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opencc-by-4.0Sep 2024View details →

The time between symptom onset and various clinical outcomes: A statistical analysis of MERS-CoV patients in Saudi Arabia

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dryad28/100

Data from: Pearls & Oy-sters: Adolescent-onset adrenomyeloneuropathy and arrested cerebral adrenoleukodystrophy

Pearls: Defects in peroxisomal transport interferes with β-oxidation of very long chain fatty acids (VLCFAs). Subsequent VLCFA accumulation triggers a cascade of events that eventually leads to adrenoleukodystrophy (ALD). Attention-deficit/hyperactivity disorder (ADHD) can be one of the early manifestations of childhood cerebral ALD (CCALD). Patients with adrenomyeloneuropathy (AMN) may have signs of occult self-halted CCALD on MRI, which can help point to a diagnosis of AMN. Oy-sters: AMN can present in adolescence, although it typically presents in adult men between 20 and 40 years of age, and at older age in women. MRI findings in the spinal cord could be normal or show minimal white matter involvement with significant bilateral spastic paraparesis. Blood pressure, glucose, and electrolytes can be normal in patients with adrenal insufficiency.

opencc-zeroJul 2019View details →

dryad28/100

Data from: Protective role of nano-selenium-enriched Bifidobacterium longum in delaying the onset of streptozotocin-induced diabetes

Bifidobacterium longum (B. longum) could accumulate Selenium (Se) and nano-Se in the form of Se-B. longum and Nano-Se-B. longum, respectively. In this study, the effect of Nano-Se-B. longum in diabetic mice was evaluated. Physiological and metabolic parameters such as blood glucose, body weight, serum insulin level, intraperitoneal glucose tolerance test (IPGTT), food intake, water consumption, and urine output were evaluated. The expression of insulin signaling pathway-related proteins was evaluated by western blotting. Hematoxylin and eosin (H&E) was used for histological examination of the liver, pancreas, and kidney sections. Creatinine levels in serum (SCr) and blood urea nitrogen (BUN) were measured. Nano-Se-B. longum was the best in terms of delaying the onset of diabetes. Nano-Se-B. longum decreased blood glucose and body weight compared with those noted for the model group. IPGTT, food intake, water consumption, and urine output significantly increased and serum insulin levels significantly decreased in the model group compared with those in all the Nano-Se-B. longum-treated mice. Histological results showed that the Nano-Se-B. longum-treated mice were better than the model group mice in terms of pathological changes. The expression of insulin signaling pathway-related proteins was upregulated in the Nano-Se-B. longum-treated groups. A significant increase in SCr and BUN levels was noted in the model group. This study for the first time reported the dose-dependent preventive effect of Nano-Se-B. longum on the onset of diabetes and renal damage. The mechanism may be related to changes in insulin signaling.

opencc-zeroDec 2017View details →

opencc-by-4.0Dec 2022View details →

"Onset of post-cratering melting of target rocks at the impact melt contact: observations from the Vredefort impact structure, South Africa" µCT data

µCT Dataset.

opencc-by-4.0Jan 2023View details →

Template matching earthquake catalog from the 1st of January 2009 to the onset of the 2016 Central Italy sequence (24th of August 2016)

Earthquake catalog obtained using the template matching technique from the 1st of January 2009 to the onset of the 2016 Central Italy sequence (24th of August 2016): it corresponds to a list of earthquake locations with magnitude estimation; the average cross correlation, the threshold, the associated template and the number of channels above the cross correlation threshold are indicated as well. Other details in Sugan et al., 2023. Sugan, M., Campanella, S., Chiaraluce, L., Michele, M., & Vuan, A. (2023). The unlocking process leading to the 2016 Central Italy seismic sequence. Geophysical Research Letters, 50, e2022GL101838. https://doi.org/10.1029/2022GL101838.

