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5,946 results for “Type 2 diabetes”
Supplemental material for "Statins, type 2 diabetes and body mass index: a univariable and multivariable Mendelian randomization study"
<p>Supplemental material for "Statins, type 2 diabetes and body mass index: a univariable and multivariable Mendelian randomization study" by Guoyi Yang and C Mary Schooling.</p>
Feasibility and acceptability of a tailored health coaching intervention to improve type 2 diabetes self-management in Saudi Arabia: A mixed-methods randomised feasibility trial
<p><em>Background:</em> Around a third of the population of Saudi Arabia have been diagnosed with Type 2 diabetes, a condition often requiring lifestyle changes. Personalised health coaching, a strategy developed to assist individuals in overcoming challenges to adopt healthy behaviours, has not yet been widely applied in the country.</p> <p><em>Aims: </em>We aim to explore the feasibility and acceptability of tailored health coaching in Saudi Arabia, in order to help those with Type 2 diabetes to more effectively manage their condition.</p> <p><em>Methods:</em> Using a mixed-methods approach, this research involved a randomised controlled trial with 30 Saudi adults who have Type 2 diabetes. They were randomly allocated into either the intervention or control arm for 12 weeks. The Capability, Opportunity, Motivation, and Behaviour framework was used to guide the intervention implementation along with the Behaviour Change Techniques Taxonomy version 1. The primary goal was to assess the suitability and duration of the intervention, recruitment, retention, and completion rates. The secondary outcome focused on the preliminary efficacy of the health coaching measured by the glycaemic index, blood pressure, body mass index, waist circumference, weight, patient self-efficacy, and diabetes self-management.</p> <p><em>Results:</em> The results showed high rates of eligibility, recruitment, and retention (a screening rate of 90%, a recruiting rate of 79%, and a retention rate of 97%). Notable improvements were observed in the health coaching group across five outcomes: HbA1c, BMI, waist circumference, patient self-efficacy, and diabetes self-care. Qualitative findings highlighted the participants' perceived benefits from the intervention, including enhanced motivation, better understanding of diabetes management, and a supportive coaching relationship. Participants expressed high satisfaction with the intervention and advocated for its expansion.</p> <p><em>Conclusion:</em> The findings demonstrated positive outcomes, supporting the need for a larger randomised controlled trial to evaluate the efficacy of health coaching in improving diabetes self-management among individuals with Type 2 diabetes.</p>
Effect of heat-killed Streptococcus thermophilus on type 2 diabetes rats
<p>The linkage between gut microbiota and type 2 diabetes (T2D) has been addressed by immense studies. Streptococcus thermophilus(S.thermophilus) which was found in fermented milk products ,has been used as a probiotic by previous research. However, whether heat-killed S.thermophilus can improve glycaemic parameters on T2D subjects remains unanswered. In this study, we evaluated the effect of heat-killed S.thermophilus on T2D model rats and the potential mechanisms of the effect.</p>
Multi-omic Mapping of Human Pancreatic Islet Endoplasmic Reticulum and Cytokine Stress Responses Provide Type 2 Diabetes Genetic Insights
<p>The following data accompanying the manuscript can be found here:</p> <ul> <li>Expression (bulk RNA-seq & scRNA-seq) matrices</li> <li>Chromatin accessibility (bulk ATAC-seq) matrices</li> <li>TDF files for IGV browser visualization of cis-regulatory elements</li> </ul>
Comparative Efficacy and Safety of Sitagliptin Phosphate Combined with Gliclazide Sustained-Release Tablets Versus Metformin in Treatment-Naïve Patients with Type 2 Diabetes Mellitus and Glucotoxicity: A Single-Center, Prospective, Randomized Controlled Non-Inferiority Study
<p>This dataset supports the manuscript titled "Comparative Efficacy and Safety of Sitagliptin Phosphate Combined with Gliclazide Sustained-Release Tablets Versus Metformin in Treatment-Naïve Patients with Type 2 Diabetes Mellitus and Glucotoxicity: A Single-Center, Prospective, Randomized Controlled Non-Inferiority Study." The study aims to compare the efficacy and safety of sitagliptin phosphate combined with gliclazide sustained-release tablets against metformin in treatment-naïve patients with type 2 diabetes mellitus and glucotoxicity. Data include clinical measurements, laboratory test results, and adverse event records collected throughout the trial period. Statistical analyses were conducted to assess non-inferiority between the two treatment groups. This dataset provides valuable insights for researchers interested in diabetes management, pharmacotherapy, and randomized controlled trials.</p>
Data from: Modelling of dysregulated glucagon secretion in type 2 diabetes by considering mitochondrial alterations in pancreatic alpha cells
Type 2 diabetes mellitus (T2DM) has been associated with insulin resistance and the failure of β-cells to produce and secrete enough insulin as the disease progresses. However, clinical treatments based solely on insulin secretion and action have had limited success. The focus is therefore shifting towards α-cells, in particular to the dysregulated secretion of glucagon. Our qualitative electron-microscopy-based observations gave an indication that mitochondria in α-cells are altered in Western-diet-induced T2DM. In particular, α-cells extracted from mouse pancreatic tissue showed a lower density of mitochondria, a less expressed matrix, and a lower number of cristae. These deformities in mitochondrial ultrastructure imply a decreased efficiency in mitochondrial ATP production, which prompted us to theoretically explore and clarify one of the most challenging problems associated with T2DM, namely the lack of glucagon secretion in hypoglycemia and its oversecretion at high blood glucose concentrations. To this purpose, we constructed a novel computational model that links α-cell metabolism with their electrical activity and glucagon secretion. Our results show that defective mitochondrial metabolism in α-cells can account for dysregulated glucagon secretion in T2DM, thus improving our understanding of T2DM pathophysiology and indicating possibilities for new clinical treatments.
