Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
21,320
datasets available to search
ShareScore release 0.9.0
Dataset results
21,320 results for “Transcription”
Data from: A gene for genetic background in Zea mays: fine-mapping enhancer of teosinte branched1.2 to a YABBY class transcription factor
Open the record for dataset details and reuse information.
Data from: Transcriptional markers of sub-optimal nutrition in developing Apis mellifera nurse workers
Open the record for dataset details and reuse information.
Transcriptional acclimation and spatial differentiation characterize drought response by the ectomycorrhizal fungus Suillus pungens
Open the record for dataset details and reuse information.
Data from: Transcription factors involved in retinogenesis are co-opted by the circadian clock following photoreceptor differentiation
Open the record for dataset details and reuse information.
Data from: Epigenomic study identifies a novel mesenchyme homeobox2-GLI1 transcription axis involved in cancer drug resistance, overall survival and therapy prognosis in lung cancer patients
Open the record for dataset details and reuse information.
Integron array MICs and cassettes transcription data
Open the record for dataset details and reuse information.
Data from: Oxidative phosphorylation gene transcription in whitefish species pairs reveals patterns of parallel and non-parallel physiological divergence
Open the record for dataset details and reuse information.
Systematic dissection of transcriptional regulatory networks by genome-scale and single-cell CRISPR screens
Open the record for dataset details and reuse information.
Data from: Variation in the transcriptional response of threatened coral larvae to elevated temperatures
Open the record for dataset details and reuse information.
Transitions in paternal social status predict patterns of offspring growth and metabolic transcription
Open the record for dataset details and reuse information.
Altering transcription factor binding reveals comprehensive transcriptional kinetics of a basic gene
Open the record for dataset details and reuse information.
Data from: Severe childhood speech disorder: Gene discovery highlights transcriptional dysregulation
Open the record for dataset details and reuse information.
Data for: Longitudinal metatranscriptomic sequencing of Southern California wastewater representing 16 million people from August 2020-21 reveals widespread transcription of antibiotic resistance genes
Open the record for dataset details and reuse information.
Raw data related to: "Transcriptional Regulators of T Helper 17 Cell Differentiation in Health and Autoimmune Diseases"
<p><strong>Introduction</strong></p> <p>T helper (Th) 17 cells are a subtype of CD4 T lymphocytes characterized by the expression of retinoic acid-receptor (RAR)-related orphan receptor (ROR)γt transcription factor, encoded by gene <em>Rorc</em>. These cells are implicated in the pathology of autoimmune inflammatory disorders as well as in the clearance of extracellular infections. The main function of Th17 cells is the production of cytokine called interleukin (IL)-17A.</p> <p><strong>Methods</strong></p> <p>We described the lineage defining transcription factor RORγt and other factors that regulate transcription of <em>Il17a, Rorc </em>and Th17-related genes, such as Il17f, Il21, Il23r, which may positively or negatively influence their expression.</p> <p><strong>Results</strong></p> <p>We discussed the potential new therapeutic approaches for Th17-related diseases targeting these transcription factors. The wide knowledge of transcriptional regulators of Th17 cells is crucial for the better understanding of the pathogenic role of these cells and for development of therapeutic strategies aimed at fighting Th17-related diseases.</p>
The rat brain transcripts after cocaine abstinence and relapse: data from the Maj Institute of Pharmacology Polish Academy of Sciences
<p>Substantially altered transcripts in the rat PFC during early (3. day) cocaine abstinence with extinction training identify by microarray analysis – supplementary material – Neurotoxicity research, 2017. Supported by the National Science Centre grant no. UMO-2012/06/A/NZ3/00022</p>
Figure 7 from: Walton S, Livermore L, Dillen M, De Smedt S, Groom Q, Koivunen A, Phillips S (2020) A cost analysis of transcription systems. Research Ideas and Outcomes 6: e56211. https://doi.org/10.3897/rio.6.e56211
Figure 7 Distribution of the time to transcribe a single herbarium sheet. All times greater than 1000 seconds have been aggregated in a single bar. Graph generated in R 3.6.1.
