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821
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ShareScore release 0.9.0
Dataset results
821 results for “epigenetic regulation”
S-adenosylhomocysteine hydrolase deficiency exacerbates clonal 1 hematopoiesis and atherosclerosis via epigenetic regulation of inflammation [Bisulfite-Seq]
GEO Series GSE316331. Mus musculus. 6 samples. Type: Methylation profiling by high throughput sequencing.
Rna-seq profiling of epigenetic regulator Phf2 in neural stem cells
GEO Series GSE159311. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
Epigenetic and Post-transcriptional Regulation of LYPD2 Modulates Smoking-associated Phenotype via CHRNA7 and DNMT1 in the Human Airway Epithelium
GEO Series GSE135624. Homo sapiens. 66 samples. Type: Expression profiling by high throughput sequencing.
Glutamine metabolism suppresses neutrophil recruitment via epigenetic regulation to control inflammatory resolution and skin repair [Multiomic]
GEO Series GSE289255. Mus musculus. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing.
The H3K27M mutation alters stem cell growth, epigenetic regulation, and differentiation potential [RNA-Seq]
GEO Series GSE159070. Homo sapiens. 24 samples. Type: Expression profiling by high throughput sequencing.
Deciphering Epigenetic Regulation of Enhancers in High-Risk Prostate Cancer
GEO Series GSE245609. Homo sapiens. 37 samples. Type: Methylation profiling by array.
SRC2 and SRC3 cooperatively promote pathogenic function of Th17 cells via regulation of epigenetic activation
GEO Series GSE133641. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Epigenetical regulation in zebrafish heart regeneration
GEO Series GSE98857. Danio rerio. 6 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
The Epigenetic Regulator PHF16 Redresses Homeostasis During Intestinal Injury Repair
GEO Series GSE207746. Mus musculus. 24 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Integrated single-cell sequencing reveals principles of epigenetic regulation of human gastrulation and germ cell development in a 3D organoid model
GEO Series GSE181724. Homo sapiens. 23 samples. Type: Expression profiling by high throughput sequencing.
Identification of epigenetic regulators of fibrotic transformation in cardiac fibroblasts through bulk and single-cell CRISPR screens [scRNA-seq]
GEO Series GSE261783. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
Identification of lineage-specific epigenetic regulators FOXA1 and GRHL2 through chromatin accessibility profiling in breast cancer cell lines [ATAC-seq]
GEO Series GSE254216. Homo sapiens. 29 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Non-Canonical Epigenetic Regulation of HIV Infection in Macrophage
GEO Series GSE156072. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
High-throughput sequencing and analysis of gene modification regulated by epigenetics modification in adult and old intracerebral hemorrhage rats. [RNA-Seq]
GEO Series GSE106924. Rattus norvegicus. 4 samples. Type: Expression profiling by high throughput sequencing.
Transcriptomics-informed pharmacology identifies epigenetic and cell cycle regulators as enhancers of AAV production
GEO Series GSE269485. Homo sapiens. 45 samples. Type: Expression profiling by high throughput sequencing.
Epigenetic regulation of gene expression is instructed by promoter sequence and refined by developmental progression [expression]
GEO Series GSE41449. Mus musculus. 5 samples. Type: Expression profiling by array.
Epigenetic regulation of NK cell-mediated immune response in multiple myeloma [ATAC-Seq]
GEO Series GSE228766. Homo sapiens. 3 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Elucidating Transcription Regulation by Epigenetics in Neuroblastoma
Whole-genome profiles of the epigenetic modification 5-hydroxymethylcytosine (5-hmC) are robust diagnostic biomarkers in adult patients with cancer. We investigated if 5-hmC profiles would serve as novel prognostic markers in neuroblastoma, a clinically heterogeneous pediatric cancer. Because this DNA modification facilitates active gene expression, we hypothesized that 5-hmC profiles would identify transcriptomic networks driving the clinical behavior of neuroblastoma.
