Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
2,021
datasets available to search
ShareScore release 0.7.1
Dataset results
2,021 results for “non-invasive”
Differences in dogs’ event related potentials in response to human and dog vocal stimuli: A non-invasive study
Open the record for dataset details and reuse information.
Data from: Non-invasive age estimation based on fecal DNA using methylation-sensitive high-resolution melting for Indo-Pacific bottlenose dolphins
Open the record for dataset details and reuse information.
Data from: Wildlife fecal microbiota exhibit community stability across a semi-controlled longitudinal non-invasive sampling experiment
Open the record for dataset details and reuse information.
Data from: Non-invasive estimation of absorbed ionizing radiation dose in mice using Near-Infrared Spectroscopy (NIRS) and aquaphotomics
Open the record for dataset details and reuse information.
Data from: Non-invasive biophysical measurement of travelling waves in the insect inner ear
Frequency analysis in the mammalian cochlea depends on the propagation of frequency information in the form of a travelling wave (TW) across tonotopically arranged auditory sensilla. TWs have been directly observed in the basilar papilla of birds and the ears of bush-crickets (Insecta: Orthoptera) and have also been indirectly inferred in the hearing organs of some reptiles and frogs. Existing experimental approaches to measure TW function in tetrapods and bush-crickets are inherently invasive, compromising the fine-scale mechanics of each system. Located in the forelegs, the bush-cricket ear exhibits outer, middle and inner components; the inner ear containing tonotopically arranged auditory sensilla within a fluid-filled cavity, and externally protected by the leg cuticle. Here, we report bush-crickets with transparent ear cuticles as potential model species for direct, non-invasive measuring of TWs and tonotopy. Using laser Doppler vibrometry and spectroscopy, we show that increased transmittance of light through the ear cuticle allows for effective non-invasive measurements of TWs and frequency mapping. More transparent cuticles allow several properties of TWs to be precisely recovered and measured in vivo from intact specimens. Our approach provides an innovative, non-invasive alternative to measure the natural motion of the sensilla-bearing surface embedded in the intact inner ear fluid.
Comparing Non-invasive Diabetes Risk Scores for Detecting Patients in Clinical Practice
<p>The Cork and Kerry Diabetes and Heart Disease Study (Phase II – Mitchelstown Cohort) was a single centre study conducted between 2010 and 2011. A random sample was recruited from a large primary care centre in Mitchelstown, County Cork, Ireland. The Livinghealth Clinic serves a population of approximately 20,000 Caucasian-European subjects, with a mix of urban and rural residents. Stratified sampling was employed to recruit equal numbers of men and women from all registered attending patients in the 46–73-year age group. In total, 3,807 potential participants were selected from the practice list. Following the exclusion of duplicates, deaths and subjects incapable of consenting or attending appointment, 3,051 were invited to participate in the study and of these, 2,047 (49% male) completed the questionnaire and physical examination components of the baseline assessment (response rate: 67%). Individuals with pre-existing cardiovascular disease or T2DM were not excluded from the cohort.</p>
DNA sequence data generated using non-invasive feather and eggshell samples from the Grenada Dove for two gene regions: Cyt b and ND2
<p>As an island endemic with a decreasing population, the Critically Endangered Grenada Dove <em>Leptotila wellsi</em> is threatened by accelerated loss of genetic diversity resulting from ongoing habitat fragmentation. Small, threatened populations are difficult to sample directly but advances in molecular methods mean that non-invasive samples can be used. We performed the first assessment of genetic diversity of populations of Grenada Dove by a) assessing mtDNA genetic diversity in the only two areas of occupancy on Grenada, b) defining the number of haplotypes present at each site and c) evaluating evidence of isolation between sites. We used non-invasively collected samples from two locations: Mt Hartman (n=18) and Perseverance (n=12). DNA