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671 results for “Dilatancy”
Dataset related to the article "CarDiac magnEtic Resonance for prophylactic Implantable-cardioVerter defibrillAtor ThErapy in Non-Ischaemic dilated CardioMyopathy: an international Registry"
<p>This record contains raw data related to the article “CarDiac magnEtic Resonance for prophylactic Implantable-cardioVerter defibrillAtor ThErapy in Non-Ischaemic dilated CardioMyopathy: an international Registry” <br> </p> <p>Abstract</p> <p><strong>Aims: </strong>The aim of this registry was to evaluate the additional prognostic value of a composite cardiac magnetic resonance (CMR)-based risk score over standard-of-care (SOC) evaluation in a large cohort of consecutive unselected non-ischaemic cardiomyopathy (NICM) patients.</p> <p><strong>Methods and results: </strong>In the DERIVATE registry (www.clinicaltrials.gov/registration: RCT<a href="http://clinicaltrials.gov/show/NCT03352648">#NCT03352648</a>), 1000 (derivation cohort) and 508 (validation cohort) NICM patients with chronic heart failure (HF) and left ventricular ejection fraction <50% were included. All-cause mortality and major adverse arrhythmic cardiac events (MAACE) were the primary and secondary endpoints, respectively. During a median follow-up of 959 days, all-cause mortality and MAACE occurred in 72 (7%) and 93 (9%) patients, respectively. Age and >3 segments with midwall fibrosis on late gadolinium enhancement (LGE) were the only independent predictors of all-cause mortality (HR: 1.036, 95% CI: 1.0117-1.056, P < 0.001 and HR: 2.077, 95% CI: 1.211-3.562, P = 0.008, respectively). For MAACE, the independent predictors were male gender, left ventricular end-diastolic volume index by CMR (CMR-LVEDVi), and >3 segments with midwall fibrosis on LGE (HR: 2.131, 95% CI: 1.231-3.690, P = 0.007; HR: 3.161, 95% CI: 1.750-5.709, P < 0.001; and HR: 1.693, 95% CI: 1.084-2.644, P = 0.021, respectively). A composite clinical and CMR-based risk score provided a net reclassification improvement of 63.7% (P < 0.001) for MAACE occurrence when added to the model based on SOC evaluation. These findings were confirmed in the validation cohort.</p> <p><strong>Conclusion: </strong>In a large multicentre, multivendor cohort registry reflecting daily clinical practice in NICM work-up, a composite clinical and CMR-based risk score provides incremental prognostic value beyond SOC evaluation, which may have impact on the indication of implantable cardioverter-defibrillator implantation.</p>
Tricuspid annular dilation in patients undergoing early mitral valve surgery: is it an old story?
<p>This record contains raw data related to the article "Tricuspid annular dilation in patients undergoing early mitral valve surgery: is it an old story?"</p> <p>Patients with mitral valve prolapse (MVP), undergoing early surgery for severe regurgitation, are usually characterized by<br> a low degree of right chambers’ remodeling. In this selected population, the mechanisms leading to tricuspid annular (TA)<br> dilatation (TAD) are not well understood. In this setting, we aimed to evaluate, using three-dimensional echocardiography<br> (3DE), how right chambers affect TA size and might contribute to functional tricuspid regurgitation (FTR) progression.<br> We studied 159 patients treated with early isolated surgery for MVP, characterized by: sinus rhythm; normal biventricular<br> function; normal or elevated pulmonary artery pressure; tricuspid regurgitation (TR) ≤ mild; no concomitant cardiac disease.<br> All patients reached a 3-year echocardiographic follow-up. Based on two-dimensional echocardiography, patients were<br> divided in Group 1 (N = 68, 43%, TAD, TA ≥ 21 mm/m2) and Group 2 (N = 91, 57%, no TAD, TA < 21 mm/m2). By 3DE,<br> Group 1 showed larger TA size, right atrial (RA) volume and right ventricular (RV) conical remodeling compared to Group<br> 2 (p < 0.05). The multivariate analysis revealed that RA volume, RV basal diameter and function were independently correlated<br> to TA size (p < 0.05). At the 3-year follow-up there was a low incidence of FTR, with a trend towards FTR progression<br> in Group 1 (p = 0.07). In patients undergoing early surgery for MVP, TAD seems to result from distinctive early-onset<br> geometrical changes of the right chambers, preceding TR, RV dilatation and pulmonary hypertension at rest. An integrated<br> approach, including right chambers’ assessment by 3DE, might help to better recognized patients at higher risk for TAD<br> and, potentially for FTR.</p>
Clinical Considerations for a Family with Dilated Cardiomyopathy, Sudden Cardiac Death, and a Novel TTN Frameshift Mutation.
