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256 results for “Aedes aegypti”
Figure 4 in Mosquito Surveillance Program Using Ovitraps Detected Aedes aegypti at the Honolulu International Airport in 2012
Figure 4. Mean number of eggs collected per week using ovitraps and mean rainfall per week at Honolulu International Airport from May 2010 to June 2012. * shows the weeks (87 and 110) in which A. aegypti was collected.
Figure 5. Neighbor-joining tree for A in Mosquito Surveillance Program Using Ovitraps Detected Aedes aegypti at the Honolulu International Airport in 2012
Figure 5. Neighbor-joining tree for A. aegypti based on COI (450bp) and ND4 (322bp) sequences. Labels are Genbank accession numbers combined with country names.
Figure 3 in Mosquito Surveillance Program Using Ovitraps Detected Aedes aegypti at the Honolulu International Airport in 2012
Figure 3. Frequency distribution of egg collections for each ovitrap site at Honolulu International Airport
Data for: Thermal Infrared Directs Host-seeking Behavior in Aedes Aegypti Mosquitoes
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Microsatellite data for Aedes aegypti populations in Florida and southern California
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SNP Data for Aedes aegypti populations in Florida and southern California
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Data from: Blockade of dengue virus transmission from viremic blood to Aedes aegypti mosquitoes using human monoclonal antibodies
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Pairwise FST values for Aedes aegypti populations in Florida and southern California
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Carbon dioxide and blood-feeding shift visual cue tracking during navigation in Aedes aegypti mosquitoes
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Enhanced Zika virus susceptibility of globally invasive Aedes aegypti populations
<p>The worldwide variation of <em>Aedes aegypti </em>susceptibility to ZIKV infection was investigated using a panel of 14 laboratory colonies recently established from field-collected specimens.</p>
Data from: Efficacy of Aedes aegypti control by indoor Ultra Low Volume (ULV) insecticide spraying in Iquitos, Peru
Background: Aedes aegypti is a primary vector of dengue, chikungunya, Zika, and urban yellow fever viruses. Indoor, ultra low volume (ULV) space spraying with pyrethroid insecticides is the main approach used for Ae. aegypti emergency control in many countries. Given the widespread use of this method, the lack of large-scale experiments or detailed evaluations of municipal spray programs is problematic. Methodology/Principal Findings: Two experimental evaluations of non-residual, indoor ULV pyrethroid spraying were conducted in Iquitos, Peru. In each, a central sprayed sector was surrounded by an unsprayed buffer sector. In 2013, spray and buffer sectors included 398 and 765 houses, respectively. Spraying reduced the mean number of adults captured per house by ~83 percent relative to the pre-spray baseline survey. In the 2014 experiment, sprayed and buffer sectors included 1,117 and 1,049 houses, respectively. Here, the sprayed sector's number of adults per house was reduced ~64 percent relative to baseline. Parity surveys in the sprayed sector during the 2014 spray period indicated an increase in the proportion of very young females. We also evaluated impacts of a 2014 citywide spray program by the local Ministry of Health, which reduced adult populations by ~60 percent. In all cases, adult densities returned to near-baseline levels within one month. Conclusions/Significance: Our results demonstrate that densities of adult Ae. aegypti can be reduced by experimental and municipal spraying programs. The finding that adult densities return to approximately pre-spray densities in less than a month is similar to results from previous, smaller scale experiments. Our results demonstrate that ULV spraying is best viewed as having a short-term entomological effect. The epidemiological impact of ULV spraying will need evaluation in future trials that measure capacity of insecticide spraying to reduce human infection or disease.
Data from: Indoor resting behavior of Aedes aegypti (Diptera: Culicidae) in Acapulco, Mexico
The markedly anthropophilic and endophilic behaviors of Aedes aegypti (L.) make it a very efficient vector of dengue, chikungunya, and Zika viruses. Although a large body of research has investigated the immature habitats and conditions for adult emergence, relatively few studies have focused on the indoor resting behavior and distribution of vectors within houses. We investigated the resting behavior of Ae. aegypti indoors in 979 houses of the city of Acapulco, Mexico, by performing exhaustive indoor mosquito collections to describe the rooms and height at which mosquitoes were found resting. In total, 1,403 adult and 747 female Ae. aegypti were collected, primarily indoors (98% adults and 99% females). Primary resting locations included bedrooms (44%), living rooms (25%), and bathrooms (20%), followed by kitchens (9%). Aedes aegypti significantly rested below 1.5 m of height (82% adults, 83% females, and 87% bloodfed females); the odds of finding adult Ae. aegypti mosquitoes below 1.5 m was 17 times higher than above 1.5 m. Our findings provide relevant information for the design of insecticide-based interventions selectively targeting the adult resting population, such as indoor residual spraying.
