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362 results for “sex effects”
Data from: Multi-generation genetic contributions of immigrants reveal cryptic elevated and sex-biased effective gene flow within a natural meta-population
<p>Impacts of immigration on micro-evolution and population dynamics fundamentally depend on net rates and forms of resulting gene flow into recipient populations. Yet, the degrees to which observed rates and sex ratios of physical immigration translate into multi-generational genetic legacies have not been explicitly quantified in natural meta-populations, precluding inference on how movements translate into effective gene flow and eco-evolutionary outcomes. Our analyses of three decades of complete song sparrow (<em>Melospiza melodia</em>) pedigree data show that multi-generational genetic contributions from regular natural immigrants substantially exceeded those from contemporary natives, consistent with heterosis-enhanced introgression. Further, while contributions from female immigrants exceeded those from female natives by up to three-fold, male immigrants' lineages typically went locally extinct soon after arriving. Both the overall magnitude, and the degree of female bias, of effective gene flow therefore greatly exceeded those which would be inferred from observed physical arrivals, reshaping the eco-evolutionary implications of immigration.</p>
Sex-specific transgenerational effects of diet on offspring life history and physiology
<p>Dietary variation in males and females can shape the expression of offspring life histories and physiology. However, the relative contributions of maternal and paternal dietary variation to phenotypic expression of latter generations are currently unknown. We provided male and female <em>Drosophila melanogaster</em> grandparents with<em> </em>diets differing in sucrose concentration prior to reproduction, and similarly subjected their grandoffspring to the same treatments. We then investigated the phenotypic consequences of this dietary variation among the grandsons and granddaughters. We observed transgenerational effects of dietary sucrose, mediated through the grandmaternal lineage, which mimic the direct effects of sucrose on lifespan, with opposing patterns across sexes; low sucrose increased female, but decreased male, lifespan. Dietary mismatching of grandoffspring-grandparent diets increased lifespan and reproductive success, and moderated triglyceride levels of grandoffspring, providing insights into the physiological underpinnings of the complex transgenerational effects on life histories.</p>
Combined effect of temperature, age and sex on food consumption
<p>Abiotic and biotic factors play key roles on the feeding attributes of herbivorous insects. We therefore evaluated the combined effect of temperature, age and sex on food consumption and utilization efficiencies of Parthenium biocontrol agent, <em>Zygogramma bicolorata </em>Pallister. This Mexican beetle is known as the most promising candidate for the biocontrol agent of<em> Parthenium hysterophorus </em>Linnaeus, a serious weed of wastelands, pastures and agricultural fields. </p>
Data: Sex-specific effects of capital resources on reproductive timing and success in red squirrels
<p><span>Reproduction is an energetically expensive activity for both sexes. However, if males and females differ in their annual timing of reproduction, such that peak investment for one sex occurs during a more resource-limited period, there is an opportunity for sex-specific selection to act on the acquisition of energetic resources. Both male and female North American red squirrels (<em>Tamiasciurus hudsonicus</em>) cache conifer cones, although males typically have larger caches than females. Peak energetic investment in reproduction occurs for males during the mating season in winter and early spring (when squirrels rely almost exclusively on cached resources) and for females during lactation (which can align with fresh food availability). We provide evidence that suggests sex differences in cache size are likely driven by a stronger positive connection between cached resources and components of fitness for males than for females. Specifically, males with larger caches have greater siring success than males with smaller caches, whereas for females, only early breeding females experience a positive effect of cache size on the number of recruits produced. We also show that males sire pups and females give birth earlier in the year if they have larger caches compared with squirrels of the same sex with smaller caches. Sexual selection can thus extend beyond traits directly connected to mating behavior, and can act on traits related to acquiring resources needed to fuel reproduction that are expressed months or years in advance of breeding efforts.</span></p>
Data from: Sex-specific effects of dietary restriction on physiological variables in Japanese quails
<p>Nutritional limitation is a common phenomenon in nature that leads to trade-offs among processes competing for limited resources. These trade-offs are mediated by changes in physiological traits such as growth factors and circulating lipids. However, studies addressing the sex-specific effect of nutritional deficiency on these physiological variables are limited in birds. We used dietary restriction to mimic the depletion of resources to various degrees and investigated sex-specific effects on circulating levels of insulin-like growth factor 1 (IGF-1) and triglycerides in Japanese quails (<em>Coturnix japonica</em>) subjected to <em>ad libitum</em>, 20%, 30% or 40% restriction of their daily requirement, for two weeks. We also explored the association of both physiological variables with body mass and egg production. While dietary restriction showed no effects on circulating IGF-1, this hormone exhibited a marked sexual difference, with females having 64.7% higher IGF-1 levels than males. Dietary restriction significantly reduced plasma triglyceride levels in both sexes. Females showed more than six-fold higher triglyceride levels than males. Triglyceride levels were positively associated with body mass in females while showed not association in males. Overall, our findings revealed sex-specific expression of physiological variables under dietary restriction conditions, which coincide with body size.</p>
Inorganic Arsenic Exposure Induces Sex Disparate Effects and Exacerbates Ischemia-Reperfusion Injury in the Female Heart
<p>Supplemental Tables S1-S3. <em>Echocardiographic parameters for male and female hearts, pre- and post-iAS exposure to 0 ppb (control), 10 ppb, 100 ppb or 1000 ppb iAS for four weeks.</em></p>
Effects of elevated temperature and CO2 concentration on floral development and sex differentiation in Morus alba L.
