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opencc-zeroDec 2019View details →

Data from: Length polymorphisms at two candidate genes explain variation of migratory behaviors in blackpoll warblers (Setophaga striata)

Migratory behaviors such as the timing and duration of migration are genetically inherited and can be under strong natural selection, yet we still know very little about the specific genes or molecular pathways that control these behaviors. Studies in candidate genes Clock and Adcyap1 have revealed that both of these loci can be significantly correlated with migratory behaviors in birds, though observed relationships appear to vary across species. We investigated geographic genetic structure of Clock and Adcyap1 in four populations of blackpoll warblers (Setophaga striata), a Neotropical-Nearctic migrant that exhibits geographic variation in migratory timing and duration across its boreal breeding distribution. Further, we used data on migratory timing and duration, obtained from light-level geolocator trackers to investigate candidate genotype-phenotype relationships at the individual level. While we found no geographic structure in either candidate gene, we did find evidence that candidate gene lengths are correlated with five of the six migratory traits. Maximum Clock allele length was significantly and negatively associated with spring arrival date. Minimum Adcyap1 allele length was significantly and negatively associated with spring departure date and positively associated with fall arrival date at the wintering grounds. Additionally, we found a significant interaction between Clock and Adcyap1 allele lengths on both spring and fall migratory duration. Adcyap1 heterozygotes also had significantly shorter migration duration in both spring and fall compared to homozygotes. Our results support the growing body of evidence that Clock and Adcyap1 allele lengths are correlated with migratory behaviors in birds.

opencc-zeroDec 2018View details →

Data from: Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard

Reptiles use pterin and carotenoid pigments to produce yellow, orange, and red colors. These conspicuous colors serve a diversity of signaling functions, but their molecular basis remains unresolved. Here, we show that the genomes of sympatric color morphs of the European common wall lizard (Podarcis muralis), which differ in orange and yellow pigmentation and in their ecology and behavior, are virtually undifferentiated. Genetic differences are restricted to two small regulatory regions, near genes associated with pterin (SPR) and carotenoid metabolism (BCO2), demonstrating that a core gene in the housekeeping pathway of pterin biosynthesis has been co-opted for bright coloration in reptiles and indicating that these loci exert pleiotropic effects on other aspects of physiology. Pigmentation differences are explained by extremely divergent alleles and haplotype analysis revealed abundant trans-specific allele sharing with other lacertids exhibiting color polymorphisms. The evolution of these conspicuous color ornaments is the result of ancient genetic variation and cross-species hybridization.

opencc-zeroDec 2012View details →

Data from: Environmental adaptation contributes to gene polymorphism across the Arabidopsis thaliana genome

The level of within-species polymorphism differs greatly among genes in a genome. Many genomic studies have investigated the relationship between gene polymorphism and factors such as recombination rate or expression pattern. However, the polymorphism of a gene is affected not only by its physical properties or functional constraints, but also by natural selection on organisms in their environments. Specifically, if functionally divergent alleles enable adaptation to different environments, locus-specific polymorphism may be maintained by spatially heterogeneous natural selection. To test this hypothesis and estimate the extent to which environmental selection shapes the pattern of genome-wide polymorphism, we define the 'environmental relevance' of a gene as the proportion of genetic variation explained by environmental factors, after controlling for population structure. We found substantial effects of environmental relevance on patterns of polymorphism among genes. In addition, the correlation between environmental relevance and gene polymorphism is positive, consistent with the expectation that balancing selection among heterogeneous environments maintains genetic variation at ecologically important genes. Comparison of the gene ontology annotations shows that genes with high environmental relevance are enriched in unknown function categories. These results suggest an important role for environmental factors in shaping genome-wide patterns of polymorphism and indicate another direction of genomic study.

opencc-zeroDec 2012View details →

Data from: Candidate gene polymorphisms for behavioural adaptations during urbanization in blackbirds

