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151
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ShareScore release 0.9.0
Dataset results
151 results for “iL-17”
Analyses of IL-17-producing CD8 T cells
GEO Series GSE83841. Mus musculus. 14 samples. Type: Expression profiling by high throughput sequencing.
Arid5a directs autoimmune inflammation through an IL-17 signaling pathway [mouse]
GEO Series GSE269729. Mus musculus. 15 samples. Type: Other.
IL-17/CXCL5 signaling within the oligovascular niche mediates human and mouse white matter injury (Tie2-Cre RiboTAG)
GEO Series GSE217355. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing; Other.
RNA sequencing of human airway epithelial cultures from cystic fibrosis (CF) and non-CF donors exposed to tumor necrosis factor-alpha and interleukin-17 (TNFα+IL-17) for 48 hours
GEO Series GSE176121. Homo sapiens. 24 samples. Type: Expression profiling by high throughput sequencing.
IkappaBzeta Controls IL-17-triggered Gene Expression Program in Intestinal Epithelial Cells that Prevents Expansion of SFB and Attenuates Autoimmune Disorders
GEO Series GSE188254. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Dual role of Act1 in keratinocyte differentiation and host defense: TRAF3IP2 silencing alters keratinocyte differentiation while inhibiting IL-17 responses
GEO Series GSE86451. Homo sapiens. 32 samples. Type: Expression profiling by high throughput sequencing.
Microarray analysis of IL-17 gene transfer in murine dorsal skin.
GEO Series GSE86999. Mus musculus. 4 samples. Type: Expression profiling by array.
IL-17 signalling is critical for controlling subcutaneous adipose tissue wasting and parasite burden during chronic Trypanosoma brucei infection [single-cell RNA-seq]
GEO Series GSE233312. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
IL-17 signalling is critical for controlling subcutaneous adipose tissue wasting and parasite burden during chronic Trypanosoma brucei infection
GEO Series GSE233314. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
High salt intake exacerbates aortic dissection through IL-17 pathway
GEO Series GSE116434. Mus musculus. 24 samples. Type: Expression profiling by array.
Pityriasis rubra pilaris transcriptomics implicate IL-17 signaling and correlate with response to IL-17A inhibition
GEO Series GSE209981. Homo sapiens. 71 samples. Type: Expression profiling by high throughput sequencing.
Investigating in the implications of the γδ T cell receptor in the acquisition of IL-17 producing effector functions
GEO Series GSE284198. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing; Other.
RNA sequencing of human airway epithelial cultures from cystic fibrosis (CF) and non-CF donors exposed to tumor necrosis factor-alpha and interleukin-17 (TNFα+IL-17) for 5 hours
GEO Series GSE285099. Homo sapiens. 24 samples. Type: Expression profiling by high throughput sequencing.
An IL-17-Ly6G+Polymorphonuclear Neutrophil (PMN) axis limits protective host responses against tuberculosis.
GEO Series GSE238265. Mus musculus. 21 samples. Type: Expression profiling by high throughput sequencing.
Neutrophils negatively regulate IL-17 producing γδ T cells under physiological conditions
GEO Series GSE272418. Mus musculus. 8 samples. Type: Expression profiling by array.
IL-1beta activates IL-17 via calcium
GEO Series GSE118195. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
IL-17 mediated downregulation of miR-101 facilitates expression of EZH2 to promote epidermal hyperplasia in psoriasis
GEO Series GSE220586. Homo sapiens; synthetic construct. 8 samples. Type: Non-coding RNA profiling by array.
IL-17 activates dermal reticular fibroblasts to promote neutrophil recruitment and host defense [RNAseq]
GEO Series GSE230511. Mus musculus; Homo sapiens. 23 samples. Type: Expression profiling by high throughput sequencing.
Bulk RNA-seq of HBECs at ALI with and without stimulation of IFN-a, IL-17, and IL-13
GEO Series GSE185200. Homo sapiens. 36 samples. Type: Expression profiling by high throughput sequencing.
Data from: Prophylactic digoxin treatment reduces IL-17 production in vivo in the neonatal calf and moderates RSV-associated disease
Respiratory syncytial virus (RSV) is a leading cause of morbidity and mortality in human infants. Bovine RSV infection of neonatal calves is pathologically and immunologically similar to RSV infection in infants, and is therefore a useful preclinical model for testing novel therapeutics. Treatment of severe RSV bronchiolitis relies on supportive care and may include use of bronchodilators and inhaled or systemic corticosteroids. Interleukin-17A (IL-17) is an inflammatory cytokine that plays an important role in neutrophil recruitment and activation. IL-17 is increased in children and rodents with severe RSV infection; and in calves with severe BRSV infection. It is currently unclear if IL-17 and Th17 immunity is beneficial or detrimental to the host during RSV infection. Digoxin was recently identified to selectively inhibit IL-17 production by antagonizing its transcription factor, retinoid-related orphan receptor γ t (RORγt). Digoxin inhibits RORγt binding to IL-17 and Th17 associated genes, and suppresses IL-17 production in vitro in human and murine leukocytes and in vivo in rodent models of autoimmune disease. We demonstrate here that in vitro and in vivo digoxin treatment also inhibits IL-17 production by bovine leukocytes. To determine the role of IL-17 in primary RSV infection, calves were treated prophylactically with digoxin and infected with BRSV. Digoxin treated calves demonstrated reduced signs of clinical illness after BRSV infection, and reduced lung pathology compared to untreated control calves. Digoxin treatment did not adversely affect virus shedding or lung viral burden, but had a significant impact on pulmonary inflammatory cytokine expression on day 10 post infection. Together, our results suggest that exacerbated expression of IL-17 has a negative impact on RSV disease, and that development of specific therapies targeting Th17 immunity may be a promising strategy to improve disease outcome during severe RSV infection.
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Allen Brain Atlas
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DANDI Archive for NWB datasets
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The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
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