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Dataset results
52 results for “international relations”
Effect of Shoulder Traction on Size and Relative Position of Internal Jugular Vein to Carotid Artery
ClinicalTrials.gov study NCT01575184. IPD Sharing: Not stated. Countries: 1. Publications: 0.
International Registry Study of Neutral Lipid Storage Disease (NLSD) / Triglyceride Deposit Cardiomyovasculopathy (TGCV) and Related Diseases
ClinicalTrials.gov study NCT02918032. IPD Sharing: Not stated. Countries: 9. Publications: 0.
Transdiagnostic Intervention to Reduce Internalized Health-Related Stigma
ClinicalTrials.gov study NCT05561595. IPD Sharing: YES. Countries: 1. Publications: 0.
International Survey of Childbirth-Related Trauma - Swedish Part
ClinicalTrials.gov study NCT06207916. IPD Sharing: NO. Countries: 1. Publications: 0.
International Surveillance of Antimicrobial Resistance in Cirrhosis-Related Infections
ClinicalTrials.gov study NCT06634940. IPD Sharing: YES. Countries: 1. Publications: 0.
Exposure to elevated relative humidity in laboratory chambers alters fungal gene expression in dust from the International Space Station (ISS)
Microbes are present in all occupied indoor environments, including the International Space Station (ISS). An unexpected ventilation system failure may lead to microbial and fungal growth that is associated with material degradation or negative health effects. There is a need for improved understanding of fungal function when exposed to moisture in indoor spaces. A de novo metatranscriptomic study was performed using dust collected from within the ISS. After returning to Earth, dust was incubated in laboratory chambers to simulate relative humidity conditions of 50%, 85%, or 100% equilibrium relative humidity (ERH) for 1-week. Changes in fungal function (gene expression) were associated with moisture exposure. Genes associated with secondary metabolism and fungal growth were significantly upregulated (p ≤ 0.001, log2FC ≥ 2) at elevated RH conditions (85% or 100% ERH). Elevated moisture conditions showed an increased expression of mycotoxin and fungal allergen genes such as Asp f 4 and Alt a 7 (log2FC ≥ 5). These results demonstrate that understanding microbial gene expression in response to elevated moisture will help improve microbial monitoring standards for confined spacecraft environments and help protect astronaut health and spacecraft integrity.
Dataset related to article "Left atrial appendage closure with the II generation Ultraseal device: An international registry. The LIGATE study "
<p>This record contains raw data related to article "Left atrial appendage closure with the II generation Ultraseal device: An international registry. The LIGATE study "</p> <p>Abstract</p> <p><strong>Objectives: </strong> To assess feasibility and safety of second-generation left atrial appendage closure (LAAC) Ultraseal device in patients with nonvalvular atrial fibrillation (NVAF).</p> <p><strong>Background: </strong> LAAC with first-generation Ultraseal device (Cardia, Eagan, Minnesota) has been shown to be a feasible therapeutic option in patients with NVAF. However, there is a paucity of data regarding the novel second-generation Ultraseal device.</p> <p><strong>Methods: </strong> All patients with NVAF undergoing second-generation Ultraseal device implantation between February 2018 and September 2020 were included in a multicenter international registry. Periprocedural and post-discharge events were collected through 6-month follow-up. Co-primary efficacy endpoints were device success and technical success while primary safety endpoint was in-hospital major adverse event (MAE) occurrence.</p> <p><strong>Results: </strong> A total of 52 patients were included: mean age 75 ± 8, 30.8% women, mean HAS-BLED 3 ± 1. The device was successfully implanted in all patients. Technical success was achieved in 50 patients (96.1%). In-hospital MAEs occurred in three patients (5.8%). The incidence of 6-month all-cause death and major bleeding was 11.6% and 2.1%, respectively. No strokes, transient ischemic attacks, systemic embolisms, or device embolization were reported after discharge.</p> <p><strong>Conclusions: </strong> Second-generation Ultraseal device implantation was associated with high success rates and a low incidence of peri-procedural complications. Larger studies with longer follow-up are warranted to further evaluate the safety and the efficacy of this device, especially at long-term follow-up.</p>
Dataset related to article "Internal Guidelines for Reducing Lymph Node Contour Variability in Total Marrow and Lymph Node Irradiation "
