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756 results for “endovascular”
Data from: Endovascular treatment in older adults with acute ischemic stroke in the MR CLEAN Registry
<p><strong>Objective</strong>: To explore clinical outcomes in older adults with acute ischemic stroke treated with endovascular thrombectomy (EVT).</p> <p><strong>Methods</strong>: We included consecutive patients (2014–2016) with an anterior circulation occlusion undergoing EVT from the MR CLEAN Registry. We assessed the effect of age (dichotomized at ≥80 years, and as continuous variable) on the modified Rankin Scale [mRS] score at 90 days, symptomatic intracranial hemorrhage (sICH), and reperfusion rate. The association between age and mRS was assessed with multivariable ordinal logistic regression, and a multiplicative interaction term was added to the model to assess modification of reperfusion by age on outcome.</p> <p><strong>Results</strong>: 380/1526 (25%) of patients were 80 years or older (=older adults). Older adults had a worse functional outcome than younger patients (adjusted common OR for an mRS shift towards better outcome: 0.31, 95%CI 0.24–0.39). Mortality was also higher in older adults (51% vs. 22%, aOR 3.12, 95%CI 2.33–4.19). There were no differences in proportion of patients with mRS 4-5, sICH, or reperfusion rates. Successful reperfusion was more strongly associated with a shift towards good functional outcome in older adults than in younger patients (acOR 3.22, 95%CI 2.04–5.10 vs. 2.00, 95%CI 1.56–2.57, P<sub>interaction</sub>=0.026).</p> <p><strong>Conclusion</strong>: Older age is associated with an increased absolute risk of poor clinical outcome, while the relative benefit of successful reperfusion seems to be higher in these patients. These results should be taken into consideration when selecting older adults for EVT.</p>
Supplemental files for Clinical outcome after endovascular treatment in patients with active cancer and ischemic stroke: a MR CLEAN Registry substudy
<p>Supplemental files for Clinical outcome after endovascular treatment in patients with active cancer and ischemic stroke: a MR CLEAN Registry substudy</p>
Supplemental material for: Clinical and neuroimaging outcomes of direct endovascular thrombectomy vs. bridging therapy in large vessel occlusion patients: a secondary analysis of SELECT cohort study
<p><b>Objective:</b> To evaluate the comparative safety and efficacy of direct endovascular thrombectomy(dEVT) compared to bridging therapy(BT:IV-tPA+EVT) and assess if BT potential benefit relates to stroke severity, size and initial presentation to EVT vs. non-EVT center.</p> <p><b>Methods:</b> In a prospective multicenter cohort-study of imaging selection for endovascular thrombectomy[SELECT], anterior-circulation large vessel occlusion (LVO) patients presenting to EVT-capable centers within 4.5hours from last-known-well were stratified into BT vs. dEVT.<b><i> </i></b>The primary outcome was 90-day functional independence[modified Rankin Scale(mRS)=0-2]. Secondary outcomes included a shift across 90-day mRS grades, mortality, symptomatic intracranial hemorrhage. We also performed subgroup-analyses according to initial presentation to EVT-capable center (direct versus transfer), stroke severity and baseline infarct core volume.</p> <p><b>Results:</b> We identified 226 LVOs (54%:men, mean age:65.6±14.6years, median NIHSS-score: 17, 28% received dEVT). Median time from arrival to groin-puncture did not differ in BT-patients when presenting directly[dEVT:1.43 (IQR=1.13-1.90) hours vs. BT:1.58(IQR=1.27-2.02)hours,p=0.40] or transferred to EVT-capable centers[dEVT:1.17 (IQR: 0.90-1.48) hours vs. BT:1.27 (IQR: 0.97-1.87) hours,p=0.24]. BT was associated with higher odds of 90-day functional independence (57% vs. 44%,aOR=2.02,95%CI:1.01-4.03,p=0.046) and functional improvement (adjusted cOR=2.06,95%CI:1.18-3.60,p=0.011), and lower likelihood of 90-day mortality (11% vs. 23%,aOR: 0.20,95%CI:0.07-0.58,p=0.003). No differences in any other outcomes were detected. In subgroup-analyses, BT patients with baseline NIHSS-scores<15 had higher functional independence likelihood compared to dEVT (aOR=4.87,95%CI:1.56-15.18,p=0.006); this association was not evident for patients with NIHSS-scores≥15 (aOR=1.05,95%CI:0.40-2.74,p=0.92). Similarly, functional outcomes improvements with BT were detected in patients with core volume strata (Ischemic core <50cc: aOR: 2.10, 95% CI:1.02-4.33, p=0.044 vs ischemic core ≥50cc: aOR: 0.41,95% CI:0.01-16.02,p=0.64) and transfer status (transferred: aOR: 2.21,95% CI:0.93-9.65,p=0.29 vs direct to EVT center: aOR:1.84,95%CI:0.80-4.23,p=0.15). </p> <p><b>Conclusions:</b> Bridging therapy appears to be associated with better clinical outcomes, especially with milder NIHSS-scores, smaller presentation core volumes and those who were "dripped and shipped".</p> <p><b>Classification of Evidence: </b>This study provides Class III evidence that for patients with ischemic stroke from anterior-circulation LVO within 4.5 hours from last-known-well, bridging therapy compared to direct endovascular thrombectomy leads to better 90-day functional outcomes.</p>
iMPI – portable human-sized Magnetic Particle Imaging Scanner for real-time endovascular Interventions
<p>Supporting files for manuscript:</p> <p>"<strong><em>i</em></strong><strong>MPI – portable human-sized Magnetic Particle Imaging Scanner for real-time endovascular Interventions"</strong></p>
Fusion Imaging in Endovascular Thrombectomy for Acute Ischemic Stroke
ClinicalTrials.gov study NCT06975696. IPD Sharing: NO. Countries: 2. Publications: 10.
