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752
datasets available to search
ShareScore release 0.9.0
Dataset results
752 results for “Osteoporosis”
Recombinant Human Bone Morphogenetic Protein-2(rhBMP-2) in Patients With Osteoporosis After Lumbar Fusion
ClinicalTrials.gov study NCT05911477. IPD Sharing: YES. Countries: 0. Publications: 0.
Quantitative Ultrasound Use to Increase Geriatric Follow-up for Osteoporosis
ClinicalTrials.gov study NCT04691869. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Evaluation of Osteo-Buddy in Improving Osteoporosis Knowledge
ClinicalTrials.gov study NCT07034131. IPD Sharing: NO. Countries: 0. Publications: 0.
The Relationship Between Rheumatoid Arthritis and Osteoporosis and Factors Contributing to This Connection
ClinicalTrials.gov study NCT06038292. IPD Sharing: Not stated. Countries: 0. Publications: 0.
A Study to Determine the Satisfaction With Actonel in Postmenopausal Women With Osteoporosis
ClinicalTrials.gov study NCT00632216. IPD Sharing: Not stated. Countries: 0. Publications: 0.
To Evaluate the Efficacy and Safety of Abaloparatide Injection (QLG2128) in the Treatment of Postmenopausal Women With Osteoporosis and at High Risk of Fracture
ClinicalTrials.gov study NCT06898060. IPD Sharing: Not stated. Countries: 0. Publications: 0.
The Effect of Digital Education for Osteoporosis Patients on Fracture Risk and Related Health Outcomes.
ClinicalTrials.gov study NCT06603545. IPD Sharing: NO. Countries: 0. Publications: 0.
Awareness of Osteoporosis in Patients With Hypothyroidism
ClinicalTrials.gov study NCT05760131. IPD Sharing: UNDECIDED. Countries: 0. Publications: 0.
Awareness of Osteoporosis in Patients With Hyperthyroidism
ClinicalTrials.gov study NCT05760417. IPD Sharing: UNDECIDED. Countries: 0. Publications: 0.
Study of Investigational Drug in Osteoporosis (MK-0217-908)
ClinicalTrials.gov study NCT00092053. IPD Sharing: Not stated. Countries: 0. Publications: 0.
A Model for Risk Prediction of Fracture in Diabetic Patients With Osteoporosis
ClinicalTrials.gov study NCT04534166. IPD Sharing: UNDECIDED. Countries: 0. Publications: 0.
Awareness of Osteoporosis in HIV Patients
ClinicalTrials.gov study NCT05769413. IPD Sharing: UNDECIDED. Countries: 0. Publications: 0.
Clinical Study of Efficacy and Safety of Chung A Won in Women's Patients With Osteoporosis
ClinicalTrials.gov study NCT02592161. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Alendronate Osteoporosis Study
ClinicalTrials.gov study NCT00277251. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Determining the Risk Factors Such as Smoking, Alcohol, and Caffeine and Their Association With Osteoporosis in Men
ClinicalTrials.gov study NCT00011323. IPD Sharing: Not stated. Countries: 1. Publications: 0.
miRNA effectors of estrogen’s bone anabolic activity in a murine model of post-menopausal osteoporosis [mRNA]
GEO Series GSE222752. Mus musculus. 18 samples. Type: Expression profiling by high throughput sequencing.
Gene Expression of Circulating B Lymphocytes for Osteoporosis
GEO Series GSE7429. Homo sapiens. 20 samples. Type: Expression profiling by array.
Eldecalcitol ameliorates diabetic osteoporosis and glucolipid metabolic disorder by promoting Treg cell differentiation through SOCE
GEO Series GSE267853. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
The Role of PTHrP in Osteoblast Response to Microgravity: Implications for Osteoporosis Development.
