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101
datasets available to search
ShareScore release 0.7.1
Dataset results
101 results for “dsRNA”
EZH2 Inhibition Activates a dsRNA-STING-Interferon Stress Mechanism that Potentiates Response to PD-1 Check-Point Blockade in Prostate Cancer
GEO Series GSE146076. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
Sequence determinants of dsRNA processing by DICER [Rescue Experiment]
GEO Series GSE202533. Homo sapiens. 12 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Next Generation Sequencing Facilitates Quantitative Analysis of yeast cells lacking either M-2 dsRNA or both L-A-lus and M-2 dsRNA viruses
GEO Series GSE100290. Saccharomyces cerevisiae. 9 samples. Type: Expression profiling by high throughput sequencing.
Characterization of DCL4 missense alleles provides novel insights into its ability to process distinct classes of dsRNA substrates
GEO Series GSE106383. Arabidopsis thaliana. 6 samples. Type: Expression profiling by high throughput sequencing.
A Prenylated dsRNA Sensor Protects Against Severe COVID-19
GEO Series GSE182394. Homo sapiens. 17 samples. Type: Other.
Microarray analysis of immunity in response to injection of non-specific long dsRNA in kuruma shrimp, Marsupenaeus japonicus
GEO Series GSE61541. Penaeus japonicus. 32 samples. Type: Expression profiling by array.
Human dermal endothelial cells treated with sno U1 dsRNA and antimicrobial peptide LL-37
GEO Series GSE129160. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
The dsRNA-enriched neural transcriptome drives neuroinflammation [HuBCD]
GEO Series GSE214943. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
ICAM1 mRNA Functions Independently of Protein Coding to Inhibit Translation via a dsRNA-ILF2/ILF3 Pathway in Lung Cancer
GEO Series GSE277238. Homo sapiens. 32 samples. Type: Expression profiling by high throughput sequencing; Other.
Elimination of Saccharomyces paradoxus viral dsRNA leads to transcriptional and phenotypic alterations
GEO Series GSE153308. Saccharomyces paradoxus. 18 samples. Type: Expression profiling by high throughput sequencing.
Pro-inflammatory activity of SARS-CoV-2 viral peptide-dsRNA complex on human dermal microvascular endothelial cells (HDMVEC)
GEO Series GSE205487. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Evaluation of non-invasive dsRNA delivery methods for the development of RNA interference in the Asian tiger mosquito Aedes albopictus
<p>The Asian tiger mosquito Aedes albopictusis one of the most invasive species and an efficient vector of<br>several pathogens. RNA interference (RNAi) has been proposed as an alternative method to control<br>mosquito populations by silencing the expression of genes that are essential for their survival. However,<br>the optimal delivery method for dsRNAs to enhance an optimal RNAi remains elusive and comparative<br>studies are lacking. We have, therefore, compared the efficiency of three non-invasive delivery methods to<br>mosquito larvae: soaking, rehydration and nanoparticle ingestion. Each method was tested separately on<br>four genes predicted to code non-essential proteins (i.e. collagenase-like, kynurenine 3-monooxygenaselike, yellow-like and venom serine protease-like) in order to be able to compare the importance of gene<br>knock-down.<br>All tested methods successfully downregulated mosquito gene expression. However, silencing efficiency<br>strongly varies among methods and genes. Silencing (95.1%) was higher for Kynurenine 3-<br>monooxygenase-like with rehydration and nanoparticle ingestion (61.1%). For the Venom serine proteaselike, the most efficient silencing was observed with soaking (74.5%) and rehydration (34%). In contrast,<br>the selected methods are inefficient to silence the other genes. Our findings also indicate that gene copy<br>numbers, transcript sizes and GC content correlate with the silencing efficiency.<br>From our results, rehydration was the most specific and efficient methods to specifically knock-down<br>gene expression in Ae. albopictus larvae. Nevertheless, considering the observed variability of efficiency is<br>gene-dependent, our results also point at the necessity to test and optimize diverse dsRNA delivery<br>approaches to achieve a maximal RNAi efficiency.</p>
Comparative analysis of RNA interference and pattern-triggered immunity induced by dsRNA in response to virus infection
GEO Series GSE253964. Nicotiana benthamiana. 12 samples. Type: Expression profiling by high throughput sequencing.
Human dermal endothelial cells co-treated with dsRNA mimic poly IC and antimicrobial peptide LL-37
GEO Series GSE129152. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
The dsRBP and inactive editor, ADR-1, utilizes dsRNA binding to regulate A-to-I RNA editing across the C. elegans transcriptome
GEO Series GSE51556. Caenorhabditis elegans. 8 samples. Type: Expression profiling by high throughput sequencing.
ADAR1 regulates dsRNA formation in nuclear and mitochondrial transcripts through editing-dependent and -independent mechanisms
GEO Series GSE293278. Homo sapiens. 24 samples. Type: Expression profiling by high throughput sequencing; Other.
A specific dsRNA-binding protein complex selectively sequesters endogenous Inverted-Repeat siRNA precursors and inhibits their processing.
GEO Series GSE92309. Arabidopsis thaliana. 4 samples. Type: Non-coding RNA profiling by high throughput sequencing.
IBR1: A Novel Endogenous dsRNA Binding to the Helicase Domain of IFIH1 and Its Role in LPS-induced IFIH1 Activation and Macrophage M1 Polarization in ARDS [ATAC, ChIP]
GEO Series GSE247176. Mus musculus. 10 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Ubiquitous expression of long dsRNA in mice causes mainly RNAi effects in the oocyte
GEO Series GSE26577. Mus musculus; Homo sapiens. 4 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Pericentromeric hypomethylation elicits an interferon response in an animal model of ICF syndrome [dsRNA-seq]
GEO Series GSE116359. Danio rerio. 12 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.