Successful urban colonisation by formerly rural species represents an ideal situation in which to study adaptation to novel environments. We address this issue using candidate genes for behavioural traits that are expected to play a role in such colonisation events. We identified and genotyped 16 polymorphisms in candidate genes for circadian rhythms, harm avoidance, and migratory and exploratory behaviour in 12 paired urban and rural populations of the blackbird Turdus merula across the Western Palearctic. An exonic microsatellite in the SERT gene, a candidate gene for harm avoidance behaviour, exhibited a highly significant association with habitat type in an analysis conducted across all populations. Genetic divergence at this locus was consistent in 10 of the 12 population pairs; this contrasts with previously reported stochastic genetic divergence between these populations at random markers. Our results indicate that behavioural traits related to harm avoidance and associated with the SERT polymorphism experience selection pressures during most blackbird urbanization events. These events thus appear to be influenced by homogeneous adaptive processes in addition to previously reported demographic founder events.

opencc-by-4.0Nov 2023View details →

Underlying data for The Impact of ABCB1 (rs1045642 and rs117068084) Gene Polymorphisms on Response to Imatinib Treatment in A Sample of Iraqi Chronic Myeloid Leukemia-Chronic Phase Patients

Underlying data for The Impact of ABCB1 (rs1045642 and rs117068084) Gene Polymorphisms on Response to Imatinib Treatment in A Sample of Iraqi Chronic Myeloid Leukemia-Chronic Phase Patients

opencc-by-4.0Oct 2023View details →

Genetic variability among and within domestic Old and New World Camels at the α-lactalbumin gene (LALBA) reveals new alleles and polymorphisms responsible for differential expression

Supplementary Figure 1. Schematic representation of the LALBA gene in camelids. Boxes indicate the exons (black for the un-translated, white for the signal peptide and grey for the translated). The line shows introns, 5’- and 3’-flanking regions. Supplementary Figure 2. Alignment of the α-LA calcium-binding site (red rectangle) of 23 terrestrial species available in the UniProt database (<a href="http://www.uniprot.org/uniprot/">http://www.uniprot.org/uniprot/</a>). The calcium-binding site in the Camelus dromedarius is indicated by a yellow rectangle.

opennotspecifiedJun 2022View details →

Fig.2 in Contributions to Trachelyopterus (Siluriformes: Auchenipteridae) species diagnosis by cytotaxonomic autapomorphies: from U2 snRNA chromosome polymorphism to rDNA and histone gene synteny

Fig.2 Karyotypes of T. striatulus (a), T. galeatus (b), and Trachelyopterus aff. galeatus (c). m: metacentric; sm: submetacentric; st: subtelocentric; a: acrocentric. Probes: 18S rDNA, 5S rDNA and U2 snRNA (green signal); and H3/H4 histone genes (red signal) µm. Bar=5 µm

opennotspecifiedJun 2022View details →

Fig. 1 in Contributions to Trachelyopterus (Siluriformes: Auchenipteridae) species diagnosis by cytotaxonomic autapomorphies: from U2 snRNA chromosome polymorphism to rDNA and histone gene synteny

Fig. 1 Karyotypes of Trachelyopterus porosus (a), T. galeatus coriaceus (b), and Trachelyopterus aff. coriaceus (c). m: metacentric; sm: submetacentric; st: subtelocentric; a: acrocentric. Probes: 18S rDNA, 5S rDNA and U2 snRNA (green signal); and H3/H4 histone genes (red signal). Bar= 5 µm

opencc-by-4.0Nov 2022View details →

Demographic data, disease characteristics, and laboratory findings for Association between polymorphisms within gene coding for tumor necrosis factor (TNF)-alpha with outcomes of treatment in sample of Iraqi patients with Ankylosing Spondylitis taking Etanercept

Demographic data, disease characteristics, and laboratory findings for  Association between polymorphisms within gene coding for tumor necrosis factor (TNF)-alpha with outcomes of treatment in sample of Iraqi patients with Ankylosing Spondylitis taking Etanercept

opencc-zeroJan 2023View details →

Candidate gene polymorphisms are linked to dispersive and migratory behaviour: searching for a mechanism behind the "paradox of the great speciators"

