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144
datasets available to search
ShareScore release 0.9.0
Dataset results
144 results for “genetic modifiers”
Genetics of Charcot Marie Tooth (CMT) - Modifiers of CMT1A, New Causes of CMT2
ClinicalTrials.gov study NCT01193088. IPD Sharing: YES. Countries: 5. Publications: 1.
Genetically Modified Haploidentical Natural Killer Cell Infusions for B-Lineage Acute Lymphoblastic Leukemia
ClinicalTrials.gov study NCT00995137. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Genetic Modifiers for 22q11.2 Syndrome
ClinicalTrials.gov study NCT00916955. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Phase I Study of T-Cells Genetically Modified at the CCR5 Gene by Zinc Finger Nucleases SB-728mR in HIV-Infected Patients
ClinicalTrials.gov study NCT02388594. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Autologous T-Cells Genetically Modified at the CCR5 Gene by Zinc Finger Nucleases SB-728 for HIV
ClinicalTrials.gov study NCT00842634. IPD Sharing: NO. Countries: 1. Publications: 1.
Genetic Modifiers of Cystic Fibrosis Related Diabetes
ClinicalTrials.gov study NCT01113216. IPD Sharing: NO. Countries: 1. Publications: 5.
An Open Label Phase I Study to Eval the Safety and Tolerability of a Vaccine (GI-6207) Consisting of Whole, Heat-killed Recombinant Saccharomyces Cerevisiae (Yeast) Genetically Modified to Express CEA
ClinicalTrials.gov study NCT00924092. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Data from: Detection of airborne genetically modified maize pollen by real-time PCR
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Monitoring and traceability of genetically modified soybean event GTS 40-3-2 during soybean protein concentrate and isolate preparation
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Data from: Hybridization between genetically modified Atlantic salmon and wild brown trout reveals novel ecological interactions
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Data from: Evaluating otter reintroduction outcomes using genetic spatial capture-recapture modified for dendritic networks
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Data from: Forest trees in human modified landscapes: ecological and genetic drivers of recruitment failure in Dysoxylum malabaricum (Meliaceae)
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Data from: Monarch butterfly and milkweed declines substantially predate the use of genetically modified crops
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Data from: Mate competition and evolutionary outcomes in genetically modified Zebrafish (Danio rerio)
Demonstrating relationships between sexual selection mechanisms and trait evolution is central to testing evolutionary theory. Using zebrafish, we found that wild-type males possessed a significant advantage in mate competition over transgenic RFP Glofish™ males. In mating trials, wild-type males were aggressively superior to transgenic males in male-male chases and male-female chases; as a result, wild-type males sired 2.5x as many young as did transgenic males. In contrast, an earlier study demonstrated that female zebrafish preferred transgenic males as mates when mate competition was excluded experimentally. We tested the evolutionary consequence of this conflict between sexual selection mechanisms in a long-term study. The predicted loss of the transgenic phenotype was confirmed. More than 18,500 adults collected from 18 populations across 15 generations revealed that the frequency of the transgenic phenotype declined rapidly and was eliminated entirely in all but one population. Fitness component data for both sexes indicated that only male mating success differed between wild-type and transgenic individuals. Our predictive demographic model based on fitness components closely matched the rate of transgenic phenotype loss observed in the long-term study, thereby supporting its utility for studies assessing evolutionary outcomes of escaped or released genetically modified animals.
Data from: The conditional nature of genetic interactions: the consequences of wild-type backgrounds on mutational interactions in a genome-wide modifier screen
The phenotypic outcome of a mutation cannot be simply mapped onto the underlying DNA variant. Instead, the phenotype is a function of the allele, the genetic background in which it occurs and the environment where the mutational effects are expressed. While the influence of genetic background on the expressivity of individual mutations is recognized, its consequences on the interactions between genes, or the genetic network they form, is largely unknown. The description of genetic networks is essential for much of biology; yet if, and how, the topologies of such networks are influenced by background is unknown. Furthermore, a comprehensive examination of the background dependent nature of genetic interactions may lead to identification of novel modifiers of biological processes. Previous work in Drosophila melanogaster demonstrated that wild-type genetic background influences the effects of an allele of scalloped (sd), with respect to both its principal consequence on wing development and its interactions with a mutation in optomotor blind. In this study we address whether the background dependence of mutational interactions is a general property of genetic systems by performing a genome wide dominant modifier screen of the sdE3 allele in two wild-type genetic backgrounds using molecularly defined deletions. We demonstrate that ~74% of all modifiers of the sdE3 phenotype are background-dependent due in part to differential sensitivity to genetic perturbation. These background dependent interactions include some with qualitative differences in the phenotypic outcome, as well as instances of sign epistasis. This suggests that genetic interactions are often contingent on genetic background, with flexibility in genetic networks due to segregating variation in populations. Such background dependent effects can substantially alter conclusions about how genes influence biological processes, the potential for genetic screens in alternative wild-type backgrounds identifying new loci that contribute to trait expression, and the inferences of the topology of genetic networks.
Data from: HSP90 as a global genetic modifier for male genital morphology in Drosophila melanogaster
The molecular chaperone protein HSP90 has been proposed to modulate genotype-phenotype relationship in a broad range of organisms. To understand the genetic modifier effect of HSP90, genetic variations under the influence of HSP90 need to be identified on a genome-wide scale. Here, we show that HSP90 functions as a genetic modifier of genital morphology in Drosophila melanogaster. We identified a large number of single-nucleotide polymorphisms (SNPs) with an HSP90-dependent effect by using genome wide association analysis. We classified the SNPs into the ones under capacitance effect (smaller allelic effect under HSP90 inhibition) or the ones under potentiation effect (larger allelic effect under HSP90 inhibition). Although the majority of SNPs are under capacitance, there are a large number of SNPs under potentiation. This observation provides support for a model in which Hsp90 is not described exclusively as a 'genetic capacitor', but is described more broadly as a 'genetic modifier'. Because the majority of the candidate genes estimated from SNPs with an HSP90-dependent effect in the current study have never been reported to interact with HSP90 directly, the global genetic modifier effect of HSP90 may be exhibited through epistatic interactions in gene regulatory networks.
Fig. 3 in Genetically modified maize resistant to corn earworm (Lepidoptera: Noctuidae) in Sinaloa, Mexico
Fig. 3. Percentage of corn ears damaged by Helicoverpa zea in Agrisure® VipteraTM 3111 and its isoline at Camalote and Os`o Viejo, Culiacan (Sinaloa, Mexico). 2013. Genetically modified hybrid and isolines followed by the same letter do not differ significantly (LSD; P> 0.05). ic = insecticide control.`
Genetically Modified T Cells in Treating Patients With Stage III-IV Non-small Cell Lung Cancer or Mesothelioma
ClinicalTrials.gov study NCT02408016. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Genetically Modified Neural Stem Cells, Flucytosine, and Leucovorin for Treating Patients With Recurrent High-Grade Gliomas
ClinicalTrials.gov study NCT02015819. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Donor Lymphocyte Infusion (DLI) of T-cells Genetically Modified With iCasp9 Suicide Gene
ClinicalTrials.gov study NCT01875237. IPD Sharing: Not stated. Countries: 1. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.