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1,205 results for “vaccine responses”
Functional genomic analysis of the 68-1 RhCMV-Mycobacteria tuberculosis vaccine reveals an IL-15 response signature that is conserved with vector attenuation
GEO Series GSE273911. Macaca mulatta. 320 samples. Type: Expression profiling by high throughput sequencing.
Th1 polarization in Bordetella pertussis vaccine responses is maintained through a positive feedback loop
GEO Series GSE274944. Homo sapiens. 327 samples. Type: Expression profiling by high throughput sequencing.
Pre-existing memory B cell phenotypes determine the quality of B cell response to vaccine boosters
GEO Series GSE282932. Homo sapiens. 5 samples. Type: Other.
Impact of two and three dose COVID-19 vaccination schedule on transcriptional, humoral and T cell immune response in previously heavily treated, single agent treated and naïve CLL patients
GEO Series GSE201642. Homo sapiens. 48 samples. Type: Expression profiling by high throughput sequencing.
Transcriptional responses to RTS,S induced vaccination in controlled human malaria infection studies
GEO Series GSE107672. Homo sapiens. 0 samples. Type: Expression profiling by array; Expression profiling by high throughput sequencing; Other.
mRNA COVID-19 vaccine elicits potent adaptive immune response without the acute inflammation of SARS-CoV-2 infection [HC]
GEO Series GSE247916. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing; Other.
Data for "Integrating population and single-cell variations in vaccine responses identifies a naturally adjuvanted human immune setpoint"
<p>Data associated with the manuscript:</p> <p>"Integrating population and single-cell variations in vaccine responses identifies a naturally adjuvanted human immune setpoint"</p> <p>Please see code/documentation associated with these data at the links below: </p> <p>Analysis code + documentation: <a href="https://niaid.github.io/fsc/">https://niaid.github.io/fsc/</a></p> <p>Analysis code Github repository: <a href="https://github.com/niaid/fsc">https://github.com/niaid/fsc</a></p> <p>In the downloaded directory the subdirectory 'data' contains data files including: </p> <p><strong>flu_vacc_CITEseq_Seurat4.rds </strong>is CITE-seq data as a Seurat version 4 object for R. </p> <p><strong>flu_vacc_CITEseq_combinedassay.h5ad</strong> is CITE-seq data as a .h5ad object for python. </p>
Heterologous immunization with inactivated vaccine followed by mRNA booster elicits strong humoral and cellular immune responses against the SARS-CoV-2 Omicron variant
<p>The recent emergence of the Omicron variant has raised concerns on vaccine efficacy and the urgent need to study more efficient vaccination strategies. Here we evaluated the effect of an mRNA vaccine booster on immunogenicity in individuals vaccinated with two doses of inactivated vaccine. We observed that an mRNA vaccine booster significantly increased the plasma level of specific antibodies that bind to the receptor-binding domain (RBD) or the spike (S) ectodomain (S1+S2) of both the G614 and the Omicron variants, compared to two doses of homologous inactivated vaccine. The level of RBD- and S-specific IgG antibodies and virus neutralization titers against variants of concern in the heterologous vaccination group were similar to that in individuals receiving three doses of homologous mRNA vaccine or a boost of mRNA vaccine after infection, but markedly higher than that in individuals receiving three doses of a homologous inactivated vaccine. Moreover, this heterologous vaccination regime significantly enhanced the RBD-specific memory B cell response and S1-specific T cell response compared to two or three doses of homologous inactivated vaccine. Our study demonstrates that an mRNA vaccine booster in individuals vaccinated with inactivated vaccines can be highly beneficial, as it markedly increases the humoral and cellular immune responses against the virus, including the Omicron variant</p>
Adaptive immune responses to Omicron BA.4/BA.5-containing bivalent mRNA booster vaccination