The "paradox of the great speciators" has puzzled evolutionary biologists for over half a century. A great speciator requires excellent dispersal propensity to explain its occurrence on multiple islands, but reduced dispersal ability to explain its high number of subspecies. A rapid reduction in dispersal ability is often invoked to solve this apparent paradox, but a proximate mechanism has not been identified yet. Here, we explored the role of six genes linked to migration and animal personality differences (CREB1, CLOCK, ADCYAP1, NPAS2, DRD4, and SERT) in 20 South Pacific populations of silvereye (Zosterops lateralis) that range from highly sedentary to partially migratory, to determine if genetic variation is associated with dispersal propensity and migration. We detected genetic associations in three of the six genes: i) in a partial migrant population, migrant individuals had longer microsatellite alleles at the CLOCK gene compared to resident individuals from the same population; ii) CREB1 displayed longer average microsatellite allele lengths in recently colonised island populations (< 200 years), compared to evolutionarily older populations. Bayesian broken stick regression models supported a reduction in CREB1 length with time since colonisation; and iii) like CREB1, DRD4 showed differences in polymorphisms between recent and old colonisations but a larger sample is needed to confirm. ADCYAP1, SERT, and NPAS2 were variable but that variation was not associated with dispersal propensity. The association of genetic variants at three genes with migration and dispersal ability in silvereyes provides the impetus for further exploration of genetic mechanisms underlying dispersal shifts and the prospect of resolving a long-running evolutionary paradox through a genetic lens.

controlledIPD-YESFeb 2026View details →

POCD: Correlations With the Gene Polymorphism and the Concentrations of Plasma Homocysteine, Folic Acid and Vitamin B12.

ClinicalTrials.gov study NCT03084393. IPD Sharing: YES. Countries: 1. Publications: 1.

Irisin Expression and Gene Polymorphism in Type II Diabetic Patients With and Without CAD

ClinicalTrials.gov study NCT04957823. IPD Sharing: Not stated. Countries: 1. Publications: 1.

Desiccated Thyroid Extract Versus Synthetic T3/T4 Combination (ThyrolarTM) Versus L-T4 Alone in the Therapy of Primary Hypothyroidism With Special Attention to the Gene Polymorphism

ClinicalTrials.gov study NCT02317926. IPD Sharing: Not stated. Countries: 1. Publications: 1.

B2 Adrenergic Receptor Gene Polymorphism in Bronchial Asthma

ClinicalTrials.gov study NCT03118869. IPD Sharing: NO. Countries: 1. Publications: 1.

Assessment of FOXP3 Gene Polymorphisms and Serum Interleukin 10 in Patients With ITP

ClinicalTrials.gov study NCT05410249. IPD Sharing: NO. Countries: 1. Publications: 1.

This Study Investigates the Impact of Single Nucleotide Polymorphisms in Genes Involved in the Pharmacokinetics and Toxicity of Doxorubicin (DOX) in Egyptian Female Patients with Breast Cancer. It Als

ClinicalTrials.gov study NCT06595758. IPD Sharing: NO. Countries: 1. Publications: 2.

The Role of Angiotensinogen Gene Polymorphism in the Pathogenesis of Non-familial Sick Sinus Syndrome

ClinicalTrials.gov study NCT01310920. IPD Sharing: Not stated. Countries: 1. Publications: 1.

Association of BsmI Polymorphisms in Vitamin D Receptor Gene With Diabetic Kidney Disease

ClinicalTrials.gov study NCT03621384. IPD Sharing: UNDECIDED. Countries: 1. Publications: 13.

Association of Previously Verified Gene Polymorphisms With AMD in Turkish Population

ClinicalTrials.gov study NCT02248324. IPD Sharing: Not stated. Countries: 1. Publications: 23.

The Association of Gene Polymorphisms With Invasive Bacterial Infections in Neonates and Young Infants

ClinicalTrials.gov study NCT06985160. IPD Sharing: NO. Countries: 1. Publications: 8.