extraction and PCR were used to amplify 1,751 bps of mtDNA from two mitochondrial markers: NADH dehydrogenase 2 (<em>ND2</em>) and Cytochrome b (<em>Cyt b</em>). Haplotype diversity (<em>h</em>) of 0.4, a nucleotide diversity (π) of 0.00023 and two unique haplotypes were identified within the <em>ND2</em> sequences; a single haplotype was identified within the <em>Cyt b </em>sequences. Of the two haplotypes identified; the most common haplotype (haplotype A = 73.9%) was observed at both sites and the other (haplotype B = 26.1%) was unique to Perseverance. Our results show low mitochondrial genetic diversity and clear evidence for genetically isolated populations. The Grenada Dove needs urgent conservation action, including habitat protection and potential augmentation of gene flow by translocation in order to increase genetic resilience and diversity with the ultimate aim of securing the long-term survival of this Critically Endangered species. </p>
Multimodal Epigenetic Sequencing Analysis (MESA) of Cell-free DNA for Non-invasive Colorectal Cancer Detection
<p>Processed data (feature-by-sample matrices) of non-disruptive bisulfite-free methylation sequencing for cfDNA samples from 4 clinical cohorts (Cohort 1, Cohort 2, Cohort 3, and cfTAPS dataset). Codes used to repeat the results in our paper can be found https://rpubs.com/LiYumei/926228 and https://github.com/ChaorongC/MESA. </p>
Data from: Evaluating genotyping-in-thousands by sequencing as a genetic monitoring tool for a climate sentinel mammal using non-invasive and archival samples
<p>Genetic tools for wildlife monitoring can provide valuable information on spatiotemporal population trends and connectivity, particularly in systems experiencing rapid environmental change. Though many DNA sequencing approaches still require high quality and quantity of DNA obtained from traditional sources (e.g. blood and tissue), rapid genotyping tools such as Genotyping-in-Thousands by sequencing (GT-seq) have improved our ability to make use of degraded and less concentrated DNA commonly obtained from non-invasive and archival samples. Here, we developed a multi-purpose GT-seq panel (307 single nucleotide polymorphisms) for a climate sentinel mammal (the American pika, <em>Ochotona princeps</em>) for use as a genetic tool for monitoring populations in the Canadian Rocky Mountains. We optimized the panel using contemporary tissue samples (n = 77) and subsequently applied it to archival tissue (n = 17) and contemporary fecal pellet samples (n = 129) to evaluate its effectiveness at identifying individuals and sex, estimating relatedness, and inferring population structure. The panel demonstrated high efficacy with contemporary and archival tissue samples (94.7% and 90.5% genotyping success, respectively) and negligible genotyping error (0.001% and 0.0%, respectively). Despite relatively high genotyping success for fecal pellet samples (79.7%), high genotyping error (28.4%) limited its power as a monitoring tool to assess genetic variation using non-invasive samples and highlighted the need for further optimization around sample and data collection.</p>
Dataset from the Study: "A non-invasive approach to skin cancer diagnosis via graphene electrical tattoos and electrical impedance tomography"
<p>This repository contains the scripts and other resources used in:</p> <p>“A non-invasive approach to skin cancer diagnosis via graphene electrical tattoos and electrical impedance tomography”, Lee H et al. 10.1088/1361-6579/ad3d26</p> <p> </p> <p>>> THIS DATA IS FREE FOR USE IN ANY SCIENTIFIC RESEARCH WITH CITATION (PLEASE USE THE DOI FOR PRECISE CITATION): DOI 10.1088/1361-6579/ad3d26</p> <p> </p> <p>>> IF YOU USE THESE RESOURCES, CITE!!!</p> <p> </p> <p>The repository contains the phantom experimental data and the code and resources to generate the numerical/computational models.</p> <p> </p> <p>Note:</p> <p>Software used in this study:</p> <ul> <li>MATLAB</li> <li>EIDORS </li> </ul> <p>Measurement system used in this study:</p> <ul> <li>Sciospec EIT32 system</li> </ul>
Non-invasive genomics of respiratory pathogens infecting wild great apes using hybridization capture
<p>This dataset complements a manuscript reporting genomic analyses of respiratory pathogens cuasing lethal outbreaks in the wild chimpanzee community living in Tai National Park, Ivory Coast.</p>
