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112 results for “inflammation, oxidative stress”
Raw data related to: Sample Size for Oxidative Stress and Inflammation When Treating Multiple Sclerosis with Interferon-b1a and Coenzyme Q10
<p><strong>Abstract </strong></p> <p>Studying multiple sclerosis (MS) and its treatments requires the use of biomarkers for underlying pathological mechanisms. We aim to estimate the required sample size for detecting variations of biomarkers of inflammation and oxidative stress. This is a post-hoc analysis on 60 relapsing-remitting MS patients treated with Interferon-1a and Coenzyme Q10 for 3 months in an open-label crossover design over 6 months. At baseline and at the 3 and 6-month visits, we measured markers of scavenging activity, oxidative damage, and inflammation in the peripheral blood (180 measurements). Variations of laboratory measures (treatment eect) were estimated using mixed-eect linear regression models (including age, gender, disease duration, baseline expanded disability status scale (EDSS), and the duration of Interferon-1a treatment as covariates; creatinine was also included for uric acid analyses), and were used for sample size calculations. Hypothesizing a clinical trial aiming to detect a 70% eect in 3 months (power <strong>= </strong>80% alpha-error <strong>= </strong>5%), the sample size per treatment arm would be 1 for interleukin (IL)-3 and IL-5, 4 for IL-7 and IL-2R, 6 for IL-13, 14 for IL-6, 22 for IL-8, 23 for IL-4, 25 for activation-normal T cell expressed and secreted (RANTES), 26 for tumor necrosis factor (TNF)-, 27 for IL-1, and 29 for uric acid. Peripheral biomarkers of oxidative stress and inflammation could be used in proof-of-concept studies to quickly screen the mechanisms of action of MS treatments.</p> <p><strong>Progetto giovani ricercatori </strong>[GR-2016-02363725] dal titolo: "Immune Tolerance, Metabolism and Multiple Sclerosis: Novel Molecular Tools to Monitor Disease Pathogenesis and Progression"</p>
Raw data related to: Coenzyme Q10 supplementation reduces peripheral oxidative stress and inflammation in interferon-β1a-treated multiple sclerosis
<p><strong>Abstract</strong></p> <p>Background: Oxidative stress is a driver of multiple sclerosis (MS) pathology. We evaluated the effect of coenzyme Q10 (CoQ10) on laboratory markers of oxidative stress and inflammation, and on MS clinical severity.</p> <p>Methods: We included 60 relapsing–remitting patients with MS treated with interferon beta1a 44<strong>μ</strong>g (IFN-<strong>β</strong>1a) with CoQ10 for 3 months, and with IFN-<strong>β</strong>1a 44<strong>μ</strong>g alone for 3 more months (in an open-label crossover design). At baseline and at the 3 and 6-month visits, we measured markers of scavenging activity, oxidative damage and inflammation in the peripheral blood, and collected data on disease severity.</p> <p>Results: After 3 months, CoQ10 supplementation was associated with improved scavenging activity (as mediated by uric acid), reduced intracellular reactive oxygen species production, reduced oxidative DNA damage, and a shift towards a more anti-inflammatory milieu in the peripheral blood [with higher interleukin (IL)-4 and IL-13, and lower eotaxin, granulocyte-macrophage colonystimulating factor (GM-CSF), hepatocyte growth factor (HGF), interferon (IFN)-<strong>γ</strong>, IL-1<strong>α</strong>, IL-2R, IL-9, IL-17F, macrophage inflammatory proteins (MIP)-1<strong>α</strong>, regulated on activation-normal T cell expressed and secreted (RANTES), tumor necrosis factor (TNF)-<strong>α</strong>, and vascular endothelial growth factor (VEGF). Also, CoQ10 supplementation was associated with lower Expanded Disability Status Scale, fatigue severity scale, Beck’s depression inventory, and the visual analogue scale for pain.</p> <p>Conclusions: CoQ10 supplementation improved scavenging activity, reduced oxidative damage, and induced a shift towards a more anti-inflammatory milieu, in the peripheral blood of relapsing–remitting MS patients treated with 44<strong>μ</strong>g IFN-<strong>β</strong>1a 44<strong>μ</strong>g. A possible clinical effect was noted but deserves to be confirmed over longer follow ups.</p> <p><strong>Progetto giovani ricercatori </strong>[GR-2016-02363725] dal titolo: "Immune Tolerance, Metabolism and Multiple Sclerosis: Novel Molecular Tools to Monitor Disease Pathogenesis and Progression"</p>
Data from: Nitric oxide signals are interlinked with calcium signals in normal pancreatic stellate cells upon oxidative stress and inflammation
The mammalian diffuse stellate cell system comprises retinoid-storing cells capable of remarkable transformations from a quiescent to an activated myofibroblast-like phenotype. Activated pancreatic stellate cells (PSCs) attract attention owing to the pivotal role they play in development of tissue fibrosis in chronic pancreatitis and pancreatic cancer. However, little is known about the actual role of PSCs in the normal pancreas. These enigmatic cells have recently been shown to respond to physiological stimuli in a manner that is markedly different from their neighbouring pancreatic acinar cells (PACs). Here, we demonstrate the capacity of PSCs to generate nitric oxide (NO), a free radical messenger mediating, for example, inflammation and vasodilatation. We show that production of cytosolic NO in PSCs is unambiguously related to cytosolic Ca2+ signals. Only stimuli that evoke Ca2+ signals in the PSCs elicit consequent NO generation. We provide fresh evidence for the striking difference between signalling pathways in PSCs and adjacent PACs, because PSCs, in contrast to PACs, generate substantial Ca2+-mediated and NOS-dependent NO signals. We also show that inhibition of NO generation protects both PSCs and PACs from necrosis. Our results highlight the interplay between Ca2+ and NO signalling pathways in cell–cell communication, and also identify a potential therapeutic target for anti-inflammatory therapies.
