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763 results for “Antioxidant”
Antioxidants in culture and vitrification media alters mouse liver and placenta gene expression
GEO Series GSE179114. Mus musculus. 72 samples. Type: Expression profiling by high throughput sequencing.
Environmentally relevant concentrations of niclosamide disrupt antioxidant defense, histology, and the liver and intestine transcriptome of Chinese soft-shelled turtle
GEO Series GSE225631. Pelodiscus sinensis. 18 samples. Type: Expression profiling by high throughput sequencing.
Neofusicoccum laricinum disrupts larch defenses through coordinated cell wall degradation and antioxidant suppression
GEO Series GSE317540. Larix kaempferi. 6 samples. Type: Expression profiling by high throughput sequencing.
Liver macrophages inhibit the endogenous antioxidant response in obesity-associated insulin resistance [miRNA-Seq]
GEO Series GSE132795. Mus musculus. 15 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Fig. 3 in Antioxidant and anticholinesterase potential of Ferulago cassia with farther bio-guided isolation of active coumarin constituents *
Fig. 3. Total phenolic content of Ferulago cassia methanolic extracts.
Dataset related to the article : "The Burden of Impaired Serum Albumin Antioxidant Properties and Glyco-Oxidation in Coronary Heart Disease Patients with and without Type 2 Diabetes Mellitus"
<p>This record contains raw data related to the article: The Burden of Impaired Serum Albumin Antioxidant Properties and Glyco-Oxidation in Coronary Heart Disease Patients with and without Type 2 Diabetes Mellitus</p> <p>Abstract</p> <p>Human serum albumin (HSA) has an important antioxidant activity due to the presence of the reduced cysteine at position 34, which represents the most abundant free thiol in the plasma. In oxidative-based diseases, HSA undergoes S-thiolation (THIO-HSA) with changes in the antioxidant function of albumin that could contribute to the progression of the disease. The aim of this study was to verify, for the first time, the different burdens of THIO-HSA, glycated HSA (GLY-HSA), and advanced glycation end products (AGE) accumulation both in type 2 diabetes mellitus (T2DM) patients and in non-diabetic patients, with or without coronary heart disease (CHD). In this study, we assessed the presence of modified forms of HSA, THIO-HSA, and GLY-HSA by means of mass spectrometry in 33 patients with both T2DM and CHD, in 31 patients with T2DM and without CHD, in 30 patients without diabetes with a history of CHD, and 27 subjects without diabetes and CHD. All the patients' anthropometric and clinical data were recorded including age, sex, duration of diabetes, body mass index (BMI), blood pressure, and history of CHD defined with anamnestic data. Metabolic parameters, such as fasting plasma glucose (FPG), glycated hemoglobin (HbA1c), lipids, pentosidine, AGE, receptor for advanced glycation end-products (RAGE) and its soluble form (sRAGE), were measured. AGE and pentosidine are significantly higher in T2DM patients with and without CHD with respect to non-diabetic patients with CHD and control subjects. RAGE levels are significantly higher in T2DM patients with respect to non-diabetic patients, and among T2DM patients, the group with CHD showed significantly higher RAGE levels than those without CHD (217 ± 171 pg/mL and 140 ± 61 pg/mL, respectively). Albumin isoforms discriminate between non-diabetic patients with CHD and T2DM patients with and without CHD and control subjects, with GLY-HSA levels higher in T2DM with and without CHD, and THIO-HSA higher in CHD patients without T2DM. Finally, we demonstrated that the oxidized forms of HSA can increase the expression of the inflammatory cytokine Tumor Necrosis Factor-alpha (TNFα) in monocytic cells. In patients with CHD, GLY-HSA and THIO-HSA have a different prevalent distribution, the first one prevailing in patients with T2DM and the second one in patients without T2DM. These findings suggest that albumin quality and homeostasis balance between glyco-oxidation and thiolation might have an impact on the antioxidant defense system in cardiovascular diseases.</p>
Fig. 1 in Anti-inflammatory, hepatoprotective and antioxidant activity of ellagitannin isolated from Melaleuca styphelioides
Fig. 1. Styphelioidin (1). (A) Structure of 1. (B) HMBC correlations of 1.
Excessive Antioxidant Activity Impedes Neonatal Cardiomyocyte Regeneration
GEO Series GSE275297. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Analyzing the hippocampal gene network to determine the effects of coral calcium hydride on antioxidant ability in rat brain
GEO Series GSE48623. Rattus norvegicus. 8 samples. Type: Expression profiling by array.
Transcriptomes analysis of grains of two wheat cultivars with different antioxidant activity
GEO Series GSE192732. Triticum aestivum. 12 samples. Type: Expression profiling by high throughput sequencing.
Tissue-adhesive, antibacterial and antioxidant hydrogel sealant for sealing colorectal anastomotic leakage and preventing postoperative adhesion
GEO Series GSE281599. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
Tetrahexyldecyl Ascorbate (THDC) Degrades Rapidly under Oxidative Stress but Can Be Stabilized by Acetyl Zingerone to Enhance Collagen Production and Antioxidant Effects
GEO Series GSE182177. Homo sapiens. 20 samples. Type: Expression profiling by array.