Low-Frequency REpetitive TRanscranial Magnetic Stimulation Combined With Endovascular Treatment in ACute Ischemic StrokE
ClinicalTrials.gov study NCT06064747. IPD Sharing: NO. Countries: 1. Publications: 1.
Endovascular Versus Open Repair of the Common Femoral Artery
ClinicalTrials.gov study NCT01353651. IPD Sharing: Not stated. Countries: 1. Publications: 1.
One-Stop manaGemEnT For A Swift Initiation of Endovascular Therapy
ClinicalTrials.gov study NCT07052045. IPD Sharing: YES. Countries: 2. Publications: 2.
Prospective, Single-Arm, Multicenter Study to Evaluate the Effectiveness and Safety of Endovascular Treatment in Patients With Cerebral Aneurysms Using P64 and P48 Flow-Diverter Stents
ClinicalTrials.gov study NCT06201598. IPD Sharing: NO. Countries: 1. Publications: 16.
ATILA Project: Aspirin Versus Tirofiban in Endovascular Treatment for Patients With Acute Ischemic Stroke Due to Tandem Lesion
ClinicalTrials.gov study NCT05225961. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Endovascular Treatment of TAAA and Aortic Arch Aneurysms Using Fenestrated and Branched Stent Grafts
ClinicalTrials.gov study NCT02323581. IPD Sharing: Not stated. Countries: 1. Publications: 26.
Minocycline for Acute Ischemic Stroke Undergoing Endovascular Treatment Due to Basilar Artery Occlusion (MIST-B)
ClinicalTrials.gov study NCT05512910. IPD Sharing: NO. Countries: 1. Publications: 28.
Eptifibatide in Endovascular Treatment of Acute Ischemic Stroke (EPOCH)
ClinicalTrials.gov study NCT03844594. IPD Sharing: Not stated. Countries: 1. Publications: 1.
BEST SFA Pilot Study - Best Endovascular STrategy for Complex Lesions of the Superficial Femoral Artery
ClinicalTrials.gov study NCT03776799. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Registry of Patients Treated by Preloaded Fenestrated Stent-graft Designs for Complex Endovascular Aortic Procedures
ClinicalTrials.gov study NCT05141123. IPD Sharing: NO. Countries: 8. Publications: 5.
Mode of Sedation During Endovascular Treatment of Vertebrobasilar Stroke
ClinicalTrials.gov study NCT05525325. IPD Sharing: NO. Countries: 1. Publications: 3.
Use of Three-Dimensional Printed Models for Endovascular Planning and Follow-up in Patients Affected by Aorto-Iliac-Femoral-Popliteal Arterial Disease Undergoing Balloon Angioplasty. A Single-center,
ClinicalTrials.gov study NCT07000097. IPD Sharing: NO. Countries: 1. Publications: 0.
Endovascular Repair With Fenestrated TREO Stent-Graft System in AAA
ClinicalTrials.gov study NCT07026877. IPD Sharing: NO. Countries: 1. Publications: 18.
STARZ-TX2 Clinical Study: Study of Thoracic Aortic Aneurysm Repair With the Zenith TX2 Endovascular Graft
ClinicalTrials.gov study NCT00111176. IPD Sharing: Not stated. Countries: 3. Publications: 1.
Prognostic Prediction Model of Patients With AcUte Stroke undeRgoing EndOvascular TheRApy (AURORA)
ClinicalTrials.gov study NCT06009315. IPD Sharing: Not stated. Countries: 1. Publications: 1.
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