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117 results for “network inference”
scMEGA: Single-cell Multiomic Enhancer-based Gene Regulatory Network Inference
<p>The increasing availability of single-cell multi-omics data allow to quantitatively characterize gene regulation. We here describe scMEGA (Single-cell Multiomic Enhancer-based Gene Regulatory Network Inference) to infer gene regulatory network by combining single cell gene expression and chromatin accessibility profiles. This allows to study complex gene regulation mechanisms for dynamic biological processes, such as cellular differentiation and disease development. We provide a case study on gene regulatory networks controlling myofibroblast activation in human myocardial infarction.</p>
Inference and Test Generation Using Program Invariants in Chemical Reaction Networks Artifacts
<p>The artifacts for Inference and Test Generation Using Program Invariants in Chemical Reaction Networks, published at ICSE 2022.</p> <p>The pdf of the paper can be accessed at <a href="https://ieeexplore.ieee.org/document/9794130">IEEEXplore</a>.</p> <p><strong>To cite this work, please use the citation below:</strong></p> <pre>@INPROCEEDINGS{GertenICSE22, author={Gerten, Michael C. and Marsh, Alexis L. and Lathrop, James I. and Cohen, Myra B. and Miner, Andrew S. and Klinge, Titus H.}, booktitle={2022 IEEE/ACM 44th International Conference on Software Engineering (ICSE)}, title={Inference and Test Generation Using Program Invariants in Chemical Reaction Networks}, month={May}, year={2022}, pages={1193-1205}, doi={10.1145/3510003.3510176}}</pre> <p>The artifacts are also available on <a href="https://github.com/LavaOps/ICSE-2022-Artifacts">GitHub</a>.</p> <p><strong>This is an updated version of the ChemFlow tool. The update addressed an overflow error when computing gaussian elimination that could result in incorrect invariants with certain model inputs. After verification, all models in this work were not affected by this bug and have the same set of invariants generated by both versions. We have updated the docker file to use the new code as well.</strong></p>
FIGURE 4. TCS haplotype network inferred from ITS-2 in The polyphasic approach revealed new species of Chloroidium (Trebouxiophyceae, Chlorophyta)
FIGURE 4. TCS haplotype network inferred from ITS-2 rDNA sequences of Chloroidium saccharophilum. This network was inferred using the algorithm described by Clement et al. (2002). Sequence nodes corresponding to samples collected from different geographical region and from different habitats.
FIGURE 5. TCS haplotype network inferred from ITS-2 in The polyphasic approach revealed new species of Chloroidium (Trebouxiophyceae, Chlorophyta)
FIGURE 5. TCS haplotype network inferred from ITS-2 rDNA sequences of Chloroidium ellipsoideum and C. lichenum. This network was inferred using the algorithm described by Clement et al. (2002). Sequence nodes corresponding to samples collected from different geographical region and from different habitats.
Double shrinking (DOSH), a regression-based algorithm for gene regulatory network inference from co-expression data
<p>Data for the preprint "Double shrinking (DOSH), a regression-based algorithm for gene regulatory network inference from co-expression data". The preprint is live on ResearchSquare: <a href="http://t.researchsquare.com/track/click/31114617/doi.org?p=eyJzIjoiWVJQQUYtT09mMXFoWnRoMGk0SlpQZTZqWWpJIiwidiI6MSwicCI6IntcInVcIjozMTExNDYxNyxcInZcIjoxLFwidXJsXCI6XCJodHRwczpcXFwvXFxcL2RvaS5vcmdcXFwvMTAuMjEyMDNcXFwvcnMuMy5ycy0yNzM4NjgzXFxcL3YxXCIsXCJpZFwiOlwiZDMzODNjZGNhNWNiNGE2Yjk5NWRkY2UyNmIyODI5NTlcIixcInVybF9pZHNcIjpbXCIzZGQwZTAxMmExMzk4NDhkNTAzYjI4ZTBiZmU1Y2QxMDcxNzhlZTgwXCJdfSJ9">10.21203/rs.3.rs-2738683/v1</a>.</p>
Dataset associated with Inferring Cell-Type-Specific Causal Gene Regulatory Networks during Human Neurogenesis
<p>Full summary statistics for QTLs generated in study titled "Inferring Cell-Type-Specific Causal Gene Regulatory Networks during Human Neurogenesis"</p> <p>The big "data" folder includes datasets for each model under subfolders Model 1A, Model 1B and Model 2 as following tree</p> <p>data<br> │ ├───Model1A<br> │ │ ├───caQTL<br> │ │ │ ├───neuron<br> │ │ │ └───progenitor<br> │ │ └───eQTL<br> │ │ ├───neuron<br> │ │ └───progenitor<br> │ ├───Model1B<br> │ └───Model2</p> <p> </p> <p> </p>
Data for "Monte Carlo samplers for efficient network inference"
<p>This directory contains data corresponding to all figures in the publication "Monte Carlo samplers for efficient network inference" in PLOS Computational Biology by Z. Kilic et al.</p>
Data from: Does detection range matter for inferring social networks in a benthic shark using acoustic telemetry?