Data for: Phenotypic adaptation to temperature in the mosquito vector, Aedes aegypti
<p><span>Most models exploring the effects of climate change on </span><span>mosquito-borne disease ignore thermal adaptation. However, if local adaptation leads to changes in mosquito thermal responses, 'one size fits all' models could fail to capture current variation between populations and future adaptive responses to changes in temperature. Here we assess phenotypic adaptation to temperature in <em>Aedes aegypti</em>, the primary vector of dengue, Zika, and chikungunya viruses. First, to explore whether there is any difference in existing thermal response of mosquitoes between populations we used a thermal knockdown assay to examine five populations of <em>Ae. aegypti </em>collected from climatically diverse locations in Mexico, together with a longstanding laboratory strain. We identified significant phenotypic variation in thermal tolerance between populations. Next, to explore whether such variation can be generated by differences in temperature we conducted an experimental passage study by establishing six replicate lines from a single field-derived population of <em>Ae. aegypti </em>from Mexico, maintaining half at 27<strong><span class="nounderlines">°</span></strong>C and the other half at 31<strong><span class="nounderlines">°</span></strong>C. After 10 generations we found a significant difference in mosquito performance, with the lines maintained under elevated temperatures showing greater thermal tolerance. Moreover, these differences in thermal tolerance translated to shifts in the thermal performance curves for multiple life history traits, leading to differences in overall fitness. Together, these novel findings provide compelling evidence that <em>Ae. aegypti </em>populations can and do differ in thermal response, suggesting that simplified thermal performance models might be insufficient for predicting the effects of climate on vector-borne disease transmission. </span></p>
Adaptive genomic signatures of globally invasive populations of the yellow fever mosquito Aedes aegypti
<p><strong>* These authors contributed equally: </strong>Alejandro N. Lozada-Chávez, Irma Lozada-Chávez.</p> <h3> </h3> <h1>Supplementary Dataset</h1> <p> </p> <p>This repository contains the <strong> Supplementary Data (from 1 to 12) </strong>cited in our paper "Adaptive genomic signatures of globally invasive populations of the yellow fever mosquito Aedes aegypti" in <em>Nature Ecology and Evolution</em>: <a title="Aedes aegypti domestication." href="https://doi.org/10.1038/s41559-025-02643-5">https://doi.org/10.1038/s41559-025-02643-5</a></p> <p>These datasets are available in the section "Supplementary Information" of our paper, but with the absence of the SD-9 due its large big size (~3Gb after decompressed). Here you can find the complete set of datasets in a single ZIP file:</p> <p><strong>41559_2025_2643_MOESM5_ESM_Supplementary_Data.zip</strong></p> <p> </p> <p><strong>LIST OF DATASETS:</strong></p> <p>1) Supplementary Data 1. SNP statistics for populations through genomic regions (TXT). <br>2) Supplementary Data 2. Sequences of new detected nrEVEs (FASTA). <br>3) Supplementary Data 3. Phylogenetic trees for populations and individuals (NEWICK). <br>4) Supplementary Data 4. Information for 8,120 hard selective sweeps detected with RAiSD in out-of-Africa populations (TXT). <br>5) Supplementary Data 5. Information for 1,030 SNP outliers detected with PCAdapt within 2,266 genes (VCF format). <br>6) Supplementary Data 6. Matrix with DoS scores for 11,651 orthologous protein-coding genes in AaegL5 and each Ae. aegypti population (TXT). <br>7) Supplementary Data 7. Matrix with MKT scores for 11,651 orthologous protein-coding genes in AaegL5 and each Ae. aegypti population (TXT). <br>8) Supplementary Data 8. Matrix with DoS scores used to estimate relaxed selection (TXT). <br>9) Supplementary Data 9. Matrix with SNPs and genomic coordinates within adaptive protein-coding genes and ncRNAs that are shared or private for out-of-Africa populations against African populations (TXT). <br>10) Supplementary Data 10. Matrix with 483 nonsynonymous SNPs and their allele frequencies for our 40 populations Florida and Colombia (TXT).<br>11) Supplementary Data 11. Genomic coordinates of SNPs in AaegL5 obtained from the literature and VectorBase (TXT). <br>12) Supplementary Data 12. Source data of metrics used to plot Figure 4b (TXT).</p> <p> </p> <p><strong>UPDATES NOTE:</strong></p> <ul> <li><strong>Repository version 3.</strong> Final version of datasets for the accepted manuscript.</li> <li><strong>Repository version 2.</strong> Incomplete datasets: Files as prelimary versions and their content may vary. The SD-10 is not present (matrix with 483 SNPs) was added. The SD-7 is a broken file (cannot be opened).