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14,866 results for “cancer cell”
EGCG-treated non-small cell lung cancer associated signature miRNA expression analysis: NGS approach for novel miRNA sequence detection
GEO Series GSE110514. Homo sapiens. 3 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Atypical function of a centrosomal module in WNT signalling drives contextual cancer cell motility
GEO Series GSE129871. Homo sapiens. 120 samples. Type: Expression profiling by high throughput sequencing.
Open chromatin profile of primary and lymph node oral cancer cells
GEO Series GSE92479. Homo sapiens. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Data from: Monoallelic chromatin conformation flanking long-range silenced domains in cancer-derived and normal cells
Epigenetic inactivation of chromatin plays an important role in determining cell phenotype in both normal and cancer cells, but our knowledge is still incomplete with respect to any potential monoallelic nature of the phenomenon. We have genotyped DNA isolated from chromatin of two colorectal cancer-derived lines and a culture of normal human intestinal epithelial cells (HIEC), which was immunoprecipitated with antibodies to acetylated vs. methylated histone H3K9, and presented the data as B allele frequency differences over multiple single-nucleotide polymorphism (SNP) moving window averages. [B allele is an arbitrary term defined as one of the two alleles at any given SNP, named A and B]. Three different validation tests confirmed that peaks exhibiting differences represented monoallelic domains. These complementary tests confirmed the following: 1) genes in the regions of high B allele frequency difference were expressed monoallelically; 2) in normal cells all five imprinting control regions which carried heterozygous SNPs were characterized by B allele difference peaks; and 3) the haplotypes in the B allele difference peaks were faithfully maintained in the chromatin immunoprecipitated with the respective antibodies. In both samples most of the monoallelic domains were found at the boundaries between regions of open and closed chromatin. With respect to the cancer line, this supports the established concept of conformation spreading, but the results from the normal cells were unexpected. Since these cells were polyclonal, the monoallelic structures were probably not determined by random choice as occurs in X-inactivation, so we propose that epigenetic inactivation in some domains may be heritable and polymorphic in normal human cells.
Data from: A methylation-to-expression feature model for generating accurate prognostic risk scores and identifying disease targets in clear cell kidney cancer
Many researchers now have available multiple high-dimensional molecular and clinical datasets when studying a disease. As we enter this multi-omic era of data analysis, new approaches that combine different levels of data (e.g. at the genomic and epigenomic levels) are required to fully capitalize on this opportunity. In this work, we outline a new approach to multi-omic data integration, which combines molecular and clinical predictors as part of a single analysis to create a prognostic risk score for clear cell renal cell carcinoma. The approach integrates data in multiple ways and yet creates models that are relatively straightforward to interpret and with a high level of performance. Furthermore, the proposed process of data integration itself captures relationships in the data that represent highly disease-relevant functions.
Data from: The lncRNA H19 mediates breast cancer cell plasticity during EMT and MET plasticity by differentially sponging miR-200b/c and let-7b
Metastasis is a multistep process by which tumor cells disseminate from their primary site and form secondary tumors at a distant site. The pathophysiological course of metastasis is mediated by the dynamic plasticity of cancer cells, which enables them to shift between epithelial and mesenchymal phenotypes through a transcriptionally regulated program termed epithelial-to-mesenchymal transition (EMT) and its reverse process, mesenchymal-to-epithelial transition (MET). Using a mouse model of spontaneous metastatic breast cancer, we investigated the molecular mediators of metastatic competence within a heterogeneous primary tumor and how these cells then manipulated their epithelial-mesenchymal plasticity during the metastatic process. We isolated cells from the primary mammary tumor, the circulation, and metastatic lesions in the lung in TA2 mice and found that the long noncoding RNA (lncRNA) H19 mediated EMT and MET by differentially acting as a sponge for the microRNAs miR-200b/c and let-7b. We found that this ability enabled H19 to modulate the expression of the microRNA targets Git2 and Cyth3, respectively, which encode regulators of the RAS superfamily member adenosine 5′-diphosphate (ADP) ribosylation factor (ARF), a guanosine triphosphatase (GTPase) that promotes cell migration associated with EMT and disseminating tumor cells. Decreasing the abundance of H19 or manipulating that of members in its axis prevented metastasis from grafts in syngeneic mice. Abundance of H19, GIT2, and CYTH3 in patient samples further suggests that H19 might be exploited as a biomarker for metastatic cells within breast tumors and perhaps as a therapeutic target to prevent metastasis.
Integrative analysis of spatial and single-cell transcriptome data from human pancreatic cancer reveals an intermediate cancer cell population associated with poor prognosis_Spatial H&E images
<p>High-resolution H&E images of spatial transcriptome data</p>
The inhibitory effects of Propofol and (-)-Epigallocatechin-3-gallate on the growth of human triple negative breast cancer MDA.MB231 cells.
