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66
datasets available to search
ShareScore release 0.7.1
Dataset results
66 results for “signal diversity”
Neuronal diversity of neuropeptide signaling, including galanin, in the mouse locus coeruleus
GEO Series GSE236349. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Distinct BMP-Smad Signaling Outputs Confer Diverse Functions in Dental Mesenchyme [CUT&Run]
GEO Series GSE297033. Mus musculus. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Analysis of early differentiation fates in human ES cells using diverse dosages of BMP and WNT signaling for the initial induction of differentiation
GEO Series GSE67155. Homo sapiens. 20 samples. Type: Expression profiling by array.
Diversely evolved xibalbin variants from remipede venom inhibit 3 potassium channels and activate PKA-II and Erk1/2 signalling
<p><span><strong>Background:</strong> </span><span>The identification of novel toxins from overlooked and taxonomically exceptional species bears potential for various pharmacological applications. The remipede <em>Xibalbanus tulumensis</em>, an underwater cave-dwelling crustacean, is the only crustacean for which a venom system has been described. Its venom contains several xibalbin peptides that have an inhibitor cysteine knot (ICK) scaffold.</span></p> <p><strong><span>Result:</span></strong><span><strong> </strong>Our screenings revealed that all tested xibalbin variants particularly inhibit potassium channels. Xib<sub>1</sub> and xib<sub>13</sub>, with their eight-cysteine domain similar to spider knottins also inhibit voltage-gated sodium channels. No activity was noted on calcium channels. Expanding the functional testing we demonstrate that xib<sub>1</sub> and xib<sub>13</sub> increase PKA-II and Erk1/2 sensitization signaling in nociceptive neurons, which may initiate pain sensitization. Our phylogenetic analysis suggests that xib<sub>13</sub> either originates from the common ancestor of pancrustaceans or earlier while xib<sub>1</sub> is more restricted to remipedes. The ten-cysteine scaffolded xib<sub>2</sub> emerged from xib<sub>1</sub>, a result that is supported by our phylogenetic and machine learning-based analyses.</span></p> <p><strong><span>Conclusions</span></strong><span><strong>: </strong>Our functional characterization of synthesized variants of xib<sub>1</sub>, xib<sub>2</sub>, and xib<sub>13</sub> elucidates their potential as inhibitors of potassium channels in mammalian systems. The specific interaction of xib<sub>2</sub> with Kv1.6 channels, which are relevant to treating variants of epilepsy, shows potential for further studies. At higher concentrations, xib1 and xib13 activate the kinases PKA-II and ERK1/2 in mammalian sensory neurons, suggesting pain sensitization and potential applications related to pain research and therapy. While tested insect channels suggest that all probably act as neurotoxins, the biological function of xib<sub>1</sub>, xib<sub>2,</sub> and xib<sub>13</sub> requires further elucidation. A novel finding on their evolutionary origin is the apparent emergence of </span><em><span>X. tulumensis</span></em><span>-specific xib<sub>2</sub> from xib<sub>1</sub>. Our study is an important cornerstone for future studies to untangle the origin and function of these enigmatic proteins as important components of remipede but also other pancrustacean and arthropod venoms.</span></p>
Distinct BMP-Smad Signaling Outputs Confer Diverse Functions in Dental Mesenchyme [ChIP-seq]
GEO Series GSE296697. Mus musculus. 6 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Diverse phospho-signaling networks mediate RTK dependent growth and survival in childhood ALL [copy number]
GEO Series GSE42054. Homo sapiens. 12 samples. Type: Genome variation profiling by SNP array.
Tumour Cell Heterogeneity Instructs Fibroblast Diversity and Reciprocal Signalling [dataset 2]
GEO Series GSE135434. Mus musculus. 36 samples. Type: Expression profiling by high throughput sequencing.
Analysis of differentiation fates in human ES cells using diverse dosages of BMP and WNT signaling for the initial induction of differentiation
GEO Series GSE67156. Homo sapiens. 20 samples. Type: Expression profiling by array.
Tumour Cell Heterogeneity Instructs Fibroblast Diversity and Reciprocal Signalling
GEO Series GSE135436. Mus musculus. 100 samples. Type: Expression profiling by high throughput sequencing.
Diverse phospho-signaling networks mediate RTK dependent growth and survival in childhood ALL
GEO Series GSE42040. Homo sapiens. 115 samples. Type: Expression profiling by array; Genome variation profiling by SNP array.
Dietary ligands diindolylmethane and resveratrol result in diverse ERα signaling not seen after E2 and a subset of diindolylmethane mediated signaling needs concurrent AHR activation.
GEO Series GSE232235. Homo sapiens. 57 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
An eRNA Transcription Checkpoint For Diverse Signal-dependent Enhancer Activation Programs
GEO Series GSE240599. Homo sapiens; Mus musculus. 130 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
An eRNA Transcription Checkpoint For Diverse Signal-dependent Enhancer Activation Programs
GEO Series GSE240603. Homo sapiens; Mus musculus. 144 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Other.
An eRNA Transcription Checkpoint For Diverse Signal-dependent Enhancer Activation Programs
GEO Series GSE240601. Homo sapiens. 10 samples. Type: Other.
Dietary ligands diindolylmethane and resveratrol result in diverse ERα signaling not seen after E2 and a subset of diindolylmethane mediated signaling needs concurrent AHR activation. [ChIP-Seq]
GEO Series GSE232234. Homo sapiens. 39 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Diverse phospho-signaling networks mediate RTK dependent growth and survival in childhood ALL [gene expression]
GEO Series GSE42001. Homo sapiens. 24 samples. Type: Expression profiling by array.
IL-33 signaling alters regulatory T cell diversity in support of tumor development
GEO Series GSE139232. Mus musculus. 2993 samples. Type: Expression profiling by high throughput sequencing.
IL-33 signaling alters regulatory T cell diversity in support of tumor development [2018]
GEO Series GSE139229. Mus musculus. 26 samples. Type: Expression profiling by high throughput sequencing.
An eRNA Transcription Checkpoint For Diverse Signal-dependent Enhancer Activation Programs
GEO Series GSE240598. Homo sapiens. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
IL-33 signaling alters regulatory T cell diversity in support of tumor development [2014]
GEO Series GSE139231. Mus musculus. 23 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.