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1,884 results for “skeletal muscle”
Processed data from "Human and rat skeletal muscle single-nuclei multi-omic integrative analyses nominate causal cell types, regulatory elements, and SNPs for complex traits"
<p>This is the processed data from our manscript "Human and rat skeletal muscle single-nuclei multi-omic integrative analyses nominate causal cell types, regulatory elements, and SNPs for complex traits"</p>
Processed data from "Human and rat skeletal muscle single-nuclei multi-omic integrative analyses nominate causal cell types, regulatory elements, and SNPs for complex traits"
<p>This is the processed data from our manscript "Human and rat skeletal muscle single-nuclei multi-omic integrative analyses nominate causal cell types, regulatory elements, and SNPs for complex traits"</p>
Processed data from "Human and rat skeletal muscle single-nuclei multi-omic integrative analyses nominate causal cell types, regulatory elements, and SNPs for complex traits"
<p>This is the processed data from our manscript "Human and rat skeletal muscle single-nuclei multi-omic integrative analyses nominate causal cell types, regulatory elements, and SNPs for complex traits"</p>
Processed data from "Human and rat skeletal muscle single-nuclei multi-omic integrative analyses nominate causal cell types, regulatory elements, and SNPs for complex traits"
<p>This is the processed data from our manscript "Human and rat skeletal muscle single-nuclei multi-omic integrative analyses nominate causal cell types, regulatory elements, and SNPs for complex traits"</p>
Processed data from "Human and rat skeletal muscle single-nuclei multi-omic integrative analyses nominate causal cell types, regulatory elements, and SNPs for complex traits"
<p>This is the processed data from our manscript "Human and rat skeletal muscle single-nuclei multi-omic integrative analyses nominate causal cell types, regulatory elements, and SNPs for complex traits"</p>
Processed data from "Human and rat skeletal muscle single-nuclei multi-omic integrative analyses nominate causal cell types, regulatory elements, and SNPs for complex traits"
<p>This is the processed data from our manscript "Human and rat skeletal muscle single-nuclei multi-omic integrative analyses nominate causal cell types, regulatory elements, and SNPs for complex traits"</p>
Data on mitochondrial respiratory function in skeletal muscle of adult male mice in response to 3-weeks heat stress
Open the record for dataset details and reuse information.
The immune landscape of murine skeletal muscle regeneration and aging
<p>This repository contains data associated with the publication Sousa, N.S. <em>et al.</em> (2024) ‘The immune landscape of murine skeletal muscle regeneration and aging’, <em>Cell Reports</em>, 43(11), p. 114975. doi:10.1016/j.celrep.2024.114975.</p> <p>The files are the following: </p> <ul> <li><a href="https://zenodo.org/api/records/14197888/draft/files/srt-all-samples.rds/content" target="_blank" rel="noopener noreferrer">srt-all-samples.rds</a> contains an RDS Seurat object with the dataset comprising all samples and all cells. Metadata, dimensionality reduction coordinates and clustering analysis results reported in the publication are also included.</li> <li><a href="https://zenodo.org/api/records/14197888/draft/files/srt-macs.rds/content" target="_blank" rel="noopener noreferrer">srt-macs.rds</a> contains an RDS Seurat object with the dataset comprising the subset of monocytes and macrophages across all samples. Metadata, dimensionality reduction coordinates and clustering analysis results reported in the publication are also included</li> <li><a href="https://zenodo.org/api/records/14197888/draft/files/metadata_all_samples.txt/content" target="_blank" rel="noopener noreferrer">metadata_all_samples.txt</a> is a table with metadata associated with the dataset comprising all samples. </li> <li><a href="https://zenodo.org/api/records/14197888/draft/files/metadata_macs.txt/content" target="_blank" rel="noopener noreferrer">metadata_macs.txt</a> is a table with metadata associated with the dataset comprising the subset of monocytes and macrophages across all samples. </li> </ul> <p> </p> <div> </div> <p> </p>
Supplemental Material - An IL-6 promoter variant (-174 G/C) augments IL-6 production and alters skeletal muscle transcription in response to exercise in mice.
