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175 results for “imiquimod”
Cellular and Molecular Events During Treatment of Actinic Keratosis With Imiquimod 5% Cream
ClinicalTrials.gov study NCT00335179. IPD Sharing: Not stated. Countries: 1. Publications: 2.
A Phase II Study of Imiquimod 5 % Cream for the Treatment of Hemangioma in Infancy
ClinicalTrials.gov study NCT00601016. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Study to Evaluate the Effectiveness of Imiquimod 5% Cream for Basal Cell Carcinoma Recurrence
ClinicalTrials.gov study NCT00129519. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Vaccine Therapy With or Without Imiquimod in Treating Patients With Grade 3 Cervical Intraepithelial Neoplasia
ClinicalTrials.gov study NCT00788164. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Predicting Response In Cervical Intraepithelial Neoplasia to Topical Imiquimod Treatment
ClinicalTrials.gov study NCT05405270. IPD Sharing: UNDECIDED. Countries: 1. Publications: 10.
Comparison of Two Schemes of Cryosurgery and Imiquimod Combination Treatment for Basal Cell Carcinoma
ClinicalTrials.gov study NCT01212549. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Imiquimod Treatment of High-grade CIN
ClinicalTrials.gov study NCT02917746. IPD Sharing: NO. Countries: 1. Publications: 7.
Topical Imiquimod Treatment of Oral Dysplasia
ClinicalTrials.gov study NCT07210775. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
MELANOMA EM EQUINO: RELATO DE CASO CLÍNICO, COM TRATAMENTO QUIMIOTERÁPICO TÓPICO IMIQUIMOD
<p>Melanomas são neoplasias de origem melanocítica, que afetam diversas espécies de animais. Os equinos são suscetíveis ao desenvolvimento, representam grande parte dos tumores cutâneos (média de 15%). Embora a maioria dos melanomas equinos seja benigna, alguns casos podem evoluir para formas malignas, com metástases em órgãos distantes e pior prognóstico. Causam desconfortos, dor, disfunções e má qualidade de vida. O diagnóstico precoce é fundamental para o sucesso do tratamento do melanoma e bem-estar do animal. Nesse estudo, utilizamos um tratamento novo que vem se destacando na medicina humana, o uso de quimioterápico tópico imiquimod. Á vista disso, o objetivo deste estudo foi relatar um caso clínico de melanoma em equino tratado com imiquimod tópico e analisar sua eficácia. A escolha deste tratamento foi baseada em estudos prévios que demonstram a segurança e eficácia do medicamento imiquimod em algumas espécies animais, em alguns casos isolados de equinos e em humanos.</p>
Figure 7 from: Almudaris SA, Gatea FK (2024) Effects of topical Ivermectin on imiquimod-induced Psoriasis in mouse model – Novel findings. Pharmacia 71: 1-14. https://doi.org/10.3897/pharmacia.71.e114753
Figure 7 Histopathological section of mice skin (clobetasol control group) showing hyperkeratosis (black arrow), absence of parakeratosis & Munro's abscess. And epidermal granular layer (yellow arrow) with mild acanthosis, mild papillary thinning, and few rete ridges (green arrow). The dermis shows mild lymphocytic infiltrate. H&E stain (4×,10×).
Figure 11 from: Almudaris SA, Gatea FK (2024) Effects of topical Ivermectin on imiquimod-induced Psoriasis in mouse model – Novel findings. Pharmacia 71: 1-14. https://doi.org/10.3897/pharmacia.71.e114753
Figure 11 Comparison between induced non-treated group and all induced treated groups regarding histopathological scores (Baker score) and observational score (PASI score).
Figure 4 from: Almudaris SA, Gatea FK (2024) Effects of topical Ivermectin on imiquimod-induced Psoriasis in mouse model – Novel findings. Pharmacia 71: 1-14. https://doi.org/10.3897/pharmacia.71.e114753
Figure 4 Histopathological section of mice skin (healthy control group) showing normal skin architecture including K = keratin, E = epidermis, D = dermis, AD = adnexa, S.C = subcutaneous tissue, M = muscles, B.V = blood vessels. H&E stain (4×,10×).
