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696 results for “adrenal”
Expression data from adult mouse adrenal tissue.
GEO Series GSE141310. Mus musculus. 12 samples. Type: Expression profiling by array.
Transcriptional profiling of adrenal glands from mice flown on the RR-23 mission
The objective of the Rodent Research-23 missions (RR-23) was to better understand the effects of spaceflight on the eyes, specifically on the structure and function of the arteries, veins, and lymphatic vessels that are needed to maintain vision. To this end, twenty male, C57BL/6J, 16-17 weeks-old mice were delivered to the ISS on SpaceX-21 in a single transporter, transferred to two rodent habitats, and maintained in microgravity for 38 days. Flight mice were then returned to Earth alive (Jan 13th, 2021). After splashdown in the Atlantic Ocean, mice were transported to Kennedy Space Center via helicopter. The 20 Flight, 20 Habitat Ground Control (HGC), and 20 Vivarium Ground Control (VGC) mice were removed from Rodent Transporters (Flight and HGC) or vivarium cages (VGC), placed into shipping containers, and flown to Texas A and M University. There, mice underwent post-flight procedures, before euthanasia and tissue collection. Flight, HGC and VGC animals were euthanized and dissected on Jan 14th, 17th or 20th of 2021, respectively. Adrenal glands were preserved by immersion in liquid nitrogen and stored at -80C until RNA was extracted, and libraries generated and sequenced (target 60 M clusters per sample, PE 150 bp). This dataset features 10 samples from the Flight group, 10 samples from the HGC group, and 10 samples from the VGC group.
Rodent Research-1 (RR1) NASA Validation Flight: Mouse adrenal gland transcriptomic, proteomic, and epigenomic data
NASA's Rodent Research (RR) project is playing a critical role in advancing biomedical research on the physiological effects of space environments. Due to the limited resources for conducting biological experiments aboard the International Space Station (ISS), it is imperative to use crew time efficiently while maximizing high-quality science return. NASA's GeneLab project has as its primary objectives to 1) further increase the value of these experiments using a multi-omics, systems biology-based approach, and 2) disseminate these data without restrictions to the scientific community. The current investigation assessed viability of RNA, DNA, and protein extracted from archived RR-1 tissue samples for epigenomic, transcriptomic, and proteomic assays. During the first RR spaceflight experiment, a variety of tissue types were harvested from subjects, snap-frozen or RNAlater-preserved, and then stored at least a year at -80C after return to Earth. They were then prioritized for this investigation based on likelihood of significant scientific value for spaceflight research. All tissues were made available to GeneLab through the bio-specimen sharing program managed by the Ames Life Science Data Archive and included mouse adrenal glands, quadriceps, gastrocnemius, tibialis anterior, extensor digitorum longus, soleus, eye, and kidney. We report here protocols for and results of these tissue extractions, and thus, the feasibility and value of these kinds of omics analyses. In addition to providing additional opportunities for investigation of spaceflight effects on the mouse transcriptome and proteome in new kinds of tissues, our results may also be of value to program managers for the prioritization of ISS crew time for rodent research activities.
Rodent Research-1 (RR1) NASA Validation Flight: Mouse adrenal gland transcriptomic proteomic and epigenomic data
NASA s Rodent Research (RR) project is playing a critical role in advancing biomedical research on the physiological effects of space environments. Due to the limited resources for conducting biological experiments aboard the International Space Station (ISS) it is imperative to use crew time efficiently while maximizing high-quality science return. NASA s GeneLab project has as its primary objectives to 1) further increase the value of these experiments using a multi-omics systems biology-based approach and 2) disseminate these data without restrictions to the scientific community. The current investigation assessed viability of RNA DNA and protein extracted from archived RR-1 tissue samples for epigenomic transcriptomic and proteomic assays. During the first RR spaceflight experiment a variety of tissue types were harvested from subjects snap-frozen or RNAlater-preserved and then stored at least a year at -80C after return to Earth. They were then prioritized for this investigation based on likelihood of significant scientific value for spaceflight research. All tissues were made available to GeneLab through the bio-specimen sharing program managed by the Ames Life Science Data Archive and included mouse adrenal glands quadriceps gastrocnemius tibialis anterior extensor digitorum longus soleus eye and kidney. We report here protocols for and results of these tissue extractions and thus the feasibility and value of these kinds of omics analyses. In addition to providing additional opportunities for investigation of spaceflight effects on the mouse transcriptome and proteome in new kinds of tissues our results may also be of value to program managers for the prioritization of ISS crew time for rodent research activities.
