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527 results for “helpers”
T Helper Cytokines in End Stage Colorectal Cancers
ClinicalTrials.gov study NCT04540146. IPD Sharing: UNDECIDED. Countries: 1. Publications: 3.
Follicular Helper T Cells: Biological Marker and Involvement in the Physiopathology of the IgG4-related Disease
ClinicalTrials.gov study NCT02899039. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Mi-Helper Transnasal Cooling for Acute Treatment of Migraine
ClinicalTrials.gov study NCT06051604. IPD Sharing: Not stated. Countries: 1. Publications: 0.
The Effect of the Helper Skin Tap Technique and Buzzy® During Vaccination
ClinicalTrials.gov study NCT06312228. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Data from: Egg size investment in superb fairy-wrens: helper effects are modulated by climate
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Data from: Helper effects in the azure-winged magpie Cyanopica cyana in relation to highly-clumped nesting pattern and high frequency of conspecific nest-raiding
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Data from: Egg investment in response to the helper presence in cooperatively breeding Tibetan ground tits
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Helpers slow senescence in a Tibetan cooperatively breeding bird
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Data from: Variable helper effects, ecological conditions, and the evolution of cooperative breeding in the acorn woodpecker
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Data from: Social genetic and social environment effects on parental and helper care in a cooperatively breeding bird
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Data from: Male and female helper effects on maternal investment and adult survival in red-winged fairy-wrens
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Helpers compensate for age-related declines in parental care and offspring survival in a cooperatively breeding bird
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Data from: Group-size dependent punishment of idle subordinates in a cooperative breeder where helpers pay to stay
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Raw data relative to: "Distinct Expression of Inflammatory Features in T Helper 17 Cells from Multiple Sclerosis Patients"
<p><strong>Introduction</strong></p> <p> Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS). T helper (Th) 17 lymphocytes play a role in the pathogenesis of MS. Indeed, Th17 cells are abundant in the cerebrospinal fluid and peripheral blood of MS patients and promote pathogenesis in the mouse model of MS. To gain insight into the function of Th17 cells in MS, we tested whether Th17 cells polarized from naïve CD4 T cells of healthy donors and MS patients display different features</p> <p><strong>Methods</strong></p> <p>We analysed several parameters that typify the Th17 profile during the differentiation process of naïve CD4 T cells obtained from relapsing-remitting (RR)-MS patients and healthy donors (HD), such as expression of surface receptors by flow cytometry.</p> <p><strong>Results</strong></p> <p>The analysis revealed that expression of IL-1R1 is significantly increased in Th17 cells derived from MS patients compared to healthy donor-derived cells. Interestingly, IL-1R1 expression is also increased in Th17 cells circulating in the blood of MS patients compared to healthy donors. Since IL-1R1 play a crucial role in the activation of immune cells, our data indicate that high expression of these molecules in Th17 cells from MS patients could be related to their high inflammatory status.</p>
Raw data related to: "Transcriptional Regulators of T Helper 17 Cell Differentiation in Health and Autoimmune Diseases"
<p><strong>Introduction</strong></p> <p>T helper (Th) 17 cells are a subtype of CD4 T lymphocytes characterized by the expression of retinoic acid-receptor (RAR)-related orphan receptor (ROR)γt transcription factor, encoded by gene <em>Rorc</em>. These cells are implicated in the pathology of autoimmune inflammatory disorders as well as in the clearance of extracellular infections. The main function of Th17 cells is the production of cytokine called interleukin (IL)-17A.</p> <p><strong>Methods</strong></p> <p>We described the lineage defining transcription factor RORγt and other factors that regulate transcription of <em>Il17a, Rorc </em>and Th17-related genes, such as Il17f, Il21, Il23r, which may positively or negatively influence their expression.</p> <p><strong>Results</strong></p> <p>We discussed the potential new therapeutic approaches for Th17-related diseases targeting these transcription factors. The wide knowledge of transcriptional regulators of Th17 cells is crucial for the better understanding of the pathogenic role of these cells and for development of therapeutic strategies aimed at fighting Th17-related diseases.</p>
Influence of videolaryngoscopy using McGrath Mac™ on the need for a helper to perform intubation during general anaesthesia: A multicentre randomised video - no-video trial