<p>The effects of global warming on floral development have been reported in many plants, but knowledge of floral development regarding gender and sex differentiation under elevated temperature, CO<sub>2</sub> concentration and their combination remains limited. So here we analysed flowering phase, sex ratio, floral morphology and biomass, total carbon and nitrogen data in male and female inflorescences (flowers) of <em>Morus alba </em>L. to determine whether and how they differ.</p> <p>This excel file contains the raw data for each data table and figure within a manuscript submitted to Annals of Forest Science.</p> <p> </p> <p> </p> <p> </p> <p> </p>
Data from: Simulating effects of fitness and dispersal on the use of Trojan sex chromosomes for invasive species management
<ol> <li>The use of Trojan Y Chromosomes (TYC) for controlling invasive species involves manipulating the sex chromosomes of captive-raised individuals. Once released, the offspring of these individuals consist of only one sex, thereby skewing the sex-ratio of the invasive population and potentially leading to eradication. Simulation models are needed that can inform managers on how to maximize the likelihood of species eradication, since implementation of this novel management approach in the field is still rare.</li> <li>Here, we present the first spatially explicit, mechanistic simulation model of a real-world TYC program for invasive species eradication. Using a brook trout (Salvelinus fontinalis) system model, we investigated the effects of competitive and reproductive fitness of the captive-raised YY males, dispersal behavior upon their release, and landscape heterogeneity on eradication success.</li> <li>Likelihood of eradication was dependent on both the competitive and reproductive fitness of the Trojan individuals. Competitive fitness (i.e., survival) had a higher threshold for eradication, below which populations failed to be eradicated.</li> <li>Movement ecology of both the wild and YY male populations was important for eradication. Under a restricted dispersal scenario for YY males following their release, the wild population was not extirpated but maintained a stable, yet reduced, population size. In terms of landscape configuration, time to eradication of local patches increased with greater connectivity within the stream network.</li> <li>In addition to sex ratio distortion, density-dependent mortality resulting from outplantings made an important contribution to eradication and therefore may also affect native competitors.</li> <li>While our results indicate that eradication is possible, maximizing its likelihood requires an understanding of the fitness and movement ecology of both the wild and YY male populations of the invasive species. Both our model and the principles derived from this study related to fitness and behavioral landscape ecology can be broadly applied to other invaded species and systems.</li> </ol>
Data from: The effects of competition on fitness depend on the sex of both competitors
<p>In intraspecific competition, the sex of competing individuals is likely to be important in determining the consequences of competition, both for the immediate outcome of competitive interactions, and for long-term effects of competition during development on adult fitness traits. Previous studies have explored differences between males and females in their response to intraspecific competition. However, few have tested how the sex of the competitors, or any interactions between focal and competitor sex, influence the nature and intensity of competition. We set up larval seed beetles <i>Callosobruchus maculatus</i> to develop either alone or in the presence of a male or female competitor, and measured a suite of traits: development time, emergence weight; male ejaculate mass, copulation duration and lifespan; and female lifetime fecundity, offspring egg-adult survival and lifespan. We found effects of competition and competitor sex on the development time and emergence weight of both males and females, and also of an interaction between focal and competitor sex: females but not males responded differently to competitor sex. There was little effect of larval competition on male and female adult fitness traits, with the exception of the effect of a female competitor on a focal female's offspring survival rate. Our results highlight the importance of directly measuring the effects of competition on fitness traits, rather than distant proxies for fitness, and suggest that competition with the sex with the greater resource requirements (here females) might have a strong effect in driving trait evolution. We also found that male-male competition during development resulted in shorter copulation times than male-female competition, a result that remained when controlling for the weight of competitors. Although it is difficult to definitively tease apart the effects of social environment and access to resources, this result suggests that something about the sex of competitors other than their size is driving this pattern.</p>
