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Dataset results
1,304 results for “Cognitive impairments”
Transcriptomic predictors of rapid progression from mild cognitive impairment to Alzheimer's Disease
GEO Series GSE282742. Homo sapiens. 116 samples. Type: Expression profiling by high throughput sequencing.
MiRNA networks mediate a compensatory response in heart failure induced cognitive impairment [RNA-Seq]
GEO Series GSE288827. Mus musculus. 26 samples. Type: Expression profiling by high throughput sequencing.
Plasma microRNA biomarker detection for mild cognitive impairment using differential correlation analysis
GEO Series GSE90828. Homo sapiens. 53 samples. Type: Expression profiling by RT-PCR.
SEX-DEPENDENT APOE4 NEUTROPHIL-MICROGLIA INTERACTIONS DRIVE COGNITIVE IMPAIRMENT IN ALZHEIMER'S DISEASE
GEO Series GSE243750. Homo sapiens; Mus musculus. 288 samples. Type: Expression profiling by high throughput sequencing.
The maternal X chromosome impairs cognition and accelerates brain aging through epigenetic modulation in female mice II
GEO Series GSE280893. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Data from: Longitudinal associations between diurnal cortisol variation and later life cognitive impairment
Objective: To determine whether HPAA dysfunction is prospectively associated with global cognitive impairment in later life Methods: This cross-cohort study integrates two large longitudinal datasets: Whitehall II and the National Survey for Health and Development (NSHD), on data collected in the Whitehall II study in 2002/2004, 2007/2009 and 2012/2013; and for NSHD in 2006/2010 and 2015. Serial salivary cortisol samples were collected multiple times within a 24-hour period at mean ages 61.2 and 65.9 years in Whitehall II and at age 60-64 from NSHD participants. Cortisol profile is defined using cortisol awakening response (CAR) and am:pm ratio. Cognitive function was measured using the MMSE in Whitehall II and ACE-III in NSHD, harmonised into a thirty-point score. Models were adjusted for age, sex, diagnoses of hypertension, diabetes, BMI, educational attainment and interval between HPAA and cognitive assessments. Results: In fully adjusted models, increased am:pm cortisol ratio was prospectively associated with better later-life cognitive function years later (0.02 fewer errors per SD increase in am:pm cortisol ratio, p<0.01) and verbal fluency (0.03 SD increase in verbal fluency per SD increase in am:pm ratio, p<0.01). Increasing age, lower educational attainment, diagnosis of hypertension, diagnosis of diabetes and increased BMI were associated with worse cognitive function and poorer verbal fluency. There were no associations between depression and later-life cognition or reverse associations between cognition and later-life cortisol profiles. Conclusions: Loss of diurnal HPAA variation is evident in individuals subsequently experiencing more cognitive impairment. It may serve as an early pre-clinical marker of cognitive decline.
The relationship between body image and emotional and cognitive impairment after brain damage: A preliminary study
<p><strong>Introduction: </strong>The image of one's own body derives from experimentation of one's own body pattern. The emotional experience can lead to a real or distorted self-representation. After brain damage, a disorder of body image is frequent. The purpose of this study was to investigate the role of body image following acquired brain injury (ABI).</p> <p><strong>Methods: </strong>Forty-six hospitalized patients were enrolled and subdivided into two groups depending on the etiology of the damage: traumatic or vascular. For each group, we considered their cognitive level and mood. Patients underwent a broad battery of tests to investigate different domains: Montreal Cognitive Assessment (MoCA); Beck's Depression Inventory (BDI-II); Hamilton Rating Scale for Anxiety (HAM-A); Clinical Insight Rating Scale (CIRS); Body Image Scale (BIS); Human Figure Drawing (HFD). The latter was used to assess the implicit body image of each patient.</p> <p><strong>Results: </strong>Both groups showed a significant relationship between BDI-II and BIS. A positive correlation was found between BIS and HAM-A, but only in the traumatic group. We showed a positive correlation between MoCA and HFD. In addition, we observed some subitems of MoCA as predictive variables in HFD, which differ in the two groups. In a traumatic group, the visuospatial domain is predictive in HFD, as well as age of patients' and education. In the vascular groups, orientation, naming, abstraction, and language domains are instead predictive.</p> <p><strong>Conclusions: </strong>The results confirm the crucial role of the cognitive level and mood on self-perception.</p>