<p><b>Objective:</b> We hypothesized was that use of a videolaryngoscope modifies the practice of tracheal intubation.</p> <p><b>Design:</b> Randomized single-blinded study.</p> <p><b>Setting:</b> Three institutions: one academic, one non-profit and one profit.</p> <p><b>Participants</b><b>:</b> Inclusion criteria were patients aged 18 years minimum, requiring orotracheal intubation, without a predicted difficult intubation (Arne score <11). Non-inclusion criteria was patients requiring a rapid-sequence intubation. 300 patients were included, 271 randomised, 256 analysed: 123 in the No-Video group and 133 in the Video group.</p> <p><b>Intervention</b>: Tracheal intubation uses a McGrath Mac™ videolaryngoscope. Patients were randomised into two groups: a Video group (screen activated) and a No-Video group (screen hidden).</p> <p><b>Primary and secondary outcome measures</b>: The main outcome was the need for help for the anaesthesiologist or the nurse anaesthetist in performing tracheal intubation, the sequence being video recorded. Secondary outcomes included the ease of intubation (intubation difficulty scale, Cormack and Lehane<b> </b>grade, percentage of glottic opening<b> </b>scale score, use of alternative techniques, duration, oxygen desaturation, especially). Other outcomes included the cooperation between members of the anaesthesiology team, the proportion of patients suffering from postoperative hoarseness or sore throat, and other adverse events.</p> <p><b>Results:</b>. Requirement for assistance was not decreased in the Video group: 36.1% <span>[95% CI</span> 27.9 to 44.9] versus 45.5% <span>[95% </span>36.5 to 54.7] in the No-Video group (p=0.124). Intubation difficulty scale was lower in the Video group (p=0.009); glottis visualization (Cormack and Lehane score and glottic opening score) was better in the Video group (p<0.001). Duration of intubation was similar between groups. Oxygen desaturation or hypotension requiring treatment during the intubation period and postoperative complications (hoarseness or sore throat) were observed similarly in both groups. No other adverse event occurred.</p> <p><b>Conclusion:</b> In patients without risk of difficulty in airway management, videolaryngoscopy did not decrease the requirement for assistance to perform intubation.</p> <p><b>Trial registration:</b> <span><a href="http://clinicaltrials.gov/">Clinicaltrials.gov</a></span> identifier: NCT02926144<b> </b></p>
TCR repertoire sequencing related to "Unique roles of coreceptor-bound LCK in helper and cytotoxic T cells"
<p>This archive contains datasets needed for recapitulating the analysis of TCR repertoires for the manuscript <em>“Unique roles of coreceptor-bound LCK in helper and cytotoxic T cells”</em> by Horkova et al., 2022. The code for the analysis can be found on GitHub: https://github.com/Lab-of-Adaptive-Immunity/lck-tcrseq. Raw data are deposited in the SRA (https://www.ncbi.nlm.nih.gov/bioproject/PRJNA872031).</p> <p>The Zenodo archive contains the following files, which are needed to run the analysis script:</p> <ul> <li>merged outputs from MiXCR <code>merged_TCR_repertoires.csv</code></li> <li>metadata file <code>metadata_Lck.csv</code></li> <li>TRA and TRB repertoires prepared for processing with the Immunarch package <code>immdata_tra.rds</code>, <code>immdata_trb.rds</code></li> </ul>
Influenza vaccination stimulates maturation of the human T follicular helper cell response
<p><strong>Data</strong></p> <p>The two rds-format (R Data Serialization) files contain Seurat objects used for analyses.</p> <p>intergrated_Tcells_harmony_bydonor.rds contains all T cells.</p> <p>intergrated_Tfh_harmony_bydonor.rds is a subset of the previous file containing the TFH and Treg lineages.</p> <p>Set2_10x_clones.tsv is paired TCR information for cells from the 10X experiment for all cells in intergrated_Tcells_harmony_bydonor.</p> <p>TwoYear_LN_Bcell_freq_time.csv contains the B cell subset frequencies in the lymph node by time point.</p> <p>Ali_paired_sc_clones_JCC283.tsv contains paired TCR sequences of cTFH and LN TFH cells obtained by single-cell sorting and target PCR. </p> <p>Ali_bulk_allDonor_clones.tsv contains bulk TCR alpha and beta chains of sorted cTFH and LN TFH generated using a 5'-RACE protocol.</p> <p><strong>The code that accompanies these data is available on GitHub (https://github.com/sschattgen/Flu_TFH_paper)</strong></p> <div> <div> <div> <p><strong>Reads for samples from year 2 for 321-05, year 1 and year 2 312-04, all samples from 321-07, and all samples from 321-08 are available on the NCBI Sequence Read Archive (SRA) under BioProject accession PRJNA1132302. Reads for year 1 samples for 321-05 are available on SRA under BioProject PRJNA610059.</strong></p> </div> </div> </div>
Presence of Circulating Cluster of Differentiation 4 Positive 28 Null T Helper Lymphocytes(CD4+CD28-) in Patients With Autoimmune Hemolytic Anemia.
ClinicalTrials.gov study NCT05711264. IPD Sharing: Not stated. Countries: 0. Publications: 6.
Efficacy and Safety of Chemoattractant Receptor-homologous Molecule Expressed on T Helper Type 2 (CRTh2) Antagonist AZD1981 in Chronic Idiopathic Urticaria (CIU) Antihistamines
ClinicalTrials.gov study NCT02031679. IPD Sharing: NO. Countries: 1. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.