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606 results for “Bioactivation”
A Three-step Process to Isolate Large Quantities of Bioactive Sesquiterpene Lactones from Cichorium intybus L. Roots and Semi-synthesis of Chicory STLs Standards
<p>Supplementary Information:</p> <p>NMR spectra of DHLc, Lc, DHLc-Me-oxalate, Lc-Me-oxalate, DHLc-oxalate, Lc-oxalate, DHLc-glycoside; Figure S1: HPLC profiles (254 and 320 nm) of a water/methanol 50/50 and pure water extracts and different content in 3-CQA; Figure S2: Base peak chromatogram (BPC, All − MS) of a water chicory extract obtained in the positive mode; diagnostic fragment ions in the positive mode for DHLc-gly, DHLc-ox, DHLc, Lc-ox, Lc.</p>
Fig. 6 in Bioactive diterpenoids and sesquiterpenoids with different skeletons from Salvia digitaloides Diels
Fig. 6. The anti-inflammatory activity of compounds 1–11, 13 and 14 toward lipopolysaccharide (LPS)-stimulated rat macrophage NR8383 cells. (a) Cells were treated with compounds 1–11, 13 and 14 (100 μM) for 24 h. Cell viability was determined using the CCK-8 assay. (b) The cells were treated with LPS (40 μg/mL) and LPS (40 μg/mL) plus compounds 1 or 13 (100 μM) for 24 h. The TNF-α level was determined using an ELISA kit from R&D Systems (p <0.05).
Fig. 7 in Bioactive diterpenoids and sesquiterpenoids with different skeletons from Salvia digitaloides Diels
Fig. 7. (a) Neuroprotective effects of compounds 2, 4, and 13 on the C. elegans model. Representative fluorescence images showing the anterior dopaminergic neurons of the transgenic strain BZ555. The efficacy was expressed in terms of the brightness of green fluorescent protein (GFP) tagged to the dopaminergic neuronal soma and indicated by the difference in fluorescence between 6-OHDA- and compound 2,4,13,n-butylidenephthalide (positive control)-coexposed worms from the intact (blank reference) and 6-OHDA-treated (negative control) groups (n = 30–60). Mean fluorescence intensity of anterior dopaminergic neurons in BZ555 C. elegans. Data are presented as the means ± standard errors of the means (SEM). (****) p <0.0001. (b) Neuroprotective effects of compounds 3 and 14 on the C. elegans model. The experimental methods and observed indicators were the same as those in (a). Data are presented as the means ± standard errors of the means (SEM). (****) p <0.0001. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)
Fig. 6 in Eudesmane type sesquiterpenes from the rhizomes of Atractylodes macrocephala and their bioactivities
Fig. 6. (a) Effect of compound 1 on SCG-7901 cell growth (24 h), with IC50 value of 31.78 ± 0.23 μM. (b) Effects of compounds 1, 2, and 22 on LPS-induced IEC-6 cell proliferation. Values are presented as the mean ± SD for three individual experiments. ****p <0.0001 vs. control. **p <0.01 vs. control. ##p <0.01 vs. LPS. #p <0.05 vs. LPS.
Fig. 4. The X in Eudesmane type sesquiterpenes from the rhizomes of Atractylodes macrocephala and their bioactivities
Fig. 4. The X-ray ORTEP diagrams of compounds 3 (left), 4 (middle), and 12 (right). The thermal ellipsoid is scaled to 30% probability level.
Fig. 2. The 1 H– 1 H in Eudesmane type sesquiterpenes from the rhizomes of Atractylodes macrocephala and their bioactivities
Fig. 2. The 1 H– 1 H COSY (thick lines) and key HMBC correlations (pink arrows, from 1 H to 13C) of compounds 1–15. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)
Fig. 6 in Bioactive constituents from the leaves of Metapanax delavayi with anti-benign prostatic hyperplasia activities
Fig. 6. Molecular docking simulations obtained at the lowest energy conformation, highlighting potential hydrogen contacts of compound 1 with 5α-reductase (A) and COX-2 (B) proteins and finasteride with 5α-reductase (C) and COX-2 (D) proteins. (Coloured by atom: carbon is cyan; nitrogen is blue; oxygen is red; hydrogen is grey; sulfur is orange). For clarity, only interacting residues are labelled. Hydrogen bonding interactions are shown by dashes. These figures were created by PyMOL. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)
Fig. 5 in Bioactive constituents from the leaves of Metapanax delavayi with anti-benign prostatic hyperplasia activities
Fig. 5. The inhibitory effect of compounds 1–12 on the growth of BPH-1 cells (n = 3). *p <0.05, **p <0.01, and ***p <0.001 compared with 50 μM group; Finasteride was used as positive control.
