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1,989 results for “Blood pressure”
Blood Pressure Change and Outcome
ClinicalTrials.gov study NCT01330004. IPD Sharing: Not stated. Countries: 1. Publications: 1.
The sodium/proton exchanger NHA2 regulates blood pressure through a WNK4-NCC dependent pathway in the kidney
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Data from: Effectiveness and safety of 1 vs 4 h blood pressure profile with clinical and laboratory assessment for the exclusion of gestational hypertension and pre-eclampsia: a retrospective study in a university affiliated maternity hospital
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Blood pressure and dementia
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Data from: Blood pressure decreases after revascularization in atherosclerotic renal artery disease: a cohort study based on a multidisciplinary meeting
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Effectiveness of community-based health education and home support program to reduce blood pressure among patients with uncontrolled hypertension in Nepal: A cluster-randomized trial
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Genetically determined blood pressure, antihypertensive drug classes and risk of stroke subtypes
<p><b>Objective: </b>We employed Mendelian Randomization to explore whether the effects of blood pressure (BP) and BP lowering through different antihypertensive drug classes on stroke risk vary by stroke etiology.</p> <p><b>Methods: </b>We selected genetic variants associated with systolic and diastolic BP and BP-lowering variants in genes encoding antihypertensive drug targets from a GWAS on 757,601 individuals. Applying two-sample Mendelian randomization, we examined associations with any stroke (67,162 cases; 454,450 controls), ischemic stroke and its subtypes (large artery, cardioembolic, small vessel stroke), intracerebral hemorrhage (ICH, deep and lobar), and the related small vessel disease phenotype of WMH.</p> <p><b>Results</b>: Genetic predisposition to higher systolic and diastolic BP was associated with higher risk of any stroke, ischemic stroke, and ICH. We found associations between genetically determined BP and all ischemic stroke subtypes with a higher risk of large artery and small vessel stroke compared to cardioembolic stroke, as well as associations with deep, but not lobar ICH. Genetic proxies for calcium channel blockers, but not beta blockers, were associated with lower risk of any stroke and ischemic stroke. Proxies for CCBs showed particularly strong associations with small vessel stroke and the related radiological phenotype of WMH.</p> <p><b>Conclusions: </b>This study supports a causal role of hypertension in all major stroke subtypes except lobar ICH. We find differences in the effects of BP and BP lowering through antihypertensive drug classes between stroke subtypes and identify calcium channel blockade as a promising strategy for preventing manifestations of cerebral small vessel disease.</p>
Pre-eclampsia and offspring blood pressure meta-analysis
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Supplementary results for: Visit-to-visit blood pressure variability, neuropathology and cognitive function
<p><b>Objective</b> Large systolic blood pressure (SBP) variability has been proposed as a novel risk factor for dementia above and beyond SBP levels, but the underlying neuropathology is largely unknown. We investigated the relationship among visit-to-visit SBP variability, cognitive deterioration and underlying neuropathological changes.</p> <p><b>Methods </b>We used longitudinal data (between 2005 and 2019) from the National Alzheimer's Coordinating Center. 13,284 dementia-free participants aged≥50 years were followed over a median of 5.0 (interquartile range: 3.1-7.6) years. Neuropathology data were available in 1,400 autopsied participants. Visit-to-visit SBP variability was quantified from repeated annual SBP measurements. Cognitive deterioration was defined as conversion from normal cognition to mild cognitive impairment (MCI) or dementia, or from MCI to dementia.</p> <p><b>Results</b> Larger visit-to-visit SBP variability was associated with cognitive deterioration (adjusted odds ratio comparing extreme quintiles: 2.64; 95%CI:2.29-3.04, P <0.001). It was also associated with a higher burden of vascular pathology (including microinfarcts, white matter lesion, atherosclerosis of the circle of Willis and arteriolosclerosis) and with neurofibrillary tangle pathology assessed by Braak staging (All P < 0.05). The association with cognitive deterioration and vascular pathology appeared stronger among those with normal cognition versus MCI at baseline. These findings were observed after adjusting for age, sex, mean SBP and other confounding variables. Similar results were observed for diastolic BP variability.</p> <p><b>Conclusion </b>Larger visit-to-visit SBP variability was associated with cognitive deterioration. It was also associated with cerebrovascular pathology and neurofibrillary tangles. These results suggest the intertwined role of vascular and Alzheimer's disease pathology in the etiology of dementia.</p>
Metabonomics to Investigate Effects of Healthy Diets on Blood Pressure: the OmniHeart Study
ClinicalTrials.gov study NCT03369535. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Evaluating Whether Treating Elevated Blood Pressure in the Inpatient Setting Impacts Patient Outcomes
ClinicalTrials.gov study NCT07208669. IPD Sharing: YES. Countries: 1. Publications: 0.
The Effect of Lavender Inhalation on Anxiety, Sleep, and Blood Pressure
ClinicalTrials.gov study NCT07192783. IPD Sharing: NO. Countries: 1. Publications: 0.
Evaluating the Relationship Between Inflammation, Genetics, and Stress in the Development of High Blood Pressure
ClinicalTrials.gov study NCT00384241. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Study to Investigate the Influence of MK0859 on Blood Pressure (MK-0859-012)(COMPLETED)
ClinicalTrials.gov study NCT00565006. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Mediterranean Diet And Blood Pressure In Hypertension
ClinicalTrials.gov study NCT07106567. IPD Sharing: NO. Countries: 1. Publications: 0.
Melatonin and Nighttime Blood Pressure in African Americans--24 mg Study
ClinicalTrials.gov study NCT01114373. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Blood Pressure in the Emergency Department
ClinicalTrials.gov study NCT03954119. IPD Sharing: UNDECIDED. Countries: 0. Publications: 1.
Pharmacological and Nonpharmacological Factors That Contribute Blood Pressure Control
ClinicalTrials.gov study NCT05513430. IPD Sharing: NO. Countries: 0. Publications: 1.
The Role of COX-2 Inhibition in Salt Sensitivity of Blood Pressure
ClinicalTrials.gov study NCT00624559. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Reducing Air Pollution to Lower Blood Pressure
ClinicalTrials.gov study NCT04908917. IPD Sharing: NO. Countries: 0. Publications: 20.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.