<p><strong>Figure 1. MDA.MB231 cells migration is inhibiteb by Propofol and EGCG. </strong>MDA.MB231 cells were incubated in medium alone <strong>A); B) </strong>Propofol 10 μg/ml, <strong>C)</strong> EGCG 40 μM , <strong>D)</strong> Propofol 10 μg/ml and EGCG 40 μM. At 48 h <strong>(D)</strong> the inhibitory effect of EGCG and TAP, was clearly evident (*<em>P value</em> < 0.05).</p>
Novel N6-methylandenosine-related long non-coding RNAs as a Prognostic Signature Associated with Tumor Immune Cell Infiltration in Breast Cancer
<p><strong>Supplementary Figure S1</strong>. The correlation between risk score and six types of tumor-infiltration immune cells in TIMER database.</p> <p><strong>Supplementary Figure S2</strong>. Expression levels of m6A-LPS related lncRNAs in 16 breast cancer tissues and paired normal breast tissues.</p>
Figure 1 from: Abbas AH, Mahmood AAR, Tahtamouni LH, Al-Mazaydeh ZA, Rammaha MS, Alsoubani F, Al-bayati RI (2021) A novel derivative of picolinic acid induces endoplasmic reticulum stress-mediated apoptosis in human non-small cell lung cancer cells: synthesis, docking study, and anticancer activity. Pharmacia 68(3): 679-692. https://doi.org/10.3897/pharmacia.68.e70654
Figure 1 Synthesis of the target compounds (4–7).
Single Cell RNA-seq Profiling of Neuroblastoma and Breast Cancer
<p>This dataset includes seven samples from three patients: neuroblastoma (n = 2) and breast cancer (n = 1). For each neuroblastoma patient, three samples were derived from bone marrow (B), peripheral blood (P), and primary tumor (T). For the breast cancer patient, one sample was derived from peripheral blood.</p>
The CXCR4 antagonist R54 targets epithelial-mesenchymal transition (EMT) in human ovarian cancer cells
<p><strong>Abstract</strong></p> <p><span>The axis CXCL12-CXCR4 is highly expressed in ovarian cancer where contributes to disease progression. Aim of the work was to evaluate the effect of the newly developed CXCR4 antagonist R54 on human ovarian cancer cells aggressiveness. CXCL12-CXCR4 axis was evaluated in human ovarian cancer cells through proliferation, migration and signaling CXCL12-dependents. Epithelial to mesenchymal transition (EMT)</span><span> </span><span>was analyzed through <em>E-CADHERIN</em>, <em>N-CADHERIN</em>, <em>VIMENTIN</em>, <em>SNAIL1</em> and <em>ΒETA-CATENIN</em> by qRT-PCR, immunofluorescence and immunoblotting.</span><span> </span><span>R54 inhibited ovarian cancer cells proliferation and migration CXCL12-induced. Moreover, R54 inhibited CXCL12 dependent pERK1/2 and pAKT and reversed the CXCL12 induced EMT in ovarian cancer cells. Targeting CXCR4 with the new antagonist R54 consistently reverted the mesenchymal transition in human ovarian cancer cells reducing migratory and chemoresistance features.</span></p>
Ixabepilone in Treating Patients With Metastatic or Recurrent Squamous Cell Cancer of the Head and Neck
ClinicalTrials.gov study NCT00033618. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Cell-Free DNA and RNA in Blood fromMetastatic Prostate Cancer Patients
ClinicalTrials.gov study NCT02853097. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Exploration on the Value of MRD Based on ctDNA Detection in Predicting Recurrence of Resected Non-small Cell Lung Cancer
ClinicalTrials.gov study NCT05965024. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
ET 140202 -T Cell Combined With TAE or Sorafenib in the Treatment of Liver Cancer
ClinicalTrials.gov study NCT03965546. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
A Study of Sintilimab in Combination With Axitinib in Advanced Renal Cell Cancer
ClinicalTrials.gov study NCT04958473. IPD Sharing: NO. Countries: 1. Publications: 0.
Outcome of Cisplatin and Vinblastine Versus Paclitaxel and Carboplatin as Sequential Chemotherapy Followed by Radiotherapy in Locally Advanced Non-small Cell Lung Cancer
ClinicalTrials.gov study NCT03092986. IPD Sharing: NO. Countries: 1. Publications: 0.
Gene-expression Profiles in CNS-metastatic Non-small Cell Lung Cancer
ClinicalTrials.gov study NCT00862173. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Study of the Safety of Atezolizumab in Participants With Locally Advanced or Metastatic Non Small Cell Lung Cancer in Argentina
ClinicalTrials.gov study NCT03321695. IPD Sharing: Not stated. Countries: 1. Publications: 0.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.