Data from: Are brood sex ratios adaptive? The effect of experimentally altered brood sex ratio on nestling growth, mortality, and recruitment
<p><span>Brood sex ratios (BSRs) have often been found to be non-random in respect of parental and environmental quality, and many hypotheses suggest that non-random sex ratios can be adaptive. To specifically test the adaptive value of biased BSRs, it is crucial to disentangle the consequences of BSR and maternal effects. In multiparous species, this requires cross-fostering experiments where foster parents rear offspring originating from multiple broods, and where the interactive effect of original and manipulated BSR on fitness components are tested. To our knowledge, our study on collared flycatchers (<em>Ficedula albicollis</em>) is the first that meets these requirements. In this species, where BSRs had previously been shown to be related to parental characteristics, we altered the original BSR of the parents shortly after hatching by cross-fostering nestlings among trios of broods, and examined the effects on growth, mortality, and recruitment of the nestlings. We found that original and experimental BSR, as well as the interaction of the two were unrelated to the fitness components considered. Nestling growth was related only to background variables, namely brood size and hatching rank. Nestling mortality was related only to hatching asynchrony. Our results therefore do not support that the observed BSRs are adaptive in our study population. However, we cannot exclude the possibility of direct effects of experimentally altered BSRs on parental fitness, which should be evaluated in the future. In addition, studies similar to ours are required on various species to get a clearer picture of the adaptive value of non-random BSRs.</span></p>
Sex-specific paternal age effects on offspring quality in Drosophila melanogaster
<p>Advanced paternal age has been repeatedly shown to modulate offspring quality via male- and/or female-driven processes, and there are theoretical reasons to expect that some of these effects can be sex-specific. For example, sex allocation theory predicts that, when mated with low-condition males, mothers should invest more in their daughters compared to their sons. This is because male fitness is generally more condition-dependent and more variable than female fitness, which makes it less risky to invest in female offspring. Here, we explore whether paternal age can affect the quality and quantity of offspring in a sex-specific way using Drosophila melanogaster as model organism. In order to understand the contribution of male-driven processes on paternal age effects, we also measured the seminal vesicle size of young and older males and explored its relationship with reproductive success and offspring quality. Older males had lower competitive reproductive success, as expected, but there was no difference between the offspring sex ratio of young and older males. However, we found that paternal age caused an increase in offspring quality (i.e., offspring weight), and that this increase was more marked in daughters than sons. We discuss different male- and female-driven processes that may explain such sex-specific paternal age effects.</p>
Data from: Developmental rate displays effects of inheritance but not of sex in interpopulation hybrids of Tigriopus californicus
<p>Coevolved genetic interactions within populations can be disrupted by hybridization resulting in loss of fitness in hybrid individuals (i.e., hybrid breakdown). However, the extent to which variation in fitness-related traits among hybrids is inherited across generations remains unclear, and variation in these traits may be sex-specific in hybrids due to differential effects of genetic incompatibilities in females and males. Here we present two experiments investigating variation in developmental rate among reciprocal inter-population hybrids of the intertidal copepod <em>Tigriopus</em> <em>californicus</em>. Developmental rate is a fitness-related trait in this species that is affected by interactions between mitochondrial-encoded and nuclear-encoded genes in hybrids that result in variation in mitochondrial ATP synthesis capacities. First, we show that F<sub>2</sub>-hybrid developmental rate is equivalent in two reciprocal crosses and is unaffected by sex, suggesting that breakdown of developmental rate is likely experienced equally by females and males. Second, we demonstrate that variation in developmental rate among F<sub>3</sub> hybrids is heritable; times to copepodid metamorphosis of F<sub>4</sub> offspring of fast-developing F<sub>3</sub> parents (12.25 ± 0.05 d, μ ± SEM) were significantly faster than those of F<sub>4</sub> offspring of slow-developing parents (14.58 ± 0.05 d). Third, we find that ATP synthesis rates in these F<sub>4</sub> hybrids are unaffected by the developmental rates of their parents, but that mitochondria from females synthesize ATP at faster rates than mitochondria from males. Taken together, these results suggest that sex-specific effects vary among fitness-related traits in these hybrids and that effects likely associated with hybrid breakdown display substantial inheritance across hybrid generations.</p>