Data from: Targeted genome-wide SNP genotyping in feral horses using non-invasive fecal swabs
<p>The development of high-throughput sequencing has prompted a transition in wildlife genetics from using microsatellites toward sets of Single Nucleotide Polymorphisms (SNPs). However, genotyping large numbers of targeted SNPs using non-invasive samples remains challenging due to relatively large DNA input requirements. Recently, target enrichment has emerged as a promising approach requiring little template DNA. We assessed the efficacy of Tecan Genomics' Allegro Targeted Genotyping (ATG) for generating genome-wide SNP data in feral horses using DNA isolated from fecal swabs. Total and host-specific DNA were quantified for 989 samples collected as part of a long-term individual-based study of feral horses on Sable Island, Nova Scotia, Canada, using dsDNA fluorescence and a host-specific qPCR assay, respectively. Forty-eight samples representing 44 individuals containing at least 10ng of host DNA (ATG's recommended minimum input) were genotyped using a custom multiplex panel targeting 279 SNPs. Genotyping accuracy and consistency were assessed by contrasting ATG genotypes with those obtained from the same individuals with SNP microarrays, and from multiple samples from the same horse, respectively. 62% of swabs yielded the minimum recommended amount of host DNA for ATG. Ignoring samples that failed to amplify, ATG recovered an average of 86.7% targeted sites per sample, while genotype concordance between ATG and SNP microarrays was 98.5%. The repeatability of genotypes from the same individual approached unity with an average of 99.9%. This study demonstrates the suitability of ATG for genome-wide, non-invasive targeted SNP genotyping, and will facilitate further ecological and conservation genetics research in equids and related species.</p>
Evaluating the use of hair as a non-invasive indicator of trace mineral status in woodland caribou (Rangifer tarandus caribou)
<p>Trace mineral imbalances can have significant effects on animal health, reproductive success, and survival. Monitoring their status in wildlife populations is, therefore, important for management and conservation. Typically, livers and kidneys are sampled to measure mineral status, but biopsies and lethal-sampling are not always possible, particularly for Species at Risk. We aimed to: 1) determine baseline mineral levels in Northern Mountain caribou (<em>Rangifer tarandus caribou</em>; Gmelin, 1788) in northwestern British Columbia, Canada, and 2) determine if hair can be used as an effective indicator of caribou mineral status by evaluating associations between hair and organ mineral concentrations. Hair, liver, and kidney samples from adult male caribou (n<sub>Hair</sub>= 31; n<sub>Liver</sub>, n<sub>Kidney</sub>= 43) were collected by guide-outfitters in 2016-2018 hunting seasons. Trace minerals and heavy metals were quantified using inductively-coupled plasma mass spectrometry, and organ and hair concentrations of same individuals were compared. Some organ mineral concentrations differed from other caribou populations, though no clinical deficiency or toxicity symptoms were reported in our population. Significant correlations were found between liver and hair selenium (rho=0.66, p<0.05), kidney and hair cobalt (rho=0.51, p<0.05), and liver and hair molybdenum (rho=0.37, p<0.10). These findings suggest that hair trace mineral assessment may be used as a non-invasive and easily-accessible way to monitor caribou selenium, cobalt, and molybdenum status, and may be a valuable tool to help assess overall caribou health.</p>
Data from: A genotyping-in-thousands by sequencing panel to inform invasive deer management using non-invasive fecal and hair samples
<p>Studies in ecology, evolution, and conservation often rely on non-invasive samples, making it challenging to generate large amounts of high-quality genetic data for many elusive and at-risk species. We developed and optimized a Genotyping-in-Thousands by sequencing (GT-seq) panel using non-invasive samples to inform the management of invasive Sitka black-tailed deer (<em>Odocoileus hemionus sitkensis</em>) in Haida Gwaii (Canada). We validated our panel using paired high-quality tissue and non-invasive fecal and hair samples to simultaneously distinguish individuals, identify sex and reconstruct kinship among deer sampled across the archipelago, then provided a