supplementary materials of NMN supplement ameliorates psoriasis-associated inflammation, oxidative stress and mitochondrial dysfunction by activating SIRT1 pathway
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The Effect of Seaweed Derived Polyphenols on Inflammation and Oxidative Stress in Vivo - The SWAFAX Study
ClinicalTrials.gov study NCT02295878. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Effect of a Single Dose of Cranberry Beverage on Inflammation and Oxidative Stress
ClinicalTrials.gov study NCT01780922. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Resveratrol's Effects on Inflammation and Oxidative Stress in Chronic Kidney Disease
ClinicalTrials.gov study NCT02433925. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Effect of Age and Fitness on Vascular Function and Oxidative Stress During Acute Inflammation
ClinicalTrials.gov study NCT03889158. IPD Sharing: NO. Countries: 1. Publications: 0.
The Effect of LINAGLIPTIN on Inflammation, Oxidative Stress and Insulin Resistance in Obese Type 2 Diabetes Subjects
ClinicalTrials.gov study NCT02372630. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Data from: Nitric oxide signals are interlinked with calcium signals in normal pancreatic stellate cells upon oxidative stress and inflammation
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RNA-seq reveals the role of miR-29c in regulating inflammation and oxidative stress of bovine mammary epithelial cells
GEO Series GSE195508. Bos taurus. 6 samples. Type: Expression profiling by high throughput sequencing.
Intermittent fasting alleviates photoreceptor degeneration and retina inflammation in oxidative stress-induced model of Age-Related Macular Degeneration
GEO Series GSE271791. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Obesogenic diet in mice leads to inflammation and oxidative stress in the mother in association with sex-specific changes in fetal development, inflammatory markers and placental transcriptome
GEO Series GSE262011. Mus musculus. 24 samples. Type: Expression profiling by high throughput sequencing.
Coumarin–Chalcone Hybrid LM-021 and Indole Derivative NC009-1 Targeting Inflammation and Oxidative Stress in Par-kinson's Disease Cell Models
<p>Figure S1: Wild type and A53T SNCA-GFP BE(2)-M17 cells; Figure S2: α-Synuclein aggregation and neurite outgrowth analyses on wild type and A53T SNCA-GFP BE(2)-M17 cells; Figure S3: Neuroprotective effects of LM-021 and NC009-1 on A53T-11 SNCA-GFP BE(2)-M17 cells; Figure S4: α-Synuclein aggregation reduction and neurite outgrowth promotion of LM-021 and NC009-1 on A53T-11 SNCA-GFP BE(2)-M17 cells.</p>
Efficacy Study of Zinc Supplementation on Anemia, Oxidative Stress and Inflammation in Hemodialysis Patients
ClinicalTrials.gov study NCT02335593. IPD Sharing: Not stated. Countries: 1. Publications: 0.
High-Intensity Interval or Concurrent Exercise on Oxidative Stress and Inflammation in Obese Women
ClinicalTrials.gov study NCT07302191. IPD Sharing: NO. Countries: 1. Publications: 0.
Acute Impact of Different Foods and Beverages on Exercise Induced Oxidative Stress and Inflammation
ClinicalTrials.gov study NCT05242978. IPD Sharing: NO. Countries: 1. Publications: 0.
Efficacy of Two Algae Formulations on Lipid Metabolism, Inflammation and Oxidative Stress Status in Individuals With Psoriasis
ClinicalTrials.gov study NCT01045395. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Morphofunctional, Gene, Inflammation Molecules and Oxidative Stress Analysis in Kidney Tissue of COVID-19 Patients
ClinicalTrials.gov study NCT06444893. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Effect of Chronic Consumption of a Cranberry Beverage on Inflammation and Oxidative Stress
ClinicalTrials.gov study NCT01527617. IPD Sharing: Not stated. Countries: 1. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.