openAug 2023View details →

Onset of mining operations

Motivation <a href="https://www.nature.com/articles/s41597-020-00624-w">Maus et al </a>created the first database of the spatial extent of mining areas by mobilizing nearly 20 years of Landsat data. This dataset is imperative for GlobES, as mining areas are specified in the IUCN habitat class scheme. Yet, this dataset is temporally static. To tackle this flaw, we mined the Landsat archive to infer the first observable year of mining. Approach For each mining area polygon, we collected 50 random samples within it and 50 random samples along its borders. This was meant to reflect increasing spectral differences between areas within and outside a mining exploration after its onset. Then, for each sample, we used Google Earth Engine to extract spectral profiles for every available acquisition between 1990 and 2020. After completing the extraction, we estimate mean spectral profiles for each acquisition date, once for the samples “inside” the mining area, and another for those “outside” of it. In this process, we masked pixels afflicted by clouds and cloud shadows using Landsat's quality information. Using the time-series of mean profiles, at each mining site and for each unique date, we normalized the “inside” and “outside” multi-spectral averages and estimated the Root Mean Square Error (RMSE) between them. The normalization step aimed at emphasizing differences in the shape of the spectral profiles rather than on specific values, which can be related to radiometric innacuracies, or simply to differences in acquisition dates. This resulted in an RMSE time-series for each mining site. We then used these data to infer the first mining year. To achieve this, we first derived a cumulative sum of the RMSE time-series with the intent of removing noise while preserving abrupt directional changes. For example, if a mine was introduced in a forest, it would drive an increase in the RMSE due to the removal of trees, whereas the outskirts of the mine would remain forested. In this example, the accumulated values would tilt upwards. However, if a mining exploration was accompanied by the removal of vegetation along its outskirts where bare land was common, a downwards shift is RMSE values is more likely as the landscape becomes more homogenization. To detect the date marking a shift in RMSE values, we used a knee/elbow detection algorithm implemented in the <a href="https://pypi.org/project/kneebow/">python package kneebow</a>, which uses curve rotation to infer the inflection/deflection point of a time series. Here, downward trends correspond to the elbow and upward trends to the knee. To determine which of these metrics was the most adequate, we use the Area Under the Curve (AUC). An elbow is characterized by a convex shape of a time-series which makes the AUC greater than 50%. However, if the shape of the curve is concave, the knee is the most adequate metric. We limited the detection of shifts to time-series with at least 100 time steps. When below this threshold, we assumed the mine (or the the conditions to sustain it) were present since 1990. Content This repository contains the infrastructure used to infer the start of a mining operation, which is organized as following: <ul> <li>00_data - Contains the base data required for the operation, including a SHP file with the mining area outlines, and validation samples.</li> <li>01_analysis - Contains several outputs of our analysis: <ul> <li>xy.tar.gz - Sample locations for each mining site.</li> <li>sr.tar.gz - Spectral profiles for each sample location.</li> <li>mine_start.csv - First year when we detected the start of mining.</li> </ul> </li> <li>02_code - Includes all code used in our analysis.</li> <li>requirements.txt - Python module requirements that can be fed to pip to replicate our study.</li> <li>config.yml - Configuration file, including information on the Landsat products used.</li> </ul>

opencc-by-4.0Sep 2023View details →

Predictive risk factors before the onset of familial rheumatoid arthritis: the Tatarstan cohort study