proof-of-concept application using field-collected feces on SGang Gwaay, an island of high ecological and cultural value. Genotyping success across 244 loci was high (90.3%) and comparable to that of high-quality tissue samples genotyped using restriction-site associated DNA sequencing (92.4%), while genotyping discordance between paired high-quality tissue and non-invasive samples was low (0.50%). The panel will be used to inform future invasive species operations (culls or eradications) in Haida Gwaii by providing individual and population information to inform management. More broadly, our GT-seq workflow that includes quality control analyses for targeted SNP selection and a modified protocol may be of wider utility for other studies and systems where non-invasive genetic sampling is employed.</p>
In vivo optimization of the experimental conditions for the non-invasive optical assessment of breast density
<p>We applied time-domain diffuse optical spectroscopy over a broad spectral range (600-1100 nm) to estimate the breast composition in terms of water, lipids, collagen, oxy- and deoxy-hemoglobin concentrations, together with scattering parameters (scattering amplitude <em>a</em> and scattering power <em>b</em>). These optical parameters are correlated with the density of the breast, which is an important risk factor involved in the development of breast cancer. We performed <em>in vivo </em>measurement on 11 healthy volunteers, using a measurement protocol that involves reflectance and transmittance geometries, different positions of the subject and different measurement locations on the breast. This work has been pubblished in Scientific Reports: https://doi.org/10.1038/s41598-024-70099-x .</p> <p>This page contains the dataset generated during this work, togheter with some tools to read it and the analysis that we performed.</p>
Validation of urine p-cresol glucuronide as renal cell carcinoma non-invasive biomarker
<p><strong>Description of the study</strong>: Renal cell carcinoma (RCC) stands among the most lethal urological malignancies. Most RCCs are incidentally diagnosed as initial symptoms are unspecific. Novel, minimally-invasive diagnostic and prognostic methods for RCC are needed, ideally in urine.</p> <p>Using UPLC-Q-ToF MS untargeted metabolomic analysis in urine, we previously revealed p-cresol glucuronide as potential RCC diagnostic marker. Additionally, urine samples one-year post-nephrectomy revealed isobutyryl-L-carnitine and L-proline betaine as potential RCC prognostic markers. Our present aim was to validate these differences in an independent cohort of RCC patients and healthy controls to strengthen their value as non-invasive biomarkers.</p> <p>In an independent cohort of 69 RCC patients and 52 controls we validated an increase in p-cresol glucuronide in urine from patients at diagnosis compared to controls (<em>P</em>=0.0043). It remained increased one-year post-nephrectomy (<em>P</em>=0.0288). The value of p-cresol glucuronide for RCC diagnosis was assessed with ROC curves analysis (AUC=0.66, 95% Confidence Interval 0.56-0.76). The role of isobutyryl-L-carnitine and <a name="_Hlk172707445"></a>L-proline betaine as prognostic markers could not be validated and will require a larger cohort.</p> <p>Our findings confirm the value of p-cresol glucuronide in urine as diagnostic marker for RCC in an independent cohort. This non-invasive method holds promise for enhancing patient care by reducing the need for potentially risky diagnostic procedures. Further metaproteomics-oriented approaches towards the tyrosine oxidation pathway and microbiota metagenomics studies may promote a holistic management of RCC.</p> <p><strong>Description of the data:</strong></p> <p>We provided data in .d format adquired with Agilent.</p> <p> </p> <p> </p>
A high-resolution finite element method (FEM) human head model for non-invasive brain stimulation
<p>High-resolution finite element method (FEM) model of a human head for non-invasive brain stimulation modeling using SimNIBS or other compatible software. The original head model (Ernie) was downloaded from the tutorial dataset of <a href="http://simnibs.org">www.simnibs.org</a> and further refined in grey matter and white matter regions.</p> <p>This supplementary dataset is released as part of the NeMo-TMS toolbox (<a href="https://github.com/OpitzLab/NeMo-TMS">https://github.com/OpitzLab/NeMo-TMS</a>). Please refer to the corresponding article for more information:</p> <p>Shirinpour, S., Hananeia, N., Rosado, J., Galanis, C., Vlachos, A., Jedlicka, P., Queisser, G., & Opitz, A. (2020). Multi-scale Modeling Toolbox for Single Neuron and Subcellular Activity under (repetitive) Transcranial Magnetic Stimulation. <em>BioRxiv</em>, 2020.09.23.310219. <a href="https://doi.org/10.1101/2020.09.23.310219">https://doi.org/10.1101/2020.09.23.310219</a></p>
