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49
datasets available to search
ShareScore release 0.9.0
Dataset results
49 results for “gene family evolution”
Epigenetic evolution of the Ly49 gene family [nanoCAGE]
GEO Series GSE226501. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Epigenetic evolution of the Ly49 gene family
GEO Series GSE226502. Mus musculus; Rattus norvegicus. 65 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Methylation profiling by high throughput sequencing; Other.
Epigenetic evolution of the Ly49 gene family [Bisulfite-Seq]
GEO Series GSE226500. Mus musculus. 8 samples. Type: Methylation profiling by high throughput sequencing.
Data from: Birth-and-death evolution of the fatty acyl-CoA reductase (FAR) gene family and diversification of cuticular hydrocarbon synthesis in Drosophila
The birth-and-death evolutionary model proposes that some members of a multigene family are phylogenetically stable and persist as a single copy over time whereas other members are phylogenetically unstable and undergo frequent duplication and loss. Functional studies suggest that stable genes are likely to encode essential functions, while rapidly evolving genes reflect phenotypic differences in traits that diverge rapidly among species. One such class of rapidly diverging traits are insect cuticular hydrocarbons (CHCs), which play dual roles in chemical communications as short-range recognition pheromones as well as protecting the insect from desiccation. Insect CHCs diverge rapidly between related species leading to ecological adaptation and/or reproductive isolation. Because the CHC and essential fatty acid biosynthetic pathways share common genes, we hypothesized that genes involved in the synthesis of CHCs would be evolutionary unstable, while those involved in fatty acid-associated essential functions would be evolutionary stable. To test this hypothesis, we investigated the evolutionary history of the fatty acyl-CoA reductases (FARs) gene family that encodes enzymes in CHC synthesis. We compiled a unique dataset of 200 FAR proteins across 12 Drosophila species. We uncovered a broad diversity in FAR content which is generated by gene duplications, subsequent gene losses, and alternative splicing. We also show that FARs expressed in oenocytes and presumably involved in CHC synthesis are more unstable than FARs from other tissues. Taken together, our study provides empirical evidence that a comparative approach investigating the birth-and-death evolution of gene families can identify candidate genes involved in rapidly diverging traits between species.
Data from: Birth-and-death evolution of the fatty acyl-CoA reductase (FAR) gene family and diversification of cuticular hydrocarbon synthesis in Drosophila
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Epigenetic evolution of the Ly49 gene family [ATAC-Seq]
GEO Series GSE226498. Mus musculus; Rattus norvegicus. 27 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Epigenetic evolution of the Ly49 gene family [NanoPore]
GEO Series GSE233982. Mus musculus. 2 samples. Type: Other.
Epigenetic evolution of the Ly49 gene family [Hi-C]
GEO Series GSE226499. Mus musculus. 5 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Coordinated Gene Family Evolution Shapes the Genome of Dimorphic Organisms
GEO Series GSE293402. Mucor lusitanicus. 27 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.