Dataset from: Functional divergence of mammalian TFAP2a and TFAP2b transcription factors for bidirectional sleep control
<p><span>Sleep is a conserved behavioral state that is found in all animals that have a nervous system. Invertebrates typically show quiet sleep, whereas in mammals, sleep is more complex, and consists of periods of non-rapid-eye-movement sleep (NREMS) and REM sleep (REMS). We previously found that the transcription factor AP-2 is required for sleep<i> </i>in<i> C. elegans </i>and <i>Drosophila</i> and that the <i>C. elegans </i>AP-2 gene <i>aptf-1</i> is required for sleep-active neurons to induce sleep. In mammals, several paralogous AP-2 transcription factors exist. Sleep-controlling genes are often conserved. However, little is known about how sleep genes evolved from controlling simpler types of sleep to govern complex mammalian sleep. Here, we studied the roles of <i>Tfap2a</i> and <i>Tfap2b</i> in sleep control in mice. Consistent with our results from <i>C. elegans</i> and <i>Drosophila</i>, the AP-2 transcription factors <i>Tfap2a</i> and <i>Tfap2b</i> also control sleep in mice. Surprisingly, however, the two AP-2 paralogs play contrary roles in sleep control. <i>Tfap2a</i> reduction of function causes stronger delta and theta power in both baseline and homeostasis analysis, thus indicating increased sleep quality, but did not affect sleep quantity. By contrast, <i>Tfap2b</i> reduction of function decreased NREM sleep time specifically during the dark phase, reduced NREMS and REMS power, and caused a weaker response to sleep deprivation. Consistent with the observed signatures of decreased sleep quality, stress resistance and memory were impaired in <i>Tfap2b</i> mutant animals. Also, the circadian period was slightly shortened. Taken together, AP-2 transcription factors control sleep behavior also in mice, but the role of the <i>AP-2</i> genes functionally diversified to allow for a bidirectional control of sleep quality. Divergence of AP-2 transcription factors might perhaps have supported the evolution of more complex types of sleep.</span></p>
Capacity for freshwater acclimation and differences in the transcription of ion transporter genes underlying different migratory life histories of Takifugu fish
<p>The genus<i> Takifugu </i>is a group of approximately 20 species of puffer fishes living in a wide range of salinity environments around East Asian countries. This group presents a broad spectrum of evolutionary stages adapted to anadromy as a result of speciation that occurred a short time (2–5 million years) ago on an evolutionary timescale. This group thus can be considered as a model for studying the evolutionary mechanisms of anadromy. We firstly conducted a transfer experiment from seawater to low-salinity waters on five <i>Takifugu</i> species: two anadromous species <i>T. obscurus</i> and <i>T. ocellatus</i>, two euryhaline wanderer marine species <i>T. rubripes</i> and <i>T. niphobles</i>, and a strictly marine species <i>T. snyderi</i>,<i> </i>and confirmed that the capacity for acclimation to hypotonic environments was associated with their life history strategies. Next, transcriptomes of the gill and intestine of these species in hypotonic condition were compared to those under hypertonic condition for each species using RNA-Sequencing so as to determine possible candidate transporters playing an important role on freshwater adaptation. As this analysis suggested that <i>cftr</i>, encoding an important ion transporter for seawater acclimation in the gill, and <i>ncc</i>, encoding a transporter that is suggested to play important osmoregulatory roles in the intestine, are important candidates, their expression was validated by quantitative real-time PCR analysis. Expression of<i> cftr</i> was downregulated in the gills of the four euryhaline species under the hypotonic condition, but no change was detected in the gill of stenohaline <i>T. snyderi</i>, which may be one reason for the poor hypotonic acclimation capacity of <i>T. snyderi</i>. Expression of <i>ncc</i> was clearly upregulated in the intestines of the two anadromous species under the hypotonic condition, but not in other three species.<b> </b>Different ion transporter expression patterns between the five species indicate that the transcriptional regulation of <i>cftr</i> in the gill and <i>ncc</i> in the intestine may be important for the improvement of hypotonic acclimation capacity and evolution of anadromy in the <i>Takifugu</i> species.</p>
Data from: Transcriptional changes during Daphnia pulex development indicate that the maturation decision resembles a rate more than a threshold
Maturation is a critical developmental process, and the age and size at which it occurs have important fitness consequences. Although maturation is remarkably variable, certain mechanisms, including a minimum size or state threshold, are proposed to underlie the process across a broad diversity of taxa. Recent evidence suggests that thresholds may themselves be developmentally plastic, and in the crustacean Daphnia pulex it is unclear whether maturation follows a threshold or is a gradual process more akin to a rate. Changes in gene expression across four instars before and during maturation were compared in a cDNA microarray experiment. Developmental stage was treated statistically both as a discontinuous and a continuous variable, to determine whether genes showed gradual or discrete changes in expression. The continuous analysis identified a greater number of genes with significant differential expression (45) than the discontinuous analysis (11). The majority of genes, including those coding for histones, factors relating to transcription and cell cycle processes, and a putative developmental hormone showed continuous increases or decreases in expression from the first to the fourth instar, suggestive of a prolonged and gradual maturation process. Three genes coding for a fused Vitellogenin/super-oxide dismutase showed increases in expression following the second instar and coincided with the posited maturation threshold, but even their expression increased in a continuous fashion.
Data from: Control of proline accumulation under drought via a novel pathway comprising the histone methylase CAU1 and the transcription factor ANAC055
Proline plays a crucial role in the drought stress response in plants. However, there are still gaps in our knowledge about the molecular mechanisms that regulate proline metabolism under drought stress. Here, we report that the histone methylase encoded by CAU1, which is genetically upstream of P5CS1 (encoding the proline biosynthetic enzyme Δ1-pyrroline-5-carboxylate synthetase 1), plays a crucial role in proline-mediated drought tolerance. We determined that the transcript level of CAU1 decreased while that of ANAC055 (encoding a transcription factor) increased in wild-type Arabidopsis under drought stress. Further analyses showed that CAU1 bound to the promoter of ANAC055 and suppressed its expression via H4R3sme2-type histone methylation in the promoter region. Thus, under drought stress, a decreased level of CAU1 led to an increased transcript level of ANAC055, which induced the expression of P5CS1 and increased proline level independently of CAS. Drought tolerance and the level of proline were found to be decreased in the cau1 anac055 double-mutant, while proline supplementation restored drought sensitivity in the anac055 mutant. Our results reveal the details of a novel pathway leading to drought tolerance mediated by CAU1.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.