</li> <li><strong>Repository version 1. </strong> Incomplete datasets: Files as prelimary versions and their content may vary. Two final SD files are not present.</li> </ul> <p> </p> <p><strong>CITATION OF THIS REPOSITORY:</strong></p> <p>Lozada-Chávez, A. N., Lozada-Chávez, I., Alfano, N., Palatini, U., Sogliani, D., Elfekih, S., Degefa, T., Sharakhova, M. V., Badolo, A., Patchara, S., Casas-Martinez, M., Carlos, B. C., Carballar-Lejarazú, R., Lambrechts, L., Souza-Neto, J. A., & Bonizzoni, M. (2024). Adaptive genomic signatures of globally invasive populations of the yellow fever mosquito Aedes aegypti [Data set]. Zenodo. https://doi.org/10.5281/zenodo.14948092</p> <p> </p> <p> </p>
single-nucleus RNA sequencing data from female Aedes aegypti maxillary palp
<p>Single-nucleus RNA sequencing data accompanying Herre*, Goldman* et al. (2022), "Non-Canonical Odor Coding in the Mosquito" (https://doi.org/10.1016/j.cell.2022.07.024)</p> <p>For further analysis see: https://github.com/VosshallLab/Younger_Herre_Vosshall2020/tree/main/snRNAseq_SupplementaryData</p> <p>For raw sequencing files see NCBI BioProject: PRJNA794050</p>
GWAS pyrethroid-resistant Aedes aegypti
<p><span><span><span><span><span><span><span><span><span><span><span>Genome-wide association studies (GWAS) use genetic polymorphism across the genomes of individuals with distinct characteristics to identify genotype-phenotype associations. In mosquitoes, complex traits such as vector competence and insecticide resistance could benefit from GWAS use. We used the <i>Ae. aegypti</i> 50k SNP chip to genotype populations with different levels of pyrethroid resistance from Northern Brazil. Pyrethroids are widely used worldwide to control mosquitoes and other agricultural pests, and their intensive use led to the selection of resistance phenotypes in many insects including mosquitoes. For <i>Ae. aegypti</i>, resistance phenotypes are mainly associated with several mutations in the voltage-gated sodium channel, known as knockdown resistance (<i>kdr</i>). We phenotyped those populations with the WHO insecticide bioassay using deltamethrin impregnated papers, genotyped the <i>kdr</i> alleles using qPCR, and the whole genomic regions with the SNP chip. We identified single-nucleotide polymorphisms (SNPs) directly associated with resistance and one epistatic SNP pair. We also observed that the novel SNPs correlated with the known <i>kdr</i> genotypes, although on different chromosomes or not in close physical proximity to the voltage-gated sodium channel gene. In addition, a pairwise comparison of resistance and susceptible mosquitoes from each population revealed differentiated genomic regions not associated with pyrethroid resistance. These new bi-allelic markers can be used to genotype other populations along with <i>kdr </i>alleles to understand their worldwide distribution. The functional roles of the genes near the newly discovered SNPs require new studies to determine if they act synergistically with <i>kdr</i> alleles or reduce the fitness cost of maintaining resistant alleles.</span></span></span></span></span></span></span></span></span></span></span></p>
Aedes aegypti in North America (Microsatellite and SNP array)
<p>The <em>Aedes aegypti</em> mosquito first invaded the Americas about 500 years ago and today is a widely distributed invasive species and the primary vector for viruses causing dengue, chikungunya, Zika, and yellow fever. Here we test the hypothesis that the North American colonization by <em>Ae. aegypti</em> occurred via a series of founder events. We present findings on genetic diversity, structure, and demographic history using data from 70 <em>Ae. aegypti</em> populations in North America genotyped at 12 microsatellite loci and/or ~20,000 single nucleotide polymorphisms (SNPs), the largest genetic study of the region to date. We find evidence consistent with a colonization driven by serial founder effect (SFE), with Florida as the putative source for a series of westward invasions. This scenario was supported by 1) a decrease in the genetic diversity of <em>Ae. aegypti </em>populations moving west, 2) a correlation between pairwise genetic and geographic distances, and 3) demographic analysis based on allele frequencies. A few <em>Ae. aegypti</em> populations on the west coast do not follow the general trend, likely due to a recent and distinct invasion history. We argue that SFE provides a helpful albeit simplified model for the movement of <em>Ae. aegypti </em>across North America, with outlier populations warranting further investigation.</p>
The current and future distribution of the yellow fever mosquito (Aedes aegypti) on Madeira Island [data set].