Underlying data for Evaluation of the effect of Modern Sulfonylureas on Oxidative Stress and Hepatorenal Function among Type 2 Diabetic Patients beyond Glycemic Control: an observational study
<p>Underlying data for Evaluation of the effect of Modern Sulfonylureas on Oxidative Stress and Hepatorenal Function among Type 2 Diabetic Patients beyond Glycemic Control: an observational study</p>
Dysregulation of early gene response to a mixed meal in skeletal muscle in obesity and type 2 diabetes
<p>Supplemental Tables for a study <strong>Dysregulation of early gene response to a mixed meal in skeletal muscle in obesity and type 2 diabetes </strong>https://journals.physiology.org/doi/abs/10.1152/physiolgenomics.00046.2023 </p>
Association between a glucagon-like peptide 1 receptor genetic polymorphism and therapeutic response to sitagliptin in a sample of type 2 diabetic patients: an observational study
<p>Association between a glucagon-like peptide 1 receptor genetic polymorphism and therapeutic response to sitagliptin in a sample of type 2 diabetic patients: an observational study</p>
Evaluation of the Effect of Pulsatile Cuts Stendo3 on Vascular Function Patients With Diabetes Type 2
ClinicalTrials.gov study NCT02359461. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Glimepiride, Empagliflozin, and Sitagliptin With Metformin for Type 2 Diabetes
ClinicalTrials.gov study NCT06759922. IPD Sharing: YES. Countries: 1. Publications: 14.
An Observational Study, Called FINEGUST, to Learn More About How People With Chronic Kidney Disease and Type 2 Diabetes Are Treated and How the Introduction of New Treatment Options, Like Finerenone,
ClinicalTrials.gov study NCT05526157. IPD Sharing: NO. Countries: 5. Publications: 1.
Taurine Effect on Glycemic, Lipidic and Inflammatory Profile in Individuals With Type 2 Diabetes
ClinicalTrials.gov study NCT04874012. IPD Sharing: NO. Countries: 1. Publications: 8.
Effects of Liraglutide on the Cognitive Function in Patients With Type 2 Diabetes Mellitus
ClinicalTrials.gov study NCT03707171. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Low Glycemic Index Diets vs. High Cereal Fibre Diets in Type 2 Diabetes
ClinicalTrials.gov study NCT00438698. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Effect of LAF237 on Glucagon Secretion in Patients With Type 2 Diabetes and in Healthy Subjects
ClinicalTrials.gov study NCT00651105. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Training, Detraining, Retraining and Glycemic Control in Patients With Type 2 Diabetes
ClinicalTrials.gov study NCT01580475. IPD Sharing: Not stated. Countries: 1. Publications: 6.
Genetic Physiopathology and Evolution of Type 2 Diabetes
ClinicalTrials.gov study NCT00879801. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Vortioxetine Monotherapy for Major Depressive Disorder in Type 2 Diabetes
ClinicalTrials.gov study NCT03580967. IPD Sharing: NO. Countries: 1. Publications: 62.
Vildagliptin vs. Glibenclamide in Endothelial Function in Type 2 Diabetes and Hypertension
ClinicalTrials.gov study NCT02145611. IPD Sharing: UNDECIDED. Countries: 1. Publications: 2.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.