Data for: Sex-specific transgenerational plasticity: Developmental temperatures of mothers and fathers have different effects on sons and daughters
<p>Each parent can influence offspring phenotypes via provisioning of the zygote or sex-specific DNA methylation. Transgenerational plasticity may therefore depend on environmental conditions experienced by each parent. We tested this hypothesis by conducting a fully factorial experiment across three generations of guppies (<em>Poecilia reticulata</em>), determining the effects of warm (28°C) and cold (21°C) thermal backgrounds of mothers and fathers on mass and length, and thermal performance (sustained [Ucrit] and sprint swimming speeds, citrate synthase and lactate dehydrogenase activities; 18, 24, 28, 32 and 36°C test temperatures) of sons and daughters. Offspring sex was significant for all traits except for sprint speed. Warmer mothers produced sons and daughters with reduced mass and length, and warmer fathers produced shorter sons. U<sub>crit</sub> of male offspring was greatest when both parents were raised at 28°C, and warmer fathers produced daughters with greater U<sub>crit</sub>. Similarly, warmer fathers produced sons and daughters with greater metabolic capacities. We show that thermal variation experienced by parents can modify offspring phenotypes, and that predicting the impacts of environmental change on populations would require knowledge of the thermal background of each mothers and fathers, particularly where sexes are spatially segregated.</p>
The effects of sex on extinction dynamics of Chlamydomonas reinhardtii depend on the rate of environmental change
<p>The continued existence of sex, despite many the costs it entails, still lacks an adequate explanation, as previous studies demonstrated that the effects of sex are environment-dependent: sex enhances the rate of adaptation in changing environments, but the benefits level off in benign conditions. To the best of our knowledge, the potential impact of different patterns of environmental change on the magnitude of these benefits received less attention in theoretical studies. In this paper, we begin to explore this issue by examining the effect of the rate of environmental deterioration (negatively correlated with population survival rate), on the benefits of sex.</p> <p>To investigate the interplay of sex and the rate of environmental deterioration, we carried out a long-term selection experiment with a unicellular alga (<em>Chlamydomonas</em> <em>reinhardtii</em>), by manipulating mode of reproduction (asexual, facultative or obligate sexual) and the rate of environmental deterioration (an increase of salt concentration). We monitored both the population size and extinction dynamics.</p> <p>The results revealed that the relative advantage of sex increased at the intermediate rate and plateaued at the highest rate of environmental deterioration. Obligate sexual populations had the slowest extinction rate under the intermediate rate of environmental deterioration, while facultative sexuality was favoured under the high rate-treatment.</p> <p>To the best of our knowledge, our study is the first to demonstrate that the interplay of sex and the rate of environmental deterioration affects the probability of survival, which indicates that mode of reproduction may be an important determinant of survival of the anthropogenic-induced environmental change.</p>
Safety and Effectiveness of HIV-1 DNA Plasmid Vaccine and HIV-1 Recombinant Adenoviral Vector Vaccine in HIV-Uninfected, Circumcised Men and Male-to-Female (MTF) Transgender Persons Who Have Sex With
ClinicalTrials.gov study NCT00865566. IPD Sharing: Not stated. Countries: 1. Publications: 4.
A Study in Men With Low Testosterone to Measure the Effects of Testosterone Solution on Testosterone Levels, Sex Drive and Energy
ClinicalTrials.gov study NCT01816295. IPD Sharing: Not stated. Countries: 9. Publications: 2.
Sex and Obesity: Effects on Heart Failure Study
ClinicalTrials.gov study NCT00776035. IPD Sharing: Not stated. Countries: 1. Publications: 8.
Reinforcement in the banded darter Etheostoma zonale: the effect of sex and sympatry on preferences
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Data from: Sex-specific effects of experimental ectoparasite infestation on telomere length in great tit nestlings
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Sex-specific effects of antagonistic coevolution: Insights from an insect host and a bacterial pathogen coevolution system
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