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Data from: Chromosome-scale inference of hybrid speciation and admixture with convolutional neural networks
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Data from: Inferring species networks from gene trees in high-polyploid North American and Hawaiian violets (Viola, Violaceae)
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Data from: Inferring HIV-1 transmission networks and sources of epidemic spread in Africa with deep-sequence phylogenetic analysis
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Data from: How to make methodological decisions when inferring social networks
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Data from: Maximum parsimony inference of phylogenetic networks in the presence of polyploid complexes
<p>Phylogenetic networks provide a powerful framework for modeling and analyzing reticulate evolutionary histories. While polyploidy has been shown to be prevalent not only in plants but also in other groups of eukaryotic species, most work done thus far on phylogenetic network inference assumes diploid hybridization. These inference methods have been applied, with varying degrees of success, to data sets with polyploid species, even though polyploidy violates the mathematical assumptions underlying these methods. Statistical methods were developed recently for handling specific types of polyploids and so were parsimony methods that could handle polyploidy more generally yet while excluding processes such as incomplete lineage sorting.</p> <p>In this paper, we introduce a new method for inferring most parsimonious phylogenetic networks on data that include polyploid species. Taking gene trees as input, the method seeks a phylogenetic network that minimizes deep coalescences while accounting for polyploidy. The method could also infer trees, thus potentially distinguishing between auto- and allo-polyploidy. We demonstrate the performance of the method on both simulated and biological data. The inference method as well as a method for evaluating given phylogenetic networks are implemented and publicly available in the PhyloNet software package.</p>
Hierarchical Inference With Bayesian Neural Networks: An Application to Strong Gravitational Lensing - Model Weights, Chains, BNN Samples, and Simulated Datasets
<p>The model weights, chains, simulated datasets, and BNN samples used to produce the results shown in LSST DESC Collaboration paper "Hierarchical Inference With Bayesian Neural Networks: An Application to Strong Gravitational Lensing." All files presented here are meant for use in tandem with the python package "ovejero" (<a href="https://github.com/swagnercarena/ovejero">https://github.com/swagnercarena/ovejero</a>).</p>
Data from: System-level insights into the cellular interactome of a non-model organism: inferring, modelling and analysing functional gene network of Soybean (Glycine max)
Cellular interactome, in which genes and/or their products interact on several levels, forming transcriptional regulatory-, protein interaction-, metabolic-, signal transduction networks, etc., has attracted decades of research focuses. However, such a specific type of network alone can hardly explain the various interactive activities among genes. These networks characterize different interaction relationships, implying their unique intrinsic properties and defects, and covering different slices of biological information. Functional gene network (FGN), a consolidated interaction network that models fuzzy and more generalized notion of gene-gene relations, have been proposed to combine heterogeneous networks with the goal of identifying functional modules supported by multiple interaction types. There are yet no successful precedents of FGNs on sparsely studied non-model organisms, such as soybean (Glycine max), due to the absence of sufficient heterogeneous interaction data. We present an alternative solution for inferring the FGNs of soybean (SoyFGNs), in a pioneering study on the soybean interactome, which is also applicable to other organisms. SoyFGNs exhibit the typical characteristics of biological networks: scale-free, small-world architecture and modularization. Verified by co-expression and KEGG pathways, SoyFGNs are more extensive and accurate than an orthology network derived from Arabidopsis. As a case study, network-guided disease-resistance gene discovery indicates that SoyFGNs can provide system-level studies on gene functions and interactions. This work suggests that inferring and modelling the interactome of a non-model plant are feasible. It will speed up the discovery and definition of the functions and interactions of other genes that control important functions, such as nitrogen fixation and protein or lipid synthesis. The efforts of the study are the basis of our further comprehensive studies on the soybean functional interactome at the genome and microRNome levels. Additionally, a web tool for information retrieval and analysis of SoyFGNs can be accessed at SoyFN: http://nclab.hit.edu.cn/SoyFN.