<p>Figures from Micaglio E, Monasky MM, Bernardini A, Mecarocci V, Borrelli V, Ciconte G, Locati ET, Piccoli M, Ghiroldi A, Anastasia L, Pappone C. Clinical Considerations for a Family with Dilated Cardiomyopathy, Sudden Cardiac Death, and a Novel <em>TTN</em> Frameshift Mutation. Int J Mol Sci. 2021 Jan 12;22(2):670. doi: 10.3390/ijms22020670. PMID: 33445410; PMCID: PMC7826882.</p> <p>Abstract</p> <p>Dilated cardiomyopathy (DCM) is the leading indication for heart transplantation. <em>TTN</em> gene truncating mutations account for about 25% of familial DCM cases and for 18% of sporadic DCM cases. The clinical relevance of specific variants in <em>TTN</em> has been difficult to determine because of the sheer size of the protein for which <em>TTN</em> encodes, as well as existing extensive genetic variation. Clinicians should communicate novel clinically-relevant variants and genotype-phenotype associations, so that animal studies evaluating the molecular mechanisms are always conducted with a focus on clinical significance. In the present study, we report for the first time the novel truncating heterozygous variant NM_001256850.1:c.72777_72783del (p.Phe24259Leufs*51) in the <em>TTN</em> gene and its association with DCM in a family with sudden death. This variant occurs in the A-band region of the sarcomere, in a known mutational hotspot of the gene. Truncating titin variants that occur in this region are the most common cause of DCM and have been rarely reported in asymptomatic individuals, differently from other pathogenic <em>TTN</em> gene variants. Further studies are warranted to better understand this particular clinically-relevant variant.</p>
Onset of dilatancy of Bunter Sandstone
<p>Movie visualising the measured values for the onset of dilatancy of a single sample of Bunter Sandstone.</p>
Identification of molecular pathways involved in oxaliplatin-associated sinusoidal dilatation
GEO Series GSE32384. Homo sapiens. 24 samples. Type: Expression profiling by array.
The dilated cardiomyopathy-associated RNA Binding Motif Protein 20 regulates long pre-mRNAs in neurons [seCLIP-Seq]
GEO Series GSE250098. Mus musculus. 10 samples. Type: Other.
LncRNA DCRT protects against dilated cardiomyopathy via binding to PTBP1 (Iso-seq)
GEO Series GSE243738. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
Dilated Cardiomyopathy
GEO Series GSE241120. Mesocricetus auratus; Homo sapiens; Mus musculus. 17 samples. Type: Expression profiling by high throughput sequencing.
Data set from the article Petrini M, Alì M, Cannaò PM, Zambelli D, Cozzi A, Codari M, Malavazos AE, Secchi F, Sardanelli F. Epicardial adipose tissue volume in patients with coronary artery disease or non-ischaemic dilated cardiomyopathy: evaluation with cardiac magnetic resonance imaging. Clin Radiol. 2019 Jan;74(1):81.e1-81.e7. doi: 10.1016/j.crad.2018.09.006. Epub 2018 Oct 15. PMID: 30336943.
<p>Data set from the article Petrini M, Alì M, Cannaò PM, Zambelli D, Cozzi A, Codari M, Malavazos AE, Secchi F, Sardanelli F. Epicardial adipose tissue volume in patients with coronary artery disease or non-ischaemic dilated cardiomyopathy: evaluation with cardiac magnetic resonance imaging. Clin Radiol. 2019 Jan;74(1):81.e1-81.e7. doi: 10.1016/j.crad.2018.09.006. Epub 2018 Oct 15. PMID: 30336943.</p> <p> </p> <p>This is the abstract:</p> <p><strong>Aim: </strong> To compare the amount of epicardial adipose tissue (EAT) in patients with coronary artery disease (CAD) or non-ischaemic dilated cardiomyopathy (NIDCM) with that in patients with negative cardiac magnetic resonance imaging (CMR).</p> <p><strong>Materials and methods: </strong> One hundred and fifty patients (median age 57 years, interquartile range [IQR] 46-66 years) who underwent CMR were evaluated retrospectively: 50 with CAD, 50 with NIDCM, and 50 with negative CMR. For each patient, the EAT mass index (EATMI) to body surface area, end-diastolic volume index (EDVI), end-systolic volume index (ESVI), stroke volume (SV), ejection fraction (EF) for both ventricles, and left ventricle (LV) mass index were estimated. Intra and inter-reader reproducibility was tested in a random subset of 30 patients, 10 for each group. Mann-Whitney U test, Kruskal-Wallis test, Spearman's correlation, and Bland-Altman statistics were used.</p> <p><strong>Results: </strong> The EATMI in CAD patients (median 15.7 g/m<sup>2</sup>, IQR 8.3-25.7) or in NIDCM patients (15.9 g/m<sup>2</sup>, 11.5-18.1) was significantly higher than that in negative CMR patients (9.1 g/m<sup>2</sup>, 6-12; p<0.001 both). No significant difference was found between CAD and NIDCM patients (p=1.000). A correlation between EATMI and LV mass index was found in NIDCM patients (r=0.455, p=0.002). Intra- and inter-reader reproducibility were up to 80% and 72%, respectively.</p> <p><strong>Conclusion: </strong> Patients with NIDCM or CAD exhibited an increased EATMI in comparison to negative CMR patients. CMR can be used to estimate EAT with good reproducibility.</p>
Onset of dilatancy of Z-sample of Opalinus Clay
<p>Movie visualising the onset of dilatancy of a single sample of Opalinus Clay with Z-orientation (bedding in a 45° angle to the sample's longitudinal axis).</p>
Onset of dilatancy of P-sample of Opalinus Clay
<p>Movie visualising the onset of dilatancy of a single sample of Opalinus Clay with P-orientation (bedding parallel to the sample's longitudinal axis).</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.