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700
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ShareScore release 0.9.0
Dataset results
700 results for “ex vivo”
RNA-seq analysis of freshly isolated and ex-vivo cultured human cord blood CD34+ cells
GEO Series GSE179928. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Identification of mode of action for cell-based immunotherapy with ex-vivo expanded and activated autologous killer cells (AKCs) to recurrent glioblastoma (GBM) patients
GEO Series GSE142693. Homo sapiens. 12 samples. Type: Expression profiling by array.
Gene expression of mouse lung CD11b+ dendritic cells before and after ex vivo culture
GEO Series GSE156763. Mus musculus. 24 samples. Type: Other.
CPEB4-mediated translational regulation in ex vivo activated CD8 Tcells [RNA-seq]
GEO Series GSE189592. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Low-temperature prevents side effects of an anti-cancer drug, cyclophosphamide, on organ development: a study of ex vivo organ culture model
GEO Series GSE182499. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Single-cell dissection of ex vivo human heart tissue reveals pro-inflammatory microvascular changes in the right atrium in ischemic heart disease and heart failure
GEO Series GSE214731. Homo sapiens. 15 samples. Type: Expression profiling by high throughput sequencing.
Staphylococcus aureus ST398 gene expression profiling during ex vivo colonization of porcine nasal epithelium
GEO Series GSE47910. Staphylococcus aureus. 24 samples. Type: Expression profiling by array.
A mosaic renal myeloid subtype linked to immune escape correlates with poor patient survival in clear cell renal cell carcinoma [ex vivo]
GEO Series GSE108310. Homo sapiens. 18 samples. Type: Expression profiling by array.
Bulk RNA sequencing study on PBMCs collected from rhesus macaques treated with IL-15/IL-15Ra ex-vivo
GEO Series GSE292112. Macaca mulatta. 216 samples. Type: Expression profiling by high throughput sequencing.
Expression data of ex vivo and stimulated p14 TE (day 8) and p14 TM (day 46)
GEO Series GSE143632. Mus musculus. 14 samples. Type: Expression profiling by array.
CPEB4-mediated translational regulation in ex vivo activated CD8 Tcells [RIP-seq]
GEO Series GSE189765. Mus musculus. 20 samples. Type: Other.
Experimental data of ex vivo treated human cord blood (CB) derived hematopoietic stem and progenitor cells (HSPCs) with Ciclopirox ethanolamine.
GEO Series GSE159100. Homo sapiens. 12 samples. Type: Expression profiling by array.
Wnt/β-catenin signaling activation induces differentiation in human limbal epithelial stem cells cultured ex vivo
GEO Series GSE234403. Homo sapiens. 12 samples. Type: Expression profiling by array.
An ex vivo human precision-cut lung slice platform provides insight into SARS-CoV-2 pathogenesis and antiviral drug efficacy
GEO Series GSE226702. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Dataset related to the article "Characterization of aspirin esterase activity in health and disease: in vitro and ex vivo studies"
<p>This record contains raw data related to the article “Characterization of aspirin esterase activity in health and disease: In vitro and ex vivo studies"</p> <p>ABSTRACT</p> <p>Due to its ability to irreversibly inactivate platelet cyclooxygenase, low-dose aspirin (ASA) is the most widely used antithrombotic agent. Although, studies in specific types of patients with cardiovascular disease (CVD) have shown an incomplete inhibition of platelet’s cyclooxygenase, which may increase the variability in drug response. Some aspects of ASA pharmacokinetics (PK) still need further investigation. In this study, we aimed to characterise the contribution of esterase enzymes to ASA hydrolysis in the peripheral blood and to assess their activity in 36 healthy subjects (Ctrl) and 77 CVD patients. To this aim, an in vitro assay testing esterase activity in parallel to a liquid chromatography-tandem mass spectrometry method simultaneously detecting ASA and its main metabolites salicylic (SA) and gentisic acids, have been developed. Michaelis-Menten constant (Km) calculation, ASA esterase isoforms characterisation, and ASA PK study were then achieved. The calculated Km identified plasma esterases as the enzymes with the higher affinity for the substrate compared to the RBC ones. Both rivastigmine and 4-bis-nitrophenyl phosphate inhibited plasma esterase activities, suggesting that acetylcholinesterase and carboxylesterase largely contribute to ASA hydrolysis. The feasibility of the method here developed has been explored in Ctrl and CVD patients. The effect of ASA treatment on enzyme activity was further evaluated on an age, sex and BMI matched subgroup of patients and Ctrl (n = 10 for each subgroup, on and off ASA). No overall variations were evidenced in both CVD and Ctrl groups, even when the effect of ASA treatment was tested. This result suggests the absence of any influence of disease state, drug treatments, and comorbidities on plasma esterase and the inability of ASA intake to induce esterase function. In conclusion, the method here developed allows a better characterisation of ASA esterase activity and could be helpful to define the PK-related determinants of ASA responsiveness in order to personalise regimen in specific pathological conditions.</p>
An in vitro and ex vivo model of biomimetic regenerative devices to treat bone metastases and soft tissue tumors: BIOBOS PROJECT (Moh GR-2016-02364704)
<p>Biobos is a project funded by Italian MoH <strong>GR-2016-02364704 Other Italian Institutes involved: Istituto Ortopedico Rizzoli, Bologna CNR, Faenza</strong></p> <p>The hypothesis of BIOBOS is that the development of nanostructured biomimetic materials medicated with a chemotherapeutic drug and with one used for tissue regeneration will be an innovative strategy to be integrated with the current multidisciplinary treatment options on patients with bone metastases from breast cancer and on patients with soft tissue sarcomas. Three types of medicated materials have been developed: i) porous scaffolds and ii) self-regulating biomimetic pastes (bone cements) with anti-osteoporotic functions to be applied in the future in patients with bone metastases; both materials were functionalized with the standard chemotherapy doxorubicin, and an anti-RANKL antibody, which by blocking osteoclast differentiation, helps tissue regeneration in lytic-type metastases; iii) polymeric nanofibrous tissue-nonwoven mesh functionalized with the chemotherapeutic epirubicin and the anti-inflammatory diclofenac, used to evaluate its regenerative potential. After the synthesis and characterization of the materials, the functionalization of the drugs at optimal concentrations for local release was optimized for the bone cements and for the meshes, so as to have the release of the chemotherapeutic and subsequently of the regenerative drug. Meanwhile, on non-medicated materials, the monoculture and coculture conditions of tumor cells (of breast cancer for bone metastasis applications; an epithelial sarcoma cell line for application on sarcomas) and stromal cells (osteoclasts and osteoblasts for applications on bone metastases, a cell line of healthy murine fibroblasts for application on sarcomas. For both pathologies, after approval by the Local Ethics Committee, biological samples were collected to test the ex vivo efficacy of the materials medicated on explants or primary cultures.</p>
qRT-PCR of ex vivo Salmonella enterica in NRAMP-1 minus/plus macrophage background
GEO Series GSE26806. Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S. 4 samples. Type: Expression profiling by RT-PCR.
Expression data ex vivo CD4 T cells systemic lupus erythematosus patients
GEO Series GSE103760. Homo sapiens. 16 samples. Type: Expression profiling by array.
Identification of an effective early signaling signature during neo-vasculogenesis in vivo by ex vivo proteomic profiling
GEO Series GSE45896. Homo sapiens. 4 samples. Type: Protein profiling by protein array.
Adult and neonatal astrocytes exhibit diverse gene expression profiles during exposure to beta amyloid ex vivo
GEO Series GSE29317. Mus musculus. 12 samples. Type: Expression profiling by array.
ScienceDex guides
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.