<p>This record contains raw data related to article “Internal Guidelines for Reducing Lymph Node Contour Variability in Total Marrow and Lymph Node Irradiation"</p> <p><strong>Background: </strong> The total marrow and lymph node irradiation (TMLI) target includes the bones, spleen, and lymph node chains, with the latter being the most challenging structures to contour. We evaluated the impact of introducing internal contour guidelines to reduce the inter- and intraobserver lymph node delineation variability in TMLI treatments.</p> <p><strong>Methods: </strong> A total of 10 patients were randomly selected from our database of 104 TMLI patients so as to evaluate the guidelines' efficacy. The lymph node clinical target volume (CTV_LN) was recontoured according to the guidelines (CTV_LN_GL_RO1) and compared to the historical guidelines (CTV_LN_Old). Both topological (i.e., Dice similarity coefficient (DSC)) and dosimetric (i.e., V95 (the volume receiving 95% of the prescription dose) metrics were calculated for all paired contours.</p> <p><strong>Results: </strong> The mean DSCs were 0.82 ± 0.09, 0.97 ± 0.01, and 0.98 ± 0.02, respectively, for CTV_LN_Old vs. CTV_LN_GL_RO1, and between the inter- and intraobserver contours following the guidelines. Correspondingly, the mean CTV_LN-V95 dose differences were 4.8 ± 4.7%, 0.03 ± 0.5%, and 0.1 ± 0.1%.</p> <p><strong>Conclusions: </strong> The guidelines reduced the CTV_LN contour variability. The high target coverage agreement revealed that historical CTV-to-planning-target-volume margins were safe, even if a relatively low DSC was observed.</p>
Dataset related to the article "CarDiac magnEtic Resonance for prophylactic Implantable-cardioVerter defibrillAtor ThErapy in Non-Ischaemic dilated CardioMyopathy: an international Registry"
<p>This record contains raw data related to the article “CarDiac magnEtic Resonance for prophylactic Implantable-cardioVerter defibrillAtor ThErapy in Non-Ischaemic dilated CardioMyopathy: an international Registry” <br> </p> <p>Abstract</p> <p><strong>Aims: </strong>The aim of this registry was to evaluate the additional prognostic value of a composite cardiac magnetic resonance (CMR)-based risk score over standard-of-care (SOC) evaluation in a large cohort of consecutive unselected non-ischaemic cardiomyopathy (NICM) patients.</p> <p><strong>Methods and results: </strong>In the DERIVATE registry (www.clinicaltrials.gov/registration: RCT<a href="http://clinicaltrials.gov/show/NCT03352648">#NCT03352648</a>), 1000 (derivation cohort) and 508 (validation cohort) NICM patients with chronic heart failure (HF) and left ventricular ejection fraction <50% were included. All-cause mortality and major adverse arrhythmic cardiac events (MAACE) were the primary and secondary endpoints, respectively. During a median follow-up of 959 days, all-cause mortality and MAACE occurred in 72 (7%) and 93 (9%) patients, respectively. Age and >3 segments with midwall fibrosis on late gadolinium enhancement (LGE) were the only independent predictors of all-cause mortality (HR: 1.036, 95% CI: 1.0117-1.056, P < 0.001 and HR: 2.077, 95% CI: 1.211-3.562, P = 0.008, respectively). For MAACE, the independent predictors were male gender, left ventricular end-diastolic volume index by CMR (CMR-LVEDVi), and >3 segments with midwall fibrosis on LGE (HR: 2.131, 95% CI: 1.231-3.690, P = 0.007; HR: 3.161, 95% CI: 1.750-5.709, P < 0.001; and HR: 1.693, 95% CI: 1.084-2.644, P = 0.021, respectively). A composite clinical and CMR-based risk score provided a net reclassification improvement of 63.7% (P < 0.001) for MAACE occurrence when added to the model based on SOC evaluation. These findings were confirmed in the validation cohort.</p> <p><strong>Conclusion: </strong>In a large multicentre, multivendor cohort registry reflecting daily clinical practice in NICM work-up, a composite clinical and CMR-based risk score provides incremental prognostic value beyond SOC evaluation, which may have impact on the indication of implantable cardioverter-defibrillator implantation.</p>
Dataset related to the article "Cardiac magneticresonanceforprophylactic implantable-cardioverter defibrillator therapy international study:prognosticvalueofcardiac magnetic resonance-derivedrightventricular parameters substudy"
<p>This record contains partial raw data related to the article “Cardiac magneticresonanceforprophylactic implantable-cardioverter defibrillator therapy international study:prognosticvalueofcardiac magnetic resonance-derivedrightventricular parameters substudy"</p> <p><strong>Aims: </strong>Right ventricular (RV) systolic dysfunction (RVSD) has been recognized as an important determinant of outcomes in heart failure (HF) patients. However, assessment of RV volumes is challenging as the geometric complexity of the RV prohibits quantitative assessment by traditional 2D-echocardiography. Cardiac magnetic resonance (CMR) is the gold standard for RV chamber quantification with its high spatial resolution, precise definition of anatomy, and excellent reproducibility. In this study, we sought to investigate the incremental prognostic value of CMR-derived RV volumetric parameters in a large cohort of HF patients with reduced ejection fraction (HFrEF).