Figure 3 from: Almudaris SA, Gatea FK (2024) Effects of topical Ivermectin on imiquimod-induced Psoriasis in mouse model – Novel findings. Pharmacia 71: 1-14. https://doi.org/10.3897/pharmacia.71.e114753
Figure 3 Scoring for skin inflammation severity, the pictures show different inflammation levels of the dorsal skin on which the test substances were applied on day 8 of the Experiment. A. Represents the healthy group; B. Represents the IMQ-induced group; C. Represents the vehicle group; D. Represents Clobetasol treated group; E. Represents the Ivermectin treated group; F. Represents Ivermectin + Clobetasol treated group.
Figure 6 from: Almudaris SA, Gatea FK (2024) Effects of topical Ivermectin on imiquimod-induced Psoriasis in mouse model – Novel findings. Pharmacia 71: 1-14. https://doi.org/10.3897/pharmacia.71.e114753
Figure 6 Histopathological section of mice skin (vehicle group) showing hyperkeratosis, parakeratosis (black arrow), with focal neutrophilic infiltration (the Munro's abscess) in red arrow, with epidermal acanthosis and thinning papillae and elongated rete ridges (green arrow), and lack of granular layer. The dermis shows moderate to severe inflammatory lymphocytic infiltration (blue arrow). H&E stain (4×,10×).
Figure 9 from: Almudaris SA, Gatea FK (2024) Effects of topical Ivermectin on imiquimod-induced Psoriasis in mouse model – Novel findings. Pharmacia 71: 1-14. https://doi.org/10.3897/pharmacia.71.e114753
Figure 9 Histopathological section of mice skin (Ivermectin treatment group) showing mild keratosis (black arrow), with the absence of Munro's abscess and parakeratosis and epidermal mild acanthosis with few rete ridges and mild papillary thinning (green arrow). The dermis shows severe lymphocytic infiltrate. H&E stain (4×,10×).
Figure 2 from: Almudaris SA, Gatea FK (2024) Effects of topical Ivermectin on imiquimod-induced Psoriasis in mouse model – Novel findings. Pharmacia 71: 1-14. https://doi.org/10.3897/pharmacia.71.e114753
Figure 2 Induction of Psoriasis in mice. A Mouse before Induction. B Mouse after Induction by Imiquimod cream.
Figure 8 from: Almudaris SA, Gatea FK (2024) Effects of topical Ivermectin on imiquimod-induced Psoriasis in mouse model – Novel findings. Pharmacia 71: 1-14. https://doi.org/10.3897/pharmacia.71.e114753
Figure 8 Histopathological section of mice skin (Ivermectin treatment group) showing mild keratosis (black arrow), with the absence of Munro's abscess and parakeratosis and epidermal mild acanthosis with few rete ridges and mild papillary thinning (green arrow). The dermis shows severe lymphocytic infiltrate. H&E stain (4×,10×, 40×).
Figure 10 from: Almudaris SA, Gatea FK (2024) Effects of topical Ivermectin on imiquimod-induced Psoriasis in mouse model – Novel findings. Pharmacia 71: 1-14. https://doi.org/10.3897/pharmacia.71.e114753
Figure 10 Comparison between induced non-treated group and all induced treated groups regarding tissue biomarkers (IL-10, IL-17, TNF-a, and VEGF).
Figure 5 from: Almudaris SA, Gatea FK (2024) Effects of topical Ivermectin on imiquimod-induced Psoriasis in mouse model – Novel findings. Pharmacia 71: 1-14. https://doi.org/10.3897/pharmacia.71.e114753
Figure 5 Histopathological section of mice skin (induction group) showing hyperkeratosis, parakeratosis (black arrow), with multifocal dense neutrophilic infiltration (the Munro's abscess) in red arrow, with epidermal acanthosis and thinning papillae and rete ridges appearance (green arrow), and lack of granular layer. The dermis shows moderate to severe inflammatory lymphocytic infiltration (blue arrow). H&E stain (4×,10×, 40×).
Imiquimod is Effective in Reducing Cervical Intraepithelial Neoplasia: A Systematic Review and Meta-Analysis
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