<p>This repository contains the immunoSEQ T-cell receptor (TCR) and B-cell receptor (BCR) repertoire data used in the manuscript titled "Adaptive immune responses to Omicron BA.4/BA.5-containing bivalent mRNA booster vaccination". This data set is composed of the TCR/BCR repertoire clonotype sequences and abundances derived from human peripheral blood mononuclear cell (PBMC) samples sorted for CD4, CD8 and CD19 before and after bivalent COVID mRNA booster vaccination. In total, 84 TCR samples (CD4+/CD8+ T cell populations at pre-/post-vaccination from 21 subjects) and 42 BCR samples (CD19+ populations at at pre-/post-vaccination from 21 subjects) are present in the data set.</p> <ul> <li><em><strong>Delmonte_TCR_data_84samples.rds</strong></em><br>R object with the amino acid and nucleotide sequences, VDJ gene calls, and abundances of the TCR clonotypes.</li> <li><strong><em>Delmonte_BCR_data_42samples.rds </em></strong> <br>R object with the amino acid and nucleotide sequences, VDJ gene calls, and abundances of the BCR clonotypes.</li> <li><em><strong>Delmonte_TCR_data_compact_84samples.rds</strong></em><br>R object with the amino acid sequences, VDJ gene calls, and abundances of the TCR clonotypes.</li> <li><em><strong>Delmonte_BCR_data_compact_42samples.rds </strong></em><br>R object with the amino acid sequences, VDJ gene calls, and abundances of the BCR clonotypes.</li> <li><em><strong>sampleExport_TCR.zip</strong></em><br>Compressed folder that includes the individual sample level TCR repertoire files in .tsv format.</li> <li><em><strong>sampleExport_BCR.zip</strong></em><br>Compressed folder that includes the individual sample level BCR repertoire files in .tsv format.</li> </ul> <p><br><em>Funding statement: This work was supported by the Division of Intramural Research Programs of the National Institute of Allergy and Infectious Diseases and of the National Institute of Dental and Craniofacial Research, National Institutes of Health (grant AI001270).</em><br><br></p> <p> </p>
Evaluation of Immune Response Against the Strain of Neisseria Meningitidis B: 14, P1-7, 16 in Patients Having to be Vaccinated MenBVac® (Extension EFFIVAC)
ClinicalTrials.gov study NCT01621945. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Effects of Aging on Primary and Secondary Vaccine Responses
ClinicalTrials.gov study NCT03312699. IPD Sharing: YES. Countries: 1. Publications: 0.
A Study on the Safety, Reactogenicity, and Immune Response to the GVGH iNTS-GMMA Vaccine Against Invasive Nontyphoidal Salmonella in Adults, Children, and Infants
ClinicalTrials.gov study NCT06213506. IPD Sharing: YES. Countries: 1. Publications: 0.
Immune Response to a Delayed Second Dose of Oral Cholera Vaccine
ClinicalTrials.gov study NCT05453253. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Impact of FLU Vaccination on Nasal Resident Memory Immune Responses and Peripheral Respiratory-tropic Memory Immune Responses
ClinicalTrials.gov study NCT06824779. IPD Sharing: NO. Countries: 1. Publications: 0.
Evaluating the Safety of and Immune Response to a Dengue Vaccine (TV003) in Healthy Adults, Adolescents, and Children in Thailand
ClinicalTrials.gov study NCT02332733. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Safety and Immunological Response Rate Study of THERATOPE® Vaccine in Metastatic Breast Cancer Patients
ClinicalTrials.gov study NCT00046371. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Immune Response to COVID-19 Vaccine in Recipients of Living Donor Liver Transplantation
ClinicalTrials.gov study NCT05051605. IPD Sharing: Not stated. Countries: 1. Publications: 0.
COVID-19 Vaccine Induced Adaptive Immune Responses
ClinicalTrials.gov study NCT04729374. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Assess if Immune Response of GSK Biologicals' Tritanrix™-HepB/Hib-MenAC Given Without or With Hepatitis B Vaccine at Birth is at Least as Good as Tritanrix™-HepB/Hiberix™ Without Hepatitis B Vaccine a
ClinicalTrials.gov study NCT00290303. IPD Sharing: YES. Countries: 1. Publications: 0.
Humoral and Cellular Responses to Vaccination Against Coronavirus Disease 2019 (COVID-19) in the Very Elderly Living in Geriatric Institutions
ClinicalTrials.gov study NCT04961502. IPD Sharing: Not stated. Countries: 1. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.