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857 results for “alternative splicing;”
The effect of progerin expression on alternative splicing in keratinocytes of HGPS mice
GEO Series GSE67288. Mus musculus. 16 samples. Type: Expression profiling by array.
Human PRPF39 is an alternative splicing factor recruiting U1 snRNP to weak 5' splice sites
GEO Series GSE210544. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing; Other.
Cell type-specific alternative splicing of cytoskeletal domains governs cell fate in the developing cerebral cortex
GEO Series GSE76198. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
The study of alternative splicing events in human induced pluripotent stem cells from a Down's syndrome patient
GEO Series GSE168111. Homo sapiens. 6 samples. Type: Expression profiling by array.
Alternative splicing regulates the physiological adaptation of the mouse hind limb postural and phasic muscles to microgravity
We sought to comprehensively elucidate the transcriptomic underpinnings of microgravity-induced muscle phenotypes in mice by evaluating both differential gene expression (DGE) and changes in alternative splicing (AS) due to extended spaceflight. Total RNA was isolated from the gastrocnemius and quadriceps, postural and phasic muscles of the hind limb, respectively, of 32-week-old female BALB/c mice exposed to microgravity or ground control conditions for nine weeks. RNA sequencing revealed that DGE and AS varied across postural and phasic muscle types with preferential employment of DGE in the gastrocnemius and AS in the quadriceps. Gene ontology analysis indicated that DGE and AS regulate distinct molecular processes. Various non-differentially expressed transcripts encoding musculoskeletal proteins (Tnnt3, Tnnt1, Neb, Ryr1, and Ttn) and muscle-specific RNA binding splicing regulators (Mbnl1 and Rbfox1) were found to have significant changes in AS that altered critical functional domains of their protein products. In striking contrast, microgravity-induced differentially expressed genes were associated with translation/ribosomal function and lipid metabolism. Our work serves as the first comprehensive investigation of coordinate changes in DGE and AS in large limb muscles across spaceflight. We propose that substantial remodeling of pre-mRNA by AS is a major component of transcriptomic adaptation of skeletal muscle to microgravity. The alternatively spliced genes identified here could be targeted by small molecule splicing regulator therapies to address microgravity-induced changes in muscle during spaceflight.
LncRNA RP11-284N8.3 regulates the expression and alternative splicing of genes associated with sepsis-induced acute lung injury
GEO Series GSE299503. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
TFRC-RNA interactome revealed the expression and alternative splicing regulation of genes associated with IgAN in human renal tubule mesangial cells [RNA-seq]
GEO Series GSE223356. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
SRSF7-mediated Alternative Splicing of USO1 Promotes Hepatocellular Carcinoma by Activating the MAPK/ERK1-ELK1 Pathway
GEO Series GSE262667. Homo sapiens. 19 samples. Type: Expression profiling by high throughput sequencing.
Global Regulation of Alternative RNA Splicing by the SR-Rich Protein RBM39 CLIP-seq
GEO Series GSE101631. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
Talaromyces marneffei suppresses macrophage inflammation by regulating host alternative splicing
GEO Series GSE200512. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Mycobacterial Pstp Impairs Host RNA Alternative Splicing by Dephosphorylation of Spliceosome RBMX at S189
GEO Series GSE264715. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
A primate-specific alternative splicing of CCNE1 (pCCNE1) is an activator for evolutionally-gained enhancer
GEO Series GSE128440. Homo sapiens. 20 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
A chromatin code for alternative splicing involving an association between CTCF and HP1α proteins
GEO Series GSE60094. Homo sapiens. 34 samples. Type: Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing.
THUMPD3 regulates alternative splicing of ECM transcripts in human lung cancer cells and promotes proliferation and migration
GEO Series GSE278089. Homo sapiens. 23 samples. Type: Expression profiling by high throughput sequencing.
The Exserohilum turcicum effector EtEC81 reprograms alternative splicing in maize and activates immunity
GEO Series GSE273918. Zea mays. 27 samples. Type: Expression profiling by high throughput sequencing.
Alternative Splicing of bunched Confers a Dual Role in Hippo Pathway-dependent Growth and Tumorigenesis
GEO Series GSE274246. Drosophila melanogaster. 3 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
RBM6 promotes tumor cell apoptosis and disrupts the alternative splicing of related genes in HeLa cells
GEO Series GSE196600. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
BCAS2 regulates oocyte meiosis by participating in alternative mRNA splicing
GEO Series GSE228983. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Analysis of whole transcriptome RNA-seq data reveals the involvement of alternative splicing in the drought response of Glycyrrhiza uralensis
GEO Series GSE197490. Glycyrrhiza uralensis. 30 samples. Type: Expression profiling by high throughput sequencing.
Wiskott-Aldrich Syndrome-causative mutations disrupt alternative splicing and promote gene networks predisposed to hematologic malignancies
GEO Series GSE77129. Homo sapiens. 5 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.