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99 results for “protocol optimization”
The Prevalence, Risk Factors and Optimal Biopsy Protocol of BE
ClinicalTrials.gov study NCT05818072. IPD Sharing: NO. Countries: 1. Publications: 12.
Optimizing tDCS Protocol for Clinical Use in Major Depressive Disorder
ClinicalTrials.gov study NCT06165445. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Preoperative Ultrasound-based Protocol for Optimization of Fluid Therapy to Prevent Early Intraoperative Hypotension
ClinicalTrials.gov study NCT05171608. IPD Sharing: NO. Countries: 1. Publications: 6.
Data from: An optimized protocol for large-scale in situ sampling and analysis of volatile organic compounds
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Data from: Optimizing stimulation and analysis protocols for neonatal fMRI
The development of brain function in young infants is poorly understood. The core challenge is that infants have a limited behavioral repertoire through which brain function can be expressed. Neuroimaging with fMRI has great potential as a way of characterizing typical development, and detecting abnormal development early. But, a number of methodological challenges must first be tackled to improve the robustness and sensitivity of neonatal fMRI. A critical one of these, addressed here, is that the hemodynamic response function (HRF) in pre-term and term neonates differs from that in adults, which has a number of implications for fMRI. We created a realistic model of noise in fMRI data, using resting-state fMRI data from infants and adults, and then conducted simulations to assess the effect of HRF of the power of different stimulation protocols and analysis assumptions (HRF modeling). We found that neonatal fMRI is most powerful if block-durations are kept at the lower range of those typically used in adults (full on/off cycle duration 25-30s). Furthermore, we show that it is important to use the age-appropriate HRF during analysis, as mismatches can lead to reduced power or even inverted signal. Where the appropriate HRF is not known (for example due to potential developmental delay), a flexible basis set performs well, and allows accurate post-hoc estimation of the HRF.
Data from: Comparison and optimization of hiPSC forebrain cortical differentiation protocols
Several protocols have been developed for human induced pluripotent stem cell neuronal differentiation. We compare several methods for forebrain cortical neuronal differentiation by assessing cell morphology, immunostaining and gene expression. We evaluate embryoid aggregate vs. monolayer with dual SMAD inhibition differentiation protocols, manual vs. AggreWell aggregate formation, plating substrates, neural progenitor cell (NPC) isolation methods, NPC maintenance and expansion, and astrocyte co-culture. The embryoid aggregate protocol, using a Matrigel substrate, consistently generates a high yield and purity of neurons. NPC isolation by manual selection, enzymatic rosette selection, or FACS all are efficient, but exhibit some differences in resulting cell populations. Expansion of NPCs as neural aggregates yields higher cell purity than expansion in a monolayer. Finally, co-culture of iPSC-derived neurons with astrocytes increases neuronal maturity by day 40. This study directly compares commonly employed methods for neuronal differentiation of iPSCs, and can be used as a resource for choosing between various differentiation protocols.
Fig. 3 in Protocol Optimization For Genomic Dna Extraction And Rapd-Pcr Of Alien Ponto-Caspian Amphipod Pontogammarus Robustoides
Fig. 3. RAPD fingerprints results from different samples of Pontogammarus robustoides with primers OPA-02 (M- marker, 1-15 runners- different samples of Pontogammarus robustoides; K- control) using RAPD-PCR 10 × Taq buffer with (NH4)2SO4.
Continued Access Protocol for the Evaluation of the OPTIMIZER Smart System
ClinicalTrials.gov study NCT03102437. IPD Sharing: NO. Countries: 1. Publications: 0.
Blood Collection Sub-Study of Exact Sciences Protocol 2019-01: "Clinical Validation of an Optimized Multi-Target Stool DNA (Mt-sDNA 2.0) Test, For Colorectal Cancer Screening BLUE-C"
ClinicalTrials.gov study NCT04144751. IPD Sharing: YES. Countries: 1. Publications: 0.
Protocol for a Multi-site Pilot Study of the OptiMed Clinical Trial
ClinicalTrials.gov study NCT06688591. IPD Sharing: NO. Countries: 0. Publications: 18.
Data from: Comparison and optimization of hiPSC forebrain cortical differentiation protocols
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Data from: Optimizing stimulation and analysis protocols for neonatal fMRI
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Data from: Comparison of capture and storage methods for aqueous macrobial eDNA using an optimized extraction protocol: advantage of enclosed filter
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An optimized protocol for retina single-cell RNA sequencing [scRNA-Seq]
GEO Series GSE153673. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
An optimized protocol for retina single-cell RNA sequencing [snRNA-Seq]
GEO Series GSE153672. Mus musculus. 1 samples. Type: Expression profiling by high throughput sequencing.
Optimized Infra-red photoactivatable ribonucleoside-enhanced crosslinking and immunoprecipitation (IR-PAR-CLIP) protocol identifies novel IGF2BP3-interacting RNAs in colon cancer cells
GEO Series GSE229653. Homo sapiens. 6 samples. Type: Other.
An optimized protocol for retina single-cell RNA sequencing
GEO Series GSE153674. Mus musculus. 7 samples. Type: Expression profiling by high throughput sequencing.
Time series scRNAseq analysis in mouse and human informs optimization of rapid astrocyte differentiation protocols
GEO Series GSE211140. Homo sapiens; Mus musculus. 45 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Optimized Protocol for Culturing Porcine Retinal Explants and RNA Isolation
GEO Series GSE318246. Sus scrofa. 80 samples. Type: Expression profiling by high throughput sequencing.
AF Burden and Echo-guided Persistent AF Ablation Strategy Using Either PV Isolation Alone (CLOSE Protocol) or Optimized Compartmentalization of the Left Atrium (Pseudo-maze Technique)
ClinicalTrials.gov study NCT04773119. IPD Sharing: NO. Countries: 1. Publications: 0.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.