The effect of Computer Assisted Rehabilitation Environment (CAREN) in cognitive impairment and coping strategies in Parkinson's disease: a preliminary study
<p>Parkinson's disease is a neurodegenerative disorder characterized by different motor, vegetative, behavioral, and cognitive impairments, with worsening quality of life. Virtual reality devices have given promising results in neurorehabilitation as they can provide multisensory stimulation in a realistic environment. This study aims to test the efficacy of virtual reality training by using Computer Assisted Rehabilitation Environment in cognitive impairment in a sample of PD. 31 patients affected by PD were enrolled. All PD patients underwent 24 sessions of Computer Assisted Rehabilitation Environment training. The participants were assessed at baseline (T0) and after two months (T1). Our results suggested that Computer Assisted Rehabilitation Environment training may be effective in the cognitive and emotional domains, particularly by improving executive function, anxiety, and depressive symptoms. These changes have helped to improve self-efficacy and coping strategies. These results indicate greater cognitive and physical effort to overcome stressors. Our results show that Computer Assisted Rehabilitation Environment training was beneficial in improving cognitive functions. Longer duration training may be especially beneficial for patients with mild cognitive impairment. Our findings open the door to tailored personalized treatments based on the patient's motor and cognitive profiles.</p>
Effect of Non-pharmacological Therapy on Cognitive Function of Patients With Cognitive Impairment
ClinicalTrials.gov study NCT01819623. IPD Sharing: Not stated. Countries: 1. Publications: 0.
The Effects of Music Listening on Anxiety and Agitation in People With Mild and Moderate Cognitive Impairment
ClinicalTrials.gov study NCT05858541. IPD Sharing: YES. Countries: 1. Publications: 0.
An Attention-Restorative Therapy (ART)-Based Virtual Reality Intervention to Address Cancer-Related Cognitive Impairments Among Breast Cancer Survivors
ClinicalTrials.gov study NCT05030792. IPD Sharing: NO. Countries: 1. Publications: 0.
NEUROFEEDBACK TRAINING FOR OLDER ADULTS WITH MILD COGNITIVE IMPAIRMENT: A PILOT STUDY
ClinicalTrials.gov study NCT04027725. IPD Sharing: NO. Countries: 1. Publications: 0.
tDCS and Cognitive Training for Mild Cognitive Impairment and Alzheimer's Dementia
ClinicalTrials.gov study NCT04507815. IPD Sharing: NO. Countries: 1. Publications: 0.
Exploring the Predicting Biomarkers From Mild Cognitive Impairment to Dementia (EBMID)
ClinicalTrials.gov study NCT05697588. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
A Study to Evaluate the Efficacy and Safety of KarXT + KarX-EC for Cognitive Impairment in Alzheimer's Disease
ClinicalTrials.gov study NCT06976216. IPD Sharing: YES. Countries: 17. Publications: 0.
The Use of Rhythmic Light Therapy in Mild Cognitive Impairment
ClinicalTrials.gov study NCT07318038. IPD Sharing: NO. Countries: 1. Publications: 0.
Improve Cancer-related Cognitive Impairment
ClinicalTrials.gov study NCT05864274. IPD Sharing: NO. Countries: 1. Publications: 0.
Speech Intelligibility and Cognition: Are Inpatients Impaired by Noise?
ClinicalTrials.gov study NCT00695162. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Effect of Frontal Transcranial Direct Current Stimulation on BDNF in Stroke Patients With Cognitive Impairment
ClinicalTrials.gov study NCT06386614. IPD Sharing: NO. Countries: 1. Publications: 0.
Comprehensive Cognitive and Affective Intervention for Mild Cognitive Impairment (MCI) for Foreign-Born Arab Americans
ClinicalTrials.gov study NCT05854290. IPD Sharing: NO. Countries: 1. Publications: 0.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.