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Dataset results
844 results for “germline”
IG receptor germline set for species: Mouse subgroup: DBA/1J set_name: DBA/1J IGKV
<p>Germline Reference set published on the Open Germline Receptor Database (OGRDB)</p>
IG receptor germline set for species: Mouse subgroup: NOD/ShiLtJ set_name: NOD/ShiLtJ IGLV
<p>Germline Reference set published on the Open Germline Receptor Database (OGRDB)</p>
IG receptor germline set for species: Mouse subgroup: CBA/J set_name: CBA/J IGLV
<p>Germline Reference set published on the Open Germline Receptor Database (OGRDB)</p>
IG receptor germline set for species: Mouse subgroup: DBA/2J set_name: DBA/2J IGLV
<p>Germline Reference set published on the Open Germline Receptor Database (OGRDB)</p>
IG receptor germline set for species: Mouse subgroup: CBA/J set_name: CBA/J IGKV
<p>Germline Reference set published on the Open Germline Receptor Database (OGRDB)</p>
IG receptor germline set for species: Mouse subgroup: CAST/EiJ set_name: CAST/EiJ IGKV
<p>Germline Reference set published on the Open Germline Receptor Database (OGRDB)</p>
IG receptor germline set for species: Mouse subgroup: CAST/EiJ set_name: CAST/EiJ IGH
<p>Germline Reference set published on the Open Germline Receptor Database (OGRDB)</p>
IG receptor germline set for species: Mouse subgroup: CAST/EiJ set_name: CAST/EiJ IGLV
<p>Germline Reference set published on the Open Germline Receptor Database (OGRDB)</p>
IG receptor germline set for species: Mouse subgroup: NOR/LtJ set_name: NOR/LtJ IGLV
<p>Germline Reference set published on the Open Germline Receptor Database (OGRDB)</p>
IG receptor germline set for species: Mouse subgroup: LEWES/EiJ set_name: LEWES/EiJ IGLV
<p>Germline Reference set published on the Open Germline Receptor Database (OGRDB)</p>
IG receptor germline set for species: Mouse subgroup: NOR/LtJ set_name: NOR/LtJ IGKV
<p>Germline Reference set published on the Open Germline Receptor Database (OGRDB)</p>
IG receptor germline set for species: Mouse subgroup: MSM/MsJ set_name: MSM/MsJ IGH
<p>Germline Reference set published on the Open Germline Receptor Database (OGRDB)</p>
IG receptor germline set for species: Mouse subgroup: MRL/MpJ set_name: MRL/MpJ IGLV
<p>Germline Reference set published on the Open Germline Receptor Database (OGRDB)</p>
IG receptor germline set for species: Mouse subgroup: C3H/HeJ set_name: C3H/HeJ IGLV
<p>Germline Reference set published on the Open Germline Receptor Database (OGRDB)</p>
IG receptor germline set for species: Mouse subgroup: C57BL/6J set_name: C57BL/6J IGKV
<p>Germline Reference set published on the Open Germline Receptor Database (OGRDB)</p>
IG receptor germline set for species: Mouse subgroup: C57BL/6J set_name: C57BL/6J IGLV
<p>Germline Reference set published on the Open Germline Receptor Database (OGRDB)</p>
Data from: SMAD4 promotes somatic-germline contact during murine oocyte growth
<p>Development of the mammalian oocyte requires physical contact with the surrounding granulosa cells of the follicle, which provide it with essential nutrients and regulatory signals. This contact is achieved through specialized filopodia, termed transzonal projections (TZPs), that extend from the granulosa cells to the oocyte surface. Transforming growth factor (TGFβ) family ligands produced by the oocyte increase the number of TZPs, but how they do so is unknown. Using an inducible Cre recombinase strategy together with expression of green fluorescent protein to verify Cre activity in individual granulosa cells, we examined the effect of depleting the canonical TGFβ mediator, SMAD4. We observed a 20-50% decrease in the total number of TZPs in SMAD4-depleted granulosa cell-oocyte complexes, and a 50% decrease in the number of newly generated TZPs when the granulosa cells were reaggregated with granulosa cell-free wild-type oocytes. Three-dimensional image analysis revealed that TZPs of SMAD4-depleted cells were also longer than controls and more frequently oriented towards the oocyte. Strikingly, the transmembrane proteins, N-cadherin and Notch2, were reduced by 50% in these cells. SMAD4 may thus modulate a network of cell adhesion proteins that stabilize the attachment of TZPs to the oocyte, thereby amplifying signalling between the two cell types.</p>
Data and code of "Germline mutation rate predicts cancer mortality across 37 vertebrate species" article
<p>Data and code used in this article.</p> <p>The "Data.csv" file contains information about each species class, common name, average yearly mutation rate, trophic level, number of animals per species that died from cancer, records of mortality per species, the minimum confidence interval (CI) for the cancer mortality values, the maximum CI for the cancer mortality values, the standard error (SE) of the records of mortality per species, cancer mortality, average parental age (measured in months), maximum lifespan (measured in months), average parental age (measured in months), and whether a species is reported as domesticated/semidomesticated or not. The way the authors obtained these data, and the original sources of these data, are described in the methodology section of the article.</p> <p>The "Regression_analyses.R" file is the code we used in the regression analyses conducted in this article. The .phy file is the phylogenetic tree used in the regression analyses.</p> <p>The .txt, .nwk, .Rproj, and "germFit.R" files are the data and code we used for comparing the different models of phenotype evolution (comparison of 3 different models: Ornstein–Uhlenbeck, Brownian, and Early Burst).</p>
IG receptor germline set for species: Human set_name: IGLambda_VJ
<p>Germline Reference set published on the Open Germline Receptor Database (OGRDB)</p>
IG receptor germline set for species: Human set_name: IGKappa_VJ
<p>Germline Reference set published on the Open Germline Receptor Database (OGRDB)</p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.