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1,356
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ShareScore release 0.9.0
Dataset results
1,356 results for “Human Activities”
Ex-vivo Human Hematopoietic Stem Cell Expansion Requires Coordination of Cellular Reprogramming with Mitochondrial Remodeling and P53 Activation
GEO Series GSE110974. Homo sapiens. 17 samples. Type: Expression profiling by high throughput sequencing.
Physiological glucocorticoid receptor activation programs key cell phenotypes and functional epigenomic patterns in human fibroblasts [RNA-seq]
GEO Series GSE210302. Homo sapiens. 24 samples. Type: Expression profiling by high throughput sequencing.
Pro-inflammatory activity of SARS-CoV-2 viral peptide-dsRNA complex on human dermal microvascular endothelial cells (HDMVEC)
GEO Series GSE205487. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
H3K18la marks active tissue-specific enhancers [Cut & Tag human]
GEO Series GSE195854. Homo sapiens. 10 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Mapping cis-regulatory elements in human excitatory and inhibitory neurons links psychiatric disease heritability and activity-regulated transcriptional programs [ATAC-seq]
GEO Series GSE196854. Homo sapiens. 18 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Transcriptome analysis of primary human CD4+ T-cell activation
GEO Series GSE33272. Homo sapiens. 16 samples. Type: Expression profiling by array.
Macrophages amplify damaged sensory neuron spontaneous activity in a human co-culture model of neuropathic pain [human]
GEO Series GSE298325. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing; Other.
Base editing mutagenesis maps functional alleles to tune human T cell activity
GEO Series GSE244774. Homo sapiens. 52 samples. Type: Other.
LncRNA Tuna is activated in cadmium-induced placental insufficiency and drives the NRF2-mediated oxidative stress response [human Jeg3]
GEO Series GSE233281. Homo sapiens. 16 samples. Type: Expression profiling by high throughput sequencing.
An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells
GEO Series GSE137756. Homo sapiens. 24 samples. Type: Expression profiling by high throughput sequencing.
High-resolution genome-wide dissection of transcriptional regulatory activity and function in human cells
GEO Series GSE104001. Homo sapiens. 11 samples. Type: Other; Expression profiling by high throughput sequencing.
H3K27ac changes upon overexpression of the active NOTCH1 intracellular domain (N1ICD) in human adipose tissue endothelial cells.
GEO Series GSE195537. Homo sapiens. 6 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Inhibitory effect of a human microRNA, miR-6133-5p, on the fibrotic activity of hepatic stellate cells in culture
GEO Series GSE158478. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Figure 1 from: Ilieva V, Kondeva-Burdina M, Georgieva T (2020) In vitro analysis of the activity of human monoamine oxidase type B (hMAOB), treated with the cyanotoxin anatoxin-a: supposed factor of neurodegenerative diseases. Pharmacia 67(2): 111-114. https://doi.org/10.3897/pharmacia.67.e50806
Figure 1 Preparation of the final fluorescent product resorfin (Held 2003).
Data from: Effects of a 60 Hz magnetic field exposure up to 3000 µT on human brain activation as measured by functional magnetic resonance imaging
Several aspects of the human nervous system and associated motor and cognitive processes have been reported to be modulated by extremely low-frequency (ELF, < 300 Hz) time-varying Magnetic Fields (MF). Due do their worldwide prevalence; power-line frequencies (60 Hz in North America) are of particular interest. Despite intense research efforts over the last few decades, the potential effects of 60 Hz MF still need to be elucidated, and the underlying mechanisms to be understood. In this study, we have used functional Magnetic Resonance Imaging (fMRI) to characterize potential changes in functional brain activation following human exposure to a 60 Hz MF through motor and cognitive tasks. First, pilot results acquired in a first set of subjects (N=9) were used to demonstrate the technical feasibility of using fMRI to detect subtle changes in functional brain activation with 60 Hz MF exposure at 1800 μT. Second, a full study involving a larger cohort of subjects tested brain activation during 1) a finger tapping task (N=20), and 2) a mental rotation task (N=21); before and after a one-hour, 60 Hz, 3000 μT MF exposure. The results indicate significant changes in task-induced functional brain activation as a consequence of MF exposure. However, no impact on task performance was found. These results illustrate the potential of using fMRI to identify MF-induced changes in functional brain activation, suggesting that a one-hour 60 Hz, 3000 μT MF exposure can modulate activity in specific brain regions after the end of the exposure period (i.e., residual effects). We discuss the possibility that MF exposure at 60 Hz, 3000 μT may be capable of modulating cortical excitability via a modulation of synaptic plasticity processes.
