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51 results for “prenatal stress”
Exclusive breastfeeding mitigates the association between prenatal maternal pan-demic-related stress and children sleep problems at 24 months of age
<p>This database includes the raw data linked with the paper “Exclusive breastfeeding mitigates the association between prenatal maternal pan-demic-related stress and children sleep problems at 24 months of age” accepted for publication on Development and Psychopathology. This study is part of the longitudinal and multi-centric “Measuring the outcomes of maternal COVID-19-related prenatal exposure (MOM-COPE)” study. Here, we report on the interactive influence of variations in antenatal exposures to maternal pandemic-related stress (PRS) and exclusive breastfeeding on infant sleep disturbances at 24 months of age.</p> <p>Procedures</p> <p>Mother-infant dyads were recruited from May 2020 to February 2021 in ten neonatal units in Northern Italy and followed until 24 months of age. Between 12 and 48 h after childbirth (T0), women retrospectively reported on their PRS experience during pregnancy, as well as on their current anxiety levels and breastfeeding practices. Maternal anxiety and breastfeeding were also assessed at 3 (T1) and 6 (T2) months after childbirth. Infants’ sleep disturbances were reported 24 months after childbirth (T3). An initial sample of 320 mother-infant dyads were recruited at birth. From this sample, 220 dyads (around 69%) completed the T1 assessment, whereas 85 mothers (around 26,5%) provided data at the 24-months follow-up assessment (T3). Given the presence of missing-data for some of the study measures in the T3 sample, we decided to use a listwise deletion approach resulting in a final analytic sample of 78 participants.</p> <p>Analytical plan</p> <p>A series of linear models were fitted and compared using a full Bayesian approach for estimating parameters. Model comparison allows for the selection of the most plausible models given the data and a set of candidate models. Specifically, we compared the following models: model 0 (M00), i.e., a model assuming that there were no associations among the study variables; model 1 (M01), including only exclusive breastfeeding as predictor; model 2 (M02), including only maternal PRS; model 3 (M03), including both exclusive breastfeeding and maternal PRS main effects and, lastly, model 4 (M04), testing the interactive effect between maternal PRS and exclusive breastfeeding. Finally, we addressed our exploratory research question by including maternal anxiety factor score (i.e., estimated values for maternal anxiety assessed at 0, 3 and 6 months of infant age) in our statistical model.</p> <p>Findings in brief</p> <p>Bayesian analyses revealed that maternal PRS was positively associated with sleep problems in children who were not exclusively breastfed from birth to 6 months, while the association became non-significant among infants that were exclusively continuously breastfed until 6 months of age. Interestingly, exploratory analyses indicate that maternal postnatal anxiety might not represent a substantial modifier of these effects.</p>
The Effect of Mindfulness-Based Web-Based Stress Reduction Program Applied to Primigravidas on Perceived Stress Level in Pregnancy, Birth Self-Efficacy and Prenatal Attachment
ClinicalTrials.gov study NCT06316518. IPD Sharing: UNDECIDED. Countries: 0. Publications: 0.
Prenatal Stress-induced Depressive-like Behavior is Associated with Brain Metabotranscriptome Remodeling and is Reversed by Acetyl-carnitine
GEO Series GSE171275. Mus musculus. 20 samples. Type: Expression profiling by array.
PKN2 deficiency leads both to prenatal ‘congenital’ cardiomyopathy and defective angiotensin II stress responses
GEO Series GSE206779. Mus musculus. 20 samples. Type: Expression profiling by high throughput sequencing.
Sex-specific effects of prenatal stress in 5-Htt deficient mice: towards molecular mechanisms of gene x environment interactions
GEO Series GSE26025. Mus musculus. 12 samples. Type: Expression profiling by array.
Maternal antioxidant treatment prevents behavioural and neurological changes in offspring exposed to prenatal social stress
GEO Series GSE130574. Rattus norvegicus. 36 samples. Type: Expression profiling by array; Other; Expression profiling by high throughput sequencing.
DNA methylation in CD34 positive cells derived from cord blood at birth following prenatal stress
GEO Series GSE84018. Homo sapiens. 18 samples. Type: Methylation profiling by genome tiling array.
Male Rat DNA methylation in the Prefrontal Cortex at postnatal day 62 following prenatal restraint stress
GEO Series GSE84021. Rattus norvegicus. 8 samples. Type: Methylation profiling by genome tiling array.
Prenatal stress alters mouse offspring dorsal striatal development and placental function in sex-specific ways
GEO Series GSE287771. Mus musculus. 24 samples. Type: Expression profiling by high throughput sequencing.
Is brain-derived neurotropic factor methylation involved in the association between prenatal stress and maternal postnatal anxiety during the covid-19 pandemic?
