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15,738 results for “stem cell”
Study to Assess Efficacy and Safety of Cx601, Adult Allogeneic Expanded Adipose-derived Stem Cells (eASC) for the Treatment of Complex Perianal Fistula(s) in Participants With Crohn's Disease (CD)
ClinicalTrials.gov study NCT03279081. IPD Sharing: YES. Countries: 15. Publications: 0.
A Study of Oral Ixazomib Citrate (MLN9708) Maintenance Therapy in Participants With Multiple Myeloma Following Autologous Stem Cell Transplant
ClinicalTrials.gov study NCT02181413. IPD Sharing: YES. Countries: 33. Publications: 4.
Safety and Efficacy of Ruxolitinib Versus Best Available Therapy in Patients With Corticosteroid-refractory Acute Graft vs. Host Disease After Allogeneic Stem Cell Transplantation
ClinicalTrials.gov study NCT02913261. IPD Sharing: YES. Countries: 22. Publications: 5.
A Study of Maribavir Compared to Valganciclovir to Treat Cytomegalovirus Infections in People Who Have Received Stem Cell Transplants
ClinicalTrials.gov study NCT02927067. IPD Sharing: YES. Countries: 23. Publications: 3.
Multimodal Mobile Intervention Application (App) to Address Sexual Dysfunction in Hematopoietic Stem Cell Transplant Survivors
ClinicalTrials.gov study NCT03967379. IPD Sharing: YES. Countries: 1. Publications: 0.
Patient-specific induced pluripotent stem cell properties implicate Ca2+-homeostasis in clinical arrhythmia associated with combined heterozygous RYR2 and SCN10A variants
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Computational simulations show proof-of-concept for optogenetic suppression of ectopic activity in cardiac stem cell therapy
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Raw fluorescent images of the stem cell based embryoids
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'CellTrajectory' for cellular automata modelling of leukaemic stem cell dynamics in acute myeloid leukaemia: insights into predictive outcomes and targeted therapies
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Enzyme-like nanoparticle engineered-mesenchymal stem cell secreting HGF promotes visualized therapy for idiopathic pulmonary fibrosis in vivo
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Population-based computational simulations elucidate mechanisms of focal arrhythmia following stem cell injection
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Data for: Emergent dynamics of adult stem cell lineages from single nucleus and single cell RNA-Seq of Drosophila testes
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'Biosim' for cellular automata modelling of leukaemic stem cell dynamics in acute myeloid leukaemia: insights into predictive outcomes and targeted therapies
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Wolbachia endosymbionts manipulate the self-renewal and differentiation of germline stem cells to reinforce fertility of their fruit fly host
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Recognized trophoblast-like cells conversion from human embryonic stem cells by BMP4 based on convolutional neural network
<p>The use of models of stem cell differentiation to trophoblastic cells provides an effective perspective for understanding the early molecular events in the establishment and maintenance of human pregnancy. In combination with the newly developed deep learning technology, the automated identification of this process can greatly accelerate the contribution to relevant knowledge. Based on the transfer learning technique, we used a convolutional neural network to distinguish the microscopic images of Embryonic stem cells (ESCs) from differentiated trophoblasts -like cells (TBL). To tackle the problem of insufficient training data, the strategies of data augmentation were used. The results showed that the convolutional neural network could successfully recognize trophoblast cells and stem cells automatically, but could not distinguish TBL from the immortalized trophoblast cell lines in vitro (JEG-3 and HTR8-SVneo). We compare the recognition effect of the commonly used convolutional neural network, including DenseNet, VGG16, VGG19, InceptionV3, and Xception. This study extends the deep learning technique to trophoblast cell phenotype classification and paves the way for automatic bright-field microscopic image analysis of trophoblast cells in the future.</p>
Intracellular delivery of nitric oxide enhances the therapeutic efficacy of mesenchymal stem cells for myocardial infarction
<p>Cell therapy by autologous mesenchymal stem cells (MSCs) is a clinically acceptable strategy for treating various diseases. Unfortunately, the therapeutic efficacy is largely affected by the low quality of MSCs collected from patients. Herein, we showed that the gene expression of MSCs from patients with diabetes was differentially regulated compared to that of MSCs from healthy controls. Then, MSCs were genetically engineered to catalyse an NO prodrug to release NO intracellularly. Compared to extracellular NO conversion, intracellular NO delivery effectively prolonged survival and enhanced the paracrine function of MSCs, as demonstrated by in vitro and in vivo assays. The enhanced therapeutic efficacy of engineered MSCs combined with intracellular NO delivery was further confirmed in mouse and rat models of myocardial infarction, and a clinically relevant cell administration paradigm through secondary thoracotomy has been attempted.</p>
Interspecies chimerism with human embryonic stem cells generates functional human dopamine neurons at low efficiency