Data from: Bayesian inference of reticulate phylogenies under the multispecies network coalescent
The multispecies coalescent (MSC) is a statistical framework that models how gene genealogies grow within the branches of a species tree. The field of computational phylogenetics has witnessed an explosion in the development of methods for species tree inference under MSC, owing mainly to the accumulating evidence of incomplete lineage sorting in phylogenomic analyses. However, the evolutionary history of a set of genomes, or species, could be reticulate due to the occurrence of evolutionary processes such as hybridization or horizontal gene transfer. We report on a novel method for Bayesian inference of genome and species phylogenies under the multispecies network coalescent (MSNC). This framework models gene evolution within the branches of a phylogenetic network, thus incorporating reticulate evolutionary processes, such as hybridization, in addition to incomplete lineage sorting. As phylogenetic networks with different numbers of reticulation events correspond to points of different dimensions in the space of models, we devise a reversible-jump Markov chain Monte Carlo (RJMCMC) technique for sampling the posterior distribution of phylogenetic networks under MSNC. We implemented the methods in the publicly available, open-source software package PhyloNet and studied their performance on simulated and biological data. The work extends the reach of Bayesian inference to phylogenetic networks and enables new evolutionary analyses that account for reticulation.
Unexpected high accuracy of landscape genetics inference with convolutional neural networks
<p>During the last decade convolutional neural networks (CNNs) have revolutionized the application of machine learning methods to classification tasks and object recognition. These procedures can summarize with great effectiveness image data in key features that allow to classify and predict with exceptional precision. Here we show for the first time how CNNs provide highly accurate predictions of small-scale genetic differentiation and diversity in a subterranean rodent from central Argentina. Using microsatellite genotypes and high resolution satellite imagery we trained a simple CNN which was able to predict local Fst and allele diversity accounting for more than 99% of their variation. When trained with changed landscape settings the CNN still highly accounted for ~60% of variation emerging as a promising tool for population and conservation genetics.</p>
MUSDB18-HQ Test Set Inference Outputs for Models from "A Generalized Bandsplit Neural Network for Cinematic Audio Source Separation"
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Data from: Spatial familial networks to infer demographic structure of wild populations
<p class="List1">In social species, reproductive success and rates of dispersal vary among individuals resulting in spatially structured populations. Network analyses of familial relationships may provide insights on how these parameters influence population-level demographic patterns. These methods have however rarely been applied to genetically-derived pedigree data from wild populations.</p> <p class="List1">Here we use parent-offspring relationships to construct familial networks from polygamous boreal woodland caribou (<i>Rangifer tarandus caribou</i>) in Saskatchewan, Canada, to inform recovery efforts. We collected samples from 933 individuals at 15 variable microsatellite loci along with caribou-specific primers for sex identification. Using network measures, we assess the contribution of individual caribou to the population with several centrality measures and then determine which measures are best suited to inform on the population demographic structure. We investigate the centrality of individuals from eighteen different local areas, along with the entire population.</p> <p class="List1">We found substantial differences in centrality of individuals in different local areas, that in turn contributed differently to the full network, highlighting the importance of analyzing networks at different scales. The full network revealed that boreal caribou in Saskatchewan form a complex, interconnected familial network, as the removal of edges with high betweenness did not result in distinct subgroups. Alpha, betweenness, and eccentricity centrality were the most informative measures to characterize the population demographic structure and for spatially identifying areas of highest fitness levels and family cohesion across the range. We found varied levels of dispersal, fitness and cohesion in family groups.</p> <p class="List1"><i>Synthesis and applications</i>: Our results demonstrate the value of different network measures in assessing genetically-derived familial networks. The spatial application of the familial networks identified individuals presenting different fitness levels, short and long-distance dispersing ability across the range in support of population monitoring and recovery efforts.</p>
road network inference algorithms
<p>The document includes the Chicago trajectory dataset and several map inference algorithms.</p>
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.