Rodent Research-3-CASIS: Mouse adrenal gland transcriptomic, proteomic, and epigenomic data
The Rodent Research-3 (RR-3) mission was sponsored by the pharmaceutical company Eli Lilly and Co. and the Center for the Advancement of Science in Space to study the effectiveness of a potential countermeasure for the loss of muscle and bone mass that occurs during spaceflight. Twenty BALB/c, 12-weeks old female mice (ten controls and ten treated) were flown to the ISS and housed in the Rodent Habitat for 39-42 days. Twenty mice of similar age, sex and strain were used for ground controls housed in identical hardware and matching ISS environmental conditions. Basal controls were housed in standard vivarium cages. Spaceflight, ground controls and basal groups had blood collected, then were euthanized, had one hind limb removed, and finally whole carcasses were stored at -80 C until dissection. All mice in this data set received only the control/sham injection.
Rodent Research-3-CASIS: Mouse adrenal gland transcriptomic proteomic and epigenomic data
The Rodent Research-3 (RR-3) mission was sponsored by the pharmaceutical company Eli Lilly and Co. and the Center for the Advancement of Science in Space to study the effectiveness of a potential countermeasure for the loss of muscle and bone mass that occurs during spaceflight. Twenty BALB/c 18-weeks old female mice (ten controls and ten treated) were flown to the ISS and housed in the AEM-X habitat for 39-42 days. Twenty mice of similar age sex and strain were used for ground controls housed in identical hardware and matching ISS environmental conditions. Basal controls were housed in standard vivarium cages. Spaceflight ground controls and basal groups had blood collected then were euthanized had one hind limb removed and finally whole carcasses were stored at -80 C until dissection. All mice in this data set received only the control/sham injection.
Multipotent Schwann cell precursors generate steroid-producing cells of the adrenal cortex and chromaffin cells of the adrenal medulla
GEO Series GSE140247. Mus musculus. 11 samples. Type: Expression profiling by high throughput sequencing.
IFNG production by self-reactive CD4 T cells drives the adrenal autoimmune pathology in the mouse model of Addison’s disease
GEO Series GSE303645. Mus musculus. 3 samples. Type: Other; Expression profiling by high throughput sequencing.
In vivo verification of the pathophysiology of lipoid congenital adrenal hyperplasia in the adrenal cortex
GEO Series GSE123300. Mus musculus. 13 samples. Type: Expression profiling by high throughput sequencing.
HIF1α is an essential regulator of steroidogenesis in the adrenal gland
GEO Series GSE154032. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Impact of Exposure to an Environmentally Relevant Mixture of Organophosphate Esters on the Adrenal Glands of Sprague Dawley Rats
GEO Series GSE275797. Rattus norvegicus. 40 samples. Type: Expression profiling by high throughput sequencing.
Real-time quantitative PCR miRNA expression data of normal foetal adrenal neuroblasts and cortex cells, neuroblastoma tumors and embryonic stem cells
GEO Series GSE121513. Homo sapiens. 117 samples. Type: Expression profiling by RT-PCR.
Transcriptional profiling of 8Br-cAMP treated human H295R adrenal cortex
GEO Series GSE32926. Homo sapiens. 23 samples. Type: Expression profiling by array.
Effect of LPS treatment on gene expression in the murine adrenal cortex
GEO Series GSE200220. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Programming effects of intrauterine hyperthermia on adrenal gland development
GEO Series GSE235160. Bos taurus. 24 samples. Type: Expression profiling by high throughput sequencing.
A spatiotemporal regulatory network for steroidogenesis of human fetal adrenal glands and gonads
GEO Series GSE167860. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
Expression data from mouse adrenal glands extracted from wild-type and sf1:Cre; Prkar1a Fl/Fl (KO) adrenals
GEO Series GSE77630. Mus musculus. 8 samples. Type: Expression profiling by array.
Changes of gene expression in adrenal gland after Ephb6 gene knockout in mice
GEO Series GSE120400. Mus musculus. 18 samples. Type: Expression profiling by array.
Microarray study of aldosterone-producing adenomas (APA) and their adjacent normal adrenal glands
GEO Series GSE156931. Homo sapiens. 24 samples. Type: Expression profiling by array.
High expression of adrenal cortisol synthases is acquired after intrauterine inflammation in periviable sheep fetuses
GEO Series GSE230267. Ovis aries. 10 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.