<p>Interspecies chimeras offer great potential for regenerative medicine and creation of human disease models. Whether human pluripotent stem cell (hPSC) derived neurons in an interspecies chimera can differentiate into functional neurons and integrate into host neural circuity is not known. Here we show, using Engrailed 1 (En1) as a development niche that human naïve-like ES cells can incorporate into embryonic and adult mouse brains. Human-derived neurons including tyrosine hydroxylase (TH) positive neurons integrate into the mouse brain at low efficiency. These TH-positive neurons have electrophysiologic properties consistent with their human origin. Additionally, these human-derived neurons in the mouse brain accumulate pathologic phosphorylated α-synuclein in response to α-synuclein preformed fibrils. Optimization of human/mouse chimeras could be utilized to study human neuronal differentiation and human brain disorders.</p>
Aneuploid embryonic stem cells drive teratoma metastasis: source data
<h3>The dataset of "<strong>Aneuploid embryonic stem cells drive teratoma metastasis</strong>"</h3><p>1. Pathway enrichment of scRNA-seq.csv: a table containing the pathway enrichment results. (<strong>Supplementary fig10 d</strong>)</p><p>2. Bulk_RNA_processed.RDS: a Seurat object containing the results of bulk RNA-seq. (<strong>Supplementary fig11 h-l</strong>)</p><p>3. Relative cell abundance of ES captured by scRNA-seq.csv: A table containing the relative abundance of ES sub-populations in all ES cells for each sample. (<strong>fig5 c</strong>)</p><p>4. WES_out.RDS: an R object containing the results of WES processed by maftools. (<strong>fig2 b-g</strong>)</p><p>5. bulk_RNA_raw_matrix.RDS: an R object containing the raw count matrix of bulk RNA-seq samples. (<strong>Supplementary fig11 h-l</strong>)</p><p>6. scRNA-seq DEGs -- ES_stem vs. ES_Ori(WT).csv: a table containing the results of DEG analysis. (<strong>fig5 f</strong>)</p><p>7. scRNA-seq DEGs -- ES_stem vs. ES_Ori(AC).csv: a table containing the results of DEG analysis. (<strong>fig5 f</strong>)</p><p>8. pseudo time DEGs of scRNA-seq.csv: DEGs that change as ES differentiation. (<strong>fig5 e</strong>)</p><p>9. scRNA-seq_meta_info.tsv.gz: the meta information of scRNA-seq data. (<strong>fig5 and Supplementary fig10</strong>)</p><p>10. scRNA-seq_raw_matrix.mtx.gz: the raw count matrix of scRNA-seq data. (<strong>fig5 and Supplementary fig10</strong>)</p>
Reactivating PTEN to impair glioma stem cells by inhibiting cytosolic iron-sulfur assembly pathway
<p>Glioblastoma (GBM), the most lethal primary brain tumor, harbors glioma stem cells (GSCs) that not only initiate and maintain malignant phenotypes but also enhance therapeutic resistance. Although frequently mutated in GBMs, the function and regulation of PTEN in PTEN-intact GSCs are unknown. Here we found that PTEN directly interacts with MMS19 and competitively disrupts MMS19-based cytosolic iron-sulfur (Fe-S) cluster assembly (CIA) machinery in the differentiated glioma cells (DGCs). Interrogation of GSCs, when compared with their matched DGCs, revealed that PTEN is specifically succinated at cysteine (C) 211 in GSCs. Isotope tracing coupled with mass spectrometry analysis confirmed that fumarate, generated by adenylosuccinate lyase (ADSL) in <em>de novo</em> purine synthesis pathway which is highly activated in GSCs, promotes PTEN C211 succination. This modification abrogates the interaction between PTEN and MMS19, thereby reactivating CIA machinery pathway in GSCs. Functionally, inhibiting PTEN C211 succination through re-expressing PTEN C211S mutant, depleting ADSL, or consuming fumarate by N-acetylcysteine (NAC), an FDA-approved prescription drug, impairs GSC maintenance. Importantly, re-expressing PTEN C211S or treating with NAC sensitizes GSC-derived brain tumors to temozolomide and irradiation, the standard-of-care treatments for GBM patients, by retarding CIA machinery-mediated DNA damage repair. These findings reveal an immediately practicable strategy to target GSCs for treating GBMs by combined therapy with repurposing NAC.</p>
Induced pluripotent stem cell-derived cardiomyocyte in vitro models: tissue fabrication protocols, assessment methods, and quantitative maturation metrics for benchmarking progress
<p>The advent of human induced pluripotent stem cells (hiPSCs) and techniques to differentiate cardiomyocytes from them has opened a viable path to creating <em>in vitro</em> models of normal and diseased hearts, accelerating more predictive drug screening and therapeutic strategies for cardiac pathologies. Currently, hiPSC-derived cardiomyocytes (hiPSC-CMs) are more similar to fetal than adult cardiomyocytes, leading many in the field to explore approaches to enhance cell and tissue maturation. There are over 2,000 studies utilizing hiPSC-CMs in models composed of various combinations of cell and extracellular matrix components, using a plethora of differentiation protocols, culture formats, and methods for quantifying cardiomyocyte function. To assess the current state of this rapidly growing area, we systematically analyzed 300 studies using hiPSC-CM models for their selection of hiPSC lines, hiPSC-CM differentiation protocols, types of <em>in vitro </em>models, maturation techniques, and metrics used to assess cardiomyocyte functionality and maturity. Here, we provide the data compiled from our analysis of these papers so others in the field can utilize it to inform their research.</p> <p>Based on this analysis, we highlight the diversity of, and current trends in, <em>in vitro</em> model designs and highlight the most common and promising practices for functional assessments. We further analyzed outputs spanning structural maturity, contractile function, electrophysiology, and gene expression and note field-wide improvements over time. Finally, we observe that a persistent lack of coordination amongst investigators is limiting the field's ability to benchmark and advance hiPSC-CM function against previous studies. We discuss opportunities to collectively pursue the common goal of hiPSC-CM model development, maturation, and assessment that we believe are critical to drive the entire community forward in engineering mature cardiac tissue.</p>
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.