<p>This database includes the raw data linked with the paper “IIs brain-derived neurotropic factor methylation involved in the association between prenatal stress and maternal postnatal anxiety during the covid-19 pandemic?”. This publication is part of the longitudinal and multi-centric “Measuring the outcomes of maternal COVID-19-related prenatal exposure (MOM-COPE)” research project. In this paper, we report data on the association among pandemic-related stress during pregnancy, maternal BDNF methylation, and postnatal anxiety symptoms.<br> <strong>Procedures. </strong>At birth, the mothers filled in the ad-hoc questionnaire attached about the pandemic related stress (file name: 22-06-14_momcope_bdnf_adhoc.pdf) and the State-Trait Anxiety Inventory (Spielberger, 1983). The maternal BDNF methylation was estimated in 11 CpG sites in DNA from mothers’ buccal cells by PCR amplification of bisulfite-treated DNA followed by Next Generation Sequencing (NGS) on a NEXTSeq-500 (Illumina, San Diego, California, USA).<br> <strong>Analytical plan. </strong>Separate Pearson’s bivariate correlations were used to assess the presence of significant associations among pandemic-related stress during pregnancy, maternal anxious symptoms after delivery, and CpG-specific BDNF % methylation. CpG-specific BDNF % methylation values for which a significant association emerged with both pandemic-related stress and anxious symptoms were subsequently tested in a mediation model to assess their role as significant mediators of the relationship between pandemic-related stress and maternal anxious symptoms.<br> <strong>Findings in brief. </strong>Results showed that pandemic-related stress was associated with an increased risk of postnatal anxiety (r = .20, p <.05). CpG-specific BDNF methylation was significantly associated with both prenatal pandemic-related stress (r = .21, p < .05) and postnatal maternal anxious symptoms (r = .25, p = .01). Moreover, a complete mediation by the BDNF CpG6 methylation emerged between pandemic-related stress during pregnancy and postnatal maternal anxiety (ACME = .66, p < .05).</p>
Prenatal exposure to environmental air pollution and psychosocial stress jointly contribute to the epigenetic regulation of the serotonin transporter gene in newborns
<p>This database includes the raw data linked with the paper “Prenatal exposure to environmental air pollution and psychosocial stress jointly contribute to the epigenetic regulation of the serotonin transporter gene in newborns” accepted for publication on Molecular Psychiatry. This study is part of the longitudinal and multi-centric “Measuring the outcomes of maternal COVID-19-related prenatal exposure (MOM-COPE)” study. Here, we report on the interactive influence of variations in antenatal exposures to maternal pandemic-related stress (PRS) and PM2.5 on SLC6A4 DNAm levels in newborns.</p> <p>Procedures</p> <p>Mother–infant dyads (N=307) were enrolled at delivery during the COVID-19 pandemic. Infants’ methylation status was assessed in 13 CpG sites within the SLC6A4 gene’s region (chr17:28562750–28562958) in buccal cells at birth and women retrospectively report on PRS. PM2.5 exposure throughout the entire gestation and at each gestational trimester was estimated using a spatiotemporal model based on residential address.</p> <p> </p> <p>Among several potentially confounding socio-demographic and health-related factors, infant’s sex was significantly associated with infants’ SLC6A4 DNAm levels, thus hierarchical regression models were adjusted for infant’s sex.</p> <p>Mother–infant dyads (N = 276) were recruited at delivery. Maternal trait anxiety, as a marker of antenatal chronic stress exposure, was assessed soon after delivery using the Stait-Trait Anxiety Inventory (STAI-Y). Infants’ BDNF DNAm at birth was assessed in 11 CpG sites in buccal cells whereas infants’ NE was assessed at 3 (N = 225) and 6 months (N = 189) using the Infant Behavior Questionnaire-Revised (IBQ-R).</p> <p>Analytical plan</p> <p>Principal component analysis (PCA) was used to reduce the number of CpG sites into a smaller set of factors.</p> <p>A four-factor solution, where the targeted CpG sites were aggregated in 4 main factors, showed the best fit to the data (Table 2). Principal Component 1 (PC1; composed of 6 CpG sites) and Principal Component 2 (PC2; composed of 3 CpG sites) accounted, respectively, for 31.6% and 12.8% of the total variance in SLC6A4 DNAm and were used in further analyses. Pearson correlations and independent samples t-tests were employed to explore the potential effect of sociodemographic and health-related variables on infant methylation levels. All variables found to be significantly associated with the outcomes examined were included as covariates in subsequent analyses. Separate hierarchical regression analyses were performed to evaluate the independent and interactive effects of maternal PRS and exposure to air pollution on infant methylation levels.</p> <p>Findings in brief</p> <p>Higher levels of SLC6A4 DNAm at 6 CpG sites were found in newborns born to mothers reporting higher levels of antenatal PRS and greater PM2.5 exposure across gestation, while adjusting for infant’s sex. These effects were especially evident when exposure to elevated PM2.5 occurred during the second trimester of pregnancy.</p>
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.