<p>Supplemental Material for article: "An IL-6 promoter variant (-174 G/C) augments IL-6 production and alters skeletal muscle transcription in response to exercise in mice."</p>
Molecular and biochemical markers of oxidative stress in skeletal muscle
<p>Dataset of experimental animal study involved high-intensity interval training and molecular aspects of skeletal muscle.</p>
The effect of dietary supplementation with blueberry, cyanidin-3-O-β-glucoside, yoghurt and its peptides on gene expression associated with glucose metabolism in skeletal muscle obtained from a high-fat-high-carbohydrate diet induced obesity model
<p><span>Obesity is a leading global health problem contributing to various chronic diseases, including type II diabetes mellitus</span> <span>(T2DM). The aim of this study was to investigate whether blueberries, yoghurt, and their respective bioactive components, Cyanidin-3-O-β-glucoside (C3G) and peptides alone or in combinations, alter the expression of genes related to glucose metabolism in skeletal muscles from diet-induced obese mice. In extensor digitorum longus (EDL), yoghurt up-regulated the expression of activation of 5'adenosine monophosphate-activated protein kinase (AMPK), insulin receptor substrate-1 (IRS-1), phosphatidylinositol-3 kinase (PI3K) and glucose transporter 4 (GLUT4), and down-regulated the expression of angiotensin II receptor type 1 (AGTR-1). The combination of blueberries and yoghurt down-regulated the mRNA expression of AGTR-1 and Forkhead box protein O1 (FoxO1) in the EDL. Whereas the combination of C3G and peptides down-regulated AGTR-1 and up-regulated GLUT4 mRNA expression in the EDL. In the soleus, blueberries and yoghurt alone, and their combination down-regulated AGTR-1 and up-regulated GLUT4 mRNA expression. In summary blueberries and yoghurt, regulated multiple genes associated with glucose metabolism in skeletal muscles, and therefore may play a role in the management and prevention of T2DM.</span></p>
d13C and d15N of Pacific halibut skeletal muscle tissue from the Gulf of Alaska, 2018
<p>In 2018, white muscle samples were collected from the lateral musculature of a random sample of up to 4 fish from each survey station of the International Pacific Halibut Commission's Fishery Independent Setline Survey (total n = 1653). Muscle samples were stored at -20°C, thawed, oven-dried to a constant mass at 42°C, and ground to a fine powder. Approximately 0.5 to 1.0 mg of each powdered sample was loaded into a tin capsule for stable isotope analysis. d<sup>13</sup>C and d<sup>15</sup>N values were determined using a Carlo Erba 1110 Elemental Analyzer (Carlo Erba Reagents, CE Instruments, ThermoQuest Italia S.p.A. Milan, Italy) coupled to a Thermo Delta Plus XP IRMS (Thermo Finnigan, Bremen, German) at the University of Wyoming's Stable Isotope Facility (Laramie, Wyoming, USA). Long-term analyses of quality control standards have yielded precisions of 0.3‰ for d<sup>13</sup>C and 0.4‰ for d<sup>15</sup>N. Stable isotope data are presented in ‰ relative to Pee Dee Belemnite for <sup>13</sup>C and atmospheric nitrogen for <sup>15</sup>N.</p>
Mueller matrix and GPSE during dehydration of bovine skeletal muscle
<p>This video shows the changes in the Mueller matrix and GPSE during dehydration of bovine skeletal muscle</p>
Knockout of Hsp70 genes significantly affects locomotion speed and gene expression in leg skeletal muscles of Drosophila melanogaster
<p>Supplemental data for a study <strong>Knockout of </strong><em><strong>Hsp70 </strong></em><strong>genes significantly affects locomotion speed and gene expression in leg skeletal muscles of </strong><em><strong>Drosophila melanogaster </strong></em>(Physiol Genomics 56: 567–575, 2024.<br><a href="https://doi.org/10.1152/physiolgenomics.00143.2023">https://doi.org/10.1152/physiolgenomics.00143.2023</a> )</p>
Contractile activity-specific transcriptome response to acute endurance exercise and training in human skeletal muscle
<p>Supplemental Figure for a study <strong>Contractile activity-specific transcriptome response to acute endurance exercise and training in human skeletal muscleи </strong> <a href="https://www.ncbi.nlm.nih.gov/pubmed/30779632#">Am J Physiol Endocrinol Metab.</a> 2019 Feb 19. <strong> </strong> https://www.ncbi.nlm.nih.gov/pubmed/30779632</p>
Contractile activity-specific transcriptome response to acute endurance exercise and training in human skeletal muscle
<p>Supplemental Tables for a study <strong>Contractile activity-specific transcriptome response to acute endurance exercise and training in human skeletal muscle </strong> <a href="https://www.ncbi.nlm.nih.gov/pubmed/30779632#">Am J Physiol Endocrinol Metab.</a> 2019 Feb 19. <strong> </strong>https://www.ncbi.nlm.nih.gov/pubmed/30779632</p>
Figure S1. Representative blots of bear skeletal muscle proteins.
