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ShareScore release 0.9.0
Dataset results
56 results for “parasite virulence”
Data from: Limiting opportunities for cheating stabilizes virulence in insect parasitic nematodes
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Data from: Coevolution between mutualists and parasites in symbiotic communities may lead to the evolution of lower virulence
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Data from: Minor environmental concentrations of antibiotics can modify bacterial virulence in co-infection with a non-targeted parasite
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Data from: Host age modulates parasite infectivity, virulence and reproduction
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Data from: No immediate or future extra costs of raising a virulent brood parasite chick
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Data from: Impact of host nutritional status on infection dynamics and parasite virulence in a bird-malaria system
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Data from: Tracking changes in life-history traits related to unnecessary virulence in a plant-parasitic nematode
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Nutrient sensing modulates malaria parasite virulence.
GEO Series GSE69629. Plasmodium berghei. 36 samples. Type: Expression profiling by high throughput sequencing; Expression profiling by array.
Data from: Expression of parasite genetic variation changes over the course of infection: implications of within-host dynamics for the evolution of virulence
How infectious disease agents interact with their host changes during the course of infection and can alter the expression of disease-related traits. Yet by measuring parasite life-history traits at one or few moments during infection, studies have overlooked the impact of variable parasite growth trajectories on disease evolution. Here we show that infection-age-specific estimates of host and parasite fitness components can reveal new insight into the evolution of parasites. We do so by characterizing the within-host dynamics over an entire infection period for five genotypes of the castrating bacterial parasite Pasteuria ramosa infecting the crustacean Daphnia magna. Our results reveal that genetic variation for parasite-induced gigantism, host castration and parasite spore loads increases with the age of infection. Driving these patterns appears to be variation in how well the parasite maintains control of host reproduction late in the infection process. We discuss the evolutionary consequences of this finding with regard to natural selection acting on different ages of infection and the mechanism underlying the maintenance of castration efficiency. Our results highlight how elucidating within-host dynamics can shed light on the selective forces that shape infection strategies and the evolution of virulence.
Data from: Phosphatidylthreonine and lipid-mediated control of parasite virulence
The major membrane phospholipid classes, described thus far, include phosphatidylcholine (PtdCho), phosphatidylethanolamine (PtdEtn), phosphatidylserine (PtdSer), and phosphatidylinositol (PtdIns). Here, we demonstrate the natural occurrence and genetic origin of an exclusive and rather abundant lipid, phosphatidylthreonine (PtdThr), in a common eukaryotic model parasite, Toxoplasma gondii. The parasite expresses a novel enzyme PtdThr synthase (TgPTS) to produce this lipid in its endoplasmic reticulum. Genetic disruption of TgPTS abrogates de novo synthesis of PtdThr and impairs the lytic cycle and virulence of T. gondii. The observed phenotype is caused by a reduced gliding motility, which blights the parasite egress and ensuing host cell invasion. Notably, the PTS mutant can prevent acute as well as yet-incurable chronic toxoplasmosis in a mouse model, which endorses its potential clinical utility as a metabolically attenuated vaccine. Together, the work also illustrates the functional speciation of two evolutionarily related membrane phospholipids, i.e., PtdThr and PtdSer.
Data from: Phosphatidylthreonine and lipid-mediated control of parasite virulence
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Data from: Expression of parasite genetic variation changes over the course of infection: implications of within-host dynamics for the evolution of virulence
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Small RNA pyrosequencing in the protozoan parasite Entamoeba histolytica reveals strain-specific small RNAs that target virulence genes
GEO Series GSE43668. Entamoeba histolytica. 2 samples. Type: Non-coding RNA profiling by high throughput sequencing.
A system for functional studies of the major virulence factor of malaria parasites [WGS]
GEO Series GSE275671. Plasmodium falciparum. 3 samples. Type: Other.
A system for functional studies of the major virulence factor of malaria parasites
GEO Series GSE267413. Plasmodium falciparum. 24 samples. Type: Expression profiling by high throughput sequencing.
The Plasmodium falciparum ApiAP2 transcription factor PfAP2-V controls parasite proliferation and virulence in intra-erythrocytic developmental cycle
GEO Series GSE288146. Plasmodium falciparum 3D7. 2 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.