Data in support to the manuscript: Testing a novel sensor design to jointly measure cosmic-ray neutrons, muons and gamma rays for non-invasive soil moisture estimation by Gianessi et al. (2024)
<p>The files contain data presented and discussed in the manuscript: Testing a novel sensor design to jointly measure cosmic-ray neutrons, muons and gamma rays for non-invasive soil moisture estimation by Gianessi et al. (2024).</p> <div> <div>Gianessi, Stefano, Matteo Polo, Luca Stevanato, Marcello Lunardon, Till Francke, Sascha E. Oswald, Hami Said Ahmed, et al. “Testing a Novel Sensor Design to Jointly Measure Cosmic-Ray Neutrons, Muons and Gamma Rays for Non-Invasive Soil Moisture Estimation.” <em>Geoscientific Instrumentation, Methods and Data Systems</em> 13, no. 1 (January 16, 2024): 9–25. <a href="https://doi.org/10.5194/gi-13-9-2024">https://doi.org/10.5194/gi-13-9-2024</a>.</div> </div> <p> </p>
The soundscape of swarming: Proof of concept for a non-invasive acoustic species identification of swarming Myotis bats
<p>Bats emit echolocation calls to orientate in their predominantly dark environment. Recording of species-specific calls can facilitate species identification, especially when mist-netting is not feasible. However, some taxa, such as Myotis bats are hard to distinguish acoustically. In crowded situations where calls of many individuals overlap the subtle differences between species are additionally attenuated. Here we sought to non-invasively study the phenology of <em>Myotis</em> bats during autumn swarming at a prominent hibernaculum. To do so we recorded sequences of overlapping echolocation calls (N=564) during nights of high swarming activity and extracted spectral parameters (peak frequency, start frequency, spectral centroid) and Linear Frequency Cepstral Coefficients (LFCCs) which additionally encompass the timbre (vocal 'colour') of calls. We used this parameter combination in a stepwise discriminant function analysis (DFA) to classify the call sequences to species level. A set of previously identified call sequences of single flying <em>Myotis</em> <em>daubentonii</em> and <em>Myotis</em> <em>nattereri</em>, the most common species at our study site, functioned as a training set for the DFA. 90.2% of the call sequences could be assigned to either <em>M</em>. <em>daubentonii</em> or <em>M</em>. <em>nattereri</em>, indicating the predominantly swarming species at the time of recording. We verified our results by correctly classifying a second set of previously identified call sequences with an accuracy of 100%. In addition, our acoustic species classification corresponds well to the existing knowledge on swarming phenology at the hibernaculum. Moreover, we successfully classified call sequences from a different hibernaculum to species level and verified our classification results by capturing swarming bats while we recorded them. Our findings provide the basis for a new non-invasive acoustic monitoring technique that analyses "swarming soundscapes" by combining classical acoustic parameters and LFCCs, instead of analysing single calls. Our approach for species identification is especially beneficial in situations with multiple calling individuals, such as autumn swarming.</p>
Predictive modelling of brain metastasis risk and non-invasive biomarker detection using DNA methylation signatures
<p>Methylated cell-free DNA was sequenced for 123 BM plasma and compared to plasma methylomes from 107 gliomas, central nervous system (CNS) lymphomas (CNSL), and non-CNS tumor controls. Plasma methylome-based classifiers of BM from other entities were built in fifty 80% discovery set iterations of 92/123 BM samples. External publicly-available tissue methylation data on 442 LUAD, 85 BM, and 146 glioma/CNSL/control samples were acquired for validation and the remaining 31/123 BM plasma samples were used for additional validation.</p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.