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61
datasets available to search
ShareScore release 0.9.0
Dataset results
61 results for “molecular switch”
A conserved molecular logic for neurogenesis to gliogenesis switch in the cerebral cortex
GEO Series GSE254693. Mus musculus. 70 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
A molecular switch at the yeast mitoribosomal tunnel exit controls cytochrome b synthesis
GEO Series GSE283176. Saccharomyces cerevisiae. 23 samples. Type: Other.
Molecular characterization of hybridoma subclones spontaneously switching at high frequencies in vitro
GEO Series GSE15357. Mus musculus. 4 samples. Type: Expression profiling by array.
A molecular switch governs mitochondrial metabolism and cellular senescence during aging
GEO Series GSE184897. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing; Other.
A conserved molecular logic for neurogenesis to gliogenesis switch in the cerebral cortex [CUT&RUN]
GEO Series GSE254691. Mus musculus. 24 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Lysine methylation of EHMT1/GLP as a molecular switch to reprogram transcription networks in prostate cancer
GEO Series GSE201771. Homo sapiens. 48 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing.
Lysine methylation of EHMT1/GLP as a molecular switch to reprogram transcription networks in prostate cancer [ChIP-seq]
GEO Series GSE201769. Homo sapiens. 18 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
The RelA hydrolase domain acts as a molecular switch for (p)ppGpp synthesis
GEO Series GSE150416. Escherichia coli. 10 samples. Type: Expression profiling by high throughput sequencing.
A conserved molecular logic for neurogenesis to gliogenesis switch in the cerebral cortex [CUT&RUN 22]
GEO Series GSE254692. Mus musculus. 28 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Designing Molecular RNA Switches with Restricted Boltzmann Machines
GEO Series GSE266263. Bacteria; synthetic construct. 22 samples. Type: Other; Expression profiling by high throughput sequencing.
Molecular mechanism for switching of P.falciparum invasion pathways into human erythrocytes
GEO Series GSE2878. Plasmodium falciparum. 3 samples. Type: Expression profiling by array.
Molecular basis of BMP-responsiveness switching during neural development
GEO Series GSE174306. Mus musculus. 5 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
A Molecular Switch from Tumor Suppressor to Oncogene in ER-Positive Breast Cancer: Role of Androgen Receptor, JAK-STAT, and Lineage Plasticity [RNA-seq I]
GEO Series GSE274720. Homo sapiens. 30 samples. Type: Expression profiling by high throughput sequencing.
Transcriptome and translatome profiling of Mtb-infected human DC identifies GSK-3beta as a molecular switch of rapamycin-driven immune stimulation
GEO Series GSE163531. Homo sapiens. 32 samples. Type: Expression profiling by array.
Vemurafenib acts as molecular switch in Langerhans Cell Histiocytosis
GEO Series GSE175480. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
A molecular switch between mammalian MLL complexes dictates response to Menin-MLL inhibition [RNA-seq]
GEO Series GSE186709. Mus musculus; Homo sapiens. 42 samples. Type: Expression profiling by high throughput sequencing.
Dataset related to article "Intratumoral Switch of Molecular Phenotype and Overall Survival in Muscle Invasive Bladder Cancer"
<p>This record contains raw data related to article “Intratumoral Switch of Molecular Phenotype and Overall Survival in Muscle Invasive Bladder Cancer"</p> <p>Abstract</p> <p>In recent years, immunohistochemical protein expression was studied as a surrogate to the molecular classification of bladder cancer, although no tissue biomarkers are available for clinical use to predict survival or the response to neoadjuvant chemotherapy (CT) in UC, as the literature produced conflicting results. This retrospective study included TURB specimens harboring foci of HG pT2 muscle-invasive bladder carcinoma (MIBC) from 251 patients who subsequently underwent radical cystectomy. We performed immunohistochemical analysis on tumor samples, for relevant gene-expression-based markers for basal type (<em>CD44</em>, <em>CK5/6</em>) and luminal type (<em>CK20</em> and <em>pPARγ</em>). Piescore, investigated in both non-muscle-invasive (NMI) and muscle-invasive (MI) components of the tumor, divided basal and luminal UC-types when at least three of the four markers were consistent with a specific phenotype, mixed types if one/two luminal and basal markers were present simultaneously, and neu-like types when all four markers investigated were negative. Eighteen selected cases were also investigated with RT-PCR to validate, and to increase the specificity of, the immunohistochemical results. We observe an immunophenotypical difference in the NMI and MI components in 96/251 UC patients (38.25%): half of tumors (44/96 cases) have a transition to basal, 36.46% (35/96 cases) to neu-like, 12.5% (12/96 cases) to mixed, and 5.2% (5/96 cases) to luminal phenotypes. Mixed tumors in the NMI component are more likely to change phenotype than other groups, particularly compared with basal tumors, which demonstrate greater stability (only 8/96 cases, <em>p</em> &lt; 0.00001). The transition of luminal tumors to basal display a better OS compared with the transition toward neu-like tumors (<em>p</em> = 0.027). Overall, the phenotypical switch does not affect lymphovascular invasion, pT, DFS, or OS compared with non-switched cases. In the MI component, the presence of <em>CD44</em> expression, irrespective of score-related phenotype, shows a protective effect in papillary-type UC (OS <em>p</em> = 0.008, HR 0.453, PFS <em>p</em> = 0.07, HR 0.599), and in UC naïve for CT (<em>p</em> = 0.0479). Piescore immunophenotyping reveals an intratumoral phenotypical transition between the NMI and MI components of the same tumor. The molecular change is a common event in the mixed and luminal categories, but not in basal tumors, which show better phenotypical stability. This phenomenon could partially explain the sensitivity of a subset of luminal UC to chemotherapy: good responders could be "non-real" luminal UC, which acquire nasal markers, such as <em>CD44</em>.</p>
A molecular switch between mammalian MLL complexes dictates response to Menin-MLL inhibition [ChIP-seq]
GEO Series GSE186695. Mus musculus. 30 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
A Molecular Switch for Neuroprotective Astrocyte Reactivity
GEO Series GSE245816. Homo sapiens. 5 samples. Type: Expression profiling by high throughput sequencing.
A molecular switch between mammalian MLL complexes dictates response to Menin-MLL inhibition
GEO Series GSE186711. Homo sapiens; Mus musculus. 72 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.