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Dataset results
897 results for “Therapeutic targets”
Integrative Epigenetic Analysis Reveals Therapeutic Targets to the DNA Methyltransferase Inhibitor SGI-110 in Hepatocellular Carcinoma Cells
GEO Series GSE105067. Homo sapiens. 68 samples. Type: Expression profiling by array; Methylation profiling by array.
Integrating genomic alterations in diffuse large B-cell Lymphoma identifies new relevant pathways and potential therapeutic targets
GEO Series GSE94705. Homo sapiens. 119 samples. Type: Genome variation profiling by SNP array.
Combined MYC and TP53 defects emerge at medulloblastoma relapse and define rapidly progressive, therapeutically targetable disease
GEO Series GSE62626. Mus musculus; Homo sapiens. 88 samples. Type: Expression profiling by array; Genome variation profiling by genome tiling array.
SPRR1A is a potential therapeutic target for osteosarcoma: in vitro and in vivo evaluations using novel generated artificial osteosarcoma cancer stem cell-like cells
GEO Series GSE268670. Homo sapiens. 3 samples. Type: Expression profiling by high throughput sequencing.
Cell Cycle-Targeting MicroRNAs as Therapeutic Tools Against Refractory Cancers [dermatofibrosarcoma]
GEO Series GSE77228. Homo sapiens. 1 samples. Type: Expression profiling by array.
Identification of new therapeutic targets by genome-wide analysis of gene expression in the ipsilateral cortex of aged rats after stroke
GEO Series GSE55260. Rattus norvegicus. 6 samples. Type: Expression profiling by array.
The m6A Reader IGF2BP2 Regulates Glutamine Metabolism and Represents a Therapeutic Target in Acute Myeloid Leukemia
GEO Series GSE211619. Homo sapiens. 36 samples. Type: Expression profiling by high throughput sequencing; Other.
Pre-clinical spheroid models identify BMX as a therapeutic target for metastatic MYCN non-amplified neuroblastoma (ChIP-Seq)
GEO Series GSE223901. Homo sapiens. 12 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
ELAVL3 stabilizes MYCN mRNA and provides a therapeutic target in neuroendocrine prostate cancer [RIP-seq]
GEO Series GSE224910. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
The promising miRNAs, Let-7b-5p and miR-24-3p, have the potential to serve as therapeutic agents targeting pancreatic cancer stem cells.
GEO Series GSE294243. Homo sapiens; synthetic construct. 4 samples. Type: Non-coding RNA profiling by array.
Aurora kinase A is upregulated in cutaneous T-cell lymphoma and represents a potential therapeutic target
GEO Series GSE59307. Homo sapiens. 22 samples. Type: Expression profiling by array.
De novo lipogenesis represents a therapeutic target in Kras mutant NSCLC
GEO Series GSE113717. Mus musculus. 8 samples. Type: Expression profiling by array.
Adult High Grade B-cell Lymphoma with Burkitt Lymphoma Signature: Genomic features and Potential Therapeutic Targets
GEO Series GSE168422. Homo sapiens. 112 samples. Type: Expression profiling by array.
The mitochondrial-targeted peptide therapeutic elamipretide improves cardiac and skeletal muscle function during aging without detectable changes in tissue epigenetic or transcriptomic age.
GEO Series GSE280700. Macaca mulatta; Homo sapiens; Rattus; Mus musculus. 114 samples. Type: Expression profiling by high throughput sequencing; Methylation profiling by genome tiling array.
Multiscale Drug Screening for Cardiac Fibrosis Identifies MD2 as a Therapeutic Target
GEO Series GSE276566. Homo sapiens. 12 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Functionally-defined Therapeutic Targets in Diffuse Intrinsic Pontine Glioma
Diffuse Intrinsic Pontine Glioma (DIPG) is a universally fatal childhood cancer. Here, we performed a chemical screen in patient-derived DIPG cell cultures along with RNAseq expression analysis and integrated computational modeling to identify potentially effective therapeutic strategies. Panobinostat, among the more promising agents identified, demonstrated efficacy in pontine orthotopic xenograft models of both H3K27M and histone WT DIPG. These data suggest the potential utility of specific drug combinations and provides evidence of in vivo treatment efficacy of the multi-histone deacetylase inhibitor panobinostat.
Therapeutic targeting of GCB- and ABC-DLBCLs by rationally designed BCL6 inhibitors
GEO Series GSE79888. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
Genome-scale CRISPR-Cas9 screen of Wnt/β-catenin signalling identifies therapeutic targets for Colorectal Cancer
GEO Series GSE156083. Homo sapiens. 20 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing.
Fig. 4 in Geraniol and Citral as potential therapeutic agents targeting the HSP90 activity: An in silico and experimental approach
Fig. 4. Graphical representation showing the (A) rate of reaction vs concentration of different compounds (B) Screening of salts for ATPase inhibition, (C) ATPase activity inhibition by different salts in their optimized range ATPase activity inhibition by mixture of salts and essential oil components, (D) The effect of essential oil components individually and their mixture with Na+/K+ salts on ATPase activity (E) HSP90-ATPase activity was increased by Calcium sulfate. All of the experiments were done in triplicate, and the error bars reflect the standard error of the mean, with * p 0.05 being deemed a significant difference.
Identification of Prognostic Factors and New Therapeutic Targets in Cutaneous Lymphomas
ClinicalTrials.gov study NCT04520529. IPD Sharing: UNDECIDED. Countries: 0. Publications: 0.
ScienceDex guides
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.