Liver macrophages inhibit the endogenous antioxidant response in obesity-associated insulin resistance
GEO Series GSE132801. Mus musculus. 30 samples. Type: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing.
High-throughput Sequencing Facilitates Quantitative Analysis of Transcriptome Difference Underlying Quercetin Antioxidant Action in Ox-LDL-induced HUVECs Damage
GEO Series GSE167393. Homo sapiens. 18 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Expression data from primary human skin fibroblasts treated with vehicle (DMSO) and the antioxidant Trolox (0.5 mM, 96 hrs)
GEO Series GSE32502. Homo sapiens. 6 samples. Type: Expression profiling by array.
Exercise-Derived Exosomal miR-151-3p: An Innovative Anti-inflammatory and Antioxidant Exerkine for Spinal Cord Injury
GEO Series GSE317223. Rattus norvegicus. 4 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Expression data from the complex I mutant gas-1 (fc21) C. elegans worms in comparison to wildtype N2 Bristol worm and under the inluence of antioxidant drug treatment
GEO Series GSE66680. Caenorhabditis elegans. 75 samples. Type: Expression profiling by array.
Data related to the article "N-Acetyl-Cysteine Regenerates Albumin Cys34 by a Thiol-Disulfide Breaking Mechanism: An Explanation of Its Extracellular Antioxidant Activity"
<p>This record contains raw data related to the article “N-Acetyl-Cysteine Regenerates Albumin Cys34 by a Thiol-Disulfide Breaking Mechanism: An Explanation of Its Extracellular Antioxidant Activity”</p> <p><strong>Abstract</strong></p> <p>In the present paper, the extracellular antioxidant activity of N-acetyl-cysteine (NAC) is explained by considering its ability to regenerate the free form of albumin Cys34 by breaking the disulfide bond of the cysteinylated form (HSA-Cys). NAC’s capability to regenerate albumin Cys34 (HSA-SH) was studied by MS intact protein analysis in human plasma and in a concentration range of NAC easily achievable after oral and i.v. administration (5–50 µg/mL). NAC dose-dependently broke the HSA-Cys bond to form the dimer NAC-Cys thus regenerating Cys34, whose reduced state was maintained for at least 120 min. Cys was faster in restoring Cys34, according to the reaction constant<br> determined with the glutathione disulfide (GSSG) reaction, but after 60 min the mixed disulfide HSA-Cys turned back due to the reaction of the dimer Cys-Cys with Cys34. The explanation for the different rate exchanges between Cys-Cys and Cys-NAC with Cys34 was given by molecular modelling studies. Finally, the Cys34 regenerating effect of NAC was related to its ability to improve the total antioxidant capacity of plasma (TRAP assay). The results well indicate that NAC greatly increases the plasma antioxidant activity and this effect is not reached by a direct effect but through the regenerating effect of Cys34.</p>
Supplemental Tables-Murine neonatal oxidant lung injury: NRF2-dependent predisposition to adulthood respiratory viral infection and protection by maternal antioxidant
<p>This is a part of manuscript submitted for the special issue of <a href="https://www.mdpi.com/journal/antioxidants"><em>Antioxidants</em></a> (ISSN 2076-3921). This special issue belongs to the section "<a href="https://www.mdpi.com/journal/antioxidants/sections/health_outcomes_antioxidants_oxidative_stress">Health Outcomes of Antioxidants and Oxidative Stress</a>". </p> <p>Table S1: Prenatal sulforaphane-altered lung genes in postnatal air-exposed <em>Nrf2<sup>+/+</sup></em> mice (n = 523, moderated t-Test, <em>p </em>< = 0.01), Table S2: Prenatal sulforaphane-altered 918 lung genes in postnatal air-exposed <em>Nrf2<sup>-/-</sup></em> mice (n = 918, moderated t-Test, <em>p </em>< =0.01), Table S3: Prenatal sulforaphane-neonatal hyperoxia interaction 258 genes in <em>Nrf2<sup>+/+</sup></em> mice (2-Way ANOVA, <em>p </em>< =0.01), Table S4: Prenatal sulforaphane and neonatal hyperoxia interaction 239 genes in <em>Nrf2<sup>-/-</sup></em> mice (2-Way ANOVA, <em>p </em>< = 0.01), Table S5: Prenatal sulforaphane-modulated genes in <em>Nrf2<sup>+/+</sup></em> placenta (t-Test unpaired p-value <em>p </em>< = 0.05 ), Table S6: Prenatal sulforaphane-modulated genes in <em>Nrf2<sup>-/-</sup></em> placenta (t-Test unpaired p-value <em>p </em>< =0.05 ).</p>
Highly diluted bioactive compounds (HDBC) increase the antioxidant response and energy reserves of Penaeus vannamei under hypersaline conditions
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Allen Brain Atlas
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
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