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ShareScore release 0.7.1
Dataset results
756 results for “immune genes”
Gene expression profiles of high and low immune responder Holstein cows
GEO Series GSE11454. Bos taurus. 44 samples. Type: Expression profiling by array.
HPV induced R-loop formation represses innate immune gene expression while activating DNA damage repair pathways [H3K9me3 ChIP seq]
GEO Series GSE274120. Homo sapiens. 7 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
A novel prognostic risk model for cervical cancer based on immune checkpoint HLA-G-driven differentially expressed genes
GEO Series GSE208119. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
The effect of time-ordered-expression (TOE) mRNA vaccination on the expression of immune-related genes during the activation and maturation of BMDCs
GEO Series GSE279604. Mus musculus. 18 samples. Type: Expression profiling by high throughput sequencing.
Profiling gene expression of the host response to an irradiated sporozoite immunization and Plasmodium vivax malaria challenge
GEO Series GSE85263. Homo sapiens. 55 samples. Type: Expression profiling by high throughput sequencing.
Transcriptional changes in innate immunity genes in head kidney associated with Aeromonus salmonicida infection in polycyclic aromatic hydrocarbon mixture-fed rainbow trout
GEO Series GSE87920. Oncorhynchus mykiss. 62 samples. Type: Expression profiling by array.
Microarray analysis of genes involved in Streptolysin S immunity
GEO Series GSE48775. Streptococcus pyogenes. 27 samples. Type: Expression profiling by array.
The mce4D Gene of Mycobacterium tuberculosis Enhances Bacterial Invasion and Suppresses Host Cell Apoptosis to Promote Immune
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Data set related to the article: "Transfer of the longevity-associated variant of BPIFB4 gene rejuvenates immune system and vasculature by a reduction of CD38+ macrophages and NAD+ decline"
<p>As we age, our body experiences chronic, systemic inflammation contributing to the morbidity and mortality of the elderly. The senescent immune system has been described to have a causal role in driving systemic aging and therefore may represent a key therapeutic target to prevent pathological consequences associated with aging and extend a healthy lifespan. Previous studies from our group associated a polymorphic haplotype variant in the BPIFB4 gene (LAV-BPIFB4) with exceptional longevity. Transfer of the LAV-BPIFB4 in preclinical models halted the progression of cardiovascular diseases (CVDs) and frailty by counterbalancing chronic inflammation. In the present study, we aimed to delineate the action of systemic adeno-associated viral vector-mediated LAV-BPIFB4 gene transfer (AAV-LAV-BPIFB4) on the deleterious age-related changes of the immune system and thereby the senescence-associated events occurring in C57BL/6J mice aged 26 months. Our in vivo data showed that 26-months-old mice had a higher frequency of CD45+SA-beta Gal+ immune cells in peripheral blood than young (4-months-old) C57BL/6J mice. Notably, AAVLAV-BPIFB4 gene transfer in aged mice reduced the pool of peripheral immunosenescent cells that were shown to be enriched in the spleen. In addition, the proper tuning of the immune secretory phenotype (IL1βlow, IL6low, IL10high) associated with a significant reduction in SA-beta Gal-positive area of aorta from AAV-LAV treated mice. At the functional level, the reduction of senescenceassociated inflammation ensured sustained NAD+ levels in the plasma of AAV-LAV-BPIFB4 old mice by preventing the NADase CD38 increase in F4/80+ tissue-resident macrophages and Ly6Chigh pro-inflammatory monocytes of the spleen and bone marrow. Finally, to validate the clinical implication of our findings, we showed that Long-living-individuals (LLIs, >95 years), which delay CVDs onset, especially if LAV-carriers, were characterized by high NAD+ levels. In conclusion, the new senotherapeutic action of LAV-BPIFB4 may offer a valuable therapeutic tool to control aging and reduce the burden of its pathophysiological disorders, such as CVDs.</p>
Gene expression during innate immunity in tobacco triggered by bacteria.
GEO Series GSE10482. Solanum tuberosum; Nicotiana tabacum; Nicotiana langsdorffii x Nicotiana sanderae. 30 samples. Type: Expression profiling by array.
Gene Expression Profiling of Immune System Cells Stimulated with Components of Lactobacillus acidophilus
GEO Series GSE6372. Gallus gallus. 72 samples. Type: Expression profiling by array.
HPV induced R-loop formation represses innate immune gene expression while activating DNA damage repair pathways [H3K36me3 ChIP seq]
GEO Series GSE274109. Homo sapiens. 7 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
FosB/ΔFosB are induced in mast cells and regulate gene expression to modulate inflammatory responses to allergens and immune stimuli in male mice
GEO Series GSE286256. Mus musculus. 20 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
The human pathogen Mycobacterium tuberculosis and the fish pathogen Mycobacterium marinum trigger the same core set of late immune response genes in zebrafish larvae
GEO Series GSE252417. Danio rerio. 32 samples. Type: Expression profiling by high throughput sequencing.
Gene expression of immune-related genes in peripheral blood of children with Down syndrome
GEO Series GSE55865. Homo sapiens. 24 samples. Type: Expression profiling by RT-PCR.
Immune gene expression profiling to inform individualized treatment of early-stage basal-like breast cancer
GEO Series GSE237290. Homo sapiens. 57 samples. Type: Expression profiling by array.
ScienceDex guides
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.