Fig. 4 in Bioactive constituents from the leaves of Metapanax delavayi with anti-benign prostatic hyperplasia activities
Fig. 4. Calculated and experimental ECD spectra of compounds 1 (A), 2 (B), 4 (C), and 5 (D) in MeOH.
Fig. 6 in Bioactive pentacyclic triterpenoids from the whole plants of Pterocephalus hookeri
Fig. 6. The induced ECD spectra of 8 (upside: starting spectrum; downside: finally processed spectrum after subtracting the starting one).
Fig. 1. A in Bioactive terpenoids derived from plant endophytic fungi: An updated review (2011-2020)
Fig. 1. A) The proportions of terpenoids from endophytic fungi; B) the number of terpenoids reported in endophytic fungi; and, C) the most redundant endophytic fungi as terpeoid producers (2011–2020).
Fig. 4 in Bioactive prenylated phenolic compounds from the aerial parts of Glycyrrhiza uralensis
Fig. 4. The docking model and IC50 values of (1''R, 2''S)-1 and (1''S, 2''R)-1 against 3CLpro and PLpro. Each data point is displayed as the mean SD of three ± independent tests.
Fig. 3 in Bioactive prenylated phenolic compounds from the aerial parts of Glycyrrhiza uralensis
Fig. 3. The comparison of experimental and calculated ECD spectra of (1′′R, 2′′S)-1, (1′′S, 2′′R)-1, and 6.
Fig. 5 in Bioactive prenylated phenolic compounds from the aerial parts of Glycyrrhiza uralensis
Fig. 5. Bioactivity screening of compounds 1-26 [1a, (1''R, 2''S)-1; 1b, (1''S, 2''R)-1]. Each data point is displayed as the mean ± SD of three independent tests. ×: not tested.
Fig. 6 in Bioactive specialised metabolites from the endophytic fungus Xylaria sp. of Cudrania tricuspidata
Fig. 6. Inhibitory activity of compounds 1c and 8 against NO production in RAW 264.7 cells. Cells were tread with various concentrations of compounds along with LPS (1 μg/mL) for 24 h, and the accumulation of nitrite was evaluated by Griess reagent. Values were presented as mean ± SD from three independent experiments. **P <0.01, ***P <0.001. Column: relative NO level; Dot: cell viability. C: control.
Fig. 7 in Bioactive pentacyclic triterpenoids from the whole plants of Pterocephalus hookeri
Fig. 7. Inhibitory effects of 1 on the production of TNF-α and IL-6 in LPSinduced RAW264.7 macrophages. (**p <0.01 versus the control group treated with LPS only).
Fig. 4 in Isolation and structural elucidation of bioactive obovatol dimeric neolignans from the bark of Magnolia officinalis var. biloba
Fig. 4. Neuroprotective effects of racemate 1, (+)-1, ()-1, and 5 on glutamic acid-induced injury of SK-N-SH cells (10 μM, means ± SEM, n = 3). ***p <0.001, *p <0.05, **p <0.01. Positive controls: n-butylphthalide (NBP).
Fig. 13 in Non-volatile constituents from Monimiaceae, Siparunaceae and Atherospermataceae plant species and their bioactivities: An up-date covering 2000-2021
Fig. 13. Distribution of alkaloid-type isolated between 2000 and 2021 from different genera in the Monimiaceae (Hortonia, Mollinedia, Peumus, Tambourissa, Xymalos), Siparunaceae (Siparuna, Glossocalyx) and Atherospermataceae (Doryphora, Laureliopsis).
Fig. 12 in Non-volatile constituents from Monimiaceae, Siparunaceae and Atherospermataceae plant species and their bioactivities: An up-date covering 2000-2021
Fig. 12. Distribution of the non-volatile constituents isolated between 2000 and 2021 from different genera in the Monimiaceae (Hortonia, Mollinedia, Peumus, Tambourissa, Xymalos), Siparunaceae (Siparuna, Glossocalyx) and Atherospermataceae (Doryphora, Laureliopsis).
Fig. 2 in Non-volatile constituents from Monimiaceae, Siparunaceae and Atherospermataceae plant species and their bioactivities: An up-date covering 2000-2021
Fig. 2. Previously undescribed and known terpenoids isolated from Hortonia genus in the Monimiaceae family.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.