Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
237
datasets available to search
ShareScore release 0.9.0
Dataset results
237 results for “Antifungals”
Antifungal Prophylaxis in Pediatric Acute Leukemia
ClinicalTrials.gov study NCT00624143. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Beta-Glucan Driven vs. Empirical Antifungal Therapy in Critically Ill Patients
ClinicalTrials.gov study NCT03117439. IPD Sharing: NO. Countries: 1. Publications: 1.
Study of EL219 vs Standard of Care for Early Antifungal Therapy of Suspected Invasive Mould Infections
ClinicalTrials.gov study NCT07215273. IPD Sharing: UNDECIDED. Countries: 1. Publications: 38.
Evaluation of Antifungal Prophylaxis on Graft-versus-host Disease (GVHD) Patients
ClinicalTrials.gov study NCT01282879. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Data from: Effectiveness of antifungal treatments during chytridiomycosis epizootics in populations of an endangered frog
Open the record for dataset details and reuse information.
Structure-guided discovery of potent antifungals that prevent Ras signaling by inhibiting protein farnesyltransferase
Open the record for dataset details and reuse information.
Data from: Phase-dependent differential in vitro and ex vivo susceptibility of Aspergillus flavus and Fusarium keratoplasticum to azole antifungals
Open the record for dataset details and reuse information.
Data from: Antifungal activity of water-stable copper-containing metal–organic frameworks
Open the record for dataset details and reuse information.
Data from: Young but not defenseless: antifungal activity during embryonic development of a social insect
Open the record for dataset details and reuse information.
Young but not defenseless: Antifungal activity during embryonic development of a social insect
<p> Termites live in environments heavily colonized by diverse microbial communities, including pathogens. Eggs laid within the nest likely experience similar pathogenic pressures as their older nestmates. Consequently, they may have also been under selective pressures to be immune-competent. Through <i>in vitro</i> experiments, we tested the ontogeny, location and strength of embryos' antifungal activity against the fungus <i>Metarhizium brunneum</i>. Extraembryonic washes and intraembryonic components were incubated with fungal conidia, which was then scored for viability. Fungistatic activity was location- and stage-dependent. Extraembryonic washes had relatively weak antifungal activity. Conversely, intraembryonic contents were highly antifungal, exhibiting increased potency through development. Boiling both embryonic washes and intraembryonic contents rescued conidia viability, indicating the antifungal agent(s) is (are) heat-sensitive, and likely proteinaceous. Embryonic protein profiles shifted from putative vitellogenins in young embryos to multiple proteins in subsequent stages, suggesting that the increase in fungistatic activity may be due to the expression of endogenous proteins during embryogenesis. This study is the first to address embryonic antifungal activity in a hemimetabolous, eusocial taxon. Our results support the hypothesis that microbes have been significant agents of selection, fostering the evolution of antifungal properties in termite eggs, the most immature and supposed, most vulnerable stage of development.</p>
Figure 1 from: Hrytsyk RA, Kutsyk RV, Yurchyshyn OI, Struk ОА, Kireev IV, Grytsyk AR (2021) The investigation of antimicrobial and antifungal activity of some Artemisia L. species. Pharmacia 68(1): 93-100. https://doi.org/10.3897/pharmacia.68.e47521
Figure 1 Antimicrobial activity of Artemisia absinthium L., Artemisia vulgaris L., Artemisia abrotanum L. extracts in relation to the test cultures of microorganisms: АEsherichia coli, BStaphylococcus epidermidis, CCandida tropicalis, DAspergillus niger, EEnterococcus faecalis, FStaphylococcus aureus
Data from: Identification and evaluation of novel acetolactate synthase inhibitors as antifungal agents
High-throughput phenotypic screening against yeast Saccharomyces cerevisiae revealed a series of triazolo-pyrimidine-sulfonamide compounds with broad-spectrum antifungal activity, no significant cytotoxicity, and low protein binding. To elucidate the target of this series we have applied a chemogenomic profiling approach using the S. cerevisiae deletion collection. All compounds of the series yielded highly similar profiles that suggested acetolactate synthase (Ilv2p, catalyzes the first common step in branched chain amino acid biosynthesis) as a possible target. High correlation to profiles of known Ilv2p inhibitors like chlorimuron-ethyl provided further evidence for a similar mechanism of action. Genome-wide mutagenesis in S. cerevisiae identified 13 resistant clones with 3 different mutations in the catalytic subunit of acetolactate synthase that also conferred cross-resistance to established Ilv2p inhibitors. Mapping the mutations into the published Ilv2p crystal structure outlined the chlorimuron-ethyl binding cavity and it was possible to dock the triazolo-pyrimidine-sulfonamide compound into this pocket in silico. However, fungal growth inhibition could be bypassed through supplementation with exogenous branched chain amino acids, or by the addition of serum to the medium in all of the fungal organisms tested except for Aspergillus fumigatus. Thus, these data support the identification of triazolo-pyrimidine-sulfonamide as inhibitors of acetolactate synthase but suggest that targeting may be compromised due to the possibility of nutrient bypass in vivo.
