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1,283
datasets available to search
ShareScore release 0.7.1
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1,283 results for “Copying”
Genome-Wide Copy Number Variation Analysis of Chinese Patients with Intellectual Disability
GEO Series GSE83414. Homo sapiens. 31 samples. Type: Genome variation profiling by SNP array; SNP genotyping by SNP array.
Single-cell copy number analysis in melanoma
GEO Series GSE151409. Homo sapiens. 1 samples. Type: Expression profiling by high throughput sequencing.
Copy Number Variation of human hepatocellular carcinoma (HCC) and Cholangiocarcinoma (CCA) from the Thailand Initiative in Genomics and Expression Research for Liver Cancer (TIGER-LC)
GEO Series GSE76213. Homo sapiens. 304 samples. Type: Genome variation profiling by SNP array.
Genome-wide changes in DNA methylation and copy number play a role in deregulation of gene expression in osteosarcoma
GEO Series GSE12885. Homo sapiens. 58 samples. Type: Expression profiling by array; Genome variation profiling by genome tiling array; Methylation profiling by genome tiling array.
Analysis of copy number variants on chromosome 21 in Down syndrome-associated congenital heart defects
GEO Series GSE93004. Homo sapiens. 526 samples. Type: Genome variation profiling by array.
Evaluation of affinity-based genome-wide DNA methylation data: effects of CpG density, amplification bias and copy number variation
GEO Series GSE24546. Homo sapiens. 40 samples. Type: Methylation profiling by genome tiling array; Methylation profiling by high throughput sequencing; Genome variation profiling by SNP array.
Analysis of transgenerational effects on DNA copy number aberrations in male mice exposed to continuous 20mGy/day gamma-rays for 400 days (Secondary screening for 20mGyZ familly).
GEO Series GSE95336. Mus musculus. 14 samples. Type: Genome variation profiling by genome tiling array.
Genomic copy number variations in the genomes of leukocytes predict prostate cancer clinical outcomes
GEO Series GSE70650. Homo sapiens. 273 samples. Type: Genome variation profiling by SNP array.
High-resolution map of copy number variations in motor cortex of Control and Sporadic Amyotrphic Lateral Sclerosis patients by using a customized exon-centric comparative genomic hybridization array.
GEO Series GSE107375. Homo sapiens. 40 samples. Type: Genome variation profiling by array.
DNA copy number alterations in endobronchial squamous metaplastic lesions predict lung cancer
GEO Series GSE23644. Homo sapiens. 58 samples. Type: Genome variation profiling by array.
Acquired Genomic Copy Number Aberrations and Survival in Adult Acute Myelogenous Leukemia
GEO Series GSE23452. Homo sapiens. 226 samples. Type: SNP genotyping by SNP array; Genome variation profiling by SNP array.
Primary tumor grafts as advanced models for breast cancer that authentically reflect tumor histopathology, growth, metastasis, and patient outcomes (copy number)
GEO Series GSE32530. Homo sapiens. 24 samples. Type: Genome variation profiling by SNP array.
DNA copy number, including telomeres and mitochondria, assayed using next-generation sequencing
GEO Series GSE21159. Homo sapiens. 3 samples. Type: Genome variation profiling by high throughput sequencing.
Investigation of MET copy number in various cancer cell lines
GEO Series GSE77414. Homo sapiens. 21 samples. Type: Genome variation profiling by genome tiling array.
IO Islamic 2102. Copies of Orders by Tîpû Sulṭân.
<p>IO Islamic 2102. Copies of Orders by Tîpû Sulṭân.</p>
Data from: Evaluation of the innate immunostimulatory potential of originator and non-originator copies of insulin glargine in an in vitro human immune model
Background: The manufacture of insulin analogs requires sophisticated production procedures which can lead to differences in the structure, purity, and/or other physiochemical properties of resultant products that can affect their biologic activity. Here, we sought to compare originator and non-originator copies of insulin glargine for innate immune activity and mechanisms leading to differences in these response profiles in an in vitro model of human immunity. Methods: An endothelial/dendritic cell-based innate immune model was used to study antigen-presenting cell activation, cytokine secretion, and insulin receptor signalling pathways induced by originator and non-originator insulin glargine products. Mechanistic studies included signalling pathway blockade with specific inhibitors, analysis of the products in a Toll-like receptor reporter cell line assay, and insulin removal from the products by immunopurification. Findings: All insulin glargine products elicited at least a minor innate immune response comparable to human insulin, but some lots of a non-originator copy product induced the elevated secretion of the cytokines, IL-8 and IL-6. In studies aimed at addressing the mechanisms leading to differential cytokine production by these products, we found (1) the inflammatory response was not mediated by bacterial contaminants, (2) the innate response was driven by the insulin receptor through the MAPK pathway, and (3) the removal of insulin significantly reduced their capacity to induce innate activity. No evidence of product aggregates was detected, though the presence of some high molecular weight proteins argues for the presence of insulin dimers or others contaminants in these products. Conclusion: The data presented here suggests some non-originator insulin glargine product lots drive heightened in vitro human innate activity and provides preliminary evidence that changes in their biochemical composition (dimers, impurities) might be responsible for their greater immunostimulatory potential.
Association of copy number alterations with the immune transcriptomic landscape in cancer
<p>This repository contains supplementary materials for the research paper "Association of copy number alterations with the immune transcriptomic landscape in cancer". The materials are organized in the following folders:</p> <ul> <li>00_code: code to reproduce the analysis</li> <li>01_ica_datasets: transcriptional components, sample mixing matrix activities, and gene set enrichment analysis results of the GPL570, ARCHS4, and TCGA datasets</li> <li>02_ica_cna_tc: identified CNA-TCs and their captured CNA regions, genomic plots of CNA-TCs</li> <li>03_ica_immune_tc: identified immune-TCs, list of immune gene sets</li> <li>04_ica_tc_dataset_overlap: reproducibility results of CNA-TCs and immune-TCs across datasets</li> <li>05_immune_gene_occurences: frequency of genes with high gene weight in immune-TCs, list potential novel immune involved ORFs</li> <li>06_projection_immune_tc_datasets: GPL570 and TCGA cancer samples corrected mixing matrix activitiy for CNA-TCs and immune-TCs of the other dataset</li> <li>07_inferred_cna_profiles: TACNA profiles and CNA burden per cancer sample</li> <li>08_cna_burden_immune_tc_association: cancer sample associations of CNA burden, individual CNAs, and single gene CNAs with immune-TCs</li> <li>09_projection_single_cell: cell type activity of immune-TCs in a single-cell tumor immune atlas for precision oncology </li> <li>10_projection_spatial_transcriptomics: activity of CNA-TC and immune-TC for each spot in spatial transcriptomic datasets from 10xGenomics</li> <li>11_immunotherapy_response: gene expression data, sample annotation, and mixing matrix of projected GPL570 immune-TCs for 13 immunotherapy response datasets with predictive performance</li> </ul>
IO Islamic 1785. Rauḍat-alṣafa. A Complete Copy of Mîr-khwând's
<p>IO Islamic 1785. Rauḍat-alṣafa. A Complete Copy of Mîr-khwând’s</p>
IO Islamic 3277. Rauḍat-alṣafa. A Copy of Mîr-khwând's
<p>IO Islamic 3277. Rauḍat-alṣafa. A Copy of Mîr-khwând’s</p>
IO Islamic 1111. Rauḍat-alṣafa. A Complete Copy of Mîr-khwând's
<p>IO Islamic 1111. Rauḍat-alṣafa. A Complete Copy of Mîr-khwând’s</p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.