Data from: Trophoblast survival signaling during human placentation requires HSP70 activation of MMP2-mediated HBEGF shedding
Survival of trophoblast cells in the low oxygen environment of human placentation requires metalloproteinase-mediated shedding of HBEGF and downstream signaling. A matrix metalloproteinase (MMP) antibody array and quantitative RT-PCR revealed upregulation of MMP2 post-transcriptionally in human first trimester HTR-8/SVneo trophoblast cells and placental villous explants exposed to 2% O2. Specific MMP inhibitors established the requirement for MMP2 in HBEGF shedding and upregulation. Because α-amanitin inhibited the upregulation of HBEGF, differentially expressed genes were identified by next-generation sequencing of RNA from trophoblast cells cultured at 2% O2 for 0, 1, 2 and 4 h. Nine genes, all containing HIF-response elements, were upregulated at 1 h, but only HSPA6 (HSP70B') remained elevated at 2–4 h. The HSP70 chaperone inhibitor VER 155008 blocked upregulation of both MMP2 and HBEGF at 2% O2, and increased apoptosis. However, both HBEGF upregulation and apoptosis were rescued by exogenous MMP2. Proximity ligation assays demonstrated interactions between HSP70 and MMP2, and between MMP2 and HBEGF, supporting the concept that MMP2-mediated shedding of HBEGF, initiated by HSP70, contributes to trophoblast survival at the low O2 concentrations encountered during the first trimester, and is essential for successful pregnancy outcomes. Trophoblast survival during human placentation, when oxygenation is minimal, required HSP70 activity, which mediated MMP2 accumulation and the transactivation of anti-apoptotic ERBB signaling by HBEGF shedding.
Figure 1 from: Shkondrov A, Kondeva-Burdina M, Stambolov I, Krasteva I (2024) Activity of an oleanane-type tritrepenoid saponin from A. glycyphyllos on human recombinant MAO enzymes. Pharmacia 71: 1-6. https://doi.org/10.3897/pharmacia.71.e114786
Figure 1 Chromatograms of Sg in the negative (a) and positive (b) ionization modes.
Figure 2 from: Shkondrov A, Kondeva-Burdina M, Stambolov I, Krasteva I (2024) Activity of an oleanane-type tritrepenoid saponin from A. glycyphyllos on human recombinant MAO enzymes. Pharmacia 71: 1-6. https://doi.org/10.3897/pharmacia.71.e114786
Figure 2 HRESIMS spectrum of compound Sg in the (a) negative and (b) positive modes.
Spatially-diverse High-dimensional Channel State Information (CSI) based Dataset for Human Activity Recognition (HAR)
<p><strong>Introduction</strong></p> <p>The data collection for this novel channel state information (CSI)-based human activity recognition (HAR) dataset was conducted in a rigorously controlled laboratory environment. The space, measuring 5 meters x 8 meters x 3 meters, served as a well-defined testing ground. Four strategically positioned ESP32 devices formed transceiver pairs in a diagonal network, functioning as both transmitters and receivers, which are separated by a distance of 1.5 meters. The transmitters, powered by external power banks for consistent operation, were mounted on tripods at a height of 1.5 meters on the north and east corners. Their corresponding receivers, connected to laptops via USB for real-time CSI data acquisition, were positioned on the south and west corners.</p> <p>This dataset captures a wider range of activities (including subtle movements) and accounts for variations in body type and environmental conditions. It achieves this by collecting CSI data in a controlled environment using multiple transmitter-receiver pairs positioned at different orientations. This setup captures CSI information across 166 subcarriers used in Wi-Fi Wi-Fi IEEE 802.11n on channel 11, providing a richer and more nuanced view of human movement compared to traditional datasets. This data is expected to lead to the development of more robust and generalizable HAR models with higher accuracy and real-world applicability.</p> <p><strong>Description of Dataset</strong></p> <p>The dataset is housed within a directory named "SHD-HAR-Dataset-main" in the repository. This directory is further divided into "raw" and "amplitude" subdirectories. Data in "raw" and "amplitude" directories is further categorized based on participant orientation relative to the transceivers ("front/side"). It's important to note that the samples are synchronized between the "front" and "side" folders. This is because both devices collected data simultaneously for a particular activity. To summarize, the file "activityX.csv" in the "front" folder was collected at the same time as the corresponding "activityX.csv" file in the "side" folder, where "X" represents a unique identifier for each sample. </p> <p>The "raw" directory stores the unprocessed CSI data for each activity sample. These samples are stored as individual CSV files ("activityX.csv") containing 300-450 packets of CSI data obtained within 5 seconds. Each packet encompasses 25 distinct data fields, resulting in a total of 300-450 x 25 data entries per activity stored within the ".csv" file. </p> <p>The "amplitude" directory contains the processed signal amplitude data for 166 subcarriers. This directory mirrors the structure of the "raw" directory, with subdirectories for "front" and "side" orientations and "activityX.csv" files for each sample. However, the data within these files is transformed into a 300-450 x 166 matrix, representing the extracted signal amplitudes from the original CSI data. This format significantly reduces dimensionality while preserving key information for HAR analysis.</p>
Simultaneous optogenetic activation and MEG source imaging show non-human primate brain circuits
<p>MEG and MRI data used to generate Figures 2-5 of manuscript titled, "Simultaneous optogenetic activation and MEG source imaging show non-human primate brain circuits". </p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.