Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
47
datasets available to search
ShareScore release 0.9.0
Dataset results
47 results for “intracellular signals”
An environmental code tunes the intracellular signaling network activity to shape cellular responses
GEO Series GSE121485. Homo sapiens. 34 samples. Type: Expression profiling by high throughput sequencing.
Trastuzumab Priming on aggregate formation, Intracellular signaling, and the Tumor Microenvironment
GEO Series GSE245593. Homo sapiens. 21 samples. Type: Expression profiling by high throughput sequencing.
IMPACT: Unraveling intracellular signal transduction and pathway crosstalk by exploring pathway landscape
GEO Series GSE50564. Homo sapiens. 12 samples. Type: Expression profiling by array; Third-party reanalysis.
The effect of CPXM2-aligned collagen on gene expresssion and the intracellular signaling pathway in PaTu 8988t cells.
GEO Series GSE292740. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Hydrogen peroxide treatment of Jurkat T lymphoma cells leads to upregulation of genes involved in intracellular signalling pathways
GEO Series GSE206509. Homo sapiens. 16 samples. Type: Expression profiling by high throughput sequencing.
EFFECTS OF IDURSULFASE® TREATMENT ON EXTRACELLULAR MATRIX COMPONENTS, INTRACELLULAR SIGNALING AND PROLIFERATION/DIFFERENTIATION REGULATION IN CALVARIA-DERIVED BONE TISSUE OF APERT SYNDROME PATIENTS
GEO Series GSE94718. Homo sapiens. 12 samples. Type: Expression profiling by array.
Dataset related to the article " Nicotinic Acid Adenine Dinucleotide Phosphate Induces Intracellular Ca2+ Signalling and Stimulates Proliferation in Human Cardiac Mesenchymal Stromal Cells"
<p>This record contains raw data related to the article “Nicotinic Acid Adenine Dinucleotide Phosphate Induces Intracellular Ca<sup>2+</sup> Signalling and Stimulates Proliferation in Human Cardiac Mesenchymal Stromal Cells"</p> <p>Abstract</p> <p>Nicotinic acid adenine dinucleotide phosphate (NAADP) is a newly discovered second messenger that gates two pore channels 1 (TPC1) and 2 (TPC2) to elicit endo-lysosomal (EL) Ca<sup>2+</sup> release. NAADP-induced lysosomal Ca<sup>2+</sup> release may be amplified by the endoplasmic reticulum (ER) through the Ca<sup>2+</sup>-induced Ca<sup>2+</sup> release (CICR) mechanism. NAADP-induced intracellular Ca<sup>2+</sup> signals were shown to modulate a growing number of functions in the cardiovascular system, but their occurrence and role in cardiac mesenchymal stromal cells (C-MSCs) is still unknown. Herein, we found that exogenous delivery of NAADP-AM induced a robust Ca<sup>2+</sup> signal that was abolished by disrupting the lysosomal Ca<sup>2+</sup> store with Gly-Phe β-naphthylamide, nigericin, and bafilomycin A1, and blocking TPC1 and TPC2, that are both expressed at protein level in C-MSCs. Furthermore, NAADP-induced EL Ca<sup>2+</sup> release resulted in the Ca<sup>2+</sup>-dependent recruitment of ER-embedded InsP<sub>3</sub>Rs and SOCE activation. Transmission electron microscopy revealed clearly visible membrane contact sites between lysosome and ER membranes, which are predicted to provide the sub-cellular framework for lysosomal Ca<sup>2+</sup> to recruit ER-embedded InsP<sub>3</sub>Rs through CICR. NAADP-induced EL Ca<sup>2+</sup> mobilization via EL TPC was found to trigger the intracellular Ca<sup>2+</sup> signals whereby Fetal Bovine Serum (FBS) induces C-MSC proliferation. Furthermore, NAADP-evoked Ca<sup>2+</sup> release was required to mediate FBS-induced extracellular signal-regulated kinase (ERK), but not Akt, phosphorylation in C-MSCs. These finding support the notion that NAADP-induced TPC activation could be targeted to boost proliferation in C-MSCs and pave the way for future studies assessing whether aberrant NAADP signaling in C-MSCs could be involved in cardiac disorders.</p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.