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348 results for “hair cells”
Inner hair cell dysfunction in Klhl18 mutant mice leads to low frequency progressive hearing loss
<p>Age-related hearing loss in humans (presbycusis) typically involves impairment of high frequency sensitivity before becoming progressively more severe at lower frequencies. Pathologies initially affecting lower frequency regions of hearing are less common. Here we describe a progressive, predominantly low-frequency recessive hearing impairment in two mutant mouse lines carrying different mutant alleles of the <i>Klhl18</i> gene: a spontaneous missense mutation (<i>Klhl18<sup>lowf</sup></i>) and a targeted mutation (<i>Klhl18<sup>tm1a(KOMP)Wtsi</sup></i>). Both males and females were studied, and the two mutant lines showed similar phenotypes. Threshold for auditory brainstem responses (ABR; a measure of auditory nerve and brainstem neural activity) were normal at 3 weeks old but showed progressive increases from 4 weeks onwards. In contrast, distortion product otoacoustic emission (DPOAE) sensitivity and amplitudes (a reflection of cochlear outer hair cell function) remained normal in mutants. Electrophysiological recordings from the round window of <i>Klhl18<sup>lowf</sup></i> mutants at 6 weeks old revealed 1) raised compound action potential thresholds that were similar to ABR thresholds, 2) cochlear microphonic potentials that were normal compared with wildtype and heterozygous control mice and 3) summating potentials that were reduced in amplitude compared to control mice. Scanning electron microscopy showed that <i>Klhl18<sup>lowf</sup></i> mutant mice had abnormally tapering of the tips of inner hair cell stereocilia in the apical half of the cochlea while their synapses appeared normal. These results suggest that Klhl18 is necessary to maintain inner hair cell stereocilia and normal inner hair cell function at low frequencies.</p>
Scalp Cooling to Prevent Hair Loss in Patients Undergoing Stem Cell Transplantation for Multiple Myeloma
ClinicalTrials.gov study NCT05961215. IPD Sharing: NO. Countries: 1. Publications: 0.
Data from: Macrophages contribute to the cyclic activation of adult hair follicle stem cells
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Inner hair cell dysfunction in Klhl18 mutant mice leads to low frequency progressive hearing loss
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Data from: Mechanotransduction current is essential for stability of the transducing stereocilia in mammalian auditory hair cells
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RNA-seq profiling of the Tg(myo6b:GFP-2A-rpl10a-3xHA) zebrafish hair cell IP vs. whole fish IN
GEO Series GSE102861. Danio rerio. 7 samples. Type: Expression profiling by high throughput sequencing.
DNA methylation in the mouse cochlea promotes maturation of supporting cells and contributes to the failure of hair cell regeneration
GEO Series GSE224563. Mus musculus. 52 samples. Type: Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Temporal Layering of Signaling Effectors Drives Chromatin Remodeling during Hair Follicle Stem Cell Lineage Progression [ATAC-seq]
GEO Series GSE100875. Mus musculus. 8 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
H2AK119ub dynamics controls hair follicle stem cell quiescence [RNA-Seq 1]
GEO Series GSE279012. Mus musculus. 5 samples. Type: Expression profiling by high throughput sequencing.
High-resolution transcriptional analysis reveals stepwise fate conversion of supporting cells to hair cells in the chicken auditory epithelium
GEO Series GSE209791. Gallus gallus. 2400 samples. Type: Expression profiling by high throughput sequencing.
Single cell RNA-Seq reveals Fgf signaling dynamics during sensory hair cell regeneration
GEO Series GSE123241. Danio rerio. 3 samples. Type: Expression profiling by high throughput sequencing.
Mapping the regulatory landscape of auditory hair cells from single cell multi-omics data
GEO Series GSE157398. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Regulatory T cells in skin utilize the Cxcr4-Cxcl12 axis to promote hair follicle regeneration
GEO Series GSE305547. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
Single cell RNA-seq analysis of hair cell regeneration in the mammalian vestibular system and its potentiation by Atoh1
GEO Series GSE127683. Mus musculus. 56 samples. Type: Expression profiling by high throughput sequencing.
Effect of N1-acetylspermidine treatment on the translatome of hair follicle stem cell organoid cultures
GEO Series GSE164806. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing; Other.
RNA-seq analysis of hair follicle stem cell transcriptome upon loss of the transcription factor FOXC1
GEO Series GSE77256. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Tracing the origin of hair follicle stem cells
GEO Series GSE147372. Mus musculus. 1666 samples. Type: Expression profiling by high throughput sequencing.
Precise genetic control of ATOH1 enhances maturation of regenerated hair cells in mouse utricle
GEO Series GSE251854. Mus musculus. 57 samples. Type: Expression profiling by high throughput sequencing.
RNA-seq for miR-205 inducible hair follicle stem cells and ScRNAseq for miR-205 inducible back skin samples
GEO Series GSE185117. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
RNA-seq analysis of hair cell regeneration in the mammalian vestibular system and its potentiation by Atoh1
GEO Series GSE122732. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.