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86 results for “optogenetic”
Mouse substantia nigra responses to optogenetic stimulation of projections from striatum and globus pallidus
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Data and code for Chong, Moroni, et al. (2020) Science: "Manipulating synthetic optogenetic odors reveals the coding logic of olfactory perception"
<p>Behavioral response dataset, mitral cell responses, and code to implement the STM model in Chong, Moroni, Wilson, Shoham, Panzeri and Rinberg (2020) Science. </p> <p>Please contact Edmund Chong (edmund.w.chong@gmail.com) and Monica Moroni (monica.moroni@outlook.com) for questions</p>
Data from: Optogenetic dissection of descending behavioral control in Drosophila
In most animals, the brain makes behavioral decisions that are transmitted by descending neurons to the nerve cord circuitry that produces behaviors. In insects, only a few descending neurons have been associated with specific behaviors. To explore how descending neurons control an insect's movements, we developed a novel method to systematically assay the behavioral effects of activating individual neurons on freely behaving terrestrial D. melanogaster. We calculated a two-dimensional representation of the entire behavior space explored by these flies and we associated descending neurons with specific behaviors by identifying regions of this space that were visited with increased frequency during optogenetic activation. Applying this approach across a large collection of descending neurons, we found that (1) activation of most of the descending neurons drove stereotyped behaviors, (2) in many cases multiple descending neurons activated similar behaviors, and (3) optogenetically-activated behaviors were often dependent on the behavioral state prior to activation.
Data from: Optogenetic recruitment of dorsal raphe serotonergic neurons acutely decreases mechanosensory responsivity in behaving mice
The inhibition of sensory responsivity is considered a core serotonin function, yet this hypothesis lacks direct support due to methodological obstacles. We adapted an optogenetic approach to induce acute, robust and specific firing of dorsal raphe serotonergic neurons. In vitro, the responsiveness of individual dorsal raphe serotonergic neurons to trains of light pulses varied with frequency and intensity as well as between cells, and the photostimulation protocol was therefore adjusted to maximize their overall output rate. In vivo, the photoactivation of dorsal raphe serotonergic neurons gave rise to a prominent light-evoked field response that displayed some sensitivity to a 5-HT1A agonist, consistent with autoreceptor inhibition of raphe neurons. In behaving mice, the photostimulation of dorsal raphe serotonergic neurons produced a rapid and reversible decrease in the animals' responses to plantar stimulation, providing a new level of evidence that serotonin gates sensory-driven responses.
Data from: Inferring neural circuit properties from optogenetic stimulation
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Data from: Optogenetic dissection of descending behavioral control in Drosophila
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Data from: Optogenetic recruitment of dorsal raphe serotonergic neurons acutely decreases mechanosensory responsivity in behaving mice
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Targeted Cortical Reorganization using Optogenetics in Non-human primates: Electrocorticography in Sensorimotor Cortex during Optogenetic Stimulation
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Optogenetic Clustering of Human IRE1 Reveals Differential Regulation of Transcription and mRNA Splice Isoform Abundance by the UPR
GEO Series GSE302406. Homo sapiens. 39 samples. Type: Expression profiling by high throughput sequencing.
Optogenetics-integrated gut organ culture system connects enteric neurons dynamics and gut homeostasis [RNASeq supp]
GEO Series GSE299578. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Optogenetics-integrated gut organ culture system connects enteric neurons dynamics and gut homeostasis [RNASeq]
GEO Series GSE299575. Mus musculus. 40 samples. Type: Expression profiling by high throughput sequencing.
Whole worm transcriptomics after optogenetically induced mechanical muscle stress (OptIMMuS)
GEO Series GSE241906. Caenorhabditis elegans. 16 samples. Type: Expression profiling by high throughput sequencing.
Optogenetic mitochondrial preconditioning enhances cardiomyocyte survival under stress
GEO Series GSE290222. Homo sapiens. 13 samples. Type: Expression profiling by high throughput sequencing.
Optogenetic Stimulation of Prelimbic Pyramidal Neurons Maintains Fear Memories and Modulates Amygdala Pyramidal Neuron Transcriptome
GEO Series GSE162417. Mus musculus. 14 samples. Type: Expression profiling by high throughput sequencing.
Optogenetics-integrated gut organ culture system connects enteric neurons dynamics and gut homeostasis [16S]
GEO Series GSE299577. feces metagenome. 12 samples. Type: Other.
Light induced expression of gRNA allows for optogenetic gene editing of T lymphocytes in vivo
GEO Series GSE275757. Homo sapiens. 8 samples. Type: Other.
An optogenetic switch for the Set2 methyltransferase provides evidence for transcription-dependent and independent dynamics of H3K36 methylation
GEO Series GSE153539. Saccharomyces cerevisiae. 134 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Data from: Optogenetically induced low-frequency correlations impair perception
Deployment of covert attention to a spatial location can cause large decreases in low-frequency correlated variability among neurons in macaque area V4 whose receptive-fields lie at the attended location. It has been estimated that this reduction accounts for a substantial fraction of the attention-mediated improvement in sensory processing. These estimates depend on assumptions about how population signals are decoded and the conclusion that correlated variability impairs perception, is purely hypothetical. Here we test this proposal directly by optogenetically inducing low-frequency fluctuations, to see if this interferes with performance in an attention-demanding task. We find that low-frequency optical stimulation of neurons in V4 elevates correlations among pairs of neurons and impairs the animal's ability to make fine sensory discriminations. Stimulation at higher frequencies does not impair performance, despite comparable modulation of neuronal responses. These results support the hypothesis that attention-dependent reductions in correlated variability contribute to improved perception of attended stimuli.
Optogenetic stimulation of kisspeptin neurones within the posterodorsal medial amygdala increases LH pulse frequency in female mice
<p>Kisspeptin within the arcuate nucleus of the hypothalamus is a critical neuropeptide in the regulation of reproduction. Together with neurokinin B and dynorphin A, arcuate kisspeptin provides the oscillatory activity that drives the pulsatile secretion of GnRH, and therefore LH pulses, and is believed to be a central component of the GnRH pulse generator. It is well established that the amygdala also exerts an influence over gonadotrophic hormone secretion and reproductive physiology. The discovery of kisspeptin and its receptor within the posterodorsal medial amygdala (MePD), and our recent finding showing that intra-MePD administration of kisspeptin or a kisspeptin receptor antagonist results in increased LH secretion and decreased LH pulse frequency, respectively, suggests an important role for amygdala kisspeptin signalling in the regulation of the GnRH pulse generator. To further investigate the function of amygdala kisspeptin, the present study used an optogenetic approach to selectively stimulate MePD kisspeptin neurones and examine the effect on pulsatile LH secretion. MePD kisspeptin neurones in conscious Kiss1-Cre mice were virally infected to express the channelrhodopsin 2 protein and selectively stimulated by light via a chronically implanted fibre optic cannula. Continuous stimulation using 5 Hz resulted in an increased LH pulse frequency, which was not observed at the lower stimulation frequencies of 0.5 and 2 Hz. In wild-type animals, continuous stimulation at 5 Hz did not affect LH pulse frequency. These results demonstrate that selective activation of MePD <em>Kiss1</em> neurons can modulate hypothalamic GnRH pulse generator frequency.</p>
Simultaneous optogenetic activation and MEG source imaging show non-human primate brain circuits
<p>MEG and MRI data used to generate Figures 2-5 of manuscript titled, "Simultaneous optogenetic activation and MEG source imaging show non-human primate brain circuits". </p>
ScienceDex guides
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.