Data for / Comparison of Antifungal Activity of Thymus Vulgaris Essential Oil and Triple Antibiotic Paste Against Candida Albicans Isolated from Root Canal (In Vitro Study)
Open the record for dataset details and reuse information.
Figure 1 from: Fadhilah QG, Santoso I, Maryanto AE, Abdullah S, Yasman Y (2021) Evaluation of the antifungal activity of marine actinomycetes isolates against the phytopathogenic fungi Colletotrichum siamense KA: A preliminary study for new antifungal compound discovery. Pharmacia 68(4): 837-843. https://doi.org/10.3897/pharmacia.68.e72817
Figure 1 Results of the antibiosis assay of SM14 isolate in PDA filtrate medium. A. control, B. 6 days, C. 9 days, D. 12 days.
Figure 3 from: Fadhilah QG, Santoso I, Maryanto AE, Abdullah S, Yasman Y (2021) Evaluation of the antifungal activity of marine actinomycetes isolates against the phytopathogenic fungi Colletotrichum siamense KA: A preliminary study for new antifungal compound discovery. Pharmacia 68(4): 837-843. https://doi.org/10.3897/pharmacia.68.e72817
Figure 3 Phylogenetic analysis of marine actinomycetes isolates. The neighbor-joining tree of the three marine actinomycetes isolates (SM11, SM14, and SM15) was based on the 16S rRNA gene sequences. Streptomyces albus subsp. albus DSM 40313T is represented as an outgroup. The bootstrap values, based on 1,000 replications, are shown at the nodes; only values above 50% are given. The scale bar indicates 0.0050 substitutions per nucleotide position.
Figure 5 from: Santoso I, Fadhilah QG, Safitri SD, Handayani S, Maryanto AE, Yasman Y (2022) Inhibition of the phytopathogenic fungi Curvularia lunata BM and Ganoderma sp. TB4 by antifungal compounds produced by Bacillus siamensis LDR grown on hanjeli (Coix lacryma-jobi L.) starch. Pharmacia 69(1): 203-210. https://doi.org/10.3897/pharmacia.69.e80180
Figure 5 The chromatogram profile of the crude extract of Bacillus siamensis LDR : A. C14 iturin A; B. C14 bacillomycin F; C. C15 bacillomycin F; D. C16 bacillomycin F; E. C12 surfactin; F. C13 surfactin.
Figure 4 from: Santoso I, Fadhilah QG, Safitri SD, Handayani S, Maryanto AE, Yasman Y (2022) Inhibition of the phytopathogenic fungi Curvularia lunata BM and Ganoderma sp. TB4 by antifungal compounds produced by Bacillus siamensis LDR grown on hanjeli (Coix lacryma-jobi L.) starch. Pharmacia 69(1): 203-210. https://doi.org/10.3897/pharmacia.69.e80180
Figure 4 Thin layer chromatography of crude extract Bacillus siamensis LDR : A. lipid moiety; B. protein moiety.
Figure 6 from: Santoso I, Fadhilah QG, Safitri SD, Handayani S, Maryanto AE, Yasman Y (2022) Inhibition of the phytopathogenic fungi Curvularia lunata BM and Ganoderma sp. TB4 by antifungal compounds produced by Bacillus siamensis LDR grown on hanjeli (Coix lacryma-jobi L.) starch. Pharmacia 69(1): 203-210. https://doi.org/10.3897/pharmacia.69.e80180
Figure 6 The results of mass spectrometry analysis: A. C14 iturin A (m/z 1043.5526); B. C14 iturin A (m/z 1044.5375); C. C14 bacillomycin F (m/z 1057.5688); D. C15 bacillomycin F (m/z 1071.5848); E. C16 bacillomycin F (m/z 1085.6011); F. C12 surfactin (m/z 994.6440); and G. C13 surfactin (m/z 1008.6606)
Figure 2 from: Santoso I, Fadhilah QG, Safitri SD, Handayani S, Maryanto AE, Yasman Y (2022) Inhibition of the phytopathogenic fungi Curvularia lunata BM and Ganoderma sp. TB4 by antifungal compounds produced by Bacillus siamensis LDR grown on hanjeli (Coix lacryma-jobi L.) starch. Pharmacia 69(1): 203-210. https://doi.org/10.3897/pharmacia.69.e80180
Figure 2 Growth inhibition of Ganoderma sp. TB4 on potato dextrose agar (PDA)-filtrate medium: A. control, B. 12 days, C. 14 days, D. 16 days.
Figure 3 from: Santoso I, Fadhilah QG, Safitri SD, Handayani S, Maryanto AE, Yasman Y (2022) Inhibition of the phytopathogenic fungi Curvularia lunata BM and Ganoderma sp. TB4 by antifungal compounds produced by Bacillus siamensis LDR grown on hanjeli (Coix lacryma-jobi L.) starch. Pharmacia 69(1): 203-210. https://doi.org/10.3897/pharmacia.69.e80180
Figure 3 Growth inhibition of Curvularia lunata BM: A. control, B. treatment; Ganoderma sp. TB4 : C. control; D. treatment caused by the crude extract of Bacillus siamensis LDR.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.