Dataset for: https://www.frontiersin.org/articles/10.3389/fmed.2023.1227786/abstract   Predictive risk factors before the onset of familial rheumatoid arthritis: the Tatarstan cohort study   Background: A familial history of rheumatoid arthritis (RA) predisposes an individual for developing RA. This study aimed at investigating factors associated with this conversion from the Tatarstan cohort.Methods: 144 individuals, referred to as pre-RA and at risk for familial RA, were selected 2 years (range: 2 to 21 years) before conversion to RA and compared to non-converted 328 first degree relatives (FDR) from RA as assessed after ≥ 2 years follow-up, and 355 healthy controls (HC). Preclinical parameters, and socio-demographic/individual/HLA genetic factors were analyzed when data were available at the time of enrolment.Results: As compared to FDR and HC groups, pre-RA individuals were characterized before conversion to RA by the presence of arthralgia, severe morning symptoms, a lower educational level, and rural location. An association with the HLA-DRB1 SE risk factor was also retrieved with symmetrical arthralgia and passive smoking. On the contrary, alcohol consumption and childless in women were protective and associated with the HLA-DRB1*07:01 locus.Conclusion: Before RA onset, a combination of individual and genetic factors characterized those who are at risk of progressing to RA among those with familial RA relatives.

closedIPD-NOFeb 2026View details →

Phase III Study To Compare The Effect of Panzyga Versus Placebo in Patients With Pediatric Acute-onset Neuropsychiatric Syndrome (PANS/PANDAS)

ClinicalTrials.gov study NCT04508530. IPD Sharing: NO. Countries: 3. Publications: 0.

Bolus Versus Prolonged Infusion of Meropenem in Newborn With Late Onset Sepsis

ClinicalTrials.gov study NCT02503761. IPD Sharing: Not stated. Countries: 0. Publications: 1.

A Study of a Drug to be Used in Addition With Another Drug to Treat Adults With Uncontrolled Partial-onset Seizures

ClinicalTrials.gov study NCT03116828. IPD Sharing: Not stated. Countries: 2. Publications: 0.

YOD-RiSoCo: Social Cognition and Risk-taking Behaviour in Patients with Young-onset Dementia

ClinicalTrials.gov study NCT06286293. IPD Sharing: UNDECIDED. Countries: 0. Publications: 1.

Post-Authorization Safety Study to Assess the Safety of Vimpat as add-on Therapy in Patients With Partial-onset Seizures

ClinicalTrials.gov study NCT00771927. IPD Sharing: Not stated. Countries: 5. Publications: 0.

Ethnicity and Onset of Cardiovascular Disease: A CALIBER Study

ClinicalTrials.gov study NCT02176174. IPD Sharing: Not stated. Countries: 0. Publications: 2.

A Study of the Efficacy and Safety of Topiramate as add-on Therapy in the Treatment of Epilepsy Patients With Difficult to Treat, Partial-onset Seizures

ClinicalTrials.gov study NCT00236860. IPD Sharing: Not stated. Countries: 0. Publications: 1.

A Study of the Effectiveness and Safety of Topiramate Monotherapy in Patients With Recently Diagnosed Partial-Onset Seizure

ClinicalTrials.gov study NCT00230698. IPD Sharing: Not stated. Countries: 0. Publications: 1.

A Study of the Efficacy and Safety of Topiramate as add-on Therapy in the Treatment of Epilepsy Patients With Difficult to Treat, Partial-onset Seizures.

ClinicalTrials.gov study NCT00236873. IPD Sharing: Not stated. Countries: 0. Publications: 1.

Correlation of Family History, Age at Onset & Severity of Stuttering

ClinicalTrials.gov study NCT04412213. IPD Sharing: Not stated. Countries: 0. Publications: 2.

closedIPD-NOFeb 2026View details →

Randomized Double Blind Control Trial on Effects of Ranolazine on New Onset Atrial Fibrillation

ClinicalTrials.gov study NCT01590979. IPD Sharing: NO. Countries: 1. Publications: 0.

An Open Label Study of L059 Intravenous (IV) in Japanese Epilepsy Subjects With Partial Onset Seizures

ClinicalTrials.gov study NCT01407523. IPD Sharing: Not stated. Countries: 1. Publications: 0.

Compex Use With Delayed Onset Muscle Soreness: A Comparison to Other Methods

ClinicalTrials.gov study NCT01967121. IPD Sharing: Not stated. Countries: 1. Publications: 0.