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77
datasets available to search
ShareScore release 0.9.0
Dataset results
77 results for “ApoE4”
SEX-DEPENDENT APOE4 NEUTROPHIL-MICROGLIA INTERACTIONS DRIVE COGNITIVE IMPAIRMENT IN ALZHEIMER'S DISEASE [Mouse_Microglia_APOE3_4]
GEO Series GSE243747. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
SEX-DEPENDENT APOE4 NEUTROPHIL-MICROGLIA INTERACTIONS DRIVE COGNITIVE IMPAIRMENT IN ALZHEIMER'S DISEASE [Mouse_Neutro_Spleen_APOE3_4]
GEO Series GSE243748. Mus musculus. 18 samples. Type: Expression profiling by high throughput sequencing.
Sex-dependent APOE4 Neutrophil-microglia interactions drive cognitive impairment in Alzheimer's Disease
GEO Series GSE262632. Mus musculus. 39 samples. Type: Expression profiling by high throughput sequencing.
Lack of TREM2 differentially affects the phenotype and transcriptome of mice expressing human APOE3 and APOE4
GEO Series GSE144125. Mus musculus. 88 samples. Type: Expression profiling by high throughput sequencing.
SEX-DEPENDENT APOE4 NEUTROPHIL-MICROGLIA INTERACTIONS DRIVE COGNITIVE IMPAIRMENT IN ALZHEIMER'S DISEASE [Neutrophils_Spleen_Brain_E3_E4]
GEO Series GSE243749. Mus musculus. 13 samples. Type: Expression profiling by high throughput sequencing.
Plasmapheresis Versus Plasma Infusion from Young APOE3 Homozygotes Into MCI APOE4 Homozygotes to Slow Disease Progression
ClinicalTrials.gov study NCT03887741. IPD Sharing: NO. Countries: 1. Publications: 0.
Telephone Versus Videoconference Communication for Remote Genetic Disclosure in the APOE4 Trial
ClinicalTrials.gov study NCT02978729. IPD Sharing: NO. Countries: 0. Publications: 0.
ApoE4 disrupts intracellular trafficking and iron homeostasis in an improved iPSC-based model of human brain endothelial cells [scRNA-seq]
GEO Series GSE280214. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
SEX-DEPENDENT APOE4 NEUTROPHIL-MICROGLIA INTERACTIONS DRIVE COGNITIVE IMPAIRMENT IN ALZHEIMER'S DISEASE [Microglia_IL17RA]
GEO Series GSE243746. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
SEX-DEPENDENT APOE4 NEUTROPHIL-MICROGLIA INTERACTIONS DRIVE COGNITIVE IMPAIRMENT IN ALZHEIMER'S DISEASE [Human_Female_HC_MCI_APOE23_33_34]
GEO Series GSE243744. Homo sapiens. 47 samples. Type: Expression profiling by high throughput sequencing.
ApoE4 disrupts intracellular trafficking and iron homeostasis in an improved iPSC-based model of human brain endothelial cells [bulk RNA-seq]
GEO Series GSE296358. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Reconstruction of the Human Blood-Brain Barrier in vitro reveals a Pathogenic Mechanism of APOE4 in Pericytes
GEO Series GSE125869. Homo sapiens. 15 samples. Type: Expression profiling by high throughput sequencing.
Comparing the Effects of Taurine and 3-Sulfopropanoic Acid, a Metabolite of Tramiprosate, on ApoE4 Pathological Aggregation: Implications for Alzheimer's Disease
GEO Series GSE292774. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
Amelioration of Tau and ApoE4-linked glial lipid accumulation and neurodegeneration with an LXR agonist
GEO Series GSE242180. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
A ketogenic diet improves memory in females in the APOE4 mouse model of Alzheimer’s disease.
GEO Series GSE301153. Mus musculus. 20 samples. Type: Expression profiling by high throughput sequencing.
Differential gene expression in APOE3 and APOE4 gene targeted replacement mice
GEO Series GSE42930. Mus musculus. 10 samples. Type: Expression profiling by array.
Data set from the article Massaccesi L, Galliera E, Galimberti D, Fenoglio C, Arcaro M, Goi G, Barassi A, Corsi Romanelli MM. Lag-time in Alzheimer's disease patients: a potential plasmatic oxidative stress marker associated with ApoE4 isoform. Immun Ageing. 2019 Apr 1;16:7. doi: 10.1186/s12979-019-0147-x. PMID: 30984280; PMCID: PMC6444862.
<p>Data set from the article: Massaccesi L, Galliera E, Galimberti D, Fenoglio C, Arcaro M, Goi G, Barassi A, Corsi Romanelli MM. Lag-time in Alzheimer's disease patients: a potential plasmatic oxidative stress marker associated with ApoE4 isoform. Immun Ageing. 2019 Apr 1;16:7. doi: 10.1186/s12979-019-0147-x. PMID: 30984280; PMCID: PMC6444862.</p> <p>This is the astract:</p> <p>In the brain, Oxidative Stress (OS) contribute to structural and functional changes associated with vascular aging, such as endothelial dysfunction, extracellular matrix degradation, resulting in age-related reduced vasodilatation in response to agonists. For this reason, OS is considered a key factor in Alzheimer's Disease (AD) development and recent evidence correlated oxidative stress with vascular lesion in the pathogenesis of AD, but the mechanism still need to be fully clarified. The etiology of AD is still not completely understood and is influenced by several factors including Apolipoprotein E (ApoE) genotype. In particular, the Apo ε4 isoform is considered a risk factor for AD development. This study was aimed to evaluate the possible relationship between three plasmatic OS marker and Apo ε4 carrier status. Plasmatic soluble receptor for advanced glycation end products (sRAGE) levels, plasma antioxidant total defenses (by lag-time method) and plasmatic Reactive Oxygen species (ROS) levels were evaluated in 25 AD patients and in 30 matched controls. ROS were significantly higher while plasma antioxidant total defenses and sRAGE levels were significantly lower in AD patients compared to controls. In AD patients lag-time values show a significant positive linear correlation with sRAGE levels and a (even not significant) negative correlation with ROS levels. Lag-time is significantly lower in ε4 carrier (<em>N</em> = 13) than in ε4 non-carrier (<em>N</em> = 12). Our result confirms the substantial OS in AD. Lag-time levels showed a significant positive correlation with sRAGE levels and a significant association with ε4 carrier status suggesting that plasmatic lag-time evaluation can be considered as a potential useful OS risk marker in AD.</p> <p> </p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.