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49 results for “cushing disease”
Differential expression analysis between Microadenoma and Macroadenoma in Cushing's Disease
GEO Series GSE72490. Homo sapiens. 12 samples. Type: Expression profiling by array.
Cushing's disease adenomas
GEO Series GSE208112. Homo sapiens. 14 samples. Type: Expression profiling by high throughput sequencing.
RNA-seq comparing Cushing's disease adenomas and surrounding normal tissues
GEO Series GSE208107. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
3D-T1 image of Cushing disease
<p><span><a name="_Hlk27155760"></a><a name="_Hlk5056056"><b>Background:</b> The adverse effects of hypercortisolism on total human brain had been highlighted in previous neuroscience studies of Cushing's disease (CD). However, the regional alterations associated with hypercortisolism remains unclear. The present study was carried out to examine gray matter (GM) alterations according to the different stages of chronic hypercortisolism exposure.</a><a name="_Hlk10500200"> </a></span></p> <p><span><a name="_Hlk10500200"></a><a name="_Hlk10236838"><b>Design: </b>Although longitudinal studies have been traditionally used to address the question of reversibility of brain alterations in CD, these studies would probably ignore the irreversible alterations induced by hypercortisolism. Thus, information from cross-sectional neuroimaging studies may provide more useful contributions to further clarify this issue. </a></span></p> <p><span><a name="_Hlk10236838"><b>Methods: </b>To examine the GM alterations during hypercortisolism exposure and after resolution of the condition, ROI-based GM volumes (GMvs) of active and two biochemically remitted CD patient groups, as well as those of healthy control subjects were compared using the F test of one-way ANOVA. </a></span></p> <p><span><a name="_Hlk10236838"><b>Results: </b>Cross-sectional analysis demonstrated significant altered GMvs in most of the brain sub-regions. Moreover, different relationship between clinical characteristic and regional GMvs and diverse trends after resolution of hypercortisolism were found in CD patients, which suggested different response to the hypercortisolism in different brain sub-regions. </a></span></p> <p><span><a name="_Hlk10236838"> </a><b>Conclusion:</b> Our study enhances the understanding of the structural alterations due to hypercortisolism. Furthermore, our study may facilitate the development of future studies with neuropsychological tests.</span></p>
Health Status of the Patients Followed for a Disease of Cushing in the Region Large-West of 1990 to 2015
ClinicalTrials.gov study NCT03297892. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Adipokine Profile in Patients With Cushing's Disease on Pasireotide Treatment
ClinicalTrials.gov study NCT03080181. IPD Sharing: NO. Countries: 0. Publications: 0.
The Risk of Adrenal Insufficiency and Cushing Syndrome Associated With Glucocorticoid Therapy in People With Chronic Inflammatory Diseases
ClinicalTrials.gov study NCT03575247. IPD Sharing: NO. Countries: 0. Publications: 0.
3D-T1 image of Cushing disease
Open the record for dataset details and reuse information.
The Epigenomic Landscape of Pituitary Adenomas Reveals Specific Alterations and Differentiates Among Acromegaly, Cushing's Disease and Endocrine-Inactive Subtypes
GEO Series GSE147548. Homo sapiens. 36 samples. Type: Methylation profiling by array.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.