Rice interploidy crosses disrupt epigenetic regulation, gene expression, and seed development
GEO Series GSE65149. Oryza sativa Japonica Group. 7 samples. Type: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing.
Role of DNA methylation in the regulation of SLC22A17 in cutaneous melanoma. Identification of SLC22A17 methylation hotspot as potential epigenetic biomarker
<p><strong><br>Authors: Alessandro Lavoro; Luca Falzone; <span><span>Giuseppe Gattuso; Giuseppe Nicolò Conti; Rosario Caltabiano;</span></span> Gabriele Madonna; Mariaelena Capone; James Andrew McCubrey; Paolo Antonio Ascierto; Massimo Libra; Saverio Candido<br>Corresponding author: Dr Massimo Libra</strong></p> <p><strong>Abstract </strong></p> <p>Cancer onset and progression are driven by genetic and epigenetic alterations leading to oncogene activation and silencing of tumor suppressor genes. Among epigenetic mechanisms, DNA methylation (methDNA) has attracted growing interest in cancer research, playing a critical role in the regulation of gene expression. As widely reported, promoter hypomethylation is strictly associated with tumor-related gene activation. Moreover, the intragenic methDNA is involved in transcriptional elongation, alternative spicing, and activation of cryptic start sites. However, the exact role of intragenic methDNA has not been completely elucidated yet. In this context, several tumor microenvironment genes are modulated by methDNA, including the <em>Solute Carrier Family 22 Member 1</em>7 (<em>SLC22A17</em>), which is involved along with the <em>Gelatinase-Associated Lipocalin</em> (<em>NGAL</em>) ligand in iron trafficking and extracellular matrix remodeling.</p> <p>On these bases, this study aimed to investigate the role of methDNA in the regulation of <em>SLC22A17</em> in cutaneous melanoma (CM). To this purpose, correlation and differential analyses between <em>SLC22A17</em> expression and methDNA levels in CM patients and nevi samples were performed using The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) datasets. Functional studies on melanoma cell lines treated with 5-Azacytidine (5-Aza) were conducted to assess the correlation between methDNA and <em>SLC22A17</em> expression. Validation study was finally performed analyzing the <em>in silico</em> identified <em>SLC22A17</em> methDNA hotspot in Formalin-Fixed Paraffin-Embedded (FFPE) samples from a consecutive cohort of CM patients and healthy controls to test its potential application as a diagnostic and prognostic biomarker. The FFPE tissues were collected at the Melanoma Cancer Immunotherapy and Innovative Therapy Unit of the National Cancer Institute ‘Fondazione ‘G. Pascale’ (Naples, Italy), retrospectively retrieving the FFPE samples from the archives of the Pathology Unit (years 2008 – 2020) . The study was conducted in accordance with the guidelines of the Declaration of Helsinki and approved by the Institutional Review Board of the National Cancer Institute “Fondazione G. Pascale” (protocol n. 33/17 and 37/22 oss). </p> <p>The computational analyses revealed that <em>SLC22A17</em> was significantly downregulated in CM and its expression levels were strictly related to promoter hypomethylation and body hypermethylation. Moreover, <em>SLC22A17</em> overexpression, as well as hypermethylation of 2 intragenic methDNA hotspots, were associated with a better clinical outcome in CM patients. The correlation between <em>SLC22A17</em> methDNA and expression was confirmed in 5-Aza treated cell lines. In agreement with <em>in silico</em> analyses, the selected <em>SLC22A17 </em>hotspot showed higher methDNA levels in CM samples compared to nevi. In addition, the methDNA levels of this hotspot were positively correlated with advanced CM.</p> <p>Overall, the <em>SLC22A17</em> methDNA hotspot could represent a promising biomarker for CM, highlighting the regulatory role of methDNA on <em>SLC22A17</em> expression. In conclusion, these results pave the way to the identification of novel epigenetic biomarkers and therapeutic targets for the management of CM patients.</p> <p><strong> </strong></p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.