<p>Shown are representative images that have been obtained through western-blot analysis of the levels of catalase (CAT), heat shock protein HSP 90-beta (HSPAB1) mitochondrial stress-70 protein (HSPA9 or GRP75), nuclear factor E2-related factor 2 (NRF2 or NFE2L2), aflatoxin B1 aldehyde reductase member 2 (AKR7A2), carbonyl reductase (CBR1), and endoplasmic reticulum resident protein 29 (ERP29) in bear vastus lateralis muscles (N = 12/ group, except from NRF2: N = 7/ season). Corresponding quantifications can be seen in Figures 3 and 5.</p>
Resistance exercise with anti-inflammatory foods attenuate skeletal muscle atrophy induced by chronic inflammation
<p>Supplemental figures and table of "Resistance exercise with anti-inflammatory foods attenuate skeletal muscle atrophy induced by chronic inflammation".</p>
The role of action potential changes in depolarization-induced failure of excitation contraction coupling in mouse skeletal muscle
<p>Excitation-contraction coupling (ECC) is the process by which electrical excitation of muscle is converted into force generation. Depolarization of skeletal muscle resting potential contributes to failure of ECC in diseases such as periodic paralysis, intensive care unit acquired weakness and possibly fatigue of muscle during vigorous exercise. When extracellular K<sup>+</sup> is raised to depolarize the resting potential, failure of ECC occurs suddenly, over a narrow range of resting potentials. Intracellular recordings of action potentials (APs) in individual mouse skeletal muscle fibers during depolarization of the resting potential revealed small APs are still generated at resting potentials at which force production has failed. Simultaneous imaging of Ca<sup>2+ </sup>transients and recording of APs demonstrated failure to generate Ca<sup>2+ </sup>transients when APs peaked at potentials more negative than -30 mV. An AP property that closely correlated with failure of the Ca<sup>2+</sup> transient was the integral of AP voltage with respect to time. Simultaneous recording of Ca<sup>2+ </sup>transients and APs with electrodes separated by 1.6 mm revealed AP conduction fails when APs peak below -21 mV. We hypothesize propagation of APs and generation of Ca<sup>2+</sup> transients are governed by distinct AP properties: AP conduction is governed by AP peak, whereas Ca<sup>2+</sup> release from the sarcoplasmic reticulum is governed by AP integral of voltage with respect to time. The reason distinct AP properties may govern separate steps of ECC is the kinetics of the ion channels involved in the different steps of ECC. Na channels, which govern propagation, have rapid kinetics such that propagation is insensitive to AP width (and integral) whereas Ca<sup>2+</sup> release is governed by movement of gating charges in Cav1.1 channels, which have slower kinetics such that Ca<sup>2+ </sup>release is sensitive to AP width (and integral). The quantitative relationships established between resting potential, AP properties, AP conduction and Ca<sup>2+</sup> transients provide the foundation for future studies of failure of ECC induced by depolarization of the resting potential.</p>
Spatially resolved transcriptomics reveals innervation-responsive functional clusters in skeletal muscle
<p>Spatial Transcriptomics Data of murine skeletal muscle undergoing reversible nerve injury. Accompanying the manuscript, D'Ercole et al. <strong>"Spatially resolved transcriptomics reveals innervation-responsive functional clusters in skeletal muscle".</strong></p> <p> </p> <p><strong>Release v1: </strong>This release Includes all the code used to generate the figures and the processed and integrated original dataset in rds format.</p> <p> </p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.