in PDil to unseen ipsilesional stimuli. This enhancement can contribute to biasing contextual updating and predictive coding of stimuli in the ipsilesional space, thus worsening the pathological attentional bias of N+.</p>
How much can we differentiate at a brief glance: Revealing the truer limit in conscious contents through the Massive Report Paradigm (MRP)
<p><span>Upon a brief glance, how well can we differentiate what we see from what we do not? Previous studies answered this question as "poorly". This is in stark contrast with our everyday experience. Here, we consider the possibility that previous restriction in stimulus variability and response alternatives reduced what participants could express from what they consciously experienced. We introduce a novel Massive Report paradigm that probes the ability to differentiate what we see from what we do not. In each trial, participants viewed a natural scene image and judged whether a small image patch was a part of the original image. To examine the limit of discriminability, we also included subtler changes in the image as modification of objects. Neither the images nor patches were repeated per participant. Our results showed that participants were highly accurate (accuracy > 80%) in differentiating patches from the viewed images from patches that are not present. Additionally, the differentiation between original and modified objects was influenced by object sizes and/or the congruence between objects and the scene gists. Our Massive Report paradigm opens a door to quantitatively measure the limit of immense informativeness of a moment of consciousness. </span></p>
The Early Functional Abilities-revised may bridge the gap between the disorder of consciousness and the functional independence scales: evidence from Rasch analysis
<p>Raw data associated with the scientific publication “The Early Functional Abilities-revised may bridge the gap between the disorder of consciousness and the functional independence scales: evidence from Rasch analysis”</p>
Prognostication of Recovery in Early Disorders of Consciousness After COVID-19
ClinicalTrials.gov study NCT04476589. IPD Sharing: UNDECIDED. Countries: 1. Publications: 2.
Role of the Serotonin 5-HT2A Receptor in Mescaline-induced Altered States of Consciousness
ClinicalTrials.gov study NCT04849013. IPD Sharing: NO. Countries: 1. Publications: 1.
Effects of Esketamine on Consciousness-related Brain Network Characteristics in Patients With Prolonged Disorders of Consciousness
ClinicalTrials.gov study NCT06473285. IPD Sharing: Not stated. Countries: 1. Publications: 0.
The Role of Music Stimulation in Disorders of Consciousness State: an fMRI Study
ClinicalTrials.gov study NCT03492294. IPD Sharing: YES. Countries: 1. Publications: 1.
Alprazolam as Conscious Sedation for Upper Gastrointestinal Endoscopy
ClinicalTrials.gov study NCT01949038. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Remifentanil Target Controlled Infusion Versus Standard of Care for Conscious Sedation During EBUS-TBNA
ClinicalTrials.gov study NCT06033729. IPD Sharing: NO. Countries: 1. Publications: 3.
A Trial Comparing High-flow Nasal Oxygen With Standard Management for Conscious Sedation During Endoscopic Retrograde Cholangiopancreatography in Prone Position
ClinicalTrials.gov study NCT03872674. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Characterization of Altered Waking States of Consciousness in Healthy Humans
ClinicalTrials.gov study NCT03853577. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Effect of Repeated tDCS Sessions on Cognitive Improvement in Patients With Disorders of Consciousness
ClinicalTrials.gov study NCT02394691. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Recovery of Consciousness Following Intracerebral Hemorrhage
ClinicalTrials.gov study NCT03990558. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Trial of Local Anaesthesia Versus Local Anaesthesia and Conscious Sedation for Hernioplasty
ClinicalTrials.gov study NCT02444260. IPD Sharing: Not stated. Countries: 1. Publications: 1.
HD-tDCS Combined With Circadian Rhythm Reconstruction and Micro Expression Changes on Consciousness Recovery in Patients With Chronic Disturbance of Consciousness
ClinicalTrials.gov study NCT05285124. IPD Sharing: NO. Countries: 1. Publications: 1.
Use of Analgesic Treatment to Reduce Signs of Pain in Patients With Disorders of Consciousness.
ClinicalTrials.gov study NCT04330547. IPD Sharing: Not stated. Countries: 1. Publications: 4.
CONsciousness Transcranial Electric STimulation
ClinicalTrials.gov study NCT03576248. IPD Sharing: NO. Countries: 1. Publications: 4.
Neuronal Correlates of Altered States of Consciousness
ClinicalTrials.gov study NCT02308969. IPD Sharing: Not stated. Countries: 1. Publications: 4.
The Neural Mechanisms of Anesthesia and Human Consciousness (Part 6)
ClinicalTrials.gov study NCT02624401. IPD Sharing: NO. Countries: 1. Publications: 5.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.