Prolonged skeletal unloading through bedrest results in bone loss similar to that observed in elderly osteoporotic patients but with an accelerated timeframe. This rapid effect on weight-bearing bones is also observed in astronauts who lose up to 2% of their bone mass per month spent in Space. Despite important implications for Spaceflight travellers and bedridden patients on Earth the exact mechanisms involved in disuse osteoporosis have not been elucidated. Parathyroid hormone-related protein (PTHrP) regulates many physiological processes including skeletal development and has been proposed as a gravisensor. To investigate the role of PTHrP in microgravity-induced bone loss trabecular osteoblasts (TOs) from Pthrp+/+ and -/- mice were exposed to simulated microgravity for 6 days. Viability of TOs decreased in inverse proportion to PTHrP expression levels. Microarray analysis of Pthrp+/+ TOs after 6 days at 0g revealed expression changes in genes encoding prolactins,apoptosis and survival molecules bone metabolism and extra-cellular matrix composition proteins chemokines IGF family and Wnt-related signalling molecules. Importantly 88% of 0g-induced expression changes in Pthrp+/+ cells overlap those observed in Pthrp-/- cells in normal gravity. Pulsatile treatment with PTHrP1-36 peptide during microgravity exposure reversed a large proportion of 0g-induced changes in Pthrp+/+ TOs. Our results confirm PTHrP efficacy as an anabolic agent to prevent microgravity-induced cell death in TOs. Total RNA samples extracted from Pthrp+/+and -/- trabecular osteoblasts (TOs) exposed for 6 days to simulated 0g in Synthecon rotating cell or left 6 days in culture at 1g. Cells had either been treated with a pulsatile treatment (2 h/day) of PTHrP1-36 peptide (10-8M) or received a change in growth medium. In total: 8 different conditions with 2 replicates each i.e. Pthrp+/+ TOs at 0g or 1g with or without PTHrP1-36 treatment and Pthrp-/- TOs at 0g or 1 g,with or without PTHrP1-36 treatment.
The Role of PTHrP in Osteoblast Response to Microgravity: Implications for Osteoporosis Development.
Prolonged skeletal unloading through bedrest results in bone loss similar to that observed in elderly osteoporotic patients but with an accelerated timeframe. This rapid effect on weight-bearing bones is also observed in astronauts who lose up to 2% of their bone mass per month spent in Space. Despite important implications for Spaceflight travellers and bedridden patients on Earth the exact mechanisms involved in disuse osteoporosis have not been elucidated. Parathyroid hormone-related protein (PTHrP) regulates many physiological processes including skeletal development and has been proposed as a gravisensor. To investigate the role of PTHrP in microgravity-induced bone loss trabecular osteoblasts (TOs) from Pthrp+/+ and -/- mice were exposed to simulated microgravity for 6 days. Viability of TOs decreased in inverse proportion to PTHrP expression levels. Microarray analysis of Pthrp+/+ TOs after 6 days at 0g revealed expression changes in genes encoding prolactins,apoptosis and survival molecules bone metabolism and extra-cellular matrix composition proteins chemokines IGF family and Wnt-related signalling molecules. Importantly 88% of 0g-induced expression changes in Pthrp+/+ cells overlap those observed in Pthrp-/- cells in normal gravity. Pulsatile treatment with PTHrP1-36 peptide during microgravity exposure reversed a large proportion of 0g-induced changes in Pthrp+/+ TOs. Our results confirm PTHrP efficacy as an anabolic agent to prevent microgravity-induced cell death in TOs. Total RNA samples extracted from Pthrp+/+and -/- trabecular osteoblasts (TOs) exposed for 6 days to simulated 0g in Synthecon rotating cell or left 6 days in culture at 1g. Cells had either been treated with a pulsatile treatment (2 h/day) of PTHrP1-36 peptide (10-8M) or received a change in growth medium. In total: 8 different conditions with 2 replicates each i.e. Pthrp+/+ TOs at 0g or 1g with or without PTHrP1-36 treatment and Pthrp-/- TOs at 0g or 1 g,with or without PTHrP1-36 treatment.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.