<p><strong>Additional data for manuscript:</strong> "The current and future distribution of the yellow fever mosquito (<em>Aedes aegypti</em>) on Madeira Island" published in PLOS Neglected Tropical Diseases by José Maurício Santos, César Capinha, Jorge Rocha, Carla Alexandra Sousa.</p> <p><strong>Corresponding authors:</strong> José Maurício Santos (josemauriciosantos@campus.ul.pt) & César Capinha (cesarcapinha@campus.ul.pt).</p> <p> </p> <p> </p> <p> </p>
Genotypes of Aedes aegypti mosquitoes derived from SNP chip and low-coverage whole genome sequencing for platform cross-validation
<p>The mosquito <em>Aedes aegypti </em>is the primary vector of many human arboviruses such as dengue, yellow fever, chikungunya, and Zika, which affect millions of people world-wide. Population genetics studies on this mosquito have been important in understanding its invasion pathways and success as a vector of human disease. The Axiom aegypti1 SNP chip was developed from a sample of geographically diverse <em>Ae. aegypti </em>populations to facilitate genomic studies on this species. Here we evaluate the utility of the Axiom aegypti1 SNP chip for population genetics and compare it with a low-depth shot-gun sequencing approach using mosquitoes from the species' native (Africa) and invasive range (outside Africa). These analyses indicate that the results from the SNP chip are highly reproducible and have a higher sensitivity to capture alternative alleles than a low-coverage whole-genome sequencing approach. Although the SNP chip suffers from ascertainment bias, results from population structure, ancestry, demographic, and phylogenetic analyses using the SNP chip were congruent with those derived from low coverage whole genome sequencing, and consistent with previous reports on Africa and outside Africa populations using microsatellites. More importantly, we identified a subset of SNPs that can be reliably used to generate merged databases, opening the door to combined analyses. We conclude that the Axiom aegypti1 SNP chip is a convenient, more accurate, low-cost alternative to low-depth whole genome sequencing for population genetic studies of <em>Ae. aegypti</em> that do not rely on full allelic frequency spectra. Whole genome sequencing and SNP chip data can be easily merged, extending the usefulness of both approaches. </p>
Fertility decline in Aedes aegypti mosquitoes is associated with reduced maternal transcript deposition and does not depend on female age
<p>Female mosquitoes undergo multiple rounds of reproduction known as gonotrophic cycles. A gonotrophic cycle spans the period from blood meal intake to egg laying. Nutrients from vertebrate host blood are necessary for completing egg development. During oogenesis, a female pre-packages mRNA into her oocytes, and these maternal transcripts drive the first two hours of embryonic development before zygotic genome activation. In this study, we profiled transcriptional changes in 1-2 hour-old <em>Aedes aegypti</em> embryos across two gonotrophic cycles. We found that homeotic genes which are regulators of embryogenesis are downregulated in embryos from the second gonotrophic cycle. Interestingly, embryos produced by <em>Ae. aegypti</em> females progressively reduced their ability to hatch as the number of gonotrophic cycles increased. We show that this fertility decline is due to increased reproductive output and not the mosquitoes' age. Moreover, we found a similar decline in fertility and fecundity across three gonotrophic cycles in <em>Ae. albopictus</em>. Our results are useful for predicting mosquito population dynamics to inform vector control efforts.</p>
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