</p> <p><strong>Methods and Results: </strong>Study cohort comprised of patients enrolled in the CarDiac MagnEtic Resonance for Primary Prevention Implantable CardioVerter DefibrillAtor ThErapy registry who had HFrEF and had simultaneous baseline CMR and echocardiography<br> (n=2449). RVSD was defined as RV ejection fraction (RVEF) <45%. Kaplan–Meier curves and cox regression were used to investigate the association between RVSD and all-cause mortality (ACM). Mean age was 59.8±14.0 years, 42.0% were female, and mean left ventricular ejection fraction (LVEF) was 34.0±10.8. Median follow-up was 959 days (interquartile range: 560–1590). RVSD was present in 936 (38.2%) and was an independent predictor of ACM (adjusted hazard ratio=1.44; 95%CI[1.09–1.91]; P=0.01). On subgroup analyses,the prognostic value of RVSD was more pronounced in NYHA I/II than in NYHAIII/IV, in LVEF <35% than in LVEF ≥35%, and in patients with renal dysfunction when compared to those with normal renal function.</p> <p><strong>Conclusions: </strong>RV dysfunction is an independent predictor of all-cause mortality in a large cohort of patients with HFrEF, with the prognostic value of RV dysfunction being more pronounced in select subgroups; likely reflecting the importance of RV function in the early stages of HF progression.</p>
Dataset related to the article "Cardiac Magnetic Resonance for Prophylactic Implantable-Cardioverter Defibrillator Therapy in Ischemic Cardiomyopathy The DERIVATE–ICM International Registry"
<p>This record contains raw data related to the article “Cardiac Magnetic Resonance for Prophylactic Implantable-Cardioverter Defibrillator Therapy in Ischemic Cardiomyopathy The DERIVATE–ICM International Registry”</p> <p><strong>BACKGROUND</strong> Implantable cardioverter-defibrillator (ICD) therapy is the most effective prophylactic strategy against sudden cardiac death (SCD) in patients with ischemic cardiomyopathy (ICM) and left ventricle ejection fraction (LVEF) #35% as detected by transthoracic echocardiograpgy (TTE). This approach has been recently questioned because of the low rate of ICD interventions in patients who received implantation and the not-negligible percentage of patients who experienced SCD despite not fulfilling criteria for implantation.</p> <p><strong>OBJECTIVES</strong> The DERIVATE (CarDiac MagnEtic Resonance for Primary Prevention Implantable CardioVerter DebrillAtor ThErapy)-ICM registry (NCT03352648) is an international, multicenter, and multivendor study to assess the net reclassification improvement (NRI) for the indication of ICD implantation by the use of cardiac magnetic resonance (CMR) as compared to TTE in patients with ICM.</p> <p><strong>METHODS</strong> A total of 861 patients with ICM (mean age 65 [1] 11 years, 86% male) with chronic heart failure and TTE-LVEF <50% participated. Major adverse arrhythmic cardiac events (MAACE) were the primary endpoints. RESULTS During a median follow-up of 1,054 days, MAACE occurred in 88 (10.2%). Left ventricular end-diastolic volume index (HR: 1.007 [95% CI: 1.000-1.011]; P ¼ 0.05), CMR-LVEF (HR: 0.972 [95% CI: 0.945-0.999]; P ¼ 0.045) and late gadolinium enhancement (LGE) mass (HR: 1.010 [95% CI: 1.002-1.018]; P ¼ 0.015) were independent predictors of MAACE. A multiparametric CMR weighted predictive derived score identifies subjects at high risk for MAACE compared with TTE-LVEF cutoff of 35% with a NRI of 31.7% (P ¼ 0.007).</p> <p><strong>CONCLUSIONS</strong> The DERIVATE-ICM registry is a large multicenter registry showing the additional value of CMR to stratify the risk for MAACE in a large cohort of patients with ICM compared with standard of care.</p>
Dataset related to article "Reduced G protein signaling despite impaired internalization and β-arrestin recruitment in patients carrying a novel CXCR4Leu317fsX3 mutation causing WHIM syndrome"
<p>This record contains raw data related to article "IReduced G protein signaling despite impaired internalization and β-arrestin recruitment in patients carrying a novel CXCR4Leu317fsX3 mutation causing WHIM syndrome"</p><p>WHIM syndrome is an inherited immune disorder caused by an autosomal dominant heterozygous mutation in CXCR4.<i> </i>The disease is characterized by neutropenia/leukopenia (secondary to retention of mature neutrophils in bone marrow), recurrent bacterial infections, treatment-refractory warts, and hypogammaglobulinemia. All mutations reported in WHIM patients lead to the truncations in the C-terminal domain of CXCR4, R334X being the most frequent. This defect prevents receptor internalization, and enhances both calcium mobilization and ERK phosphorylation, resulting in increased chemotaxis in response to the unique ligand CXCL12. Here, we describe three patients presenting neutropenia and myelokathexis, but normal lymphocyte count and immunoglobulin levels, carrying a novel Leu317fsX3 mutation in CXCR4, leading to a complete truncation of its intracellular tail. The analysis of the L317fsX3 mutation in cells derived from patients and <i>in vitro</i> cellular models reveals unique signaling features when compared to R334X mutation. L317fsX3 mutation impairs CXCR4 downregulation and β-arrestin recruitment in response to CXCL12 and reduces other signaling events including ERK1/2 phosphorylation, calcium mobilization and chemotaxis, all processes, which are typically enhanced in cells carrying the R334X mutation. Our findings suggest that overall, the L317fsX3 mutation may be causative of a form of WHIM syndrome not associated with an augmented CXCR4 response to CXCL12.</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.