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720 results for “Neuropathic pain”
Somatosensory profiling of patients undergoing alcohol withdrawal: do neuropathic pain and sensory loss represent a problem?
<p>Chronic heavy alcohol use is known to cause neurological complications such as peripheral neuropathy. Concerning the pathophysiology, few sural nerve and skin biopsies studies showed that small fibers might be selectively vulnerable to degeneration in alcohol-related peripheral neuropathy. Pain has rarely been properly evaluated in this pathology. The aim of the present study was to assess pain intensity, potential neuropathic characteristics as well as the functionality of both small and large nerve sensitive fibers.</p> <p>In this observational study, twenty-seven consecutive adult patients, hospitalized for alcohol withdrawal and 13 healthy controls were recruited. All the participants underwent a quantitative sensory testing (QST) according to the standardized protocol of the German Research Network Neuropathic Pain, a neurological examination and filled standardized questionnaires assessing alcohol consumption and dependence as well as pain characteristics and psychological comorbidities.</p> <p>Half of the patients reported pain. Yet the intensity was weak, leading to a low interference with daily life, and the characteristics did not support a neuropathic component. A functional impairment of small nerve fibers was frequently described, with thermal hypoesthesia observed in 52% of the patients. Patients with a higher alcohol consumption over the last 2 years showed a greater impairment of small fiber function. </p>
Evaluate Long-Term Safety and Efficacy of Pregabalin in Patients With Chronic Neuropathic Pain.
ClinicalTrials.gov study NCT00141362. IPD Sharing: Not stated. Countries: 0. Publications: 0.
An Open-Label Extension Study of NGX-4010 for the Treatment of Neuropathic Pain
ClinicalTrials.gov study NCT00089557. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Metabolomic and transcriptomic profiling of DRG in SNI rat reveal a common pattern of changes in metabolites and signaling pathways in Neuropathic Pain
GEO Series GSE198020. Rattus norvegicus. 6 samples. Type: Expression profiling by high throughput sequencing.
Microarray analysis of gene expression profile of the spinal cord in the mice L5 spinal nerve ligation model of neuropathic pain
GEO Series GSE75072. Mus musculus. 4 samples. Type: Expression profiling by array.
Sustained neuronal stimulation activates paraventricular thalamus astrocytes for maintenance of chronic neuropathic pain in mice
GEO Series GSE297165. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Major differences in transcriptional alterations in dorsal root ganglia between spinal cord injury and peripheral neuropathic pain models
GEO Series GSE202111. Rattus norvegicus. 9 samples. Type: Expression profiling by high throughput sequencing.
RNA Expression Profiling of spinal cord tissues in a Rat Model of Neuropathic Pain
GEO Series GSE256472. Rattus norvegicus. 6 samples. Type: Expression profiling by high throughput sequencing.
Effective control of neuropathic pain by interrupting C/EBPβ-CLEC7A cross-talk-mediated NLRP3 inflammasome-dependent pyroptosis
GEO Series GSE185278. Rattus norvegicus. 2 samples. Type: Expression profiling by array.
Injured sensory neurons-derived Galectin-3 contributes to neuropathic pain via programming microglia in the spinal dorsal horn
GEO Series GSE242769. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Expression profiling of DRG from L5 spinal nerve ligation model of neuropathic pain in the rat
GEO Series GSE2884. Rattus norvegicus. 36 samples. Type: Expression profiling by array.
Enhancer profiling uncovers JMJD1C as essential suppressor in neuropathic pain by targeting SOCS
GEO Series GSE256469. Rattus norvegicus. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
A novel functional role for the serine protease inhibitor SerpinA3N and its substrate leukocyte elastase in neuropathic pain
GEO Series GSE63442. Rattus norvegicus. 12 samples. Type: Expression profiling by array.
ACVR1-mediated glycolytic reprogramming promotes histone lactylation and neuronal pyroptosis in neuropathic pain {ChIP-seq]
GEO Series GSE306458. Mus musculus. 12 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Analysis of mRNA Changes in the prelimbic cortex of Rat with Chronic Neuropathic Pain
GEO Series GSE145226. Rattus norvegicus. 6 samples. Type: Expression profiling by array.
Distinct microglial transcriptional responses during opioid exposure or neuropathic pain
GEO Series GSE117321. Mus musculus; Rattus norvegicus. 50 samples. Type: Expression profiling by high throughput sequencing.
Single-cell RNA sequencing reveals cellular heterogeneity of spinal microglia in neuropathic pain
GEO Series GSE246288. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Search for studies using animal models of neuropathic pain
<p>We carried out a search of 5 online databases for studies reporting animal models of neuropathic pain reporting a behavioural outcome. This search, carried out in September 2012, identified 33,814 unique publications. Two independent investigators screened these publications for inclusion or exclusion and these publications form the dataset for this study (Excel file: Original dataset). These are now being included in a family of systematic reviews categorised by the pain model used.</p> <p>Five different text-mining approaches will be developed for this neuropathic pain literature search using the results from manual screening to train the machine, where machine-learning software set rules to automatically define each publication as included or excluded without the need for human screening.</p> <p>In this project, we seek to update the neuropathic pain literature search using the original search terms and inclusion criteria defined in the online protocol. This search was updated and identified 11,880 unique publications (Excel file: Updated dataset).</p>
Semaphorin 3E as a novel therapeutic target for neuropathic pain
GEO Series GSE290407. Mus musculus. 3 samples. Type: Expression profiling by array.
Analysis of miRNA Changes in the prelimbic cortex of Rat with Chronic Neuropathic Pain
GEO Series GSE145199. synthetic construct; Rattus norvegicus. 6 samples. Type: Non-coding RNA profiling by array.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.